한방안이비인후피부과학회지에 게재된 여드름과 관련된 논문에 관한 고찰

김지수,박수연,최정화,김종한,이두희,Kim, Ji-Soo,Park, Soo-Yeon,Choi, Jeong-Hwa,Kim, Jong-Han,Rhee, Doo-Hee 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Objective : This study was carried out to analyze the trends of Acne related articles that have been published in the Journal of Korean Medicine Ophthalmology, Otolaryngology & Dermatology(JKOOD). Method : We studied 29 research papers relevant to Acne that published in JKOOD from 1998 to 2013. All the paper were classified into three categories; original article, review article and case report. We sub-classified the original articles into three categories; descriptive study, analytic study and experimental study. We analyzed the case report according to various types of treatment. Results : 1. The number of searched journals is 29 papers; 17 original ordicles, 4 review articles, 8 case reports. 2. Classification of 17 original articles into three categories; 10 experimental studies, 7 descriptive studies, 0 analytic study. 3. Method of Evaluation; Korean Acne Grading System(KAGS) is used frequently in descriptive studies and experimental studies. 4. Treatment in Case reports; 7 Case reports used External medical treatments. Conclusions : It is needed to develop the methods of grading system in acne related to Oriental medicine to obtain objectivity of studies. The number of analytic study, clinical trial and experimental study is need to increase.

생료사물탕(生料四物湯)이 DNCB로 유발된 생쥐의 아토피 피부염에 미치는 영향

김지수,최정화,김종한,정민영,박수연,Kim, Ji-Soo,Choi, Jung-Hwa,Kim, Jong-Han,Jeong, Min-Yeong,Park, Soo-Yeon 대한한방안이비인후피부과학회 2017 한방안이비인후피부과학회지 Vol.30 No.1

Objectives : Atopic Dermatitis (AD) is chronic skin disease characterized by allergic hypersensitivity reactions. Saeng-ryo-Samul-tang (SRSM) can treat skin disease by cooling down blood heat, cealering away congenital fever and detoxicating. This study was conducted to investigate the effects of SRSM on AD induced by 2,4-dinitrochlorobenzene (DNCB) in mice Methods : In this study, the effects of SRSM on changes in body weights, thicknesses of dorsum skin, thicknesses and weights of ear, changes of symptoms on the dorsum skin, histopathological degree of ear and dorsum skin, IL-10 and $TNF-{\alpha}$ in serum were observed. And the effects on the proliferation rates of splenocytes were also investigated in vivo and in vitro study. Results : In SRSM topical application (Topical) group, SRSM oral application (Oral) group and SRSM Combination (Combi) group thickness of dorsum skin decreased significantly. But in TPC, ORL and CBN group, weight of ear didn't show any changes, but thickness of ear decreased significantly. And TPC, ORL and CBN group showed meaningful effectiveness symptoms like desquamation and erythema on AD's clinical espect. In histopathological observation, spongiosis, edema and inflammatory cell infiltration of epidermal were remarkably diminished in TPC, ORL and CBN group. And SRSM diminished the proliferation rates of splenocytes in vivo and vitro study. Conclusions : The present study suggests that SRSM can significantly reduced symptoms of AD, therefore SRSM is effective to treatment of AD.

자연영상 텍스트 이진화를 위한 3단계 색상 군집화 알고리즘

김지수,김수형,Kim Ji-Soo,Kim Soo-Hyung 한국정보처리학회 2005 정보처리학회논문지B Vol.12 No.7

본 논문에서는 자연 영상에서 추출된 텍스트 영상의 이진화를 위한 3단계 색상 분할 알고리즘을 제안한다. 1단계 색상 분할은 입력 영상 중에서 텍스트색상과 배경색상이 잘 구별되는 단순 영상의 이진화를 수행하고, 2단계 색상 분할은 입력 영상에 고주파 필터를 적용하여 자연조명 이나 인공조명에 영향을 받은 영상의 이진화를 수행하며, 3단계 색상 분할은 저주파 필터를 기반으로 텍스트나 배경에 텍스쳐가 존재하는 영상의 이진화를 수행한다. 제안한 이진화 알고리즘이 그레이 정보를 이용하는 이진화 알고리즘보다 효과적으로 텍스트 영역을 이진화함을 입증하기 위해 상용문서 인식기인 아르미 6.0을 사용하여 이진화된 문자영상에 대한 인식 실험을 실행하였다. 그 결과 제안한 알고리즘의 필드 단위 인식률이 그레이 정보를 이용한 이진화 알고리즘의 인식률보다 $35\%$ 이상 우수함을 관측하였다. In this paper, we propose a three-level color clustering algerian for the binarization of text regions extracted from natural scene images. The proposed algorithm consists of three phases of color segmentation. First, the ordinary images in which the texts are well separated from the background, are binarized. Then, in the second phase, the input image is passed through a high pass filter to deal with those affected by natural or artificial light. Finally, the image Is passed through a low pass filter to deal with the texture in texts and/or background. We have shown that the proposed algorithm is more effective used gray-information binarization algorithm. To evaluate the effectiveness of the proposed algorithm we use a commercial OCR software ARMI 6.0 to observe the recognition accuracies on the binarized images. The experimental results on word and character recognition show that the proposed approach is more accurate than conventional methods by over $35\%$.

