병원 원무행정근무자의 직무소진이 직무만족과 이직의도에 미치는 영향

남진영 ( Jin Young Nam ),손명세 ( Myong Sei Sohn ),강대용 ( Dae Ryong Kang ),유승흠 ( Seung Hum Yu ) 한국보건정보통계학회(구 한국보건통계학회) 2014 보건정보통계학회지 Vol.39 No.1

Objectives: The purpose of study was to find the influence of job burnout on job satisfaction and turnover intention among admission and discharging employees working in hospital. Methods: The 241 employees who work at the admission and discharging department in 8 general hospital with more than 500 beds in Seoul and Gyeounggi province were surveyed from October 18, 2010 for 4 weeks. Descriptive statistics was used to understand general characteristics of subjects; the t-test and one way ANOVA followed by Tukey’s HSD test were used for analysis of the job burnout according to the general characteristics, and multiple regression was employed to find the factors of job burnout afecting job satisfaction and turnover intention, respectively. Results: First, the degrees of job burnout differ according to the general characteristics. The level of job burnout tends to be high among the population of younger age, college graduates, and employees whose number of years of service is between 3 and 10. Second, the level of job satisfaction decreases as the level of job burnout increases. Third, The level of turnover intention tends to increase as the level of job burnout increases. Conclusions: Based on the result of this study, hospitals may make an effort to lower the job burnout by improving the system of human resource management. Such effort may include prevention of falling into a routine through job rotation and continuing education, and creation of sense of belonging through timely promotion.

부인암 환자 말초 혈액의 CD4(+)CD25(+)조절 T림프구 분포

마진영 ( Jin Young Ma ),김용만 ( Yong Man Kim ),정민형 ( Min Hyung Jung ),송하영 ( Ha Young Song ),김대연 ( Dae Yeon Kim ),김종혁 ( Jong Hyeok Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ),목정은 ( Jung Eun Mok ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.3

