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류현지,서민석,강건욱,이대원,한세원,천기정 대한암학회 2023 Cancer Research and Treatment Vol.55 No.1
Purpose To provide a wider choice of treatment opportunities for patients with neuroendocrine tumor (NET) in Korea, we have conducted a phase 1, open-label, single-arm, dose-escalation study of SNU-KB-01, a no-carrier added (NCA) <sup>177</sup>Lu-labeled DOTATATE.Materials and Methods Seven patients with inoperable, progressive, metastatic, or locally advanced, somatostatin receptor-positive NET with Ki67 index ≤ 20% were enrolled according to the rolling six design. The study consisted of two cohorts to receive 4 cycles of SNU-KB-01 every 8 weeks for the first dose of 5.55 GBq (n=3) and 7.40 GBq (n=4). We assessed the incidence of dose-limiting toxicity (DLT) and adverse event, absorbed dose of kidneys and bone marrow, and objective tumor response.Results Seven patients completed 4 cycles (21.3-30.1 GBq total dose) of SNU-KB-01. The mean absorbed doses to kidneys and bone marrow were 0.500 mGy/MBq and 0.053 mGy/MBq, respectively, and the total body effective dose was 0.115 mSv/MBq. No DLT was observed and the maximum tolerated dose was 7.40 GBq/cycle. Grade 3 thrombocytopenia occurred in one patient, but no other grade 3 or 4 major hematologic or renal toxicity was observed. The best objective response to SNU-KB-01 was partial response. Overall response rate was 42.9% and disease control rate was 85.7%.Conclusion Treatment with 4 cycles of SNU-KB-01 was well tolerated and resulted in control of disease in most of the patients. Our results indicate SNU-KB-01, an NCA <sup>177</sup>Lu-labeled DOTATATE, as a potentially safe and efficacious treatment option for NET patients in Korea.
류현지,김일석,진상근,송영민,하경희,박기훈 한국축산식품학회 2004 심포지움 및 학술발표회 Vol.- No.34
pH는 숙성기간이 경과함에 따라 고추장소스(T1)와 불고기소스(T2)에서 모두 유의적으로 상승하였으며(P〈0.05), 전단력에서 T1은 전 숙성 기간 동안, T2는 숙성 20일까지는 유의성이 없었으나, 숙성기간이 경과함에 따라 증가하는 경향이었다. 염도와 당도는 저장기간이 경과함에 따라 모두 증가하는 경향이었다. 염도와 당도는 숙성기간에 따라 증가하는 경향이 있으며, T1이 T2보다 전 숙성기간 동안 높게 나타났다.
The Effect of Record Versus Rank Competition on the Performance of Male Marathoners
류현지,정하연,Denny Eun,문혁주,서상훈 국민체육진흥공단 한국스포츠정책과학원 2022 International Journal of Applied Sports Sciences Vol.34 No.2
We examined the performance differences in elite male marathoners when competing for record times versus ranks. Data of the top 300 male marathoners in 2019 were obtained from the World Athletics website for comparison and analysis. All competitions approved by the World Athletics were rated in the order of OW, GL, A, B, C, D, E, and F. Time comparisons were performed using one-way ANOVA and then the Bonferroni post-hoc test. Higher-grade competitions consist of top athletes with competitive qualifying record whose central motivation is to achieve the best records. Lower-grade competitions are often preliminary measures of qualification for larger competitions, motivating athletes to compete for ranks rather than records. The average time difference for each competition was statistically significant. GL's average time was the fastest at 2:13:42 (±00:03:15). From A to F, the average finishing time tended to increase from 2:09:51 (±00:03:27) to 2:14:48 (±00:03:24). The average end time at F was the slowest at 2:14:48 (±00:03:24). When comparing the athletes’ relative performance, the times for large international competitions, such as GL, A, and B, were also faster than smaller competitions, such as E and F (p<0.05). These results are interpreted to mean that competing to achieve record times is better for marathon performance than competing for ranks.
기계학습을 이용한 한국 프로야구 신인 투수들의 유형화 및 잠재력 평가
주윤태,류현지,서상훈 한국코칭능력개발원 2023 코칭능력개발지 Vol.25 No.2
The purpose of this study was to give a guideline to Korea Baseball Organization(KBO)’s draft by clustering pitchers and evaluating potential. Subjects were KBO 37 pitchers drafted between 2015~2020 and who have average fastball velocity record on debut season. Subject’s height, weight, average fastball pitch velocity on debut season, WAR(Wins Above Replacement), academic background, left or right pitcher, average fastball pitch velocity on recent seaon data was collected from KBO official website and Statiz. This data was preprocessed by minmaxscaler and clustered by use of K-means clustering algorithm. Pithcer group was clustered into 3 groups which are pitcher who has fast pitch velocity, pitcher who has good physique, and pitcher who has average pitch velocity and physique. After clustering we compare each group’s performance by WAR, left handed pitcher ratio, university graduate pitcher ratio, and increasement of pitch velocity. Also, Pearson correlation analysis is used to find a realationship between variables. We found out average fastball velocity and WAR has positive correlation. Hence, the result of this study implies pitch velocity is the most important component when drafting rookie pitcher in KBO. 본 연구는 한국 프로야구(Korea Baseball Organization; KBO) 투수의 유형별 잠재력 평가를 통해 신인 드래프트 전략의 방향성을 제시하는 데 목적이 있다. 연구의 대상은 2015년부터 2020년까지 지명된 한국 프로야구 투수 중 데뷔 시즌 속구 평균 구속 데이터 확보가가능한 37명으로 선정하였다. 연구 대상의 키, 체중, 데뷔 시즌 속구 평균 구속, WAR(Wins Above Replacement) 최종학력, 우완 좌완여부, 최근 시즌 속구 평균 구속에 대한 데이터는 한국 프로야구 공식 사이트와 스탯티즈 사이트를 통해 수집하였다. 이렇게 확보한데이터는 MinMaxscaler를 통해 전처리 후, K-평균 군집분석 알고리즘을 통해 투수들의 유형을 분류하였다. K-평균 군집분석 결과 빠른 공을 던지는 투수, 체격이 좋은 투수, 구속과 체격이 보통인 투수로 유형이 나누어졌다. 이후 유형별로 WAR을 통해 경기력 수준을 확인하였고, 대졸 투수 비율, 좌완 투수 비율, 속구 평균 구속 증가 정도를 유형별로 비교하였다. 그뿐만 아니라, 피어슨 상관계수를 이용한 상관관계 분석을 통해 키, 체중, 데뷔 시즌 속구 평균 구속, WAR 간의 연관성을 파악하였다. 그 결과 투수 유형 중 빠른공을 던지는 투수 유형이 체격이 좋은 투수 유형과 구속과 체격이 보통인 투수 유형에 비해 팀 승리에 가장 큰 기여를 하였다. 속구평균 구속과 WAR은 양의 상관관계가 있다는 것을 확인했다. 그러므로 본 연구의 결과는 한국 프로야구에서 신인 투수의 선발 시에구속이 가장 중요한 지표가 된다는 것을 암시한다.