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경직형 뇌성마비아동의 마사지 프로그램 적용이 근력, 관절가동범위 및 일상생활활동에 미치는 효과
유인우,서동기,김수현,임준오,이정원,박기대,김진아,Yu, In-Woo,Seo, Dong-Gi,Kim, Soo-Hyun,Im, Jun-Oh,Lee, Jeong-Won,Bak, Ki-Dae,Kim, Jin-A 한국임상보건과학회 2016 한국임상보건과학회지 Vol.4 No.1
Purpose. The purpose of this study was to determine the effect of massage program on muscle strength (MMT), range of motion (ROM) and activities of daily living (ADL) in children with spastic cerebral palsy. Methods. The child welfare center of J city were measurement goniometer by range of motion and evaluation of activities of daily living scale and muscle strength scale. The massage program was applicated with 40 min, 2 times per a week and total 8 weeks. Massage program constituted surface of effleurage, petrisage, deep part of effleurage, friction in regular sequence. Result. For muscle strengths were significantly differenced after 8 weeks. For range of motion were dose dependent increased different two groups. And activities of daily living scale were significantly difference between massage group and non-massage group. Conclusion. In this study, the therapeutic massage program showed a positive effect for muscle strength, range of motion and activities of daily living in spastic cerebral palsy.
글루포시네이트암모늄(glufosinate ammonium, BASTA ® ) 중독 후 발생한 뇌병증
김재환,유인우,김용덕,나상준,이기욱,윤보라 대한신경과학회 2014 대한신경과학회지 Vol.32 No.2
Glufosinate ammonium is the active ingredient in broad-spectrum contact herbicides such as BASTAⓇthat inhibits theactivity of glutamine synthetase, which is necessary for the production of the amino acid glutamine and for ammoniadetoxification. Complications of glufosinate ammonium intoxication include gastrointestinal symptoms, loss of consciousness,convulsions, memory impairment, respiratory failure, and cardiovascular instability. We report herein a case encephalopathy and reversible signal changes in the splenium of the corpus callosum, the bilateral corticospinal tracts,the hippocampi, and the cerebellar peduncles as seen in diffusion-weighted magnetic resonance imaging andfluid-attenuated inversion recovery images following BASTAⓇintoxication.
Tetramethylpyrazine이 LPS의 뇌실주입에 따른 생쥐 뇌조직의 Pro-Inflammatory Cytokines 발현에 미치는 영향
최용석 ( Yong Seok Choi ),원종우 ( Jong Woo Won ),유인우 ( In Woo Yoo ),신정원 ( Jung Won Shin ),김성준 ( Seong Joon Kim ),손낙원 ( Nak Won Sohn ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.1
Objectives : Tetramethylpyrazine (TMP) is an active ingredient in Ligusticum wallichii and has a wide range of neuroprotection effects. This study investigated anti-neuroinflammatory effect of TMP on brain regions in intracerebroventricular (i.c.v.) lipopolysaccharide (LPS)-treated C57BL/6 mice, Methods : TMP was administered intraperitoneally at doses of 10, 20, and 30 mg/kg at 1 h prior to LPS (3 mg/kg) i.c.v. injection. mRNA level of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF- α), interleukin (IL)-1β and IL-6, was measured in the cerebral cortex, hippocampus, and hypothalamus tissue using real-time polymerase chain reaction at 24 h after the LPS injection. Cyclooxygenase-2 (COX-2) positive cells in the hypothalamus was also observed using immunohistochemistry at 24 h after the LPS injection, Results : At a dose of 30 mg/kg TMP significantly attenuated up-regulation of TNF-α and IL-1β mRNA in the cerebral cortex and IL-1β mRNA in the hippocampus. In the hypothalamus, doses of 20 mg/kg and 30 mg/kg TMP significantly attenuated up-regulation of TNF-α, IL-1β, and IL-6 mRNA induced by the LPS injection. In addition, TMP (30 mg/kg) significantly reduced the number of COX-2 positive cells in the hypothalamus, Conclusion : These results indicate that TMP has an anti-inflammatory effect on neuroinflammation, especially in the hypothalamus, induced by LPS i.c.v. injection and suggest that TMP-containing Ligusticum wallichii may play a modulatory role on the systemic responses following hypothalamic inflammation.