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정성수(Sung Soo Jung),심종걸(Jong Geol Shim),한동수(Dong Soo Han),오기영(Ki Young Oh),김성윤(Seong Yoon Kim),김인순(In Soon Kim),박찬현(Chan Hyun Park),강종명(Chong Myung Kang),박한철(Han Chul Park),곽진영(Jin Young Kwack) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A Cyclosporine treated renal transplants are known to develop hyperuricemis more frequently than azathioprine treated patients. We examined the outpatient records of all patients transplanted between April 1978 and June 1988, in whom the allograft functioned for at least one year. We did this study to determine the frequency of hyperuricemia in the renal transplants and predisposing factors. The results were as follows: 1) The serum uric acid concentration in patients in the cyclosporine treated group (8.53±2.26 mg/dl; n=33) was significantly higher than that of the azathioprine treated group (6.74±1.43mg/dl; n=24) (p<0.005). 2) The serum uric acid concentration in patients using diuretics (7.83±1.50mg/dl; n=8) was significantly higher than in those not using diuretics (6.19±1.05 mg/ dl; n=16) in the azathioprine treated group (p<0.01). 3) The serum uric acid concentration in patients using diuretics (9.95±1.74mg/dl; n=12) was significantly higher than in those without diuretics (7.59±1.97 mg/dl; n=21) in the cyclosporine treated group (p<0.005). 4) The serum uric acid concentration in patients using diuretics and azathioprine was significantly lower than that in those using diuretics and cyclosporine (p<0.05). 5) Among the patients not taking diuretics, the serum uric acid level was significantly higher in the cyclosporine treated group than in the azathioprine treated group. We conclude that there is an increased incidence of hyperuricemia in renal transplants treated with cyclosporine. This effect is thought to be due to tubular toxicity by cyclosporine. It is recommended that routine measurement of the uric acid level be done in renal transplants using cyclosporine and that diuretics be avoided in patients taking cyclosporine.
신창록,심종걸,전용철,권기운,이영열,김인순,정태준,최일영 대한내과학회 1990 대한내과학회지 Vol.38 No.5
An analysis of 50 patients with metastatic carcinoma from unknown primary site, seen at Hanyang University Hospital from january 1985 to December 1987, was performed. 50 patients constituted 2.4% of the total carcinoma patients registered at Hanyang University Hospital. The mean age of the patients was 55.1 years. Histopathologic diagnosis revealed adenocarcinoma in 68% and squamous cell carcinoma in 20% of the cases. The common sites of metastases were the lymphnodes, pleura, peritoneum and bones. The overall median survival time was 4.5 months. The primary sites were identified in only four patients(8%) during the follow-up periods. There was no difference in survival time between treated and untreated adenocarcinoma patients, but in squamous cell carcinoma patients group survival for treated versus untreated was 12.8 months versus 1.7 months.
재발성 다발성 연골염(Relapsing Polychondritis) 1 예
유대현,이정희,박성수,김성윤,윤호주,안광무,심종걸,오기영 대한내과학회 1988 대한내과학회지 Vol.34 No.4
Relapsing polychondritis is a rare disorder characterized by episodic inflammation and destruction of cartilagenous structures throughout the body, It is an immune disorder probably caused by the production of autoantibodies to possibly the mucopolysaccharides. This is a case of relapsing polychondritis, A 67-yearold woman was admitted to Hanyang University Hospital because of dyspnea and pain and tenderness of right ear for 3 months, Results of examination disclosed involvement of the ear, eye, nose, larynx, trachea, and costochondral junction. We have experienced a case of relapsing polychondritis, thus report this case with literature review.
정성수,박경남,이민호,기춘석,함준수,이종철,손주현,심종걸,윤호주 대한소화기내시경학회 1988 Clinical Endoscopy Vol.8 No.1
Intestinal tuberculosis is an infectious disease which is still prevalent in the developing countries including Korea. It may occur insidously, have a vague clinical marofestation, and take a chronic course. We have analyzed 101 cases of intestinal tuberculosis. proven by clinical and histopathologic diagnosis for 10yrs since 1977. The results are as follows: 1) Intestinal tbc was prevalent in the age of 20-30 and the male to female ratio was 1:1.7. 2) Among clinical manifestations, abdominal pain, and tenderness, general malaise and abdominal mass were observed in order of frequency. 3) Active pulmonary lesion was associated in 73 cases (73.3%). 4) Ileocecal region was the most frequent site of involvement in barium study and in colonoscopy. 5) The most frequent colonoscopic finding was multiple ulceration and pseudopolyposis and chronic granulomatous inflammation was noted in 58% on hitopathology. 6) Ulcerative type was the most common type 45.4% by intestinal x-ray and colonofiberscopic examination