목적: 조절 T림프구 (regulatory T lymphocyte)는 암세포에 대한 면역관용 (immune tolerance)을 일으켜 특정 항원에 대한 T림프구의 작용을 감소 혹은 상실시킴으로써 암세포의 빠른 성장, 국소 침입과 혈행성 전이에 관여하는 것으로 알려져 있다. 현재 암환자의 말초혈액 내 조절 T림프구의 분포에 대한 연구는 초기 상태이고, 난소암을 제외한 부인암에서 CD4(+)CD25(+)조절 T림프구 분포 및 Foxp3의 발현정도에 대해서는 그 연구결과가 거의 없는 상태이다. 따라서 본 연구에서는 암환자에서 CD4(+)CD25(+)조절 T 림프구의 분포와 Foxp3의 표현정도를 확인하고자 한다. 연구 방법: 본 연구는 2005년 3월부터 2005년 9월까지 서울아산병원 산부인과에서 조직 병리학적으로 자궁경부 편평세포암종, 장액성 난소암종, 자궁내막선암종으로 처음 진단받은 환자 각각 10명의 말초혈액과 자궁경부상피내암 환자 10명 및 건강한 여성 10명의 말초혈액을 이용하여 이루어졌다. FACS (flow cytometry analysis) 를 통해 CD4(+)CD25(+)조절 T림프구 분포와 PCR과 전기영동을 통해 Foxp3의 표현 정도를 알아보았다. 각 군 간의 비교 및 유의성 검정은 ANOVA를 이용하여 분석하였으며, 두 군 간의 p값이 0.05 미만인 경우에 통계적으로 유의한 것으로 판정하였다. 결과: 첫째, 정상 대조군과 비교하여 부인암 환자의 말초혈액에서 총 CD4+ T림프구 중 CD4(+)CD25(+high)조절 T림프구의 발현이 증가되어 있었으나, CD4(+)CD25(+)조절 T림프구의 비율은 대조군과 유의한 차이가 없었다. 둘째, 자궁경부암의 전암 병소인 자궁경부상피내암에 비해 자궁경부암 환자에서 총 CD4+ T림프구 중 CD4(+)CD25(+high)조절 T림프구의 비율이 유의하게 높았다. 셋째, 각 부인암의 병기에 따른 CD4(+)CD25(+), CD4(+)CD25(+high)조절 T림프구 비율은 차이가 없었다. 넷째, 대조군과 달리 부인암 환자의 말초혈액에서 전사요소인 Foxp3의 발현이 증가되어 있어, 암세포가 존재할 경우 말초혈액에서 암세포에 의해 자연 획득한 T림프구가 증가함을 알 수 있었다. 결론: 본 연구를 통해 부인암 환자의 말초혈액에서 조절 T림프구 중 CD4+CD25+high조절 T림프구 수가 증가되어 있음을 확인하였고, 이에 의해 암세포에 대한 면역무시, 면역억제작용으로 암세포의 발현, 성장, 전이에 관여하는 것으로 보인다. 이를 토대로 현재 시도되고 있는 항암면역치료를 부인암 환자에게도 적용할 수 있는 가능성이 높을 것으로 사료된다. Objective: Recently the existence of a CD4(+)CD25(+) regulatory (Treg) population has been described in rodents and humans. It is unclear how the immune response cells interact to tumor cells effectively, but the malignant tumor cell growth was suppressed by the main effect of T lymphocytes and natural killer cells in experimental studies using various biologic response modifier. This study was performed to investigate the proportion of CD4+CD25(high) Tregs and expression of Foxp3 in Peripheral blood (PBL)s in patients with cervical, ovarian or uterine cancers. Methods: Blood samples were collected from 10 healthy women and a total of 40 patients with gynecologic cancer at department of Obstetrics and Gynecology, Asan Medical Center, Seoul, Korea, from March 2005 to September 2005, were enrolled in study group. Information regarding patient history and tumor stage was recorded. They were diagnosed at same center at first, and never been treated any therapy. The population of CD4(+)CD25(+high) Tregs as a percentage of total CD4+cells was evaluated by flow cytometric analysis. We measured the proportion of Treg cell that co-express CD4 and CD25 in the peripheral blood lymphocytes form patients with either cervical, ovarian uterine cancer or carcinoma in situ of cervix. Expression of Foxp3 in the CD4+subsets defined by electrophoresis. Results: The following tumor entities were included cervical cancer (n=10. 7 in stage Ⅰ, 1 in stage II, 1 in stage III, 1 in stage Ⅳ); ovarian cancer (n=10. 4 in stage Ⅰ, 0 in stage II, 5 in stage III, 1 in stage Ⅳ), ; uterine cancer (n=10. 9 in stage Ⅰ, 0 in stage II, 0 in stage III, 1 in stage Ⅳ). In cervical cancer patient, ovarian cancer patients, uterine cancer patients and healthy women, the proportion of CD4+CD25(high) Tregs was 4.53% (SD 2.30), 6.89% (SD 7.81), 4.37% (SD 2.43) and 0.87% (SD 0.57) of the total CD4+cells respectively. The proportion of CD4+CD25(+high) T cells was significantly higher in cervical cancer patients (p=0.016), ovarian cancer patients (p=0.001) and uterine cancer patients (p=0.038) when compared with healthy women. But there was no significant difference in proportion of CD4+CD25+ Tregs comparing with healthy women. Expression of Foxp3 was significantly thicker in tumor-associated lymphocytes than control T cells by electrophoresis. Conclusion: In conclusion, our data suggested that the increase in frequency of regulatory T cells might play a role in modulation of the immune response against cervical, ovarian, uterine cancer could be important in design of immunotherapeutic approaches.

