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김해종,Quoc Khanh Nguyen,정승남,임미애,오찬,Yudan Piao,YanLi Jin,김주희,김영일,강예은,장재원,구본석 대한이비인후과학회 2023 Clinical and Experimental Otorhinolaryngology Vol.16 No.2
Objectives. The mitochondrial ribosomal protein L14 (MRPL14) is encoded by a nuclear gene and participates in mito-chondrial protein translation. In this study, we aimed to investigate the role of MRPL14 in thyroid cancer. Methods. We investigated the association between MRPL14 expression and clinicopathological features using The CancerGenome Atlas (TCGA) and Chungnam National University Hospital (CNUH) databases. Functional studies ofMRPL14, including proliferation, migration, invasion, mitochondrial oxidative phosphorylation and reactive oxygenspecies (ROS) production, were performed in papillary thyroid cancer (PTC) cell lines (B-CPAP and KTC-1). Results. Based on the TCGA dataset, PTC tissues lost mitochondrial integrity and showed dysregulated expression of over-all mitoribosomal proteins (MRPs) compared with normal thyroid tissues. Of 78 MRPs, MRPL14 was highly ex-pressed in thyroid cancer tissues. MRPL14 overexpression was significantly associated with advanced tumor stage,extrathyroidal extension, and lymph node metastasis. MRPL14 increased cell proliferation of thyroid cancer and pro-moted cell migration via epithelial-mesenchymal transition-related proteins. Moreover, MRPL14 knockdown reducedthe expression of oxidative phosphorylation complex IV (MTCO1) and increased the accumulation of ROS. Cotreat-ment with a ROS scavenger restored cell proliferation and migration, which had been reduced by MRPL14 knock-down, implying that ROS functions as a key regulator of the oncogenic effects of MRPL14 in thyroid cancer cells. Conclusion. Our findings indicate that MRPL14 may promote cell growth, migration, and invasion by modulating ROS inthyroid cancer cells.
Ni-Cu/SiO$_2$촉매 상에서의 메탄올 분해 반응
박지영,문승현,윤형기,박성룡,이상남,정승용 한국에너지학회 1996 에너지공학 Vol.5 No.1
Ni-Cu를 SiO$_2$에 담지시켜 공간속도(Space Velocity; S.V), 메탄올 분압, 반응온도 및 Ni-Cu 조성비에 따른 메탄올 분해 반응의 활성을 조사하였다. S.V는 10,000~30,000h$^{-1}$, 반응온도는 150~40$0^{\circ}C$까지 변화시켰으며 Cu/(Ni+Cu)비는 0, 0.25, 0.5, 0.75, 1로 변화시켜 보았다. Ni 단일 촉매의 경우 온도가 상승하면서 전환율이 100%에 도달함에 따라 CO의 선택도가 급감소하는 반면 Ni에 Cu를 첨가함으로써 높은 선택도를 유지하였다. 반응의 주생성물로서 CO와 H$_2$가 생성되었고 $CO_2$와 CH$_4$가 부생성물로서 주로 생성되었다. Decomposition reaction of methanol was conducted on Ni-Cu/SiO$_2$catalysts with several variables. Variables used in this study are S.V(Space Velocity), partial pressure of methanol, reaction temperature, and composition rate of Ni-Cu. The range of S.V is 10,000-30,000h$\^$-1/, the temperature range is 150-400$^{\circ}C$ and values of Cu/(Ni+Cu) are 0, 0.25, 0.5, 0.75, and 1. Over Ni/SiO$_2$, and Ni-Cu/SiO$_2$, the conversion rate of decomposition reaction of methanol arrived at 100% with increasing of temperature. At this time the selectivity of CO on Ni/SiO$_2$, was suddenly decreased, but on Ni-Cu/SiO$_2$, it was still sustained highly. The main products of reaction were CO and H$_2$, and by-products were CO$_2$ and CH$_4$mainly.