등가정하중과 관성제거를 이용한 차량 전면 구조물 충돌 최적설계

안진석(Jin-Seok Ahn),이영명(Youngmyung Lee),박경진(Gyung-Jin Park) 한국자동차공학회 2014 한국자동차공학회 학술대회 및 전시회 Vol.2014 No.11

경부 림프절에 전이한 정상피종의 세침흡인 세포학적 소견 - 1예 보고 -

장기택,박혜림,안진석,Jang, Kee-Taek,Park, Hye-Rim,Ahn, Jin-Seok 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1

Fine needle aspiration cytology of the cervical lymph node was performed in a 63-year-old man who had had an orchiectomy for seminoma one year ago. The tumor cells were arranged in loose clusters, occasional sheets, or single cells. The nuclei were round to ovoid with fine or reticular chromatin, and had one or more prominent nucleoli. These cells were intermingled with lymphocytes in a characteristic foamy, lacelike background. Documented reports of the cytologic appearance of the seminoma are rare, especially in the metastatic lesion. The diagnosis of primary gonadal seminoma by fine needle aspiration cytology is probably not indicated since the treatment of primary gonadal tumor requires surgical resection. Because of the characteristic cytologic features, fine needle aspiration cytology may be helpful in evaluation of the extent of tumor spread in the patients with testicular tumors.

한국인에서 발생한 Sweet 증후군에 대한분석

이근석(Keun Seok Lee),이윤종(Yun Jong Lee),이원섭(Won Sup Lee),안진석(Jin Seok Ahn),이종태(Jong Tae Lee),김원석(Wen Seong Kim),허대석(Dae Seog Heo),방영주(Yung Jue Bang),박선양(Seon Yang Park),조광현(kwang Hyun Cho),김병국(Byoung Koo 대한내과학회 1996 대한내과학회지 Vol.51 No.3

N/A Objectives: Sweet`s syndrome(acute febrile neutrophilic dermetosis) is characterized by fever, neutrophilia, erythematous painful cutaneous plaques, a dense dermal infiltrate onsisting of mature neutrophils, and a rapid response to steroid therapy, This condition is clinically important because it is associated with malignancy and it should be one of the differential diagnosis in the febrile immunocompromized patients with skin lesion, In spite of its clinical importance, there was no report on the epidemiologic characteristics of Sweets syndrome in Korean patients so far because of the rarity of Sweet`s syndrome, This study was performed to investigate characteristics and clinical significance of Sweet`s syndrome in Korean patients. Methods : The authors report a case of Sweet`s syndrome associated with acute myelogenous leukemia, and review the other 23 Korean patients with Sweet's syndrome that have been published in the literature. The characteristics of malignancy-associa- ted Sweet`s syndrome are compared with those of Sweet`s syndrome without malignancy association. Results: 1) Twenty-four cases of Sweet`s syndrome were analysed. Male to female ratio was 8:16 and the mean age was 44.8± 11.7 years. In 79% of patients, fever was noticed during the episodes of Sweet's syndrome. The most frequent sites of skin lesions were the upper extremities(83%), followed by face and head(75%), the lower extremities(75%), neck(46%), and trunk (13%). 2) Associated underlying systemic disorders were present in 15(62%) of the patients. The most frequent associations were chronic inflammatory bowel disease in seven patients, hematologic neoplasia in five, and solid neoplasia in one patients. 3) Leukocyte counts(mean 13,400±8,000/mm3) were higher than 10,000/mm3 in 16(67%) of patients. Erythrocyte sedimentation rates(mean 66.8±44.4mm/ hour) were elevated in 18(82%) of patients. 4) Skin lesion improvements were observed within 2 to 5 days from the initiation of steroid therapy. 5) Malignancies were associated in 6 patients. The initial appearance of Sweet`s syndrome lesions preceded or occurred concurrently with the detection of previously unsuspected malignancy in 67%(4 of 6 patients), In malignancy associated Sweet's syndrome, relative male preponderance, older age, and higher leukocyte counts were observed compared with Sweet's syndrome which is not associated with malignancy. There were no statistical significances, however. The erythrocyte sedimentation rate was the only statistically significant parameter. Conclusion: The characteristics of Sweet`s syndrome in Korean patients were similar to the characteristics of their western counterparts. Workup for malignancy seems appropriate far newly diagnosed Sweet`s syndrome patients in case of elevated erythrocyte sedimentation rate, leukocytosis, old age, and male sex

