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위화(胃火) 1호(號)로 호전(好轉)된 만성위염(慢性胃炎) 환자(患者) 치험(治驗) 2례(例)
이경민,이세연,임성철,서정철,한상원,Lee, Kyung-min,Lee, Se-yun,Im, Sung-chul,Seo, Jung-chul,Han, Sang-won 대한침구의학회 2003 대한침구의학회지 Vol.20 No.6
Objective: This study was designed to investigate the effect of Wihwa herbal-acupuncture on chronic gastritis. Methods: Wihwa herbal-acupuncture was administered two times a week. The following points were selected: CV12(中脘), CV13(上脘), S36(足三里), Liv3(太衝). We checked pain rating score(P.R.S.), visual analogue scale (V.A.S.) and Gastroscopy. Results: After 6 weeks of treatment, the patient showed that clinical symtoms was disappeared, Lee's P.R.S. changed from 77 to 8 and Park's P.R.S. from 55 to 0 and gastric erosion disappeared on gastroscopy. Conclusions: These results suggest that and Wihwa herbal-acupuncture has good effect on chronic gastritis. But further studies are required to concretely prove the effectiveness of Wihwa herbal-acupuncture for treating chronic gastritis.
탈지분유 함유 식이를 섭취하는 흰쥐에서 칼슘과 비타민 D 수준이 무기질 대사에 미치는 영향
이경민,이연주,원은숙,이상선,Lee, Kyung-Min,Lee, Yeon Joo,Won, Eun-Sook,Lee, Sang Sun 한국식품영양학회 2014 韓國食品營養學會誌 Vol.27 No.4
The purpose of this study was to investigate the effect of calcium (Ca) and vitamin D (vit. D) levels on metabolism of various minerals such as Ca, P, Mg, Fe, Zn, Cu, and Cr. The comparison was made on the rats that were placed on diet containing powdered skim milk with different Ca and vit. D levels for 5 weeks. A total of 42 5-week-old Sprague-Dawley rats were divided into 7 groups as follows: Control group consisted of normal Ca and normal vit. D (0.5% Ca, 1,000 IU vit. D); Experimental groups were divided into low (0.25%) and high (1.0%) calcium levels; and vit. D group was divided into low (10 IU), normal (1,000 IU), and high (5,000 IU) subgroups. The weight gain and food efficiency ratios of the rats were not significantly different with increasing dietary Ca levels. The absorption rates of 7 minerals (Ca, P, Mg, Fe, Zn, Cu, and Cr) were significantly decreased with increasing dietary Ca levels. Also, fecal excretion of P significantly increased with increasing dietary vit. D levels (p<0.05), and urine excretion of Fe was significantly increased with increasing dietary vit. D levels (p<0.001). The result indicated that higher Ca intake affected on bioavailability of other minerals, due to interactions among minerals in the process of intestinal absorption. However, vitamin D intake had no effect on bioavailability of several minerals. Therefore, it could be suggested that adequate Ca intake is important for balance of the minerals.
이경민,권기록,최성모,김태희,Lee, Kyoung-Min,Kwon, Ki-Rok,Choi, Sung-Mo,Kim, Tae-Hee 대한약침학회 2002 Journal of pharmacopuncture Vol.5 No.1
Objective: It will be examined in this research whether Lacquer poison can be used as an distinguished treatment to cure incurable diseases by considering literature existing and various papers. Method: I studies origin, alias, species, toxicity, effect, treatment, component, medical action and contraindication of Rhus vemiciflua stokes through various kinds literatures. Results: Sap of Rhus vemiciflua stokes that is used for medical purposes, has an effect on anti-tumor, anti-oxidation, hangover cure, and gastritis suppression. Even though urushiol and fIavonoids, the main ingredient of lacquer, has medical cure effects. but urushiol results in a dermatropic allergy. Sincc xylem of a Rhus vemiciflua stokes, however. does not induce the allergy but has medical efficacy, research on this topic is needed.