말초성 안면신경마비에 대한 매선요법 복합치료 효과

김지수,박수연,김경수,김경옥,위통순,최창원,양승정,Kim, Ji-Soo,Park, Soo-Yeon,Kim, Kyeong-Soo,Kim, Kyeong-Ok,Wei, Tung- Shuen,Choi, Chang-Won,Yang, Seung-Joung 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.2

Objective : This study was performed to investigate the effect of Needle-Embedding Therapy on peripheral facial paralysis. Method : We investigated 60 cases of patients with peripheral facial paralysis, and devided patients into two groups : We treated one group by complex korean medical treatment with Needle-Embedding therapy, and did the other group by complex korean medical treatment without Needle-Embedding therapy. Yanagihara grading system at baseline and final were used for evaluating the effect of the treatment. Results : 1. In Needle-Embedding therapy group and non Needle-Embedding therapy group, compared with baseline, at final, Y score was significantly increased.2. At final, there was significant difference in improvement between Needle-Embedding therapy group and non Needle-Embedding therapy group. Conclusions : Needle-Embedding therapy seem to be effective to improve symptoms of peripheral facial paralysis. Further studies will be needed to identify the beneficial of Needle-Embedding therapy on peripheral facial paralysis.

공공도서관의 VR 기반 교육문화프로그램 개발에 관한 연구

김지수,김성주,박신이,신지원,권선영,Kim, Ji Soo,Kim, Seong Ju,Park, Si Ni,Shin, Ji Won,Kwon, Sun Young 한국정보관리학회 2021 정보관리학회지 Vol.38 No.2

최근 들어 다양한 분야에서 VR 기술을 활용한 콘텐츠가 점차 증가하고 있으며 기술 또한 급속도로 보급되는 추세이다. 이러한 배경에서 공공도서관 또한 시대의 흐름에 따라 VR 기술을 활용한 서비스를 제공할 필요가 있다. 이에 본 연구는 공공도서관의 교육적, 문화적 기능을 고려한 VR 기반 교육문화프로그램을 제안하는 것을 목적으로 한다. 이를 위해 VR 프로그램이 진행되고 있는 국내·외 공공도서관 및 산업군 사례 조사 그리고 선행연구, 이론분석을 통해 적용점 및 시사점을 도출하였으며 이를 종합, 검토하여 공공도서관에서의 VR 기반 교육문화프로그램을 제안하였다. 본 연구에서 제시한 VR 기반 교육문화프로그램은 향후 공공도서관에서 VR 기반 교육문화프로그램 기획을 위한 기초 자료로 활용될 수 있을 것이다. Recently, content using VR technology in various fields is gradually increasing, and the technology is also rapidly spreading. Against this background, public libraries also need to provide services using VR technology according to the flow of the times. Therefore, this study drew application points through the investigation and analysis of domestic and foreign public libraries where VR programs are underway. And based on this, a final proposal is prepared after planning and reviewing VR-based educational and cultural programs in public libraries. VR-based educational and cultural programs introduced can be used as basic data for planning VR-based cultural programs in public library.

초두구로부터 분리한 비환식 트리테르페노이드계 화합물의 세포 접착인자 저해활성

김지수,노문철,김강성,김관희,임병용,Kim, Ji-Soo,Rho, Mun-Chual,Kim, Gang-Seong,Kim, Koanhoi,Rhim, Byung-Yong 한국해양바이오학회 2007 한국해양바이오학회지 Vol.2 No.4