적정한 산전관리와 중증 모성질환 발생의 관련성 연구: 인구집단 기반 코호트 연구

남진영 ( Jin Young Nam ),박은철 ( Eun-cheol Park ) 한국모자보건학회 2018 한국모자보건학회 학술대회 연제집 Vol.2018 No.2

Purpose: This study identified the relationship between adequate prenatal care and severe maternal morbidity among delivered women. Methods: Data were extracted from the Korean National Health Insurance Service-National Sample Cohort for 91,767 cases of delivery that were delivered during 2003~2013. Severe maternal morbidity status was determined using the Center for Disease Control and Prevention’s algorithm including the diagnosis and procedure code during delivery and postpartum hospitalization. A generalized estimating equation (GEE) model with log link was performed for the relationship with severe maternal morbidity and women’s factors to estimate adjusted relative risk. Results: Of the 91,767 delivery cases, 2,248 (2.45%) had severe maternal morbidity. In the GEE model, severe maternal morbidity was higher in women who had inadequate prenatal care than in those who had adequate prenatal care (relative risk (RR) 1.39, 95% CI 1.11~1.75, p-value 0.0045). For maternal age, women who delivered at extremely young or old ages had high risks of severe maternal morbidity, which showed a U-shaped distribution through the whole age range. Women who had the lowest level of income, who had cesarean section delivery, who were nulliparous, who had twins or more than triplet births had high risks of severe maternal morbidity. Conclusion: Inadequate prenatal care delivery was associated with the occurrence of severe maternal morbidity. Therefore, policy makers should consider making quality indicators for early, timely, and sufficient visits during pregnancy and should monitor adequacy of prenatal care to prevent severe maternal morbidity.

폴라니의 인식론과 문제해결의 암묵적 차원

남진영,홍진곤,Nam, Jin-Young,Hong, Jin-Kon 한국수학사학회 2009 Journal for history of mathematics Vol.22 No.3

수학 문제해결 교육에 가장 많은 영향을 끼친 것은 폴리아(G. Polya)의 이론이다. 폴리아가 제시하는 발견술은 수학 문제해결 과정을 명시적으로 세분화여 드러내고 정리한 것이다. 이와는 달리, 수학 문제해결 과정의 암묵적 차원을 강조하고 있는 폴라니(M. Polanyi)의 이론은 폴리아의 이론과 상보적 관계에 있는 것으로 조명될 필요가 있다. 이 글에서는 폴라니의 인식론을 개관하고, 이를 바탕으로 하는 그의 문제해결 교육 이론을 고찰한다. 지식과 앎을 개인의 마음의 총체적 작용으로 보는 폴라니는 문제해결에 있어서 지적, 정서적 부분과 함께 헌신과 몰두를 강조한다. 또한 명시적 앎 이면에 있는 묵식에 있어서 교사의 역할을 중시한다. 이와 같은 폴라니의 관점은 현재 우리나라 학생들의 수학 문제 해결 양상을 이해하고 문제점을 파악하는 데에도 의미 있는 시사를 제공한다. It can be said that the teaching and learning of mathematical problem solving has been greatly influenced by G. Polya. His heuristics shows down the explicit process of mathematical problem solving in detail. In contrast, Polanyi highlights the implicit dimension of the process. Polanyi's theory can play complementary role with Polya's theory. This study outlined the epistemology of Polanyi and his theory of problem solving. Regarding the knowledge and knowing as a work of the whole mind, Polanyi emphasizes devotion and absorption to the problem at work together with the intelligence and feeling. And the role of teachers are essential in a sense that students can learn implicit knowledge from them. However, our high school students do not seem to take enough time and effort to the problem solving. Nor do they request school teachers' help. According to Polanyi, this attitude can cause a serious problem in teaching and learning of mathematical problem solving.