이경민,김남주,Kyoung Min Lee,Nam Ju Kim 대한안과학회 2008 대한안과학회지 Vol.49 No.7
Purpose: To report one case of juvenile xanthogranuloma presenting as a unilateral nodule of the eyelid. Case summary: A 4-year-old girl presented with a solitary eyelid nodule. There were no other ophthalmologic problems. Excisional biopsy and simple wound closure were performed. A biopsy showed intense infiltration of histiocytes, lymphocytes, and multinucleated giant cells in the dermis, which was compatible with juvenile xanthograunuloma. Conclusion: Juvenile xanthogranuloma should be considered in the differential diagnosis of a solitary eyelid tumor. J Korean Ophthalmol Soc 49(7):1173-1176, 2008
The possibility of low isomerization of β-lapachone in the human body
이경민,권미리,Hae Won Lee,성숙진,Young-Ran Yoon 대한임상약리학회 2021 Translational and Clinical Pharmacology Vol.29 No.3
β-Lapachone has been reported to have anticancer and various other therapeutic effects, but is limited in clinical applications by its low bioavailability. pH-Dependent isomerization can be suggested as one plausible factor influencing its low bioavailability. Since it is known that β-lapachone is converted to its isomer, α-lapachone in hydrochloric acid (HCl) solution, isomerization in the human body may be driven by HCl in the gastric fluid. The purpose of this study was to evaluate the possibility of isomerization of β-lapachone in the human body. Chemical reactions were conducted using simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.5) at 37°C. β-Lapachone was observed in SGF at 37°C for 1 hour and SIF for 3 hours. In addition, biofluid analysis was performed on plasma samples 1 hour and 4 hours, and on urine sample 12 hours after oral administration of 100 mg MB12066, a synthetic β-lapachone, in healthy adult male. All samples were analyzed using liquid chromatography-tandem mass spectrometry. Only β-lapachone peaks existed in the spectra obtained from SGF and SIF. No isomerization of β-lapachone was observed in the analysis of any of the human samples. In the current study, the possibility of pH-dependent isomerization of β-lapachone in the human body was not confirmed.
새로운 Boosted 3-D PCA 기반 Head Pose Estimation 방법
이경민,인치호,Lee, Kyung-Min,Lin, Chi-Ho 한국인터넷방송통신학회 2021 한국인터넷방송통신학회 논문지 Vol.21 No.6
In this paper, we evaluate Boosted 3-D PCA as a Dataset and evaluate its performance. After that, we will analyze the network features and performance. In this paper, the learning was performed using the 300W-LP data set using the same learning method as Boosted 3-D PCA, and the evaluation was evaluated using the AFLW2000 data set. The results show that the performance is similar to that of the Boosted 3-D PCA paper. This performance result can be learned using the data set of face images freely than the existing Landmark-to-Pose method, so that the poses can be accurately predicted in real-world situations. Since the optimization of the set of key points is not independent, we confirmed the manual that can reduce the computation time. This analysis is expected to be a very important resource for improving the performance of network boosted 3-D PCA or applying it to various application domains. 본 논문에서는 Boosted 3-D PCA 방법을 데이터 세트로 평가하고 성능을 평가한다. 그런 다음 네트워크의 특징과 성능을 분석하겠습니다. 본 논문에서는 Boosted 3-D PCA 학습방법을 사용하여 300W-LP 데이터 학습을 수행했으며 AFLW2000 데이터 세트를 사용하여 평가를 평가했다. 결과는 이 성능 결과는 기존 랜드마크 대 포즈 방법보다 자유롭게 얼굴 이미지의 데이터 세트를 사용하여 학습할 수 있으므로 실제 상황에서 포즈를 정확하게 예측할 수 있다. 키포인트 세트의 최적화는 독립적이지 않기 때문에, 우리는 계산 시간을 줄일 방법을 확인했다. 이 방법은 Boosted 3-D PCA 성능을 향상시키거나 다양한 애플리케이션 도메인에 적용하는 데 매우 중요한 자원이 될 것으로 예상한다