The present study purified two noncyclic triterpenoids, compound 1 and compound 2, that intervene interaction of ICAM-1 and LFA-1 from ethanol extracts of Alpinia katsumadai. The compound 1 and 2 inhibited adherence of sICAM-1 to THP-1 cells with an $IC_{50}$ of $7.59{\mu}g/m{\ell}$ 및 $6.98{\mu}g/m{\ell}$, respectively, without affecting viability of the cells. The compound 1 and 2 also inhibited interaction of CHO-ICAM-1 cells with THP-1 cells with an $IC_{50}$ $6.7{\mu}g/m{\ell}$ 및 $5.5{\mu}g/m{\ell}$, respectively. These findings suggest that the noncyclic triterpenoids from Alpinia katsumadai have inhibitory activities against cell adherent molecules. The present study proposes that noncyclic triterpenoids from Alpinia katsumadai can applied to therapeutic approaches to the diseases that are associated with adhesion of inflammatory cells. 1. 천연자원으로부터 ICAM-1과 LFA-1 매개성 세포접착 저해제를 탐색한 결과, 초두구 에탄올 추출물은 이에 대한 저해 활성을 나타내었다. 2. 초두구로부터 세포 접착 인자 활성에 관한 물질을 분리 정제하기 위하여, 각종 용매추출과 컬럼 크로마토그래피를 이용하여 얻은 화합물 1과 2로 세포접착인자 저해활성을 확인하였다. 3. 분리된 화합물 1과 2의 sICAM-1과 THP-1 세포와의 결합저해활성 측정 결과, $IC_{50}$ 값은 각각 $7.59{\mu}g/m{\ell}$ 및 $6.98{\mu}g/m{\ell}$로 측정되었다. 실험에 사용된 농도에서는 세포독성을 보이지 않았다. 4. 분리된 화합물 1과 2의 CHO-ICAM-1과 THP-1 세포간의 결합저해활성을 측정한 결과, $IC_{50}$ 값이 각각 $6.7{\mu}g/m{\ell}$ 및 $5.5{\mu}g/m{\ell}$로 측정되었다. 5. 이상의 실험 결과로 미루어 보아, 초두구로부터 분리한 비환식 트리테르페노이드계 화합물들은 세포 접착인자에 대한 저해활성을 가지고 있다고 볼 수 있으며 이 기전을 통하여 생길 수 있는 질환에 대한 치료제 개발에 유효할 것이다. 특히 동맥경화에 대해서는 새로운 기전으로 접근하고 있으므로 기존의 치료제들의 작용기작과는 다른 약품의 개발이 기대된다. 또한 ICAM-1은 염증반응 및 암의 전이에도 관련되어 있으므로, 동맥경화 관련 질환이외에도 다양한 질환에 대한 의약품으로의 응용도 기대된다.

희첨 추출물이 B16F10 세포에서 Melanin 생성과 Tyrosinase 활성에 미치는 억제효과

김지수,정민영,김종한,최정화,박수연,Kim, Ji-Soo,Jeong, Min-Young,Kim, Jong-Han,Choi, Jeong-Hwa,Park, Soo-Yeon 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.1

Objective : Siegesbeckia Herba can treat various skin disease by expelling wind and removing dampness and clearing away heat and toxic material effects. This study was designed to investigate effects of Siegesbeckia Herba Extracts(SHE) on skin elasticity and whitening using B16F10 cell lines. Method : In this experiment, We observed effect of SHE on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase. Results : 1. SHE treated group showed decreased cell viability rates significantly compared with non-treated group. More than SHE $250{\mu}g/ml$, $500{\mu}g/ml$ and $1,000{\mu}g/ml$ of treated groups were lower levels of melanin synthesis respectively. 2. SHE significantly showed tyrosinase inhibitory activity in vitro, SHE increased tyrosinase inhibitory activity and elastase inhibitory activity in B16F10 cells, and tyrosinase inhibitory activity in vitro. 3. Tyrosinase inhibitory activity and elastase inhibitory activity in B16F10 cells, tyrosinase inhibitory activity in vitro were not accepted statistical significance compared with non-treated group. 4. SHE treated group showed increased SOD-like activity rates significantly compared with non-treated group. More than SHE $250{\mu}g/ml$, $500{\mu}g/ml$ and $1,000{\mu}g/ml$ of treated groups were lower levels of melanin synthesis respectively. Conclusion : These results suggest that SHE can inhibit melanin synthesis and tyrosinase inhibtory activity. So, We suggest that SHE can be maintained skin whitening.

구안와사에 대한 훈증요법 복합치료 효과

김지수,박수연,최창원,김경수,김경옥,위통순,양승정,Kim, Ji-Soo,Park, Soo-Yeon,Choi, Chang-Won,Kim, Kyeong-Soo,Kim, Kyeong-Ok,Wei, Tung-Shuen,Yang, Seung-Joung 대한한의학방제학회 2015 大韓韓醫學方劑學會誌 Vol.23 No.1

Objectives : This study was performed to investigate the effect of herbal steam therapy on peripheral facial paralysis. Methods : 55 patients with peripheral facial paralysis were treated with Korean Medicine therapy including herbal steam therapy. We evaluated the effect of Korean Medicine therapy including herbal steam therapy by Yanagihara grading system. Results : 1. 55 patients were treated with Korean Medicine therapy and 23.27±14.11 times of herbal steam therapy. 2. After treatment, Y-system score was significantly increased(p-value＜0.001) from 18.00±6.5514 to 35.00±6.3404. Conclusions : Herbal stream therapy seem to be effective to improve symptoms of peripheral facial paralysis. Further studies will be needed to identify the beneficial of herbal steam therapy on peripheral facial paralysis.

