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중증 난소 과자극 증후군 환자에서 발생한 뇌경색 및 심장 내 혈전증의 성공적 치료
김소라 ( So Ra Kim ),김유진 ( Eu Jin Kim ),김지선 ( Ji Sun Kim ),구윤희 ( Yun Hee Koo ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),김정훈 ( Chung Hoon Kim ),강병문 ( Byung Moon Kang ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.11
Thromboembolism is a rare complication of ovarian hyperstimulation syndrom (OHSS). According to the numerous reports, it most commonly occurs in upper extremities, head, and neck vein. It is also well known that acute cerebral infarction, once occurred, is mainly caused by the occlusion of large arteries, especially middle cerebral artery (MCA) in most cases. Administration of heparin has been considered as the best treatment option, but many studies have been reporting successful treatment results from administrating thrombolytics in patients with cerebral infarction. Although administration of thrombolytics is invasive and has some potential side effects including bleeding or hematoma, it still has been used for treating patients with cerebral infarction. We report a case of patient with intracardiac thrombi and manifested symptoms of acute cerebral infarction originally caused by OHSS followed by the occlusion of MCA. We administered thrombolytics within one and half hours of showing left hemiparesis caused by the occlusion of right MCA, and identified reperfusion of MCA. There was no evidence of complications associated with the administration of thrombolytics on CT scan, which was taken 24 hours later. Thrombi in IVC, right atrium, and right ventricle were found on chest CT with pleural effusion, but soon were disappeared after administrating heparin anticoagulation. We report this case to show that thrombolytics and anticoagulation can be safely used to treat a patient with cerebral infarction and thrombi caused by OHSS without any side effects or complications.
유교사회와 책판 제작의 사회문화사적 의의-『선생문집개간일기』를 중심으로-
김순석 ( Kim Sun-seok ) 인하대학교 한국학연구소 2014 한국학연구 Vol.0 No.32
이 논문은 1817년(순조 17) 조선시대 대표적인 학자의 한 사람인 퇴계(退溪) 이황(李滉)의 문집인 『퇴계선생문집』의 책판의 개각(改刻) 작업 과정에 나타난 사회문화사적인 의의를 조명하였다. 『퇴계선생문집』은 1600년(선조 33) 조목(趙穆) ㆍ금응래(琴應來) 등에 의하여 도산서원에서 목판본으로 간행되었으니 이를 경자본이(庚子本)이라 한다. 『퇴계선생문집』은 경자본 이후 문도 및 후손에 의하여 여러 차례의 교정을 거쳐 개판(改版)이 되고 두주(頭註)가 덧붙여져 판각되었다. 그리고 판본(板本)의 완결(刓缺)에 따라 여러 번 개간(改刊) 및 중간(重刊)되었다. 『퇴계선생문집』은 경자본이 간행된 이후 경자본의 오류를 바로잡아 1724년(영조 1)에 중간된 것을 갑진본(甲辰本)이라고 한다. 그 후 정축년(丁丑年) 1817년 후계(後溪) 이이순(李頤淳)과 퇴계의 후대 문인들이 중심이 되어 도산서원에서 훼손된 목판 200여 장을 개간하였다. 이때 책판이 개각된 직접적인 계기는 순조가 『퇴계선생문집』을 열람하고 싶어 홍문관에 문집을 가져오라고 명하였다. 이 명은 경상감영을 통하여 도산서원에 전해졌다. 도산서원에서는 새로 문집을 인출하고자 하였으나 책판 가운데 훼손된 것이 많아서 민망한 일이 있었다. 그 후부터 『퇴계선생문집』 책판에 대한 개각 준비가 진행되고 있었으나 본격적인 논의가 진행된 것은 1817년 초부터였다. 이 당시 판각 과정의 일들을 기록한 것이 『선생문집개간일기(先生文集改刊日記)』이다. 이 일기는 1817년(순조 17) 1월 5일부터 8월 12일까지의 판각과정의 일들이 기록되어있다. 이 일기는 1817년에 『퇴계선생문집』 책판 개각의 배경과 진행과정 그리고 참여한 사람들과 재원 마련 방안 등을 자세하게 담고 있다. 이 해 개각된 책판은 『퇴계선생문집』의 모든 책판을 개각한 것이 아니고 훼손이 심한 200여 판만 새롭게 개각하였지만 구체적인 목록은 전하지 않는다. 주요 참여자는 퇴계의 후대 문인들이었으며 당시 경상도관찰사였던 김노경(金魯敬)의 도움과 사림의 정성으로 이루어졌다. 조선후기 책판 제작은 경제적인 어려움 속에서 많은 사람들의 정성을 모아서 진행되었다는 점을 규명하였다. This thesis illuminated sociocultural significance which appeared in the amendment(改刻) work process of Toegye(退溪) Ihwang(李滉)’s work collection, 『Toegye Seonseng Munjip』, who was a representative scholar in 1817(the 17th year under Sunjo) in the Joseon Dynasty. 『Toegye Seonseng Munjip』 was published in block book at Dosan Seowon by Jomok(趙穆) ㆍGeumungrae(琴應來), etc. in 1600(the 33th year under 33), which is called Gyeongjabon(庚子本). 『Toegye Seonseng Munjip』 was amended(改版) through several times of correction by disciples and descendents since Gyeongjabon, and engraved by adding headnotes(頭註). Also, along with the completion(刓缺) of woodblock-printed book(板本), it was published and halfway published for several times. 