취학전 아동의 인기도와 사회적 행동 및 어머니의 양육태도간의 관계 연구

정문자(Moon Ja Chung),안진석(Jin Seok Ahn) 한국아동학회 1982 兒童學會誌 Vol.3 No.-

The purpose of this study is to relate social behaviors and child-rearing practices to the popularity of preschool children in Korea. Specifically, four major questions were raised and studied First, the relationship between a child`s popularity and his/her social behaviors was examined. Second, this relationship was explored as a function of the child`s sex. Third, the relationship between a child`s popularity and maternal childrearing practices was investigated. Fourth, this relationship was explored as a function of the child`s sex. The subjects of this study were 113 middle class preschool aged children and their mothers. Sociometric choices and peer-perceived social behaviors were obtained from these children using Moore`s (1973) Sociometric Status Test. Mothers of these children described their childrearing practices in a Q-sort format of Child-Rearing Practices Report (CRPR) developed by Block (1965). The analyses of the data using Kendall`s Tau Correlation Coefficient bore the following results: 1. Patterns of social behaviors shown by either popular or unpopular children were distinct; Popular children were friendly and conformative, while unpopular children were aggressive, non-conformative and independent. 2. Patterns of social behaviors in relation to the popularity and the unpopularity differed as a function of the child`s sex; Popular boys tended to be active while popular girls were likely to be unaggressive, independent and not-teasing. Unpopular boys showed a great amount of discipline their daughters by means of non-punitive punishment and to express negative reaction to the sibling rivalry among their children. These mothers tended not to enjoy their 3. Certain patterns of maternal child-rearing practices tended to be related to the popularity status of the child; The mothers of popular children as compared to those of unpopular children enjoyed their roles as mothers and didn`t use non-punitive punishment. 4. Patterns of maternal child-rearing practices in relation to the child`s popularity and unpopularity differed as a function of the child`s sex; The mothers of popular boys unlike those of popular girls tended to emphasize on their sons` achievement and perceived that their husbands were greatly involved with their sons. The mothers of unpopular boys appeared to show negative affection toward their sons. The mothers of unpopular girls were likely to displine their daughters by means of non-punitive punishment and to express negative reaction to the sibling rivalry among their children. These mothers tended not to enjoy their roles as mothers and did not believe that their daughters would behave as they should.

등가정하중을 이용한 차량 전면구조물 충돌최적설계

이영명(Youngmyung Lee),안진석(Jin-Seok Ahn),박경진(Gyung-Jin Park) 한국자동차공학회 2015 한국 자동차공학회논문집 Vol.23 No.6

증례 : 유방으로 전이된 비소세포 폐암 1예

김기성 ( Ki Seong Kim ),장대영 ( Dae Young Zang ),김효정 ( Hyo Jung Kim ),안진석 ( Jin Seok Ahn ),유지연 ( Ji Youn Yoo ),홍기우 ( Ki Woo Hong ),박혜림 ( Hye Rim Park ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-

저자들은 비소세포 폐암을 진단받은 후 우폐상엽 절제술 및 림프절 곽청술을 시행 받고 추적관찰 중에 있는 환자에서 만져지는 유방 종괴가 비소세포 폐암의 유방전이로 확진되어 고식적 항암치료 중인 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Development of metastasis to the breast from lung cancer is extremely rare and the prognosis for such patients is poor. A 50-year old woman was diagnosed as non-small cell lung cancer (adenocarcinoma,well differentiated) of the right upper lobe. She underwent right upper lobectomy with radical lymph nodes dissection. After 6 months, she had a palpable mass in the upper inner quadrant of the right breast, the breast tumor was proved to be of pulmonary origin. A correct diagnosis of metastasis to the breast is of considerable importance since the treatment of primary and secondary malignancies of the breast is markedly different, with considerably different outcomes. We report a case of metastatic breast cancer from non-small cell lung cancer. (Korean J Med 69:S835-S839, 2005)