AHP를 활용한 액셀러레이터의 산업별 투자결정요인 우선순위에 대한 연구 : ICT 및 제조업 투자결정요인 비교연구

주진영(Jin Young Joo),남정민(Jeongmin Nam),이슬기(Lee Seulki) 한국진로창업경영학회 2022 한국진로창업경영학회지 Vol.6 No.1

본 연구는 초기 스타트업 액셀러레이터의 투자결정요인을 탐색하고, 투자비중이 높은 ICT 분야와 투자 비중이 가장 낮은 제조업 분야의 투자결정요인의 차이점을 비교 분석하는데 목적이 있다. 연구 목적을 달성하기 위해 민간 및 공공 액셀러레이터 기관의 대표, AC, 투자 담당자 등을 포함하여 ICT 및 제조업 분야에 투자경험이 있는 전문가들을 대상으로 AHP(Analytic Hierarchy Process)기법을 활용하여 분석하였다. 본 연구의 분석결과를 요약하면 다음과 같다. 투자결정요인의 상위요인으로 ICT 분야와 제조업 분야 모두 ‘팀원/창업자 특성’을 가장 중요하게 평가하는 것으로 나타났다. 하위요인으로 ICT 분야는 ‘시장성장성 및 신시장 창출가능성’.‘창업자의 유연한 사고 및 실행력’,‘팀원/창업자의 고객 및 시장 이해도’순으로 나타났으며, 제조업 분야에서는 ‘창업자의 관련 산업경험 및 전문성’,‘시장성장성 및 신시장 창출가능성’, ‘팀원의 관련 산업 경험 및 전문성’순으로 나타났다. 본 연구결과를 통해 초기 스타트업이 투자유치에 성공하기 위해 고려해야할 주요 요인을 제시하고, 액셀러레이터들은 어떤 요인에 중점을 두어 투자의사결정을 내릴 것인지 판별하는 주요한 자료로 활용될 것을 기대한다. The purpose of this study is to explore the investment determinants of early startup accelerators and to compare and analyze the differences between the investment determinants in the ICT sector with the highest investment share and the manufacturing sector with the lowest investment share. In order to achieve the research purpose, the analysis was conducted using the Analytic Hierarchy Process (AHP) technique for experts with investment experience in ICT and manufacturing fields, including representatives, AC, and investment managers of private and public accelerator institutions. The analysis results of this study are summarized as follows. As a top factor in investment determinants, it was found that both the ICT field and the manufacturing sector evaluated the characteristics of team members/founders As a sub-factor, the ICT field is market growth potential and possibility of creating new markets .It appeared in the order of founders flexible thinking and execution and customer and market understanding of team members/founders, followed by founders related industrial experience and expertise, market growth potential and new market creation, and team members related industrial experience and expertise. Through the results of this study, it is expected that early startups will present major factors to consider in order to succeed in attracting investment, and accelerators will be used as major data to determine which factors to focus on to make investment decisions.

자돈 설사병에 대한 형질전환 당근백신의 방어 효능 평가

김영훈,남진영,이향근,황철호,한정희,Kim, Yeong-Hun,Nam, Jin-Young,Lee, Hyang-Keun,Hwang, Cheol-Ho,Han, Jeong-Hee 대한수의학회 2011 大韓獸醫學會誌 Vol.51 No.2

The study evaluated whether a transgenic carrot vaccine could induce a K88-specific immune response in sows and whether the resultant maternal antibody could protect piglets against enterotoxigenic Escherichia coli (ETEC) K88ac infection. Sows (n = 15) selected randomly from a farm in Korea were assigned to three groups (n = 5 per group: control [untreated]), group A (orally inoculated with a nontransgenic and transgenic carrot vaccines at 2 and 4 weeks ante partum, respectively), and group B (conventionally vaccinated according to the manufacturer's instructions). After 7 days of lactation, 5 piglets selected randomly from each group were challenged with $1{\times}10^{10}$ colony forming units/mL ETEC K88ac. Group C had the lowest mean fecal consistency score on post-challenge days 1 and 7. Histiologically, On post-challenge day 7, group C showed an increased duodenum and ileum villus:crypt ratio, compared to group A in the duodenum, with group B displaying the highest ratio. Groups B and C had more increased villus width than group A in the jejunum. Group C displayed the greatest increase in villus width in the ileum. The colostrums and serum from groups B and C displayed higher concentrations of IgA and IgG against ETEC K88, compared to group A. Based on the results, it was concluded that the transgenic carrot vaccine in sow per oral may have an effect on preventing piglet diarrhea as good as commercial recombinant vaccine.

