꿀벌의 독에 의한 생쥐 피부의 조직병리학적 및 미세구조적 변화

신상희,정문진,문명진,Shin, Sang-Hee,Jeong, Moon-Jin,Moon, Myung-Jin 한국현미경학회 1997 Applied microscopy Vol.27 No.2

꿀벌(Apis mellifera)의 독에 의해 야기되는 포유동물 피부의 조직병리학적 및 미세구조적 변화와 그 수복과정을 확인하기 위하여 실험용 생쥐의 피부에 직침법으로 꿀벌의 독을 주입한 후, 회복된 시점까지 일정시간 간격으로 조직의 표본을 제작하여 광학 및 전자현미경으로 관찰하였다. 독 주입 직후의 표본에서는 표피의 상피세포와 진피의 결합조직에서 현저한 염증반응이 유도되었고, 일부세포의 괴사가 관찰되었다. 고배율의 전자현미경상에서 교원섬유의 직경이 크게 증가되었으며, 면역 단백물질로 추정되는 전자밀도가 높은 grain의 침착이 확인되었다. 이러한 조직병리현상은 독 주입 후 12시간이 경과된 조직의 표본에서 서서히 회복되는 것으로 관찰되었다. 봉침 주위 피부조직의 조직학적 및 미세구조적 변화는 수 일간 지속되었으나, 병리학적 반응은 3일 이내에 거의 거의 소멸되는 것으로 관찰되었다. 또한 생쥐 피부에 대한 꿀벌 독의 병리반응은 다른 절지동물의 독에 비하여 비교적 경미한 것으로 확인되었다. Histopathological and fine structural changes in mouse skin after injection of venoms extracted from the venom glands of the honeybee, Apis mellifera, were studied with light and electron microscopes. At this experiment the venoms were directly injected at the hairless abdominal skin of the mouse through the sting of the bee's venomous organ. Main changes appeared within one hour after injection at both epithelial and connective tissues as considerable hyperemia and angioedema, and slight edema and fibrosis. High magnified electron micrographs reveal not only increase of diameter but also deposition of electron dense grains (which seems to be an auto immunoglobulin) at the collagenous fibers characteristically. This kinds of histological and fine structural responses were diminished from 12 hour after injection, and the pathological symptoms disappeared within 3 days at most cases. So, the skin responses induced by honeybee venom seem to be not severe compare to other cases reported by other venomous arthropods.

펄스동전기법과 연속처리동전기법을 이용한 점토성-사질토의 탈수화 효율 비교

신상희(Sanghee Shin) 한국지반환경공학회 2014 한국지반환경공학회논문집 Vol.15 No.4

펄스동전기법은 점토성-사질토에서 탈수화 공정을 효율적으로 진행하기 위해 제안되었다. 제안된 동전기법은 점토성-사질토에서 토양 안정성의 증진을 위해 전류 흐름에 따르는 유체의 이동에 의한 탈수화 공정을 진행하는 것이다. 제안된 동전기법의 성능을 확인하기 위해 제작된 샘플은 총 7일간에 점진적으로 압력을 증가시켜 30 psi(2.11 kgf/㎠)의 최종압력으로 압축과정을 거쳐 완성되었다. 기존의 연속적인 처리와 펄스방식으로 처리하는 공정을 비교하여 각각의 특성을 관찰하였다. 각각의 테스트는 48시간 동안 3 V/cm의 전압 경사 조건으로 연속적인 처리공정과 48시간 동안 총 8시간씩 3회에 걸쳐 전기를 차단하는 펄스방식으로 진행하였다. 그 결과, 펄스방식의 효율이 연속처리방식의 효율과 비슷한 것으로 나타났고 펄스방식이 연속처리방식보다 전력소비가 약 50 % 감소로 그 경제성을 입증하였다. Pulse electrokinetic technology is proposed for improving the dewatering-process from clay-sandy soil. Proposed electrokinetic technology is to be the dewatering process due to fluid movement of current flow for the stability of clay-sandy soils. Samples produced in this study were completed to verify the proposed performance for 7 days by gradually increasing the pressure to the final pressure of 30 psi (2.11 kgf/㎠) through the compression process. In this study, pulse electrokinetic treatment and conventional continuous electrokinetic treatment are tested and observed, respectively. The condition of continuous electrokinetic treatment is a continuous process during 48 hours. And the condition of pulse electrokinetic treatment system is to interrupt the power three times for 48 hours, every 8 hours. These treatments are that the voltage gradient is 3 V/cm. As a result, the efficiency of pulse electrokinetic is similar to the continuous electrokinetic. The power consumption efficiency of pulse electrokinetic is better than continuous electrokinetic.

