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양성전립선비대증 증상 조절을 위해 투여되는 알파차단제의 골절위헙
이중엽,최남경,정선영,김예지,성종미,오승준,박병주,Lee, Joong-Yub,Choi, Nam-Kyoung,Jung, Sun-Young,Kim, Ye-Jee,Seong, Jong-Mi,Oh, Seung-June,Park, Byung-Joo 대한예방의학회 2009 예방의학회지 Vol.42 No.3
Objectives : We evaluated the risk of fracture associated with hypotension-related adverse drug reaction caused by taking alpha blockers to treat benign prostatic hyperplasia (BPH). Methods : We used the Health Insurance Review and Assessment Service database from January 1st 2005 to June 30th 2006 for this study. The male patients with BPH and who had a prescription for alpha blockers following any fractures were defined as the cases. We set the 20 day long hazard period prior to the index date and the four control periods whose lengths were same with hazard period. After 1:4 matching of the hazard and control periods, conditional logistic regression was used to calculate the odds ratios for the risk of fractures as related to the alpha blocker exposure. Results : Doxazosin and tamsulosin showed the increased risk of fractures, whereas terazosin did not. After stratification using the defined daily doses, a protective effect was shown for the patients who took terazosin at the doses lower than 0.4 DDD and the hazardous effect at the doses higher than or equal to 0.4 DDD. There was no significant difference for the risk of patients taking tamsulosin at the doses higher than 1.0 DDD but there was a statistically significant increase in the risk at the doses higher than or equal to 1.0 DDD. Conclusions : Alpha blockers for BPH may increase the risk of fracture in elderly patients who have comorbidities and take the concomitant medications. Alpha blockers need to be prescribed with caution, although some have high prostate specificity.
새로운 심근관류 영상 화합물로서 99mTc - Ethyl - 3 - Isocyanobutyrate의 합성 , 표지 및 체내동태에 대한 연구
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),임상무(Sang Moo Lim),이경한(Kyung Han Lee),정재민(Jae Min Jeong),조정혁(Jung Hyuck Cho),오승준(Seung Joon Oh),정수욱(Soo Wook Chung) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2
N/A Technetium labeled isonitrile analogues are widely used as myocardial perfusion imaging agents. We synthesized and characterized a new isonitrile compound, ethyl 3-isocyanobutyrate (EIB). Proton and 13C NMR spectroscopy and thin layer chromatography with a C18 coat was performed. EIB was easily labeled with 99mTcO4-with sodium dithionite. The labeling efficiency measured by RP-HPLC was over 95%. The labeled product was stable with dilution in normal saline and with prolonged incubation at room temperature. There was no formation of secondary products or free 99mTcO4. In vivo kinetics study of Tc-99m(I) labeled EIB in rabbits showed adequate myocardial uptake, good contrast against lung background, and relatively rapid liver clearance. The heart to lung ratio was over 2.5 and the heart to liver ratio was approximately from 0.4 to 5 at 60 minutes post injection. Hepatic clearance of Tc-99m-MIBI was faster (t1/2,=6 minutes) than that of Tc-99m-MIBI. In vivo kinetics observed in dog was similar to that in rabbit but there was faster gallbladder filling, and thus lower liver background. SPECT imaging of the canine myocardium showed favorable imaging characteristics. However, biodistribution in mice demonstrated a myocardial % injected dose/organ of less than 0.1%. This was thought to be due to interspecies difference in plasma esterase activity. In human plasma, Tc-99m(I) labeled EIB was stable for at least 2 hours, without production of secondary products by HPLC. We conclude that ethyl 3-isocyanobutyrate may be a potential new myocardial perfusion imaging agent and deserves further investigation as to its usefulness for clinical use.
뇌혈류 영상용 방사성의약품 PRODD의 99mTc 표지 및 생체내분포
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),정재민(Jae Min Jeong),조정혁(Jung Hyuck Cho),오승준(Seung Joon Oh),정수욱(Soo Wook Chung) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.3
N/A Tc-99m labeled PnAO(propylene amine oxime) derivatives have been widely studied as brain perfusion agents. We synthesized and characterized a PnAO derivative, (RR/SS/meso)-4,8-diaza- 3,9,dimethylundecane-2,l0-dione bisoxime(PRODD). Proton-NMR spectroscopy and thin layer chromatography(silence gel) were performed for its characterization PRODD was 1abeled with Tc- 99m using stannous chloride as reducing agent. The labeling efficiency was determined to be about 85%. Brain uptakes of 4.16±0.42 %ID/g and 3.24±0.13 %ID/g were found after l0min and 30min after intravenous injection. Brain-to-blood ratios were 1.17 and 0.75 at 10 and 30 minutes, which were lower than 1.3 and 1.9 of the ratios with commercial Tc-99m-HMPAO. Autoradiographs of rat brain sections showed the gray matter to white matter ratios of 1.13±0.10 at 30 min after intravenous injection, which was lower than 1.94±0.19 of commercial Tc-99m-HMPAO. With the above findings, we concluded that the lipophilic Tc-99m-PRODD complex was able to cross the blood-brain barrier, however the complex showed lower uptake than Tc-99m-HMPAO in mouse or rat brains. We Could suggest possibility that PRODD could be used as another Tc-99m chelator.