A Comparison of Clinical Outcomes for Breast-conserving Treatment and Mastectomy for Early Breast Cancer

Jae Myoung Noh(노재명),Won Park(박원),Seung Jae Huh(허승재),Doo Ho Choi(최두호),Jung Hyun Yang(양정현),Seok Jin Nam(남석진),Jeong Han Kim(김정한),Young Hyuck Im(임영혁),Jin Seok Ahn(안진석) 대한방사선종양학회 2008 Radiation Oncology Journal Vol.26 No.1

목 적: 조기 유방암에서 유방보존치료와 유방절제술의 치료 성적을 비교하고, 예후 인자를 알아보고자 하였다. 대상 및 방법: 1994년 9월부터 2002년 12월까지 본원에서 근치적 수술을 받은 병리학적 병기 T1~2N0 유방암 환자 1,200명을 후향적으로 분석하여 유방보존치료와 유방절제술을 사이의 차이를 비교해 보았다. 결 과: 분석에 포함된 1,174명의 환자 중 601명이(51.2%) 유방보존치료를 받았고 573명이(48.8%) 유방절제술을 받았다. 유방절제술을 받은 군에서 유의하게 종양의 크기가 컸고, 다발성(multicentricity), 에스트로겐 및 프로게스테론 수용체 음성 등의 인자가 더 많은 경향을 보였다. 유방보존치료 및 유방절제술을 받은 환자의 10년 생존율은 각각 91.96%와 91.01%였고(p=0.1274), 10년 무병생존율은 각각 80.48%와 84.95% (p=0.8795)로 유의한 차이를 보이지 않았다. 결 론: 조기 유방암에서 유방보존치료 내지는 유방절제술을 받은 군 사이에 환자 특성의 차이는 일부 있었으나 생존율에서 유의한 차이를 보이지 않았다. Purpose: To compare the treatment outcomes and to analyze prognostic factors between the use of a breast-conserving treatment (BCT) and a mastectomy for early stage breast cancer. Materials and Methods: We retrospectively reviewed 1,200 patients with pathological stage T1-2N0 breast cancer who received surgery between September 1994 and December 2002 at Samsung Medical Center. We compared the patient characteristics and treatment outcomes between the two treatment groups. Results: Among the 1,174 eligible patients, 601 (51.2%) patients received a BCT and the remaining 573 (48.8%) patients received a mastectomy. The mastectomy group of patients had significantly more cases with a larger tumor size, multicentricity, extensive intraductal component, and estrogen- and progesterone-receptor negativity. The ten-year overall survival rates (OS) of the BCT and mastectomy groups were 91.96% and 91.01%, respectively (p=0.1274). The ten-year disease-free survival rates (DFS) were 80.48% for the BCT group of patients and 84.95% for the mastectomy group of patients, respectively (p=0.8795). Conclusion: Our study shows some differences in patient characteristics between the two treatment groups. However, these differences did not result in significant survival differences.

출원품종 특성조사요령에서 사용되는 식물 형태용어

서정남(Jung-Nam Suh),신우근(Woo Gun Shin),이상금(Sang Keum Lee),박금순(Keum Sun Park),허은정(Eun Jung Heo),안진석(Jin Seok Ahn) 한국원예학회 2012 한국원예학회 학술발표요지 Vol.2012 No.10

국소 진행성 유방암 환자에서 선행 항암화학요법의 치료결과

배선현(Sun Hyun Bae) · 박 원(Won Park) · 허승재(Seung Jae Huh) · 최두호(Doo-Ho Choi) · 남희림(Heerim Nam) · 양정현(Jung-Hyun Yang) · 남석진(Seok-Jin Nam) · 이정언(Jeong Eon Lee) · 임영혁(Young-Hyuck Im) · 안진석(Jin-Seok Ahn) · 박 대한방사선종양학회 2010 Radiation Oncology Journal Vol.28 No.2

