http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Oxytocin에 의한 내수질집합관의 cAMP 생성 및 요배설의 변화
한진석(Jin Suk Han),이정상(Jung Sang Lee),김강석(Kang Seock Kim),허우성(Woo Seong Huh),김연수(Yon Su Kim),전은실(Un Sil Jeon),주권욱(Kwon Wook Joo),안규리(Curie Ahn),김성권(Suhnggwon Kim),이중건(Jung Geon Lee),나기영(Ki Young Na),정우경 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.1
N/A Oxytocin, like vasopressin, has been known to act in the IMCD by the activation of adenylyl cyclase through V2 receptor, but the exact mechanism of its action remains to be elucidated. To prove whether oxytocin is involved in the activation of adenylyl cyclase in the renal collecting duct, we measured the cAMP production and urinary cAMP excretion rate. After single IMCD segments of Sprague-Dawley rats were microdissected and treated with different con- centrations of vasopressin(10pM, 10nM) and oxytocin (10pM, 10nM), cAMP production was measured. Urinary cAMP excretion rate was measured after dehydration and intraperitoneal injection of vasopressin and oxytocin. The results are as follows. 1) cAMP production in single IMCD was significantly increased in vasopressin group(10pM: 48,9±4.7(mean±SE), 10nM:94.6±5.3fmol/mm) and oxy-tocin group(10pM: 11.3±2.9, 10nM: 65.7±6.1fmol/mm) compared with that in the control(3.2±0.2fmol/ mm). 2) Urine volume was significantly decreased in dehydration group(40±7μl/hour) and vasopressin group(420±120μl/hour), but urine volume of oxytocin group(1,480±230μl/hour) was not different from that of control(1,550±120μl/hour). Urine osmolality was significantly increased in all experimental groups(control: 737.0±132.6, dehydration group : 2,463.9± 412.5, vasopressin group : 1,702±412.5, oxytocin group 1,293.4±117.9mOsm/kg). Urinary cAMP excretion rate was significantly increased in dehydration group(4,149.5±1,072.3pmol/hour) and oxytocin group(4,843.3±2,341.8pmol/hour), but not in vasopressin group(1,358.1±690.2pmol/hour), compared with that in control(49±10.7pmoVhour). These results suggest that oxytacin has anti-diuretic effect by the activation of adenylyl cyclase through V2 receptor.
만성신부전에서 염류코르티코이드 투여가 포타시움 평형과 요 암모늄 배설에 미치는 효과
한진석(Jin Suk Han),이정상(Jung Sang Lee),김강석(Kang Seock Kim),허우성(Woo Seong Huh),전은실(Un Sil Jeon),이서진(Seo Jin Lee),주권욱(Kwon Wook Joo),김성권(Suhnggwon Kim),진호준(Ho Jun Chin),조윤숙(Yun Suk Cho) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.2
N/A Mineralocorticoids influences on acid-base homeo-stasis by the regulation of urine acidification. But its mechanism of acion is not well known in human. This study compared the acid-base status and the indices of urine acidification before and after mineralocorticoid administration in human, and analyzed the effect of mineralocorticoids on human acid-base homeostasis. We administered 9a-fludrocortisone in 6 chronic renal failure patients and 6 normal controls 0.5mg daily for 7 days. The results were as following ' 1) After administration of 9a-fludrocortisone in patients group, serum aldosterone level changed from 120.2±71.0pg/mL to 44.8±32.2pg/mL(mean±SD, p< 0.05). Serum HCO- level was not changed. Urine ammonium excretion was incresed from 24.6±12.3 mmol/day to 43.7±19.0(p<0.05), but there were no change in urine pH and urine anion gap, Serum potassium level decreased from 5.5±0.7mBq/L to 4.1±0.5mEq/L(p<0.05), and TTKG increased from 3.9 to 8.9(p<0.05). 2) After administration of 9a-fludrocortisone in control group, serum aldosterone level changed from 99.7±44.5pg/mL to 25.1±3 mL(p<0.05). Serum HCO- level was not changed. Urine ammonium ex-cretion was incresed from 44.3±21.6mmoVday to 76.3±19.6(p<0.05), but there were no change in urine pH and urine anion gap. Serum potassium level decreased from 4.8±0.5mEq/L to 3.9±0.2mHq/L(p< 0.05), but there was no change in TTKG. 3) No patient or control showed any discomfort after 9-fludrocortisoneadministration, and there was no elevation in diastolic blood pressure, increase in body weight, electrolyte abnormality. In summary, after 9α-fludrocortisane administration, urinary ammonium excretion increased in both patients and control group, and this phenomenon occured with correction of hyperkalemia without urine pH change. This result implies urinary ammonium excretion increase by mineralocorticoid. In human increase in renal distal acidification by mineralocorticoid is due to increase in renal ammo- niagenesis rather than stimulation on proton excretion.