빅데이터 분석을 통한 비탈면 붕괴 유형 평가 연구

신상희 ( Sang Hee Shin ),옥영석 ( Young Suk Oak ),김재정 ( Jae Jeong Kim ),구호본 ( Ho Bon Koo ) 대한지질공학회 2014 대한지질공학회 학술발표회논문집 Vol.2014 No.1

동굴의 비유 속에 결박된 철학자, 플라톤

신상희(Sang Hie Shin) 철학연구회 2009 哲學硏究 Vol.0 No.84

Ich versuche den Charakter der Idee des Guten im Horizont des Seinsdenkens M.Heideggers kritisch zu betrachen. Die Idee des Guten, die im Ort des Verstandes durch den Aufstieg des Menschen aus der Hohle ans Licht der Sonne zuletzt einzublicken ist, ist die hochste Ursache von allem, die jedem Seienden Sein und Wahrheit vergeben kann. Platon sagt, die hochste Idee sei die Herrin, indem sie dem zu Erkennenden die Wahrheit qua Aletheia gewahrt. Dadurch liegt die Wahrheit bei Platon unter den Joch der Idee. Dieses Joch ist das Entscheidende. Demnach wird die Grunderfahrung der Wahrheit qua Aletheia zugunsten der Erfahrung der Wahrheit qua Orthotes(Richtigkeit) verschadigt und verdunkelt. Zufolge diesem Wandel der Wahrheitserfahrung bewegt sich das Geschick der abendlandischen Metaphysik zum geschichtlichen Weg der Seinsvergessenheit. Fur Heidegger ist die Idee nur das zu Erkennende im Erkennen des erkennenden Menschen. Also laßt sich die Problematik der Idee aus der ursprunglichen verbindenden Einheit von dem Erkennenden und dem Erkennbaren erneut verfassen. Wahrend Platon diese ursprungliche Einheit im Ort des Nous durch die Idee des Guten kausalgesetzlich zu begrunden und auszulosen versucht, kritisiert Heidegger aber gerade diesen Versuch Platons, indem er darauf hinweist, dab Platon das Wahrheitsgeschehnis verkennt, in welchem die Unverborgenheit des Seienden und des Seins selbst eigens geschieht. Das, was die Unverborgenheit des Seienden vergibt und gewahrt, ist nicht die Idee des Guten, sondern liegt im Ereignis als Seins selbst. Daher versucht Heidegger gegen Platon den Charakter der Ideen zu verstehen, zwar nicht im Ort des Nous, sondern vielmehr im Ort der Wahrheit. Fur Heidegger ist die Idee des Guten nicht das Zuletzte, sondern die Wahrheit des Seins als Aletheia ist das alle Ideen umgreifende Ursprunglichste. Der Mensch ist dasjenige Seiende, das in der Wahrheit als Aletheia innesteht und dem Zuruf dieser Wahrheit eigens entspricht. Diese Entsprechung ist das Philosophieren im echten Sinne. Die Frage nach dem Wesen des Menschen und die Frage nach dem Wesen der Wahrheit gehoren zusammen in der Dimension des Ereignisses innig zueinander. Ich denke, dab unsere ekstatische Teilnahme an das jeweilig ereignende Wahrheitsgeschehnis und unser wachsame Verstandnis dem Menschen die echte Freiheit gewahren konnen.

