종축 흑색조 양상을 보인 조갑하 Bowen 병

오용섭(Yong Sub Oh),홍진호(Jin Ho Hong),계영철(Young Chul Kye),오칠환(Chil Hwan Oh) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.3

Bowens disease is an intraepithelial squamous cell carcinoma. It occur s anywhere on the surface of the body. Bowens disease involving the nail bed epithelium is very rate. Recently, some literatures showed that human papillomavirus is sssociated with squamous cell carcinoma of the finger by in situ hybridization or polymerase chain reaction. A 30-year-old housewife deve]oped longitudinal melanonychia with as imptomatic fissured nail plate on her right third finger. The hiat,ologic specimen showed diffuse anaplastic change confined to the nail bed epithelium. The subungual eyithelium was found to contain human papillomavirus DNA type 31/33/35 with the use of in situ hybridization. (Kor J Dermatol 1994; 32(3): 514-517)

항암 화학 요법과 관련된 피부 변화의 임상적 고찰

오용섭(Yong Sub Oh),홍승현(Seong Hyun Hong),계영철(Young Chul Kye),김준석(Jun Seok Kim),오칠환(Chil Hwan Oh) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.3

Background : Recently, inireaing numbers of chemotherapeutic agens are being used to treat cancer patients. Mucocutaeous complications are commonly sen in association with the administration of these medicaticins. Objective : We conducted a study in cancer chemotherapy patient so determine the suspected chemotherapeutic agents ancl frequency of various mucocutaneous side effects in these patients. Methods : The study involved 140 patients admitted from Decerrae 1993 to September 1994 for cancer chemot herapy at Korea University Guro Hospital. Results : The mucocutaneous side effects during chemotherapy were alopecia(55%), hyperpig mentation(32.9%), stomatitis(20%), phlebitis(12.9%), flushing(8.6%) descending order. Visual grade II, IV alopecia patients were most common, but as the chemot retpy cycle increased so, the severer the alopecia. Although the onset of the alopecia were variake many patients experienced alopcia within 17 to 24 days after the start of chemotherapy. Serpeitie supravenous fluorouracil hyperpigmentation were commor,(17.9%), Diffuse and longitudinal or horizontal band like nail pigmentation were observed, and, pigmented macules were also observei, epecially on the palms and digits. Stomatitis usually developed within 10 days after the start of chemotherapy and it persist ed for about 7 days and the most of the lesions were resolved spor Laeously. Other clinical manifestations accompanied with chmotherapy were tinea infection(16.4%), acne(7.1%), oral thrush (7%), white nail band(4.3%), pruritus(2.9%) in descending order. Conclusion : So, physiciars need to be aware of the widely divergnal cutaneous reactions which may occur with the use of antiancer medications. (Kor JDermatol 1995;33(3): 474-481)

Sodium Fusidate ( FucidinR 연고 ) 에 의하여 발생한 접촉 피부염 2예

김종혁(Chong Hyeok Kim),오용섭(Yong Sub Oh),홍승현(Seung Hyun Hong),계영철(Young Chul Kye),문기찬(Kee Chan Moon) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.6

Sodium fusidate, obtained by fermentation of the fungus, Fusidium coccineum, has a steroid structure and shows a very high antitaphycoccal activity. The allergic potentirl of sodium fusidate is low and few cases of contact allergy to sodium fusidate have been reported. We present two cases of allergic contact dermatitis to Fucidin cintentione developed postoperative dressing of a skin biopsy and the other after laser treatment of a vascular nevi. The patch test results showed positive reaction to sodium fusidate in both cases. (Kor J Dermatol 1993;31(6):944-947)

영상분석법을 이용한 비만세포의 정량적 연구

김일환 ( Il Hwan Kim ),오용섭 ( Yong Sub Oh ),홍진호 ( Jin Ho Hong ),송해준 ( Hae Jun Song ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2

Background: The presence of mast cells often in increased numbers, has been noted in various cutaneous disorders. Recent studies suggest that mast cells are of primary importance in these conditions and their presence does not merely represent a second event. Previous reports of mast cell enumeration in normal and pathologic tissues have revealed inconsistent results, reflecting technical difficulties in quantitation. Objective : The purpose of our study is to develop a new approach for quantifying mast cell in tissue section that is accurate, reproducible and avoids problems caused by the variation in distribution of these cells in the tissue. Methods : Mast. cells were quantitated in eight cases of mastocytosis and in the flank and back skin of three normal human controls in toluidine blue stain using a computerized image analysis system. Results : Macular and nodular mastocytosis patients had from twenty-fold to nearly a 100-fold greater mast cell content than was observed in normal skin. Conclusion : Image analysis in conjunction with toluidine blue stain offers a single and accurate method for mast cell quantification. This technique also provides a practical and important new diagnostic tool for establishing the presence of increased lesional skin mast cells in patients with mastocytosis. (Kor J Dermatol 1996;34(2): 194-198)

연성 섬유종의 임상적 특징 및 연성 섬유종과 대장용종간의 연관성

조호연 ( Ho Youn Jo ),오용섭 ( Yong Sub Oh ),홍진호 ( Jin Ho Hong ),김재선 ( Jae Sun Kim ),최현철 ( Hyun Chul Choi ),송해준 ( Hae Jun Song ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6

Background : Skin tags are benign fleshy or darker colored papillomatous dermal tumors locatei mostly in the neck, axill or groin. Recent reports on a possible association between skin tags and colonic polyps, however, caused interest in these henign tumors of the dermis, especially wite regarding to their frequercy. Objective : The purpose rate this study was to explore the clinical profiles of skin tags, the effect of obesity on the frequeny of skin tags and the association between skin tags and obesity in the normal population. We also tried to evaluate the usefulness of skin tags as a general marker for the presence of colonic piyps. Methods : The first, 524 unselected patients were examined. The patient material comprised of 240 males and 284 females. Each patient was inspected with regard to skin tags by a clermatolgist. 334 patients were classified into obese groups and nonobese groups and then we evaluated the relationship between skin tags and the degree of obesity. The second, ninety consecutive patients referred for coloniscopic evaluation were examined to determine the association between skin tags and colonic polps. Results : We found 22.9% of the males and 22.5% of the females to be skin tag carriers in the general population. We also noticed a steady increase of the frequency according to age eccept for the third decads. Of the skin tags found 51% were in the axillar region, 40% around the neck and 8% in the inguinal region. In the study for the relationship between skin tags and obesity, 44.9% of the obise patients and 23% of the nonobese patients were skin tag carriers(relative risk=1.95, p<0.05). In the study for the association between skin tags and colonic polyps in patients undergoing colonoscopic examination, 18 of patients with skin tags(45%) hnd colonic polyps and 11 of patients without skin tags(22%) had colonic polyps(relative risk=2.05, p<0.05). Conclusion : This study identified an obese group that are at risk of the developing skin tags. Consideration of skin tags as a marker for colonic polyps is likely to prove helpful. (Kor J Dermatol 1995;33(6): 1075-1078)

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.