『Toegye Seonseng Munjip』 was halfway published in 1724(the 1st year under Yeongjo) by correcting the errors of Gyeongjabon after it was published, which is called Gapjinbon(甲辰本). After that, in Jeongchuknyeon(丁丑年) in 1817, the descendant(後溪) Lee, yi-sun(李頤淳) and the literary persons of the later generation who received Toegye’s disciples’ teaching published 200 copies of the woodblocks which were damaged in Dosan Seowon. The direct reason why the book was published was the king wanted to read 『Toegye Seonseng Munjip』 and requested to send book collections to Dosan Seowon. Hereupon, they intended to newly withdraw book collections from Seowon, however it was embarrassing because the books were largely damaged. Since then, preparation for publication for 『Toegye Seonseng Munjip』 woodblock was proceeded, however, a full-scale discussion began in the early 1819. At that time, the title of diary which recorded the process of this publication is 『Seonsengmunjip Gaeganilgui(先生文集改刊日記)』. This diary is the record between January 5 to August 12, 1817(the 17th year under Sunjo). This diary recorded the background of 『Toegye Seonseng Munjip』 woodblock publication in 1817 and its process of progress, participants and financing method, etc. in detail. The woodblock book which was published in this year was not the publication of the whole books of 『Toegye Seonseng Munjip』, but only 200 woodblocks of which damage was severe were newly made, however the detailed list is not informed. Major participants were literary persons who were the descendant literary persons of Toegye, and the work was completed through 40 days’ work with Bangbaek’s help and Sarim’s earnestness. Woodblock production in the late Joseon dynasty was progressed by gathering lots of people’s earnestness in economic difficulty.
사염화탄소에 의하여 유발된 흰쥐의 간 독성에 미치는 비테인의 효과
김선여(Sun Yeou Kim),김홍표(Hong Pyo Kim),이미경(Mi Kyeong Lee),변순정(Soon Jeong Byun),김승희(Seung Hee Kim),문애리(A Ree Moon),한형미(Hyung Mi Han),허훈(Hoon Huh),김영중(Young Choong Kim) 대한약학회 1993 약학회지 Vol.37 No.5
Effects of betaine, a major component of Lycii Fructus, on carbon tetrachloride intoxicated rats were evaluated. Histological studies showed that betaine had improved the typical necrosis around centrilobular area in liver tissue due to the carbon tetrachloride intoxication. Betaine, whether it was administrated simultaneously or prior to carbon tetrachloride, prevented or retarded the elevation of liver-weight/body-weight ratio due to the carbon tetrachloride intoxication. Betaine also significantly elevated the reduced activities of some enzymes, cytochrome P-450, 7-ethoxycoumarin-O-deethylase and glutathione-S-transferase, involved in xenobiotic metabolism due to carbon tetrachloride intoxication. These results demonstrate a possible hepato-protective role of betaine against fatty liver that could be easily induced by carbon tetrachloride in rat.
뽕잎추출물이 콜레스테롤 투여 흰쥐의 혈청지질에 미치는 영향
김선여(Sun-Yeou Kim),이완주(Won-Chu Lee),김현복(Hyun-Bok Kim),김애정(Ae-Jung Kim),김순경(Soon-Kyung Kim) 한국식품영양과학회 1999 한국식품영양과학회지 Vol.27 No.6
뽕잎이 고지혈증에 미치는 영향을 알아보기 위하여 고지혈증이 유도된 흰쥐의 뽕잎추출물을 경구투여한 후 혈청학ㆍ조직학적인 검사를 행하였고, 부가적으로 뽕잎이 인체의 지질대사에 미치는 영향을 조사하였다. 뽕잎추출물을 흰쥐의 각각 0.1g/㎏ of body weight과 1g/㎏ of body weight의 농도로 투여함으로써 총 콜레스테롤과 중성지질 함량을 유의성있게 감소시켰고 또한 총 콜레스테롤 중의 HDL-콜레스테롤이 차지하는 비와 lipase의 활성을 증가시켰다. 이러한 혈청학적인 결과는 조직학적인 검사를 통하여 확인할 수 있었고 인체실험에서도 동물실험에서와 같은 경향을 나타냈고 특히 뽕잎파우더의 투여로 중성지질이 유의적으로 감소하였다. This study was conducted to investigate the effect of mulberry leaves on lipid metabolism in cholesterol-induced hypercholesterolemia rats. The mulberry treatment group showed decreases of serum lipid concentration compared with hyperlipidemic group. Also, Mulberry leaves inhibited the activity of HMG-Co A reductase, increased lipase activity. In histopathological examination, abdominal aorta showed no critical lesions with mulberry leaves treatment. These results suggest that hypolipidemic effects of mulberry leaves on rats were the inhibition of cholesterol synthesis and acceleration of cholesterol catabolism in the liver. For human, serum triglyceride contents were more significantly decreased with treatment of mulberry leaves powder.
