A Predictive Model Based on Bi-parametric Magnetic Resonance Imaging and Clinical Parameters for Clinically Significant Prostate Cancer in the Korean Population

노태일,현창완,강하은,진현정,태종현,심지성,강성구,성득제,천준,이정구,강석호 대한암학회 2021 Cancer Research and Treatment Vol.53 No.4

Purpose This study aimed to develop and validate a predictive model for the assessment of clinically significant prostate cancer (csPCa) in men, prior to prostate biopsies, based on bi-parametric magnetic resonance imaging (bpMRI) and clinical parameters. Materials and Methods We retrospectively analyzed 300 men with clinical suspicion of prostate cancer (prostate-specific antigen [PSA] ≥ 4.0 ng/mL and/or abnormal findings in a digital rectal examination), who underwent bpMRI-ultrasound fusion transperineal targeted and systematic biopsies in the same session, at a Korean university hospital. Predictive models, based on Prostate Imaging Reporting and Data Systems scores of bpMRI and clinical parameters, were developed to detect csPCa (intermediate/high grade [Gleason score ≥ 3+4]) and compared by analyzing the areas under the curves and decision curves. Results A predictive model defined by the combination of bpMRI and clinical parameters (age, PSA density) showed high discriminatory power (area under the curve, 0.861) and resulted in a significant net benefit on decision curve analysis. Applying a probability threshold of 7.5%, 21.6% of men could avoid unnecessary prostate biopsy, while only 1.0% of significant prostate cancers were missed. Conclusion This predictive model provided a reliable and measurable means of risk stratification of csPCa, with high discriminatory power and great net benefit. It could be a useful tool for clinical decision-making prior to prostate biopsies.

학교 부적응 청소년을 위한 평생교육의 방향 : 평생교육 차원에서의 대한교육을 중심으로

노태일 한국국제지역사회개발학회 2002 地域社會開發學術誌 Vol.12 No.2

청소년단체의 프로그램개발과 개선방안 : 대구청소년단체협의회를 중심으로

노태일 한국국제지역사회개발학회 2003 地域社會開發學術誌 Vol.13 No.1

The purposes of this study is to suggested the strategies of improvement for program development from the youth-organization conference in Daegu. The detail objectives of this study are as follows: (1) to investigate the relationship between youth-organization and program development through theory. (2) to understand the characteristics of program development which operating youth-organization. (3) to suggest the strategies of improvement for effective program development in youth-organization. The research methods used for accomplishing the above study purposes are literatures investigation that are related to youth-organization and program development, and field survey which is done at youth-organization conference in Daegu. The statistical methods to analyse the data were frequency and percentage. According to this study, the strategies of improvement for effective program development in youth-organization appeared to the participation of all members with planning process, implementation process, evaluation process. This analysis provides some useful strategies of improvement for program development. The results tend to emphasize the participation of everyone for effective program development in youth-organization.

Are Hypoechoic Lesions on Transrectal Ultrasonography a Marker for Clinically Significant Prostate Cancer?

노태일,신윤선,심지성,윤종현,김재헌,배재현,문두건,박재영 대한비뇨의학회 2013 Investigative and Clinical Urology Vol.54 No.10

Purpose: To investigate the relationship of transrectal ultrasound (TRUS) findings with the pathological characteristics of prostate cancer (PCa). Materials and Methods: The study was conducted retrospectively by analyzing the data for 970 patients who underwent prostate biopsies. Gleason scores and other clinical variables were compared between PCa patients with and without hypoechoic lesions on TRUS. Results: Of the 970 patients, PCa was diagnosed in 291 (30%). Of these, high-grade PCa (Gleason score of 7 or more) was diagnosed in 190 (65%). The cancer detection rate was higher in patients with hypoechoic lesions (43.9%) than in those without hypoechoic lesions (21.4%, p<0.001). High-grade PCa was detected more often in patients with hypoechoic lesions than in those without hypoechoic lesions (p<0.001). Independent predictors for high-grade PCa by logistic regression analysis included hypoechoic lesions on TRUS and abnormal digital rectal examination findings. Conclusions: Patients with PCa who had hypoechoic lesions on TRUS had more aggressive pathological disease than did those without lesions. Therefore, hypoechoic lesions on TRUS could be a marker for clinically significant PCa.