金聖權,朴正植,李重根,高昌舜 최신의학사 1977 最新醫學 Vol.20 No.8
A double blind study and 12 weeks follow-up of Clobazam were performed . from October 1976 to May 1977 in Seoul National University Hospital. They were 34 neurotic and 32 psychosomatic disorder patients. The results were followings. 1. Clobazam was more effective than placebo in both neurotic symptoms and psychosomatic symptoms, especially in anxiety, inner restlessness, depression, cardiovascular symptom, respiratory symptom and gastrointestinal symptoms. 2. There were neither difference in each disease of neurosis nor psychosomatic disorder. 3. In each disease there were neither specific change in 12 weeks follow-up period nor no drug dependence is noted after 12 weeks follow-up. 4. There were mild side effects such as fatigability, dry mouth, mild ataxia and mild impotence. but these were not clinically important. These results suggest that Clobazam is a good antianxiety drug in neurosis and psychosomatic disorder in OPD clinic. There are neither clinical significant side effect nor drug dependence.
이식 전 B형 간염 바이러스 감염이 이식 신의 예후에 미치는 영향
김윤구,한진석,김성권,이정상,김상준,김수태 대한내과학회 1990 대한내과학회지 Vol.38 No.1
To evaluate the impact of HBV infection on graft survial following renal transplantation, we studied 161 recipients whose Hepatitis B surface antigen(HBsAg) status was identified before transplantation by actuarial life table method and log-rank analysis. We considered graft loss as patient'’s death, return to maintenance dialysis or removal of graft. 1) Survival in the HBsAg positive group(18 losses among 22 recipients) was significantly diminished(p=0. 0001) compared with the HBsAg negative group(40 of 139 recipients) and the difference was highly significant in recipients with cyclosporine therapy but not in those with azathioprine. 2) In the HBsAg negative group, no obvious differences in survival were found among the groups categorized by the presence of anti-HBs or anti-HBc prior to transplantation. 3) In the HBsAg positive group, those with no mismatch for HLA showed better survial and there were no differences in graft survival compared with the HBsAg negative group. 4) There were 4 deaths from hepatic failure which occurred only in the HBsAg positive group and only in recipients with cyclosporine therapy. We conclude that patients with pre-existing HBs antigenemia may be poor candidates for renal transplantation.