Particle Image Velocimetry 기법을 이용한 CMP 공정의 Slurry유동 분석

신상희(Sanghee Shin),김문기(Munki Kim),윤영빈(Youngbin Yoon),고영호(Youngho Koh),홍창기(Changgi Hong) Korean Society for Precision Engineering 2006 한국정밀공학회지 Vol.23 No.5

장비 설계 시 정비복잡도를 활용한 현실적인 초기 정비시간 및 정비도(MTTR) 예측방법

신상희(Sang-Hee Shin),이학재(Hak-Jae Lee),황성국(Seong-Guk Hwang),김무영(Moo-Young Kim),권기상(Ki-Sang Kwon) 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.9

최근 군수장비를 설계함에 있어 개발 초기부터 장비의 신뢰도, 정비도, 정비시간 등 운용 유지에 대한 많은 관심을 보이고 있다. 그렇기 때문에 사용자 및 개발자 모두 정비시간을 고려한 설계에 대한 중요성을 강조한다. 본 논문에서는 설계 초기에 기존 방식인 MIL–HDBK-470A에서 제공하는 표준 정비 시간이 아닌, 장비의 접근 복잡도등 현실적인 정비시간을 예측하는 것에 대한 구체적인 방법론을 연구하였으며, 정비 복잡도라는 척도를 사용하여 시간변환계수를 적용하였다. 또한, 해당 결과물을 이용하여 기 개발된 장비의 실측 정비시간과 시간변환계수가 적용된 지연시간을 반영한 현실적인 정비시간을 비교/검증하여, 해당 데이터의 신뢰성을 검증해 보았다. 향후 장비 설계 시 정비도 목표값 설정 및 정비도 산출을 위한 연구에서, 초기 실 장비에 대한 정비 시간을 측정하지 못하는 장비의 정비시간을 보다 현실적인 정비시간으로 반영하고, 연구 및 설계반영 활동 등을 통하여 정비시간을 단축하여, 운용 유지 비용 등을 줄일 수 있는 활동 등을 수행할 수 있을 것으로 기대한다. Recently, in designing military equipment, considerable attention has been paid to maintaining operations, including reliability, maintenance, and maintenance time of equipment, from the early stages of development. Therefore, both users and developers stress the importance of design considering the maintenance time. This study evaluated the specific methodologies for predicting the realistic maintenance time, such as the access complexity of equipment, other than the standard maintenance time provided by the conventional method mil-hdbk-470a at the beginning of the design, and applied the time conversion factor using a measure of the maintenance complexity. In addition, the actual maintenance time reflecting the actual maintenance time of the developed equipment and the time-conversion factor applied was compared/verified to confirm the reliability of the data. In a study to set a target for repair and the repair of equipment design in the future, it is expected that the maintenance time of equipment that fails to measure the maintenance time for the initial actual equipment will be reflected as a more realistic time. Moreover, activities, such as research and design reflection activities, will be performed to reduce the maintenance time, operational maintenance cost, etc.

수면 무호흡을 보이는 비만한 11세 여자에서 진단된 ROHHAD (rapid-onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation) 증후군 1예

신상희 ( Sanghee Shin ),김수경 ( Su Kyung Kim ),정혜인 ( Hye-in Jung ),조성윤 ( Sung Yoon Cho ),김지현 ( Jihyun Kim ),주은연 ( Eun Yeon Joo ),안강모 ( Kangmo Ahn ),이보라 ( Bo Ra Lee ) 대한천식알레르기학회 2021 Allergy Asthma & Respiratory Disease Vol.9 No.4

Rapid-onset obesity with hypoventilation, hypothalamic, and autonomic dysregulation (ROHHAD) syndrome is a rare disease char-acterized by rapid progression of obesity and central hypoventilation with autonomic and endocrine dysregulation. There is no gold-standard diagnostic method for ROHHAD syndrome; it is diagnosed based on a years-long clinical course. For this reason, di-agnosis of ROHHAD syndrome is often delayed. In particular, ROHHAD has a high mortality rate due to cardiopulmonary arrest when quick diagnosis and appropriate intervention of central sleep apnea are not timely. We report a case in which an 11-year-old girl with central sleep apnea was diagnosed with ROHHAD syndrome: the clinical course with early breathing intervention using noninvasive positive pressure ventilation. We emphasize the importance of respiratory interventions in the clinical course of RO-HHAD syndrome. (Allergy Asthma Respir Dis 2021;9:249-254)