초임계 이산화탄소를 이용한 약용식물 성분의 선택적 추출

최영해,박은정,김영림,진영원,전성호,정승남,유기풍,김진웅,Choi, Young-Hae,Park, Eun-Jung,Kim, Young-Leem,Chin, Young-Won,Jeon, Seong-Ho,Joung, Seung-Nam,Yoo, Ki-Pung,Kim, Jin-Woong 한국생약학회 1999 생약학회지 Vol.30 No.1

Supercritical fluid extraction (SFE) technique was applied to extract cytotoxic substances from five medicinal plants including Angelica gigas, Angelica acutiloba, Aralia cordata, Spirodela polyrhiza, Bupleurum falcatum, and Acanthopanax sessiliflorus. The cytotoxicities against P388, A549, and HL-60 cell lines were determined for the supercritical carbon dioxide extracts of five plant materials employed and were compared with those of the conventional organic solvent extracts such as n-hexane, $CHCl_{3}$, and MeOH to evaluate the SFE as an alternative method to conventional organic solvent extraction. In most cases, the SFE extracts of plant materials showed enhanced cytotoxicities when compared with those of other organic solvent extracts. In addition, the optimum temperature and pressure of SFE for extraction of the cytotoxic substances were largely affected by both the plant species and the cell lines tested. These results suggested that SFE could be an alternative to the conventional organic solvent method for the selective extraction of cytotoxic compounds from plants.

브랜드 경험을 위한 정보원으로서의 커뮤니케이션 접점

조정식(Jung Sik Cho),남진영(Jin Young Nam),황장선(Jang Sun Hwang) 한국광고홍보학회 2012 광고연구 Vol.0 No.92

다변화되고 있는 매체 환경에서 통합적 마케팅 커뮤니케이션의 효율적인 집행을 위해서는 다양한 커뮤니 케이션 접점에 대한 통합적 이해와 총체적 브랜드 경험에의 연계가 중요하다. 본 연구는 이러한 문제의식에서 출발하여, 다섯 가지의 브랜드 경험 유형에 대해 16개의 커뮤니케이션 접점들은 얼마나 적합한지를 소비자 인식의 관점에서 실증 분석하고자 하였다. 이를 위해 설문 조사를 통해 4개의 제품군에 대하여 소비자들이 원하는 브랜드 경험의 유형에 대해 각 접점의 적합성 정도를 측정하였다. 정보 탐색 활동에 영향을 미치는 것으로 보고된 사전 지식과 제품 유형(탐색재 및 경험재)의 역할을 함께 검증하였다. 연구결과, 각 유형의 브랜드 경험에 대해 적합한 커뮤니케이션 접점은 서로 상이한 것으로 나타났으며, 사전 지식과 제품의 유형도 일부 영향을 미치는 것으로 검증되었다. 이를 통해 기업의 마케팅 커뮤니케이션전략 수립에 있어서 브랜드 경험의 유형을 세부 목표로 명확하게 설정하고, 이에 따른 커뮤니케이션 접점의 선택 및 운용을 적절하게 할 수 있는 실무적 함의를 도출하였다. 또한, 각 브랜드 경험에 대한 접점 관리의 차원에서 세부적인 검증 필요성을 비롯한 후속 연구에의 제언을 제시하였다. Under the dynamic media environment, it is critical to understand various contact points (CP) for communications and their linkages to holistic brand experiences. The current study investigates how appropriate sixteen CPs are for five types of brand experiences. Four product categories were employed, and participants evaluated each of sixteen CPs in terms of their appropriateness to brand experiences which were measured with five categories. In addition, prior knowledge and product categories were analyzed to examine their roles in evaluation of CPs as well as their fitness for each category of brand experiences. The findings show that each category of brand experiences should require different types of CPs for communication. Prior knowledge and product categories influence on the evaluation of CPs. It is suggested that advertisers need to setup the specific objectives with brand experiences in planning marketing communications. The study yields some managerial implications for the strategic selection and management of CPs for IMC.

