치은에 발생한 평활근육종 1예

왕종환,강우석,박정제,남순열 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.11

Leiomyosarcoma is a malignant mesenchymal tumor that is relatively common in the uterus, the gastrointestinal tract, and the retroperitoneum. Only 3 to 10% of leiomyosarcomas arise in the head and neck. A review of the English-language literature since 1908 revealed 11 cases of primary and one case of metastatic leiomyosarcoma of the gingiva. We report on a case of leiomyosarcoma that arose in a 34-year old male, affecting the mandibular gingiva.

성대 양성 병변 환자의 후두 미세 수술 전후 음성장애지수와음성음향학적 분석 통한 결과 비교

왕종환,박수경,이석기,최승호,김상윤,남순열 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.3

포도구균장독소에 의한 기도상피세포에서의 Rhinovirus 복제 증가

장용주,왕종환,권현자,정유삼,이봉재 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.11

Background and Objectives:The toxins generated from Staphylococcus aureus, Staphylococcal enterotoxin A (SEA) and B(SEB), are reported to have an important role in the pathogenesis of chronic rhinosinusitis. As a basic step for elucidating the pathophysiologicresponses of the nasal mucosa of chronic rhinosinusitis associated with rhinovirus infection, this study investigated theeffect of SEA and SEB on rhinovirus infection in A549 cells. Materials and Method:The effect of SEA and SEB on the rhinovirus-induced changes in intercellular adhesion molecule-1 (ICAM-1) expression was assessed by flow cytometry. The effect ofstaphylococcal toxins on the rhinovirus-induced cytokine secretion was measured by ELISA. The effect of the replication of rhinovirusin the cells was examined by viral culture with subsequent determination of viral titer. Results:ICAM-1 expression wasincreased in the rhinovirus infection group. Cytokine secretion was also increased in the rhinovirus infection group. But there wasno additional increase due to staphylococcal toxins regarding the ICAM-1 expression and cytokine secretions. Staphylococcal toxinsincreased viral titer in proportion to toxin concentrations. Conclusion:SEA and SEB increased rhinoviral replication in airwayepithelial cells. This result shows that airway epithelial cells with chronic rhinosinusitis are more favorable environments for rhinovirusinfection. (Korean J Otolaryngol 2006;49:1071-6)

코폴립점막과 접형동점막의 장기배양모델에서 리노바이러스 감염율과 시토카인 분비의 차이

장용주,왕종환,권현자,정유삼,이봉재 대한비과학회 2006 Journal of rhinology Vol.13 No.2

Background and Objectives:Human rhinovirus (HRV) infection is the primary cause of the common cold. It was often reported that the frequency of viral rhinitis is higher among patients with chronic rhinosinusitis with nasal polyposis (CRS/ NP) than normal subjects. And, patients with nasal polyps often complain that they suffer from a relatively severe degree of URI. The purpose of this article was to evaluate whether the HRV infection rate and virus-induced cytokine secretion is different between the organ culture model of the nasal polyp mucosae and the sinus mcuosae. Materials and Methods:Organ cultures of nasal polyps from sixteen CRS/NP patients and normal sphenoid sinus mucosae from nineteen patients who underwent the trans-sphenoidal pituitary surgery were tested. The successful viral infection by HRV-16 was determined by seminested reverse transcription-PCR. Immunoreactive IL-6 and IL-8 were quantitated using the ELISA. Results:A PCR product indicating the successful RV infection was detected in nine of sixteen (56.3%) polyp samples and eleven of nineteen (57.9%) normal sphenoid sinus samples were tested positive for HRV-16. Rhinovirus infection increased the IL-6 and IL-8 secretion to 236% and 173% in polyp samples and to 231% and 145% in sphenoid mucosa samples respectively. However, there was no significant difference in rhinovirus infection rate and in the rhinovirus-induced IL-6 and IL-8 secretion between the groups. Conclusion:The results of this study may suggest that the nasal polyp mucosae, when compared with normal sinus mucosae, did not show more vulnerability to HRV infection nor more intense cytokine response by HRV infection.

노인 환자에서의 음성학적 특성

배기훈,왕종환,최승호,김상윤,남순열,Pae Ki Hoon,Wang Jong Hwan,Choi Seong-Ho,Kim Sang Yoon,Nam Soon Yuhl 대한후두음성언어의학회 2005 대한후두음성언어의학회지 Vol.16 No.2

Summary: This study evaluated the relationship between voice complaint and deviant vocal fold status with special regard to presbylarynx, in patients aged more than 60 years with pharyngeal-laryngeal complaint. The material consisted of clinical histories and images obtained by laryngoscopies of 75 patients aged more than 60 years, who had sought otorhinolaryngologic treatment. Indicative glottic characteristics of the presbylarynx, such as vocal fold bowing(VFB), prominence of vocal processes (PVP), and membranous spindle shaped glottic chink(MSC) and the presence or absence of voice complaint were analyzed Also, acoustic parameters such as fundamental frequency(Fo), jitter percent and shimmer percent were analyzed. VFB showed a strong correlation with voice complaint in male. Jitter and shimmer were correlated with VFB, PVP, MSC in female.