오국환,안규리,오윤규,김현리,정우경,김연수,한진석,김진석,김성권,이정상 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2
목 적: 진균성 복막염은 지속적 외래 복막투석 환자의 이환율과 사망률을 증가시키는 중요한 질환이다. 저자들은 복막투석 환자에서 발생한 진균성 복막염의 원인 진균과 임상상, 치료 방법 및 결과 등을 살펴보고 동일한 기간에 발생한 세균성 복막염의 임상상과 비교 분석함으로써 진균성 복막염의 예방과 치료에 도움을 얻고자 하였다. 방 법: 1991년 1월부터 1999년 12월까지 서울대학교병원에서 복막투석을 시작한 환자 총376명 중 이 기간 동안에 진균성 복막염으로 진단 받은 환자 14명(총 15예)을 후향적으로 분석하였다. 결 과 : 대상 환자들의 평균 연령은 53.7±11.6세(이하 평균±표준편차)이었으며, 남·녀비는12 : 3이었다. 진균성 복막염을 진단 받은 당시까지의 복막투석 기간은 29.2±27.7개월이었다. 원인균은 Candida species가 10예(62.5%)로 가장 많았으며, Aspergillus 2예, Cryptococcus 1예, Penicillium 1예, Torulopsis 1예, Trichosporon beigelii 1예 등이었다. 5예에서 진균과 아울러 세균의 중복 감염이 확인되었다. 발병 당시의 증상은 일반적으로 알려진 세균성 복막염의증상과 유사하였다. 진균성 복막염 환자에서 복막투석 도관은 모두 제거하였으며, amphotericin B, fluconazole, flucytosine 등을 단독 혹은 병합 투여하였다. 질병의 경과 중에 4예(26.7%)에서 장폐색 또는 복막 유착이 합병되었다. 치료 결과로는, 완치 후 도관 재삽입 후 복막 투석을 지속한 경우가 3예(20%), 혈액투석으로 전환한 경우가 9예(60%)이었고, 3예(20%)는 진균성 복막염으로 인하여 사망하였다. 원인 진균이 Candida species인 환자군과 나머지 군에 있어서 사망률에 차이가 있었으나(33.3% vs 0%) 통계적으로 유의하지는 않았다(p=0.11). 투여한 항진균제의 종류에 따른 사망률의 차이는 없었다. 동일한 기간에 발생한 세균성 복막염과 진균성 복막염 환자들의 특성을 비교해 볼 때 도관 제거율과 기술적 실패율은 진균성 복막염에서 유의하게 더 높았다. 결 론 : 진균성 복막염은 드물게 발생하지만 일반적으로 알려진 세균성 복막염의 사망률보다 더 높은 사망률과 복막투석 중단의 원인이 되는 심각한 질환으로서, Candida species가 가장 흔한 원인균이었다. Purpose : Fungal peritonitis is a fatal disease with a high mortality and morbidity to the peritoneal dialysis(PD) patients. This study was implemented to provide a guideline for the prevention and treatment of fungal peritonitis in PD patients by analyzing the clinical and microbiologic features of fungal peritonitis cases. Methods : We analyzed retrospectively into the 15 cases(14 patients) of fungal peritonitis among 376 end stage renal disease(ESRD) patients who newly started PD in the Seoul National University Hospital from Jan. 1991 to Dec. 1999. Results : The patients' age was 53.6±11.6 years (mean±standard deviation) and their male to female ratio was 12:3. They have been on PD for 29.2±27.7 months before the fungal peritonitis developed. Candida species was the most common etiologic agent, accounting for 10(62.5%) out of the 16 fungal organisms isolated from our patients. Among others were two Aspergillus, one Cryptococcus, one Penicillium, one Torulopsis, and one Trichosporon beigelii cases. Bacterial agents were isolated simultaneously in five fungal peritonitis cases. Peritoneal catheters were all removed no later than 72 hours after the diagnosis was made. Patients were given a single or combined therapy with amphotericin B, fluconazole, or flucytosine on the physician's choice. The outcomes of fungal peritonitis were as follows; 20% continued PD, 60% converted to HD and 20% died of fungal peritonitis. We made a comparative analysis between the fungal and bacterial peritonitis cases which developed in the same 5-year period, which showed significantly higher catheter removal and technique failure rates in the fungal cases. Conclusion : Fungal peritonitis is a rare but a fatal disease with a high mortality and a technique failure rate. Candida species was the most prevalent microorganism in our study. (Korean J Nephrol 2002;21(2):303-311)