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Effect of CYP2C9*3 Allele on the Pharmacokinetics of Naproxen in Korean Subjects
배정우,김지홍,장춘곤,박영서,이석용,최창익,김미정,김형지,변성애,창영순 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
The genetically polymorphic CYP2C9 metabolizes many non-steroidal anti-inflammatory agents, including naproxen. This study examined the effects of a CYP2C9 genetic polymorphism on the pharmacokinetics of naproxen in Korean subjects. Twenty healthy male subjects carrying a CYP2C9*1/*1 (n=14) or CYP2C9*1/*3 (n=6) polymorphism were enrolled. After a single-dose of 275 mg naproxen Na, blood samples were collected at various times over a 72 h period and the plasma naproxen concentration was measured. The plasma concentration of naproxen was determined by HPLC analysis with UV detection, and the pharmacokinetic parameters were calculated. The mean plasma concentrationtime profiles of naproxen in the CYP2C9*1/*3 and CYP2C9*1/*1 individuals were similar. There were no significant differences in the pharmacokinetics of naproxen between CYP2C9*1/*1 and CYP2C9*1/ *3 genotypes. The AUC0-∞ (p = 0.759) and oral clearance (p = 0.823) of naproxen were also similar in individuals with CYP2C9*1/*3 and CYP2C9*1/*1. Overall, a genetic polymorphism of CYP2C9 does not significantly affect the pharmacokinetics of naproxen. Therefore, naproxen does not require a dose adjustment for individuals with the CYP2C9*1/*3 genotype.
Acarbose 제제의 약력학적 평가 및 생물학적동등성 시험법에 대한 연구
배정우,장춘곤,이석용,Bae, Jung-Woo,Jang, Choon-Gon,Lee, Seok-Yong 대한약학회 2007 약학회지 Vol.51 No.6
Arcabose is a competitive inhibitor of the intestinal ${\alpha}$-glucosidases and reduces the postprandial digestion and absorption of carbohydrate and disaccharides. Due to its negligible oral absorption, measuring drug concentration in the plasma is impractical. Thus, the common pharmacokinetic study is not available to determine the bioequivalence of the generic acarbose preparations. The aim of this study is the establishment of pharmacodynamic assessment method for the bioequivalence test of the generic acarbose preparations. Placebo-controlled cross-over ($3{\times}3$) clinical study was conducted in 23 healthy volunteers. Volunteers received a single oral dose of placebo, reference drug ($Glucoby^{(R)}$ 100 mg, Lot # D043) or test drug ($Glucoby^{(R)}$ 100 mg, Lot # E005) just before breakfast, then blood samples for evaluation of serum glucose and insulin levels were taken during for 4 hours. $C_{max},\;AUC_{0-2},\;AUC_{0-4},\;{\Delta}C_{max},\;{\Delta}AUC_{0-2}\;and\;{\Delta}AUC_{0-4}$ of the postprandial plasma glucose level significantly decreased when a single dose of acarbose 100 mg preparations was administered. However, any significant difference was not detected between the groups taken the reference drug and the test drug. These results proposed that the pharmacodynamic protocols of this study is suitable to use for bioequivalence test of acarbose preparations. On the basis of the results of this study and the data of literature on this subject, the standard protocols of bioequivalence study of acarbose preparation are proposed.
HPLC Determination of Tolperisone in Human Plasma
배정우,박영서,손의동,명창선,류병권,장춘곤,이석용 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.4
A simple high performance liquid chromatographic (HPLC) method was developed for the determination of tolperisone in human plasma. Tolperisone and internal standard (chlorphenesin) were isolated from 1 mL of plasma using 8 mL of dichlormethane. The organic phase was collected and evaporated under nitrogen gas. The residue was then reconstituted with 300 mL aliquot of mobile phase and a 100 mL aliquot was injected onto the C18 reverse-phased column. The mobile phase, 45% methanol containing 1% glacial acetic acid and 0.05% 1-hexanesulfonic acid was run at a flow rate of 1 mL/min. The column effluent was monitored using UV detector at 260 nm. The retention times for tolperisone and the internal standard were approximately 7.1 and 8.4 min, respectively. The standard curve was linear with minimal intraday and inter-day variability. The quantification limit of tolperisone in human plasma was 10 ng/ mL. The proposed method has been applied to the determination of pharmacokinetic profile of tolperisone in Koreans. The Tmax of tolperisone in Koreans (0.94±0.42 h) was not significantly differ from that reported in Europeans (0.5-1 h), but the mean half-life in Koreans (1.14±0.27 h) was shorter than that in Europeans (2.56±0.2 h). The proposed HPLC method is simple, accurate, reproducible and suitable for pharmacokinetic study of tolperisone.
