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- 저자 : 신상희(Sang-Hee Shin) (검색결과 66 건)
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꿀벌의 독에 의한 생쥐 피부의 조직병리학적 및 미세구조적 변화
신상희,정문진,문명진,Shin, Sang-Hee,Jeong, Moon-Jin,Moon, Myung-Jin 한국현미경학회 1997 Applied microscopy Vol.27 No.2
꿀벌(Apis mellifera)의 독에 의해 야기되는 포유동물 피부의 조직병리학적 및 미세구조적 변화와 그 수복과정을 확인하기 위하여 실험용 생쥐의 피부에 직침법으로 꿀벌의 독을 주입한 후, 회복된 시점까지 일정시간 간격으로 조직의 표본을 제작하여 광학 및 전자현미경으로 관찰하였다. 독 주입 직후의 표본에서는 표피의 상피세포와 진피의 결합조직에서 현저한 염증반응이 유도되었고, 일부세포의 괴사가 관찰되었다. 고배율의 전자현미경상에서 교원섬유의 직경이 크게 증가되었으며, 면역 단백물질로 추정되는 전자밀도가 높은 grain의 침착이 확인되었다. 이러한 조직병리현상은 독 주입 후 12시간이 경과된 조직의 표본에서 서서히 회복되는 것으로 관찰되었다. 봉침 주위 피부조직의 조직학적 및 미세구조적 변화는 수 일간 지속되었으나, 병리학적 반응은 3일 이내에 거의 거의 소멸되는 것으로 관찰되었다. 또한 생쥐 피부에 대한 꿀벌 독의 병리반응은 다른 절지동물의 독에 비하여 비교적 경미한 것으로 확인되었다. Histopathological and fine structural changes in mouse skin after injection of venoms extracted from the venom glands of the honeybee, Apis mellifera, were studied with light and electron microscopes. At this experiment the venoms were directly injected at the hairless abdominal skin of the mouse through the sting of the bee's venomous organ. Main changes appeared within one hour after injection at both epithelial and connective tissues as considerable hyperemia and angioedema, and slight edema and fibrosis. High magnified electron micrographs reveal not only increase of diameter but also deposition of electron dense grains (which seems to be an auto immunoglobulin) at the collagenous fibers characteristically. This kinds of histological and fine structural responses were diminished from 12 hour after injection, and the pathological symptoms disappeared within 3 days at most cases. So, the skin responses induced by honeybee venom seem to be not severe compare to other cases reported by other venomous arthropods.
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신상희 ( Sang Hee Shin ),전현숙 ( Hyun Sook Jeon ),이찬형 ( Chan Hyung Lee ),배기수 ( Gi Soo Bae ) 한국물환경학회 2013 한국물환경학회지 Vol.29 No.3
The particle counter compared with the turbidimeter provides good precision and sensitivity and can get the characteristics of particulates effectively. The purpose of this study is to provide the application of particle counter in sand and activated carbon filters. The particle count by size could be more easily sense when the water quality is changed by the influent of high turbidity or algae. We could decide the optimal backwashing cycles and detect the efficiencies of filters by monitoring the total particle count of effluent in sand and activated carbon filters.
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신상희(Shin, Sang-Hee),문수영(Moon, Soo-Young) 대한건축학회 2014 대한건축학회논문집 Vol.30 No.8
In this study, we compared and analyzed the domestic and foreign working space area standards and domestic development condition to provide the applicable optimized area of working space per person. Using field surveys combined with literature search, the layout of surveyed business facilities and the area of each space were analyzed through collected drawings and field measurements. The working space was divided into personal exclusive space (area for exclusive use) and public space. Through the survey of domestic and foreign area standards, it was found that the working space area per person of our country itself was not small. However unlike the foreign cases, the areas to be included in the public space were included in the personal exclusive space in our country. Also the field survey revealed the space provided to an individual was about 8~9㎡ in which only 2~3㎡ belonged to the personal exclusive space. Therefore, we proposed per 8.5㎡ in the optimal business facility area plan by reflecting the development condition of including various public areas in the working space area per person.