한국성인의 수면시간과 갑상샘 질환 사이의 관계성에 대한 성별차이

안정현 ( Jeong Hyun Ahn ),남진영 ( Jin Young Nam ),박수진 ( Soojin Park ) 한국보건정보통계학회 2021 보건정보통계학회지 Vol.46 No.3

목적: 본 연구는 한국 성인의 수면시간과 갑상샘 유병률의 관계성에 대해 성별 차이를 파악하고자 한다. 방법: 본 단면연구는 2016년부터 2018년까지 국민건강영양조사에 참여한 성인 17,555명이 포함되었다. 수면시간은 3가지로 분류하였다(불충분한 수면, 7시간 미만; 정상수면, 7-8시간; 장시간 수면, 9시간 이상). 일반적 특성 측정하기 위해 카이제곱 검정을 실시하였다. 일반적 특성과 갑상샘 질환 유병률 간의 관계를 확인하기 위해 다중 로지스틱 회귀분석을 사용하였다. 하위그룹 분석에서, 다중 로지스틱 회귀분석은 성별에 따라 수면시간과 갑상샘 질환 유병률 간의 관계성을 알기 위해 시행되었다. 결과: 불충분한 수면과 장시간의 수면을 취한 남성은 정상수면과 비교하였을 때 갑상샘 질환의 위험성이 증가하였다(불충분한 수면: OR=1.85, 95% CI=1.19-2.87; 장시간 수면: OR=1.71, 95% CI=1.02-2.87). 결론: 본 연구는 불충분하고 장시간의 수면을 취한 남성은 갑상샘 질환과 관련성이 있다. 추후 연구에서는 성별에 따른 수면시간과 갑상샘 질환의 관계성을 수면의 질과 함께 고려할 필요가 있다. Objectives: The study aimed to investigate sex differences associated with sleep duration and the prevalence of thyroid disease among South Korean adults. Methods: This cross-sectional study included 17,555 adults who participated in the Korea National Health and Nutrition Examination Survey from 2016 to 2018. Sleep duration was categorized into three groups (insufficient, <7 hour; normal, 7-8 hour; prolonged, ≥9 hour). A chi-squared test was performed to assess baseline characteristics. Multiple logistic regression analysis was used to identify the association between general characteristic and the prevalence of thyroid disease. In subgroup analysis, multiple logistic regression analysis was performed to find the association between sleep duration and prevalence of thyroid disease by sex. Results: For men, insufficient and prolonged sleep durations were increased risk of thyroid disease compared with normal sleep duration (insufficient sleep: odds ratio, OR=1.85, 95% confidence interval, CI=1.19-2.87; prolonged sleep: OR=1.71, 95% CI=1.02-2.87). Conclusions: This study found that men with insufficient and prolonged sleep were associated with thyroid disease. Further studies are needed to identify the relationship between sleep duration, thyroid disease, and sleep quality by sex.

축으로 고정된 승용차용 레디얼 타이어의 3차원 진동형

김용우(Kim Yong-woo),남진영(Jin young Nam) 대한기계학회 2001 대한기계학회 춘추학술대회 Vol.2001 No.9

To obtain three-dimensional mode shapes of tire using accelerometers, we have performed the experimental modal analyses for a radial tire for passenger car under fixed condition. We have obtained the three-dimensional natural modes, which makes it possible to grasp the features of the modes and to classify the vibrational modes into symmetric, non-symmetric, and anti symmetric modes in a simple way by using the experimental results.