마취 전 금식된 소아에서 주술기 동안 투여된 수액과 혈당치의 관계

양정우,안태훈 대한마취통증의학회 2011 Anesthesia and pain medicine Vol.6 No.4

Background: Fasting during the preoperative period is known to be a risk of perioperative hypoglycemia. Also, the administration of fluids containing glucose often causes postoperative hyperglycemia. So, we investigated what is the ideal fluid which does not lead to hyperglycemia as well as hypoglycemia in fasted children. Methods: Eighty ASA physical status I and II pediatric patients (1−7 years) were randomly divided into the four groups; Group I,II, III, and IV with twenty patients of each group. Patients in Group I, II, III, and IV received lactated Ringer’s solution, 1 : 2 : 3 SD solution, 1 : 2 SD solution, and 1 : 3 SD solution, respectively during the perioperative period. Blood glucose levels were checked at pre-induction, 1 hr after induction and 1 hr, 4 hr, 8 hr after end of operation. NPO time and total amounts of fluids administered were measured. Results: There was no patient with preoperative hypoglycemia. There were no significant differences in the perioperative blood glucose level among the groups. There was no relationship between blood glucose level and fasting time or age. Conclusions: We conclude that all of the four fluids with different glucose concentrations in this study were appropriate to the fasted children.

Synthesis and properties of self-healing polyurethanes derived from eugenol

양정우,이대수 한국고분자학회 2018 한국고분자학회 학술대회 연구논문 초록집 Vol.43 No.1

선천성 비후성 유문협착증

양정우 釜山醫師會 1980 釜山醫師會誌 Vol.16 No.6

입원 환자의 섬망 치료에서 멜라토닌의 효과에 관한 후향적 연구

양정우,김종우,강원섭,이상민,김영종,백종우 한국정신신체의학회 2018 정신신체의학 Vol.26 No.2

Objectives:Delirium is one of the most common mental illnesses that can affect cognitive function. Melatonin has been shown to be effective in the treatment of insomnia, and recent studies have shown a protective effect to prevent delirium. This study was conducted to investigate the efficacy of melatonin in delirium patients. Methods:All patients were referred to psychiatric department for insomnia and symptoms of delirium, and were diagnosed delirium by the DSM-5 diagnostic criteria. We compared base line severity of delirium with KDRS- R-98-R (Korean version of Delirium Rating Scale revised 98) and after taking 2mg of melatonin, retrospectively. The side effects were also identified by referring to the medical records. Results:A total 21 patients had taken melatonin for insomnia and delirious symptoms. The K-DRS-R-98 scores were decreased from 15.24±2.64 before treatment to 6.57±5.42 after treatment. And CGI-S scores were also decreased from 4.14±0.48 before treatment to 2.81±0.93 after treatment (p<0.05). Conclusions:This study illustrates the possibility of melatonin as an effective treatment option for delirious symptoms such as disorientation, motor agitation, lability of affect and hallucinations as well as insomnia, with less concerns of drug side effect. Further study with a larger sample and prospective design will be required to confirm these results. 연구목적: 섬망은 신체 질환과 같은 기저 의학적 상태의 변화에 의해 나타나는 뇌의 기능장애로 환자의 사망률을 높이고 치매의 위험도를 높이는 등 불량한 예후와 연관되어 있다. 기존 섬망의 치료에 주로 사용된 항정신병약제는치료 효과에 대한 논란이 있으며 추체외로 부작용 등에 대한 우려가 있다. 따라서 수면 주기 조절 및 섬망 예방효과가 있는 것으로 알려진 멜라토닌 투여를 통해 섬망 호전 정도와 안전성을 조사하고자 하였다. 방 법: 불면을 동반한 섬망 증상으로 정신건강의학과에 진료 의뢰되어 멜라토닌 2mg을 투여 받은 환자를 대상으로 의무기록을 통해 섬망 증상의 초기 중증도 및 멜라토닌 투여 후의 섬망 증상 변화 여부를 한국판 섬망 평가척도-98 개정판(K-DRS-R-98)과 CGI-S를 통해 확인하였으며 부작용을 검토하였다. 결 과: 총 21명의 환자가 불면을 동반한 섬망 증상으로 멜라토닌을 투여받았다. K-DRS-R-98 심각도 점수는 투약전 15.24±2.64에서 투약 후 6.57±5.42로 감소하였으며 CGI-S 점수는 4.14±0.48에서 2.81±0.93로 감소하였다(p<0.05). 의무기록 상 부작용은 관찰되지 않았다. 결 론: 약물의 기전 상 추체외로 증상과 QTc연장 등의 문제를 유발하지 않는 멜라토닌의 사용은 보다 안정성을

2002 년도 제 27 회 보건학종합학술대회 : Multiplex PCR 에 의한 한국 전통 발효실품과 농산물에서 아플라톡신 생성균주의 검색

양정우,하광수,박선자,정덕화 대한보건협회 2002 대한보건협회 보건종합학술대회 Vol.- No.-

Inhibitory Effect on Inflammatory Responses of Macrophages and Anti-Bacterial Effects of Bacillus coagulans IDCC 1201