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장비 설계 시 정비복잡도를 활용한 현실적인 초기 정비시간 및 정비도(MTTR) 예측방법
신상희(Sang-Hee Shin),이학재(Hak-Jae Lee),황성국(Seong-Guk Hwang),김무영(Moo-Young Kim),권기상(Ki-Sang Kwon) 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.9
최근 군수장비를 설계함에 있어 개발 초기부터 장비의 신뢰도, 정비도, 정비시간 등 운용 유지에 대한 많은 관심을 보이고 있다. 그렇기 때문에 사용자 및 개발자 모두 정비시간을 고려한 설계에 대한 중요성을 강조한다. 본 논문에서는 설계 초기에 기존 방식인 MIL–HDBK-470A에서 제공하는 표준 정비 시간이 아닌, 장비의 접근 복잡도등 현실적인 정비시간을 예측하는 것에 대한 구체적인 방법론을 연구하였으며, 정비 복잡도라는 척도를 사용하여 시간변환계수를 적용하였다. 또한, 해당 결과물을 이용하여 기 개발된 장비의 실측 정비시간과 시간변환계수가 적용된 지연시간을 반영한 현실적인 정비시간을 비교/검증하여, 해당 데이터의 신뢰성을 검증해 보았다. 향후 장비 설계 시 정비도 목표값 설정 및 정비도 산출을 위한 연구에서, 초기 실 장비에 대한 정비 시간을 측정하지 못하는 장비의 정비시간을 보다 현실적인 정비시간으로 반영하고, 연구 및 설계반영 활동 등을 통하여 정비시간을 단축하여, 운용 유지 비용 등을 줄일 수 있는 활동 등을 수행할 수 있을 것으로 기대한다. Recently, in designing military equipment, considerable attention has been paid to maintaining operations, including reliability, maintenance, and maintenance time of equipment, from the early stages of development. Therefore, both users and developers stress the importance of design considering the maintenance time. This study evaluated the specific methodologies for predicting the realistic maintenance time, such as the access complexity of equipment, other than the standard maintenance time provided by the conventional method mil-hdbk-470a at the beginning of the design, and applied the time conversion factor using a measure of the maintenance complexity. In addition, the actual maintenance time reflecting the actual maintenance time of the developed equipment and the time-conversion factor applied was compared/verified to confirm the reliability of the data. In a study to set a target for repair and the repair of equipment design in the future, it is expected that the maintenance time of equipment that fails to measure the maintenance time for the initial actual equipment will be reflected as a more realistic time. Moreover, activities, such as research and design reflection activities, will be performed to reduce the maintenance time, operational maintenance cost, etc.
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신상희 ( Sang Hee Shin ),고준호 ( Joon Ho Ko ),이세희 ( Se Hee Lee ),최유진 ( Yu Jin Choi ) 서울시정개발연구원 2008 연구보고서 Vol.2008 No.27
Road vehicles have long been identified as major contributors to the urban air pollution; this can be applied to Seoul. As a consequence, Seoul Metropolitan Government has introduced various schemes to reduce traffic-related air pollution, not giving noticeable improvement of air quality. It is by no means simple and easy to evaluate the effectiveness of traffic-related policies aimed at air quality improvement due to complex and nonlinear nature of air pollutants. It can be done only from systematic analyses of traffic and air pollution monitoring data and information. Currently, both traffic and air pollution monitoring networks have been operated in Seoul with their own purposes. In this study, the existing traffic and air pollution monitoring networks were investigated if the both the monitoring systems could be linked in order to understand the relations between transport emissions and air pollutant concentrations in depth and to evaluate the effectiveness of traffic-related policies. Furthermore, effective and efficient approaches to linking traffic and air monitoring data have been sought. Main results and suggestions from this study are as follows. 1. Correlation analysis of traffic and air pollution data from existing traffic and air pollution monitoring networks Initially, the traffic monitoring network was set up to check traffic flow, while air pollution monitoring network was set up to investigate air quality over the space people reside in. Hence, the monitoring sites of the both systems are not co-located. The shortest distance between current traffic and air pollution monitoring sites is around 340m, implying a fundamental limitation in simply linking the existing traffic and air pollution monitoring network systems. With this limitation in mind, various correlation analyses between the hour-by-hour concentrations of PM10, CO and NOx (NO & NO2) and traffic volumes, collected at the existing air and traffic monitoring sites for recent three years, have been carried out. The finding is that only NOx at a few sites show statistically meaningful correlations with traffic volume during the morning hours of 6 am to 9 am. Hence, we conclude that simple correlation analyses using data from current traffic and air pollution monitoring systems may not provide a direct answer to whether a potential traffic-related policy is effective in mitigating air pollution levels. 2. Approaches to linking traffic and air pollution monitoring data Foreign cases to link traffic and air pollution monitoring data have been reviewed, revealing that in most cases long-term co-located traffic and air pollution monitoring sites have been operated to investigate the relation between traffic and air pollution. From the careful review of the cases, following suggestions are made. 1) Short-term approaches Mobile monitoring stations, equipped with devices of both air pollution and traffic monitoring, should be prepared and deployed wherever and whenever needed. The traffic monitoring items must include not only traffic speed and volume but also the vehicles` body and fuel types. Traffic information collected by vehicle type and fuel type can be used for in-depth evaluations of traffic-related measures applied to specific vehicle type or fuel type. In addition, the greenhouse gases need to be monitored, considering the increasing interest in global warming. Firstly, the long-term co-located traffic and air pollution monitoring should be introduced to identify the relation of vehicle emissions and air pollution in more details. The location and items to be monitored should be carefully investigated in advance. The monitoring location may be selected using various modeling tools so that the estimation of the possible impacts of traffic-related policies on the air quality over the area of interest can be performed. Secondly, traffic management systems with air quality monitoring feedback should be developed in the future. To make it happen, a flexible framework allowing communications between transport emissions and traffic conditions needs to be developed by introducing a system providing high time/space resolution measurements of both air pollutant concentrations and traffic conditions on a real-time basis.
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