Diagnostic Accuracy and Value of Magnetic Resonance Imaging–Ultrasound Fusion Transperineal Targeted and Template Systematic Prostate Biopsy Based on Bi-parametric Magnetic Resonance Imaging

노태일,태종현,김형근,심지성,강성구,성득제,천준,이정구,강석호 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3

Purpose The purpose of this study was to investigate the diagnostic value of magnetic resonance imaging (MRI)–ultrasound (US) fusion transperineal targeted biopsy (FTB) and fusion template systematic biopsy (FSB) for prostate cancer (PCa) and clinically significant prostate cancer (csPCa) (intermediate/high grade [Gleason score ! 3+4]) based on bi-parametric MRI (bpMRI). Materials and Methods Retrospectively, we analyzed 300 patients with elevated prostate-specific antigen (! 4.0 ng/mL) and/or abnormal findings in a digital rectal examination at the Korea University Hospital. All 300 men underwent bpMRI-US fusion transperineal FTB and FSB in the period from April 2017 to March 2019. Results PCas were detected in 158 of 300 men (52.7%), and the prevalence of csPCa was 34.0%. CsPCas were detected in 12 of 102 (11.8%) with Prostate Imaging-Reporting and Data System (PI-RADS) 3, 42 of 92 (45.7%) with PI-RADS 4, respectively; and 45 of 62 (72.6%) men with PI-RADS 5, respectively. BpMRI showed a sensitivity of 95.1% and negative predictive value of 89.6% for csPCa. FTB detected additional csPCa in 33 men (12.9%) compared to FSB. Compared to FTB, FSB detected additional csPCa in 10 men (3.9%). Conclusion BpMRI-US FTB and FSB improved detection of PCa and csPCa. The accuracy of bi-parametric MRI is comparable with that of multi-parametric MRI. Further, it is rapid, simpler, cheaper, and no side effects of contrast media. Therefore, it is expected that bpMRI-US transperineal FTB and FSB could be a good alternative to conventional US-guided transrectal biopsy, which is the current gold standard.

하인리히 폰 클라이스트의 「미하엘 콜하스」와 프로이센 개혁운동

노태한 ( Noh Tae-han ) 한국독일언어문학회 2016 독일언어문학 Vol.0 No.73

Heinrich von Kleists umfangreichste, komplexeste und beruhmteste Erzahlung Michael Kohlhaas entstand in den Jahren zwischen 1805 und 1810, in denen er in engem Kontakt mit den preußischen Reformern stand. Ihnen ging es grundsatzlich nicht um eine ``Revolution von unten``, sondern vielmehr um eine ``Reform von oben``, um in Preußen einer moglichen gewaltsamen Revolution vorzubeugen. Sie versuchten den preußischen Staat ``von innen her`` so weit zu starken, dass er Kraft zum erfolgreichen Kampf gegen Napoleon entwickelte. Im Bannkreis der preußischen Reformen reflektiert Kleist kritisch, aber mit konstruktiver Absicht die Missstande des Staats und der Gesellschaft, um dabei zu helfen eine ``bessere Ordnung der Dinge`` herbeizufuhren. Seine anfanglich radikal ablehnende Gesellschaftskritik, die wegen ihrer Grundsatzlichkeit auch sehr allgemein blieb, wandelt sich in eine Kritik, die mehr auf bestimmte und konkrete und damit auch korrigierbare Missstande abzielt. Das ist vor allem am Michael Kohlhaas zu sehen. Dass Kleist in der Erzahlung das Junkertum als korrupt, ausbeuterisch und seine Privilegien zum Schaden des Volkes benutzend darstellt und als Konsequenz seines illegalen Verhaltens revolutionare Unruhen nach Art Kohlhaasens vorfuhrt, das ist als ein kaum verhullter Angriff auf die junkerliche Opposition und als Unterstutzung der Reformer zu verstehen. Es geht Kleist um Reform und nicht um Revolution. Aber er inszeniert im Michael Kohlhaas die Revolutionsgefahr als Menetekel fur den Fall, dass die Reformen ausbleiben. Er will reformerisch alarmieren.