생기와 탈존

신상희(Sang Hie Shin) 철학연구회 1994 哲學硏究 Vol.34 No.-

한국관광공사 API를 활용한 무장애 여행 일정 시스템

신상희(Sanghee Shin),조우성(Wooseong Jo),박소현(Sohyeon Park),송주혜(Juhye Song),오병우(Byoungwoo Oh) 한국정보기술학회 2023 Proceedings of KIIT Conference Vol.2023 No.6

교통-대기질 연계데이터 구축 및 관리 활용방안 연구

신상희 ( Sang Hee Shin ),고준호 ( Joon Ho Ko ),이세희 ( Se Hee Lee ),최유진 ( Yu Jin Choi ) 서울시정개발연구원 2008 연구보고서 Vol.2008 No.27

Road vehicles have long been identified as major contributors to the urban air pollution; this can be applied to Seoul. As a consequence, Seoul Metropolitan Government has introduced various schemes to reduce traffic-related air pollution, not giving noticeable improvement of air quality. It is by no means simple and easy to evaluate the effectiveness of traffic-related policies aimed at air quality improvement due to complex and nonlinear nature of air pollutants. It can be done only from systematic analyses of traffic and air pollution monitoring data and information. Currently, both traffic and air pollution monitoring networks have been operated in Seoul with their own purposes. In this study, the existing traffic and air pollution monitoring networks were investigated if the both the monitoring systems could be linked in order to understand the relations between transport emissions and air pollutant concentrations in depth and to evaluate the effectiveness of traffic-related policies. Furthermore, effective and efficient approaches to linking traffic and air monitoring data have been sought. Main results and suggestions from this study are as follows. 1. Correlation analysis of traffic and air pollution data from existing traffic and air pollution monitoring networks Initially, the traffic monitoring network was set up to check traffic flow, while air pollution monitoring network was set up to investigate air quality over the space people reside in. Hence, the monitoring sites of the both systems are not co-located. The shortest distance between current traffic and air pollution monitoring sites is around 340m, implying a fundamental limitation in simply linking the existing traffic and air pollution monitoring network systems. With this limitation in mind, various correlation analyses between the hour-by-hour concentrations of PM10, CO and NOx (NO & NO2) and traffic volumes, collected at the existing air and traffic monitoring sites for recent three years, have been carried out. The finding is that only NOx at a few sites show statistically meaningful correlations with traffic volume during the morning hours of 6 am to 9 am. Hence, we conclude that simple correlation analyses using data from current traffic and air pollution monitoring systems may not provide a direct answer to whether a potential traffic-related policy is effective in mitigating air pollution levels. 2. Approaches to linking traffic and air pollution monitoring data Foreign cases to link traffic and air pollution monitoring data have been reviewed, revealing that in most cases long-term co-located traffic and air pollution monitoring sites have been operated to investigate the relation between traffic and air pollution. From the careful review of the cases, following suggestions are made. 1) Short-term approaches Mobile monitoring stations, equipped with devices of both air pollution and traffic monitoring, should be prepared and deployed wherever and whenever needed. The traffic monitoring items must include not only traffic speed and volume but also the vehicles` body and fuel types. Traffic information collected by vehicle type and fuel type can be used for in-depth evaluations of traffic-related measures applied to specific vehicle type or fuel type. In addition, the greenhouse gases need to be monitored, considering the increasing interest in global warming. Firstly, the long-term co-located traffic and air pollution monitoring should be introduced to identify the relation of vehicle emissions and air pollution in more details. The location and items to be monitored should be carefully investigated in advance. The monitoring location may be selected using various modeling tools so that the estimation of the possible impacts of traffic-related policies on the air quality over the area of interest can be performed. Secondly, traffic management systems with air quality monitoring feedback should be developed in the future. To make it happen, a flexible framework allowing communications between transport emissions and traffic conditions needs to be developed by introducing a system providing high time/space resolution measurements of both air pollutant concentrations and traffic conditions on a real-time basis.