Oligonucleotide chip를 이용한 홍화자약침액(紅花子藥鍼液)이 간암세포주(肝癌細胞柱)의 유전자(遺傳子) 발현(發顯)에 미치는 영향(影響)
이경민,임성철,정태영,서정철,한상원,Lee, Kyung-min,Lim, Seong-chul,Jung, Tae-young,Seo, Jung-chul,Han, Sang-won 대한침구의학회 2005 대한침구의학회지 Vol.22 No.3
Objective : It has long been known about the osteogenic effect of CTF-HAS on bone tissues. However, it has not been determined the effect of CTF-HAS on cancer cells. The purpose of this study is to screen the CTF-HAS mediated differentially expressed genes in cancer cells such as HepG2 hepatoma cells lines. Oligonucleotide microarray approach were employed to screen the differential expression genes. Methods : CTF-HAS was prepared by boiling and stored at $-70^{\circ}C$ until use. Cells were treated with various concentrations of CTF-HAS(0.1, 0.5, 1.5, 10, $20mg/m{\ell}$) for 24 h. Cytotoxicity was tested by MTT assay. To screen the differentially expressed genes in cancer cells, cells were treated with $1.5mg/m{\ell}$ of CTF-HAS. For oligonucleotide microarray assay, total RNA was used for gene expression analysis using oligonucleotide genechip (Human genome U133 Plus 2.0., Affimatrix Co.). ResuIts : It has no cytotoxic effects on HepG2 cells in all concentrations (0.1, 0.5, 1.5, 10, $20mg/m{\ell}$). More than twofold up-regulated genes were 19 genes. The number of more than twofold down-regulated genes was 13. Discussion : This study showed the screening of CTF-HAS mediated differentially regulated genes using combined approaches of oligonucleotide microarray. The screened genes will be used for the better understanding in therapeutic effect of CTF-HAS on cancer field.
한국인에게 플라세보 이침의 적용이 가능한가? - 단일검맹과 무작위배정법을 통한 플라세보 이침의 효과 -
이경민,이세연,김성웅,하일도,조건호,박히준,정태영,서정철,한상원,Lee, Kyung-min,Lee, Se-yun,Kim, Sung-woong,Ha, Il-do,Cho, Geon-ho,Park, Hi-joon,Jung, Tae-young,Seo, Jung-chul,Han, Sang-won 대한침구의학회 2003 대한침구의학회지 Vol.20 No.2
Objective : This study was designed to find out whether placebo auricular acupuncture is able to be constituted as an appropriate control group for needle insertion to Korean. Methods : We performed a randomized controlled, single-blind study(n=48) comparing subjective evaluations of needles insertion and avoidance of needles insertion. Both ears were needled concurrently, one real acupuncture(needle insertion) and the other placebo acupuncture(avoidance of needle insertion with blunt tip). Subjects then completed a questionnaire rating the intensity of five sensations in each ear, and also attempted to identity which ear received placebo and which ear received real acupuncture. Results : As for the effects of real and placebo acupuncture on each item(Warmth, Fullness, Pain, Activity, Radiating), real acupuncture was significantly warmer, fuller, more painful than placebo acupuncture. In particular, the real acupuncture only in experienced acupuncture recipients was significantly warmer, fuller, more painful than placebo acupuncture. About the ability to differentiate real and placebo acupuncture, 54.2 percent correctly identified which ear received real acupuncture and which ear received placebo acupuncture. However, the ability to differentiate real and placebo acupuncture for naive and experienced acupuncture recipients was not significantly different. Conclusions : Most of the subjects(Korean) identified which ear received placebo and which ear received real acupuncture. We found that this placebo auricular acupuncture is not able to be applied to Korean, in particular for experienced acupuncture recipients. Further study is needed for new placebo auricular acupuncture or racial difference between American.