헤르만 헤세의 <빛의 나라를 찾아서 Die Morgenlandfahrt>에 대하여

노태한 ( Tae Han Noh ) 한국독어독문학교육학회 1997 獨語敎育 Vol.15 No.-

하인리히 폰 클라이스트 노벨레의 기본구조

노태한 한국헤세학회 2007 헤세연구 Vol.17 No.-

지하안전영향평가를 위한 지반안전성 검토 범위의 제안

노태길 ( Noh Tae-kil ),신상협 ( Shin Sang-hyup ),안재욱 ( An Jai-wook ),김동진 ( Kim Dong-jin ),권오식 ( Kwon O-sik ) 한국구조물진단유지관리공학회 2020 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.24 No.1

굴착 및 터널공사를 수반한 지하개발사업의 지하안전영향평가 수행 시, 지반안전성 검토 범위를 선정함에 있어 기존의 경험적인 추정 방법을 적용할 경우 복합 다층지반 조건의 특성을 나타내는 국내 실제 현장과는 다소 차이가 발생 할 수 있다. 따라서 본 연구에서는 다양한 지반조건 및 터널형상, 토피고 등을 달리 적용하여 유한요소해석을 수행하였다. 해석 결과, 터널공사 시 지반안전성 검토 범위는 1.6D∼2.0D로 분석되었으며, 지반조건 및 주변 지하매설물, 인접 건물의 노후도 등을 고려하여 최소 터널 직경의 2배 이상을 검토 범위로 선정할 것을 제안하였다.

헤르만 헤세의 데뷔소설 『페터 카멘친트』 - 성립 배경 및 과정과 서사 구조 -

노태한 한국독어독문학교육학회 2013 獨語敎育 Vol.57 No.-

Hermann Hesses “kleine Prosadichtung” Peter Camenzind, entstandzwischen 1901 und 1903 in Basel, war sein erster großer Bucherfolg undbrachte ihm den Durchbruch als Schriftsteller. Dieser “kleine Roman”, derin vieler Hinsicht Themen und Formen der späteren Romane des Autorsvorwegnimmt und damit “den Anfang des roten Fadens” seines “ganzenWerkes” darstellt, ist eine fiktive Autobiographie, die aus der dörflichenIdylle in die Welt des städtischen Lebens und der Kunst und - nachgescheiterter Anpassung an die zunehmend als dekadent empfundeneGroßstadt und die moderne Kultur - wieder zurück zur Natur und in dieHeimat führt. In der vorliegenden Arbeit setzt sich der Verfasser zum Ziel, zuerst dieHintergründe und Prozesse der Entstehung des Romanerstlings PeterCamenzind aufzuspüren und dann die Erzählstrukturen des Werkes zuanalysieren. Im ersten Hauptteil der Arbeit wird nämlich versucht, dieEntstehungsgeschichte des Romans auf Grund der vielartigen Äußerungendes Autors selbst in seinen Briefen und anderen Schriften zurekonstruieren, um daraus brauchbare Ansatzpunkte zu ihrem besserenVerständnis herauszubekommen. Im zweiten Teil wird die Struktur des Romangeschehens ausführlichbehandelt, wobei es sich, stichwortartig genannt, um Erzählsituation underzählte Zeit, Raum- und Zeitstruktur, Figurenkonstellation und Motivgeflechtdes Romans handelt. Dabei wird vor allem das Motiv der Menschenliebe in Verbindung mit der Änderung der Anschauung desProtagonisten von Dichtung und Dichter, also mit dem Wandel von NaturzuMenschendichtung, hervorgehoben.