양정우,채승아,Minjee Lee,Won Yeong Bang 건강기능식품미래포럼 2022 건강기능식품미래포럼 학술지 Vol.2 No.4

In the previous study, we isolated Bacillus coagulans IDCC 1201 from green malt and found that it was safe for use as a probiotic, based on phenotypic and genomic analysis. In the present study, we investigated the anti-inflammatory and antibacterial activity using the cell-free lysate of this strain since the two properties can be its additional advantages as a probiotic. The following results were obtained: 1) In the RAW 264.7 (a mouse macrophage cell line) treated with lipopolysaccharide, the lysate of this strain inhibited the decrease of cell viability, the increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) and the increased expressions of inducible NO synthase (iNOS) (a NO producer), inducible cyclooxygenase-2 (a PGE2 producer) and proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6. 2) The lysate also inhibited the growth of five pathogens such as Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Salmonella Typhimurium, and Streptococcus pneumoniae. These two properties obtained provide B. coagulans IDCC 1201 with merits for a probiotic that can be of help particularly to the bowel in the inflammatory condition. Thus, it is thought to be worth developing this strain as a health supplement for this purpose. In the previous study, we isolated Bacillus coagulans IDCC 1201 from green malt and found that it was safe for use as a probiotic, based on phenotypic and genomic analysis. In the present study, we investigated the anti-inflammatory and antibacterial activity using the cell-free lysate of this strain since the two properties can be its additional advantages as a probiotic. The following results were obtained: 1) In the RAW 264.7 (a mouse macrophage cell line) treated with lipopolysaccharide, the lysate of this strain inhibited the decrease of cell viability, the increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) and the increased expressions of inducible NO synthase (iNOS) (a NO producer), inducible cyclooxygenase-2 (a PGE2 producer) and proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6. 2) The lysate also inhibited the growth of five pathogens such as Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Salmonella Typhimurium, and Streptococcus pneumoniae. These two properties obtained provide B. coagulans IDCC 1201 with merits for a probiotic that can be of help particularly to the bowel in the inflammatory condition. Thus, it is thought to be worth developing this strain as a health supplement for this purpose.

Development of Hybridoma for the Production of Monoclonal Antibody against Sulfamethazine

양정우,심원보,김정숙,최주미,김지영,티라펀,타나유,박선자,강성조,정덕화 한국생명과학회 2005 한국생명과학회 심포지움 Vol.44 No.-

인터랙티브 스토리 내에서 플레이어의 도덕적 결정에 대한 캐릭터 시점의 영향 연구

양정우,강신진,배병철 한국게임학회 2016 한국게임학회 논문지 Vol.16 No.6

본 논문의 목적은 플레이어가 조작하는 캐릭터의 관점이 사용자의 도덕적인 판단에 미치는 영 향을 연구하는 것이다. 이를 위해 우리는 Unity3D 게임 엔진을 이용해 Castaway 라는 이름의 인 터랙티브 스토리를 설계하고 개발했다. Castaway의 주요 내용은 1884년 영국에서 실제로 발생했던 R v Dudley and Stephens(일명 미뇨넷호 사건)에 기반하고 있다. Castaway 인터랙티브 스토리에 서, 플레이어는 가해자의 입장과 피해자의 입장 중 하나를 선택하여 해당 캐릭터의 시점으로 스토 리를 진행할 수 있다. 플레이어의 캐릭터에 대한 공감도가, 캐릭터에 대한 도덕적 판단에 영향을 주 었는지를 알기 위해 우리는 소규모 (n=10) 파일럿 스터디를 설계하고 진행하였다. 연구 결과는 서 로 다른 캐릭터 시점이 플레이어의 캐릭터 공감도 및 도덕적 판단에 영향을 미칠 수 있음을 시사했 다. 향후 보다 많은 참가자들을 모집해 주 실험을 진행할 예정에 있다. This paper aims to study whether the perspective of the character controlled by a player can affect the player on her moral decision. To this end we designed and developed Castaway, an interactive story using Unity3D game engine. The main story plot of Castaway is based on the trial ‘R v Dudley and Stephens (also known as mignonette 1884) which occurred at 1884 in U.K. In Castaway, the player can choose either the accused or the victim, and then play the interactive story with the perspective of the chosen character. To investigate the relationship between the player’s empathy to the player character and player’s moral decision, we conducted a small-scale (n=10) pilot study. Results of the pilot study have shown that different perspectives can influence the player on her empathy to player character and her moral decision. In near future we plan to conduct a main study with more participants.

발생기 계태 장배상세포내 점액물질의 조직화학적 연구

양정우 부산의대 1974 부산의대잡지 - 부산대학교 의과대학 Vol.14 No.1

진단적 초음파 촬영술에 의한 태아의 선천성 제대 탈장의 진단

양정우,이수자 釜山醫師會 1982 釜山醫師會誌 Vol.18 No.8