목 적: 국소 진행성 유방암으로 선행 항암화학요법 후 수술과 방사선치료를 시행한 환자를 대상으로 치료 결과와 예후에 영향을 미치는 인자를 알아보고자 하였다.대상 및 방법: 1995년 4월부터 2006년 11월까지 삼성서울병원에서 유방암으로 선행 항암화학요법을 받은 환자는총 159명이었다. 이중에서 진단 당시 종양의 크기가 5.0 cm를 초과하거나 액와림프절 전이가 의심된 유방암 환자로 항암화학요법 후 근치적 수술을 시행하고 방사선치료가 시행된 105명을 대상으로 하였다. 선행 항암화학요법은2명을 제외한 모든 환자에서 anthracycline을 기반으로 하는 복합항암요법을 사용하였다. 치료 전 임상적 병기는 T13명(3%), T2 26명(25%), T3 39명(37%), T4 37명(35%)이었고 액와림프절 전이가 의심되는 사람이 98명(93%)이었다. 선행 항암화학요법을 시작한 날을 기준으로 추적 조사하였고 중앙추적조사기간은 41개월(7∼142개월)이었다.결 과: 전체 환자의 5년 국소제어율은 82.1%, 원격전이제어율은 69.9%, 무병생존율은 66.1%, 전체생존율은 77.1%이었다. 무병생존율과 전체생존율에 영향을 미치는 인자를 알아보기 위해 단변량분석을 시행하였을 때 임상적 원발병소 병기, 병리학적 원발병소 병기, 병리학적 림프절 병기 그리고 병리학적 TNM 병기가 공통적으로 통계적으로 유의한 인자들이었다. 다변량 분석을 시행하였을 때 호르몬치료 유무만 생존율과 연관된 의미 있는 인자였다.결 론: 본 연구를 통하여 삼성서울병원에서 국소 진행성 유방암으로 선행 항암화학요법이 시행된 환자의 치료 성적이 지금까지 보고된 다른 선행 항암화학요법 치료 결과와 비교할 때 비슷하거나 나은 결과를 보여주었다. 또한, 호르몬치료를 시행한 경우에만 생존율이 의미 있게 좋았고 임상적 병기나 병리학적 병기가 낮은 경우 생존율이 좋은경향을 보였다. Purpose: To evaluate the result of neoadjuvant chemotherapy, surgery, and radiation therapy in locally advanced breast cancer as well as analyze the prognostic factors affecting survival. Materials and Methods: One hundred fifty-nine patients with breast cancer were treated by neoadjuvant chemotherapy between April 1995 and November 2006 at the Samsung Medical Center. Among these patients, we retrospectively reviewed 105 patients treated with neoadjuvant chemotherapy followed by surgery and radiation therapy for a cure with an initial tumor size >5 cm or clinically positive lymph nodes. All patients received anthracycline based chemotherapy except for 2 patients. According to clinical tumor stage, 3 patients (3%) were cT1, 26 (25%) were cT2, 39 (37%) were T3 and 37 (35%) were T4. Initially, 98 patients (93%) showed axillary lymph node metastasis. The follow-up periods ranged from 7∼142 months (median, 41 months) after the beginning of neoadjuvant chemotherapy. Results: Locoregional failure free survival rate and distant metastasis free survival rate at 5 years were 82.1% and 69.9%, respectively. Disease free survival rate and overall survival rate at 5 years were 66.1% and 77.1%, respectively. The results of a univariate analysis indicate that clinical tumor stage, pathologic tumor stage, pathologic nodal stage and pathologic TNM stage were statistically significant factors for disease free survival rate and overall survival rate. Whereas, a multivariate analysis indicated that only hormone therapy was a statistically significant factor for survival. Conclusion: The current study results were comparable to other published studies for neoadjuvant chemotherapy for breast cancer. Hormone therapy was a statistically significant prognostic factor. The patients with early clinical or pathologic stage had a tendency to improve their survival rate.