한국인 폐쇄성수면무호흡증 환자들의 자동적정 비강기도 양압기 사용의 순응도

정유삼,왕종환,김영란,장용주,이봉재 대한비과학회 2006 Journal of rhinology Vol.13 No.2

Background and Objectives:Continuous Positive Airway Pressure (CPAP) is generally effective in correcting sleep-related respiratory disturbance in Obstructive Sleep Apnea Syndrome (OSAS). But the failure to comply with this treatment poses a serious limitation to its use. The aim of this study is to investigate the state of compliance and the cause of noncompliance of auto-adjusting positive airway pressure (autoPAP) treatment in Korean OSAS patients. Materials and Methods:This study performed a survey of 45 patients who had selected the autoPAP treatment between August 2000 and May 2003. Results: Twelve of the 45 patients (26.7%) refused the autoPAP treatment immediately after the first trial due to claustrophobia. Also, twenty patients (44.4%) stopped using it within 1 month. Only 13 patients (28.9%) continued to use it for more than 1 month. Twenty seven of the 33 patients (81.8%) who had used the autoPAP complained of claustrophobia after the first trial. The major factors of low compliance were claustrophobia, restricted body position while asleep, nasal symptoms, high cost, and inadequate education of patients. Conclusion:This study shows that claustrophobia is a major cause for the noncompliance of autoPAP. It also shows that the patients are encouraged by the effectiveness of the autoPAP to use it for a longer period. Therefore, we should focus on explaining the effects and drawbacks of autoPAP, desensitization and behavioral modification.

Excision of a Nasal Dermoid Sinus Cyst via Open Rhinoplasty Approach and Primary Reconstruction Using Tutoplast-Processed Fascia Lata

김지희,왕종환,장용주 대한이비인후과학회 2010 Clinical and Experimental Otorhinolaryngology Vol.3 No.1

Nasal dermoid sinus cysts are the most common congenital midline nasal lesion, accounting for 1% to 3% of all dermoid cysts, and 4% to 12% of all head and neck dermoids. Selection of the appropriate reconstruction technique, after dermoid resection, is important for treatment. Here we describe the successful management of a case with a nasal dermoid sinus cyst using an open rhinoplasty approach, and primary reconstruction using Tutoplast-processed fascia lata and crushed septal cartilage.

상악동 저류낭종에 대한 장기적인 추적 관찰

최선명,왕종환,정유삼,장용주,이봉재 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.7

흡연이 비용종 상피세포와 섬유아세포에서 MMP-9, TIMP-1, VEGF의 발현에 미치는 영향

안윤숙,김준모,왕종환,장용주 대한비과학회 2009 Journal of rhinology Vol.16 No.2

Background and Objectives:It has been known that MMP-9, TIMP-1, and VEGF play an important role in the formation of nasal polyps (NPs). The aim of this study is to investigate the effect of smoking on the expression of MMP-9, TIMP-1 and VEGF in the epithelial cells and fibroblasts of NPs. Materials and Methods:The epithelial cells and fibroblasts of NPs obtained from 10 patients who underwent endoscopic sinus surgery were cultured and used. The prepared CSE concentrations were 5%, 1%, 0.5% and 0.1%. In the control group, cells were cultured for 9 hours in the media containing 1 ml of AEGM and DMEM/F-12K. In the CSE group, cells were treated with 5%, 1%, 0.5% and 0.1% CSE for 9 hours. After washing with PBS, cells were cultured in medium for 24 hours. ELISA was performed to measure the secretion of MMP-9, TIMP-1 and VEGF proteins and real-time PCR was performed to assay their mRNAs. Results:The production of MMP-9, TIMP-1 and VEGF proteins did not change significantly in comparison with the control group in epithelial cells and fibroblasts after exposure to CSE. Conclusion:These results suggest that CSE does not appear to have an effect on the expression of MMP-9, TIMP-1 and VEGF for developing and growth of nasal polyposis. Background and Objectives:It has been known that MMP-9, TIMP-1, and VEGF play an important role in the formation of nasal polyps (NPs). The aim of this study is to investigate the effect of smoking on the expression of MMP-9, TIMP-1 and VEGF in the epithelial cells and fibroblasts of NPs. Materials and Methods:The epithelial cells and fibroblasts of NPs obtained from 10 patients who underwent endoscopic sinus surgery were cultured and used. The prepared CSE concentrations were 5%, 1%, 0.5% and 0.1%. In the control group, cells were cultured for 9 hours in the media containing 1 ml of AEGM and DMEM/F-12K. In the CSE group, cells were treated with 5%, 1%, 0.5% and 0.1% CSE for 9 hours. After washing with PBS, cells were cultured in medium for 24 hours. ELISA was performed to measure the secretion of MMP-9, TIMP-1 and VEGF proteins and real-time PCR was performed to assay their mRNAs. Results:The production of MMP-9, TIMP-1 and VEGF proteins did not change significantly in comparison with the control group in epithelial cells and fibroblasts after exposure to CSE. Conclusion:These results suggest that CSE does not appear to have an effect on the expression of MMP-9, TIMP-1 and VEGF for developing and growth of nasal polyposis.

부비동비강미분화암 1예

안윤숙,김선아,왕종환,이봉재 대한이비인후과학회 부산,울산,경남 지부회 2009 임상이비인후과 Vol.20 No.1

Sinonasal undifferentiated carcinoma (SNUC) is an uncommon, highly aggressive malignancy arising in the nasal cavity or paranasal sinuses that carries a poor prognosis despite a multimodality treatment approach. Since its recognition, different treatment regimens including combined radical resection, radiotherapy, and chemotherapy have been recommended. We have experienced a tumor that developed in the upper nasal cavity including the olfactory cleft and ethmoid sinus. Based on the location of tumor development, we initially diagnosed olfactory neuroblastoma, and its biopsy results reported the tumor to be sinonasal undifferentiated carcinoma. The tumor was completely removed through craniofacial resection. The patient underwent chemotherapy and radiation therapy and was asymptomatic at 12-month follow-up. We herein report a case of sinonasal undifferentiated carcinoma with a brief review of the literature in order to alert other clinicians to this rare tumor and to expedite appropriate management. (J Clinical Otolaryngol 2009;20:100-105)