Dione Bisoxime 계통의 화합물에 대한 테크네슘표지 원리에 관한 연구
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),이경한(Kyung Han Lee),정재민(Jae Min Jeong),곽철은(Cheol Eun Kwark),오승준(Seung Joon Oh),정수욱(Soo Wook Chung),조정혁(Jung Hyuk Cho) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.1
N/A Tc-99m Labeled hexamethylenepropyleneamineoxime ([Tc-99m-HAMPAO) is a famous amine -oxime compound and is widely used to construct SPECT images of cerebral blood flow. To investigate the relationship between chemical structure and radiolabeling in these kind of diamine -oxime compounds, we synthesized seven compounds by Schiff's base formation and successive reduction with sodium borohydride. They wese (RR/SS)-4,8-diaza-3,6,6,9-tetramethylundecane- 2,10-dione bisoxime (2), (RR/SS/meso)-4,8-diaza-3,9-dimethy-lundecane-2,10-dione bisoxime (4), (RR/SS/meso)-4,8-diaza-3,10-dimethyldodecane-2,11-dione bisoxime (6), (RR/SS/meso)-4,7-diaza- 3,6,6,8-tetramethyldecane-2,9-dione bisoxime (8), (RR/SS/meso)-4,7-diaza-5,6-cyclohexyl-3,8-dime- thyldecane-2,9-dione bisoxime(10),(RR/SS/meso)-3,4-bis (l-aza-2-methyl-3-oxime-l-butyl)-benzoic acid (12), and (RR/SS/meso)-2,3-bis(1-aza-2-methyl-3-oxime-l-butyl) benzophenone (14). Chem- ical structures of al1 the synthesized compounds were identified by taking 1H spectrum. Among them, 2 and 4 are propyleneamine oxime(PnAO), 6 is butyleneamine oxime(BnAO) and 8, 10, 12 and 14 are ethyleneamine oxime (EnAO), Each compound (0.5 mg) was incubated with stannous chloride(0.5 g - 8 g), carbonate-bicarbonate buffer (final concentration = 0.1 M, pH7 - pH 10 ) and Tc-9mm- pertechenate ( 1 ml). Tc-99m labeling of these compounds were checked by ITLC (acetone), ITLC (normal saline), reverse phase TLC (50% acetonitrile) and ITLC (ethyl acetate). According to the results, EnAO's were not labeled by Tc-99m in any of above condition. About 11 % of maximum labeling efficiency was obtained with BnAO. However, 4 (PnAO) was labeled with Tc-99m to 85 % which is similar to the labeling efficiency of 2 (HMPAO). Hydrophilic impurity (9 %) was the most significant problem with the labeling of 4, however, pertechnetate (3 %) and colloid (3 %) were minor problem. In conclusion, we synthesized seven diamine bisoxime compounds, Among them, four EnAO compounds were not labeled by Tc-99m. A BnAO was labeled poor.
정위 인공방광대체술 및 방광확대술 후 발생한 심한 고염소혈증 대사성 산증 2예
이한규 ( Han Kyu Lee ),선휘경 ( Hui Kyuoung Sun ),김동기 ( Dong Ki Kim ),오국환 ( Kook Hwan Oh ),김연수 ( Yon Su Kim ),안규리 ( Cu Rie Ahn ),한진석 ( Jin Suk Han ),김성권 ( Sunhn Gwon Kim ),곽철 ( Cheol Kwak ),오승준 ( Seung June 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.5
The use of intestinal segments in the reconstruction and plasty of urinary bladder for malignant or nonmalignant conditions is widely accepted. Metabolic derangements including hyperchloremic metabolic acidosis and malabsorption of lipid may occur after surgery. Main pathophysiology of hyperchloremic metabolic acidosis is the exchange of urinary chloride with luminal bicarbonate and duration of urine in contact with the intestinal mucosa can affect the severity of metabolic acidosis. We experienced two cases of severe hyperchloremic metabolic acidosis which developed in patients with chronic kidney disease, urinary tract infection and orthotopic neobladder or augmentation enterocystoplasty for the treatment of bladder cancer and neurogenic bladder, respectively.