와파린의 HPLC 분석법 및 한국인에서의 약동학적 특징
배정우,김현경,양상인,김지홍,김경혜,장춘곤,박영서,손의동,이석용,Bae, Jung-Woo,Kim, Hyun-Kyung,Yang, Sang-In,Kim, Ji-Hong,Kim, Kyung-Hye,Jang, Choon-Gon,Park, Young-Seo,Sohn, Uy-Dong 대한약학회 2005 약학회지 Vol.49 No.2
Warfarin is a widely used oral anticoagulant agent used to treat thromboembolic disease. The purpose of this study was to develop the efficient assay method of warfarin sodium i n human plasma and to assess the pharmacokinetic profile of the warfarin in healthy Korean volunteers. The pharmacokinetics of warfarin administered orally was evaluated after a dose of 10 mg. Warfarin in plasma was assayed using a specific HPLC method with UV absorbance at 304 nm. AUC was 46.33${\pm}9.95{\mu}g/ml.hr$, $C_{max}$ $1.22{\pm}0.22{\mu}g/ml, $T_{max}$$2.50{\pm}1.41$ hr and half-life $43.49{\pm}4.33$ hr. $T_{max}$ was slightly shorter than that in Caucasian (3~9 hr), whereas the half-life was longer than that in Caucasian (10~45 hr, mean: 36 hr). These results suggest that warfarin may have a longer duration in Korean than in Caucasian.
프로카인아미드의 HPLC 분석법 및 한국인에서의 약동학적 특징
배정우(Jung-woo Bae),김현경(Hyun-Kyung Kim),양상인(Sang-In Yang),김지홍(Ji-Hong Kim),김경혜(Kyung-Hye Kim),장춘곤(Choon-Gon Jang),박영서(Young-Seo Park),손의동(Uy-Dong Sohn),이석용(Seok-Yong Lee) 大韓藥學會 2005 약학회지 Vol.49 No.3
Procainamide is the drug of second choice (after lidocaine) in most coronary care units for the treatment of sustained ventricular arrhythmias associated with acute myocardial infarction. The purpose of this study was to develop the efficient assay method of procainamide in human plasma and to assess the pharmacokinetic profile of procainamide in healthy Korean volunteers. The pharmacokinetics of procainamide administered orally was evaluated after a dose of 250 mg. Procainamide in plasma was assayed using a specific HPLC method with UV absorbance at 275nm. AUC was 4.58±0.90 μg/ml.hr, Cmax 1.34±0.39 μg/ml, Tmax 1.06±0.34 hr and half-life 3.07±0.34 hr. Tmax was slightly shorter than that in Caucasian (1~2hr), whereas the half-life was similar to that in Caucasian (2.5~4.1 hr).
에토석시미드의 HPLC 분석법 및 한국인에서의 약동학적 특징
배정우(Jung-Woo Bae),김지홍(Ji-Hong Kim),양상인(Sang-In Yang),김현경(Hyun-Kyung Kim),장춘곤(Choon-Gon Jang),한혜원(Hye-Won Han),박영서(Young-Seo Park),손의동(Uy-Dong Sohn),이석용(Seok-Yong Lee) 대한약학회 2003 약학회지 Vol.47 No.6
Ethosuximide is an oral anticonvulsantic agent used in the first choice anti-absence seizure drug. The purpose of this study was to assess the pharmacokinetic profile of the ethosuximide in healthy Korean volunteers and to develop the efficient assay method of ethosuximide in human plasma. The pharmacokinetics of ethosuximide administered orally was evaluated after a dose of 500 mg. Ethosuximide was assayed from plasma by a specific HPLC method reading absorbance at 195 nm. AUC was 1222±160 μg/ml·hr, Cmax 14.21±1.74 μg/ml, Tmax 1.06±0.62 hr and half-life 77.83±12.46 hr. The half-life in Korean was longer than, in Caucasian (53~56 hr).
고등학생을 위한 대인관계능력 증진 집단상담 프로그램의 개발 및 효과
배정우 ( Jeong Woo Bae ),천성문 ( Seong Moon Cheon ) 한국동서정신과학회 2004 동서정신과학 Vol.7 No.1
The purpose of this research is to develop an Interpersonal Relationship Ability Enhancement Group Counseling Program for High School students with difficulties in interpersonal relationships. The target groups for the research were students who wanted to improve their interpersonal relationship ability. In order to accomplish this, I created a program that balanced both the recognizant side and the emotional side of each student. The main goals of the program are that each student in the program will have the right understanding and analysis of himself and others, the feeling purification and the resolution of interpersonal conflict by solving unresolved problems, and the learning of interpersonal relationship ability enhancement techniques. The program took place at B Foreign Language High School located in Busan Metropolitan City. The participants of the program were 24 volunteer second year female students with an educational length of 10.1 years and an average age of 16.3 years old. From March 12th, 2003 to April 9th, 2003, each student participated in the program twice a week for 90 minute sessions for a total of ten sessions. The 24 students were randomly separated into two groups, the Experimental and Control Group, with 12 students in each group. In order to maximize the effectiveness of the research, I developed not only a counselors guidebook for assistance, but also a clients workbook to motivate the subjects active participation in the program. To prove the effectiveness of this program. I examined both the Experimental Group and the Control Group before and after using an Interpersonal Competence Questionnaire and the Self-efficacy Scale. The results of my research concluded that the Interpersonal Relationship Ability Enhancement Group Counseling Program is effective for improving the interpersonal relationship ability of high school students and that the Interpersonal Relationship Ability Enhancement Group Counseling Program also effective in improving the self-efficiency of high school students.