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만성 증식성 캔디다증에서 hBD-2의 발현과 T 림프구 침윤에 관한 연구
윤대웅,조영아,김수진,윤혜정,홍성두,이재일,홍삼표 대한구강악안면병리학회 2012 대한구강악안면병리학회지 Vol.36 No.3
Chronic hyperplastic candidiasis (CHC) is characterized by epithelial hyperplasia of the oral mucosa associated with candidal hyphae. The immune status of host is one of the factors that induce clinically evident candidal infection. Host defense mechanisms include inflammatory cells, epithelial barrier, and antimicrobial peptides such as human beta 2 defensin (hBD-2). In the present study, we investigated the densities of CD4+/CD8+ T lymphocytes and hBD-2 expression of epithelial cells in CHC. Immunohistochemical staining was performed on 10 cases of CHC using CD4, CD8 and hBD-2. Ten specimens of chronic mucositis were selected for comparison, and went through the same examination. hBD-2 was expressed in the spinous cell layers and the keratin layers of 7 CHC patients, while the epithelium of chronic mucositis did not demonstrate the hBD-2 expression except for one case. Also, hBD-2 expression was stronger when the hyphae invaded the upper stratum spinosum (P =.019). However, the densities of CD8+ T lymphocytes were significantly lower in the CHC patients, suggesting that the ability of CD8+ T cells to enter the epithelium and target the pathogenic hyphae was decreased in CHC. Increased hBD-2 expression seemed to be significantly associated with the candidal infection, while not promoting the cell-mediated immune reaction in CHC.
빅데이터 분석 방법을 이용한 중학교 정보 교과서 핵심 개념 분석
윤대웅,최현종 한국창의정보문화학회 2019 창의정보문화연구 Vol.5 No.2
Big data is a field that has been utilized and developed in various fields in our society recently. Big data analysis techniques are frequently used to analyze various big data in various fields of politics, economy, and society to grasp various meanings hidden in the data. However, big data analysis is used some case studies of in fields of analysis of educational data, but analysis of the curriculum and direction is still inadequate. Therefore, this study aims to identify and analyze the core concepts of middle school informatics textbooks using big data analysis techniques. Text mining was used for big data analysis for informatics textbook analysis. Through the core concepts of middle school informatics textbooks identified using this techniques, we could confirm the concepts to be emphasized in the textbooks and the possibility of using big data in the field of education. 빅데이터는 최근 우리 사회에 다양한 분야에서 활용하고 발전하고 있는 분야이다. 정치, 경제, 사회의 각 분야에서 많은 자료를 분석하여 자료에 숨어 있는 다양한 의미를 파악하는 빅데이터 분석 기법이 자주 활용되고 있다. 하지만 교육이라는 부분에 있어서 빅데이터는 단순한 분석 등에 활용하기는 하지만 교육과정과 방향에 대한 분석은 아직 미비한 실정이다. 이에 본 연구에서는 빅데이터 분석 기법을 활용하여 중학교 정보 교과서의 핵심 개념을 파악하여 분석하고자 한다. 정보 교과서 분석을 위한 빅데이터 분석법은 텍스트 마이닝을 사용하였다. 이 프로그램을 활용하여 파악된 중학교 정보 교과서의 핵심 개념들을 통해 교과서에서 강조하고자 하는 개념을 확인할 수 있었고, 교육 분야에서도 빅데이터 활용 가능성을 확인할 수 있었다.
만성 증식성 캔디다증에서 hBD-2의 발현과 T 림프구 침윤에 관한 연구
윤대웅,조영아,김수진,윤혜정,홍성두,이재일,홍삼표 대한구강악안면병리학회 2012 대한구강악안면병리학회지 Vol.36 No.3
Chronic hyperplastic candidiasis (CHC) is characterized by epithelial hyperplasia of the oral mucosa associated with candidal hyphae. The immune status of host is one of the factors that induce clinically evident candidal infection. Host defense mechanisms include inflammatory cells, epithelial barrier, and antimicrobial peptides such as human beta 2 defensin (hBD-2). In the present study, we investigated the densities of CD4+/CD8+ T lymphocytes and hBD-2 expression of epithelial cells in CHC. Immunohistochemical staining was performed on 10 cases of CHC using CD4, CD8 and hBD-2. Ten specimens of chronic mucositis were selected for comparison, and went through the same examination. hBD-2 was expressed in the spinous cell layers and the keratin layers of 7 CHC patients, while the epithelium of chronic mucositis did not demonstrate the hBD-2 expression except for one case. Also, hBD-2 expression was stronger when the hyphae invaded the upper stratum spinosum (P =.019). However, the densities of CD8+ T lymphocytes were significantly lower in the CHC patients, suggesting that the ability of CD8+ T cells to enter the epithelium and target the pathogenic hyphae was decreased in CHC. Increased hBD-2 expression seemed to be significantly associated with the candidal infection, while not promoting the cell-mediated immune reaction in CHC.