동종골수이식 후 Variable Number of Tandem Repeat 다형성을 이용한 생착의 확인과 키메리즘 양상의 감시

안진석,박영이,정철원,양성현,이숭덕,이정빈,박선양,김병국 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.1

연구배경: 성공적인 동종골수이식 후 조혈세포는 공여자에서 유래하는 세포로 완전 대치된다. 따라서 키메리즘을 분석하는 것이 이식의 생착과 실패를 조기에 발견하는 데 도움을 줄 수 있다. 그러나 환자 세포와 공여자 세포가 혼재하는 혼합 키메리즘이 지속되어도 생착과 무병생존이 가능하므로 그 임상적 의미에 대한 규명이 필요하다. 한편 VNTR은 다형성이 높아 개체 감별력이 우수하다. 저자들은 VNTR에 대한 PCR 조건을 확립하고 이식 초기의 생착 확인과 이식 후 환자의 추적 조사에서의 유용성을 알아보고자 하였다. 방법: 각종 혈액질환으로 동종골수이식을 받은 50명의 환자를 대상으로 하였다. 이식 전에 환자와 공여자의 혈액을 채취하였다. 이식 후 첫 1개월 동안에는 1주 간격으로, 이후로는 수개월 간격으로 환자의 혈액 혹은 골수를 채취하였다. 혈액 혹은 골수의 단핵세포층에서 DNA를 분리하여 D1S80, D17S5, ApoB, vWF, MBP, TC-11, Col2A1 유전자자리에 대한 PCR을 시행하였다. 증폭 생성물은 4% 폴리아크릴아미드겔에서 전기영동 후 은염색으로 확인하였다. 결과: 환자와 공여자 50쌍 모두에서 정보를 제공하는 유전자자리를 확인하였다. 50명 중 46명이 1개월 내에 공여자 완전 키메리즘으로 전환되었다. 1개월 내에 완전 키메리즘으로 전환되지 않은 환자 4명 가운데 2명은 이식 거부, 1명은 질환의 재발을 보였고, 1명은 관해 상태로 1년 후 완전 키메리즘으로 전환되었다. 이식 후 추적기간 동안 질환이 재발한 10명 중 9명에서 사전에 혼합 키메리즘을 발견하지 못한 반면 경과 중 일시적 혼합 키메리즘을 보였던 5명의 백혈병 환자는 재발 없이 관해를 유지하고 있었다. 결론: 동종골수이식에서 VNTR에 대한 PCR은 공여자와 환자 세포의 감별, 이식 초기의 생착 및 이식 거부의 확인에 유용한 검사 방법이었다. 추적 기간 중 혼합 키메리즘의 의미에 대해서는 더 많은 연구가 필요할 것으로 생각한다. Background: After successful allogeneic bone marrow transplantation (BMT), Donor cells replace patient's hematopoietic cells. Therefore, it is useful to evaluate chimerism for the early detection of engraftment and graft failure. However persistence of host cells, so called mixed chimerism, can be compatible with engraftment and prolonged disease-free survival. So, it is necessary to document the significance of mixed chimerism. Variable number of tandem repeat (VNTR) is very polymophic and excellent marker for individual identification. We intended to establish the PCR condition for VNTR and the usefulness of VNTR in the early documentation of engraftment and monitoring of chimerism after BMT. Methods: Fifty patients who were treated with allogeneic BMT for hematologic diseases were studied. Blood samples of both patient and donor were drawn before BMT. Blood or marrow samples from patient were drawn with 1-week interval during the first month and a few month intervals thereafter. DNA was extracted from mononuclear cells of blood or bone marrow and amplified by PCR for D1S80, D17S5, ApoB, vWF, MBP, TC-11, and Col2A1. The amplified product was separated on 4% polyacrylamide gel and was confirmed by silver staining. Results: We identified the informative loci in all 50 patient/ donor pairs. Forty-six out of 50 had complete chimerism within 1 month after BMT. Of 4 patients who did not achieve complete chimerism within 1 month, 2 developed graft rejection, 1 developed disease relapse, and 1 was in complete remission and achieved delayed complete chimerism after 1 year. While we could not find mixed chimerism beforehand in 9 out of 10 patients who developed relapse after BMT, 5 leukemic patients who showed temporary mixed chimerism during follow-up period sustained complete chimerism without relapse. Conclusion: PCR amplification of VNTR is a useful method for the identification of cell origin between patient and donor, thus, early documentation of engraftment or graft failure. More studies with regular follow up are needed to evaluate the significance of mixed chimerism after BMT.