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심진영,이연실,임순성,현진이,김성연,이은방,신국현,Shim, Jin-Young,Lee, Yeon-Sil,Lim, Soon-Sung,Hyun, Jin-Ee,Kim, Seung-Yeun,Lee, Eun-Bang,Shin, Kuk-Hyun 한국생약학회 2000 생약학회지 Vol.31 No.2
Cordyceps is reputed for its broad biological activities and as a tonic for replenishing vital function in Chinese traditional medicines. As an attempt to obtain fundamental data for the development of a new type Cordyceps, the effects of the fruiting bodies of cultivated fungus of Paecilomyces japonica grown on silkworm larvae on hyperglycemia induced by streptozotocin(STZ) and by epinephrine in rats and in mice as well as on immunological functions in mice were investigated. The 70% methanol extract of the fungus, when administered orally at 100 and 300 mg/kg in STZ-induced hyperglycemic rats, caused a significant decrease in blood glucose level 3hr after sample treatments. The methanol extract, when administered p.o. at the same dose levels in epinephrine-induced hyperglycemic mice, also caused a significant decrease in serum glucose levels as well as a significant reversal of the liver glycogen contents suggesting its hypoglycemic activity might be due to glycogen breakdown in the liver. Treatment of normoglycaemic mice with the methanol extract of the fungus exhibited a significant glucose tolerance up to 3hr after oral glucose load(2.0 g/kg). The methanol extract also showed immuno-stimulating activity as measured by carbon clearance in mice and a significant antifatigue effect as measured by weight loaded forced swimming performance in mice.
심진영,이승원,이현우,최준혁,송영준,이형숙,정윤석,이관우 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.2
A myxedema coma, representing the extreme feature of hypothyroidism is rare. Despite early vigorous treatment, a myxedema coma is associated with a mortality rate as high as 60%. Herein, a case of a myxedema coma, with severe hypoventilation, is described. When the patient arrived at the emergency room, she complained of dyspnea and general weakness, and was of a drowsy mental status. 7 days after admission, she was more confused and disoriented, and respiratory insufficiency had developed. Although levothyroxine was continued and her respiration improved, she still had a confused mentality and seizure developed. Despite medication her consciousness did not improve, so was discharged in despair by her family members. The respiratory abnormality with a myxedema coma is a depressed ventilatory response to hypercapnea, resulting in a decrease in alveolar ventilation, with progressive CO2 retention. An upper airway obstruction, especially during sleep, and neuromuscular dysfunction in breathing may be shown in hypothyroidism. Therefore, a myxedema coma, accompanied by severe hypoventilation, should be intensively treated with thyroid hormone replacement therapy and mechanical ventilatory support. 저자들은 심각한 호흡부전과 의식 변화를 주소로 내원한 점액수종성 혼수 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.
A Quantitative Analysis of the Effects of Screen English via the Internet.
심진영 영상영어교육학회 2007 영상영어교육 (STEM journal) Vol.8 No.1
The establishment of university level education through cyber space in Korea began in 2001. Since then, more and more colleges have substituted their regular off-line classes with Internet mediated instruction. The reason behind adopting such an education system was, without doubt, in training high-quality human resources and cultivating global leaders through the most advanced yet inexpensive technology. However, the question remains as to whether such economizing of education costs and promotion of convenience, do not, in fact, hinder the effectiveness of education itself. Thus this study attempts to investigate the effectiveness of teaching English via the Internet by evaluating the change in general proficiency level of students participating in a web-based course. The material for the course was built on the movie Notting Hill on the basis of previous research results that maximum teaching effectiveness can be achieved by using movies as instructional materials.
심진영(Jin Young Shim),김진석(Jin Seok Kim) 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.2
N/A CKD602, a camptothecin derivative, is a synthetic and water-soluble anticancer agent possessing of topoisomerase I inhibiting activity. DPPC and DSPE-PEG liposomal formulations entrapped with CKD602 were developed. DSPE-PEG liposome, or PEGylated liposome, encapsulating CKD602 composed of dipalmitoylphosphatidylcholine (DPPC), cholesterol and distearoyl-N-monoethoxy poly (ethyleneglycol) succinylphosphatidylethanolamine (DSPEPEG_2000) (22:11:2) was prepared by reverse-phase evaporation method. Formed liposomes were characterized in terms of the morphology, size and encapsulation efficiency. To elucidate the in vitro stability, PEGylated liposome was incubated in human plasma, and the adsorbed proteins onto the surface of liposomes were applied to the SDS-PAGE. In vitro cytotoxicity of CKD602 encapsulated in PEGylated liposome was studied in human cervical cancer cell line (HeLa). CKD602 in PEGylated liposome was found to be 40-fold more effective (IC_50 = 1 nM) than free CKD602 (IC_50 = 40 nM) in inhibiting the growth of HeLa cells in vitro.
Development of Liposomal Formulations of bcl-2 Antisense Oligodeoxynucleotide
Shim, Jin-Young,Jeon, Eunjung,Kim, Jin-Seok 숙명여자대학교 약학연구소 2002 약학논문집-숙명여자대학교 Vol.18 No.-
Liposomal formulations of bcl-2 antisense oligodeoxynucleotide (ODN) were developed and tested for its apoptotic effect on SK-OV-3 cells in vitro. The SGTA119-2009(S), a synthetic conjugate of 20-mer bcl-2 oligodeoxy-nucleotide (2009) with a GeneChem's proprietary mitomycin derivative by covalent bond, was used throughout the experiment. Negatively charged SGTA119-2009(S) was incorporated by the REV method into various liposomal formulations; either neutral one using DPPC: Choi: l,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) (6:3:1) or cationic one using stearylamine (SA): DPPC : Choi: DOPE (1:6:3:1). Formed liposomes were characterized in terms of morphology, size and encapsulation efficiency. Average size of liposomes is 400~500nm in diameter. Structure of liposomes observed by scanning electron microscope (SEM) was globular shape and had multi lamellars. SGTA119-2009(S) had 12% encapsulation efficiency on neutral liposome and 34% encapsulation efficiency on cationic liposome. IC_(50) of SGTA119-2009(S) in DPPC liposomes was about lOOOnM in SK-OV-3 cells, whereas free antisense ODN did not show cytotoxic effect at this range. Western blotting was also carried out to confirm the Bcl-2 protein downregulation, though it was not semi-quantitatively matched with the growth inhibition results. More vigorous studies are under going to evaluate this and other basic matters.
E-Navigation을 위한 선박네트워크 NMEA2000에 관한 연구
허진영(Jinyoung Hir),박동현(Donghyun Park),김종현(Jonghyun Kim),유영호(Yungho Yu),신옥근(Ok Shin),심진보 한국마린엔지니어링학회 2009 한국마린엔지니어링학회 학술대회 논문집 Vol.2009 No.-
NMEA1000 protocol known as IEC61162-3 of Multi-talker, Multi-listener, PnP communication is adopted as standard network for SaLAS ship by ISO in 2008 for e-navigation ages. NMEA2000 network uses well known CAN in physical layer. In this paper address claim function is implemented for protocol converter device which can be used easily in combination with CPU of non network device. We are going to implement full function of NMEA2000 protocol and provide guideline to develop ship equipment to be networked easily.