집속이온빔장치와 주사전자현미경을 이용한 박막 트랜지스터 구조불량의 3차원 해석

김지수,이석열,이임수,김재열,Kim, Ji-Soo,Lee, Seok-Ryoul,Lee, Lim-Soo,Kim, Jae-Yeal 한국현미경학회 2009 Applied microscopy Vol.39 No.4

TFT-LCD의 구조불량이 발생한 박막 트랜지스터에 대해서 집속이온빔 가공장치(Dual-beam FIB/SEM)를 이용하여 연속절편법(Serial sectioning)과 일련의 연속적인 2차원 주사전자현미경 이미지를 얻었고, IMOD 소프트웨어를 통해서 3차원 구조구현(3D reconstruction) 연구를 하였다. 3차원 구조구현 결과, Gate막과 Data막이 접합되어 있는 불량이 관찰되었다. 두 막이 접합되어서 ON/OFF 역할을 하는 Gate의 기능이 상실되었고, Data신호는 Drain을 통해서 투명전극에 전류를 공급하여 계속 빛나는 선 불량(line defect)이 발생한 것으로 판단된다. 이 논문의 결과인 집속이온빔 가공장치(Dual-Beam FIB/SEM)를 이용한 3차원 구조구현 연구와 연속절편법, 주사전자현미경 이미지작업, 이미지 프로세싱에 대한 결과는 향후 연구의 기초자료로 활용될 수 있을 것으로 판단된다. In this paper we have constructed three dimensional images and examined structural failure on thin film transistor (TFT) liquid crystal display (LCD) by using dual-beam focused ion beam (FIB) and IMOD software. Specimen was sectioned with dual-beam focused ion beam. Series of two dimensional images were obtained by scanning electron microscopy. Three dimensional reconstruction was constructed from them by using IMOD software. The short defect between Gate layer and Data layer was found from the result of three dimensional reconstruction. That phenomena made the function of the gate lost and data signal supplied to the electrode though the Drain continuously. That signal made continuous line defect. The result of the three dimensional reconstruction, serial section, SEM imaging by using the FIB will be the foundation of the next advanced study.

색상레이어를 이용한 스팸메일 영상에서의 텍스트 영역 추출

김지수,김수형,한승완,남택용,손화정,오성열,Kim Ji-Soo,Kim Soo-Hyung,Han Seung-Wan,Nam Taek-Yong,Son Hwa-Jeong,Oh Sung-Ryul 한국정보처리학회 2006 정보처리학회논문지B Vol.13 No.4

In this paper, we propose an algorithm for extracting text regions from spam-mail images using color layer. The CLTE(color layer-based text extraction) divides the input image into eight planes as color layers. It extracts connected components on the eight images, and then classifies them into text regions and non-text regions based on the component sizes. We also propose an algorithm for recovering damaged text strokes from the extracted text image. In the binary image, there are two types of damaged strokes: (1) middle strokes such as 'ㅣ' or 'ㅡ' are deleted, and (2) the first and/or last strokes such as 'ㅇ' or 'ㅁ' are filled with black pixels. An experiment with 200 spam-mail images shows that the proposed approach is more accurate than conventional methods by over 10%. 본 논문에서는 스팸메일 영상에서 텍스트 영역의 추출을 위한 색상 레이어기반의 알고리즘을 제안한다. CLTE(color layer-based text extraction)는 색상 레이어를 사용하여 영상을 8개로 나눈다. 8개 각각의 영상에서 연결요소를 추출한 후, 연결요소의 크기에 의해서 텍스트 영역과 비텍스트 영역을 분류하고 텍스트 영역을 추출한다. 또한, 추출된 텍스트 영역으로부터 회손된 획 정보를 복구하는 알고리즘을 제안한다. 이진영상내의 한글 문자에는 두 가지 형태의 손상된 획이 존재한다. 첫째 중성 획에 해당하는 'ㅣ' 나 'ㅡ' 등의 획들이 지워지는 경우와, 둘째 초 종성 획에 해당하는 'ㅁ' 이나 'ㅇ'이 흑화소로 채워지는 경우가 있다. 제안한 알고리즘은 이러한 두 가지 손상된 획들을 복구해준다. 200개의 스팸메일 영상을 사용한 실험 결과 제안한 알고리즘이 기존의 텍스트 추출 알고리즘보다 10% 이상 우수함을 관측하였다.