일차 배양한 흰쥐의 간세포에서 사염화탄소로 인한 독성에 미치는 비테인의 효과
김선여(Sun Yeou Kim),김홍표(Hong Pyo Kim),이미경(Mi Kyeong Lee),김승희(Seung Hee Kim),문애리(A Ree Moon),한형미(Hyung Mi Han),허훈(Hoon Huh),김영중(Young Choong Kim) 대한약학회 1993 약학회지 Vol.37 No.5
Betaine, a major component of Lycii Fructus, was evaluated for its anti-hepatotoxic activity on carbon tetrachloride-induced hepatotoxicity in primary cultured rat hepatocytes. Betaine was found to attenuate carbon tetrachloride-induced hepatotoxicity both morphologically and biochemically. Typical hepatocyte necrosis due to carbon tetrachloride seemed to be reduced by 50 to 500mcM of betaine under microscopical observation. The value of glutamic pyruvic transaminase released from the hepatocytes into the medium significantly decreased as betaine concentration increased. Betaine also significantly elevated the reduced activities of some enzymes, cytochrome P-450, 7-ethoxycoumarin-O-deethylase and glutathione-S-transferase, involved in xenobiotic metabolism due to carbon tetrachloride-induced hepatotoxicity. These results demonstrate a possible hepato-protective role of betaine against fatty liver that could be easily induced by carbon tetrachloride.
유방암 수술 환자의 추후관리를 위한 베하스[BeHaS] 프로그램이 자아존중감, 피로와 불안에 미치는 영향
김종임(Kim Jong Im),민효숙(Min Hyo Suk),박선영(Park Sun Young),김선애(Kim Sun Ae),전영숙(Jun Young Suk),임정선(Lim Joung Sun),김소현(Kim So Hyun),장일성(Chang Eil Sung) 기본간호학회 2009 기본간호학회지 Vol.16 No.3
Purpose: The purpose of the study was to identify effects of the BeHaS program on self esteem, fatigue and anxiety in postoperative care patients with breast cancer who had surgery with, chemotherapy, radiotherapy, with or without current hormone therapy. Methods: This study was a 2-group quasi-experimental research study with a pre and post test design. Fifty-four patients with breast cancer were assigned to the experimental (n=29) or control group (n=25). The BeHaS program which strengthens self esteem through support over a 90-minute period, consists of theme activity (30 minutes), education (15 minutes), group support (15 minutes) and exercise (30 minutes). The experimental group participated in the program once a week for 10 weeks, but the control group was not involved. Data were gathered from October to December, 2008 using a questionnaire with measures of self esteem, fatigue and anxiety. Data were analyzed using t-test with SPSS Win 12.0 to identify differences between the groups. Results: Self esteem was significantly increased (p= .001) and fatigue significantly decreased (p= .013) in the experimental group. But there was no significant difference in anxiety (p= .868). Conclusion: These results suggest that the BeHaS program for patients with breast cancer had beneficial effects on self esteem and fatigue.
운동이상형 소화불량증을 호소하는 당뇨병 환자에서 주석산 시사프리드의 효과
김선명(Sun Myung Kim),추교영(Kyo Young Choo),최명규(Myung Gyu Choi),김진일(Jin Il Kim),방춘상(Choon Sang Bhang),한석원(Sok Won Han),김병욱(Byung Wook Kim),최황(Hwang Choi),김성수(Sung Soo Kim),이동수(Dong Soo Lee),최규용(Kyu Yong Ch 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.1
N/A evaluated the effects of cisapride tartrate on gastrointestinal symptoms and gastric emptying times in diabetic patients with dysmotility like dyspeptic symptoms. Methods: Cisapride was administered before each meal in 61 patients for 4 weeks. The intensity of gastrointestinal symptoms before and after cisapride administration was scored from 0 to 4, in the order of increasing severity of symptoms. In addition, a gastric emptying test was performed. Results: A significant reduction in the total intensity score of symptoms was observed during the first two weeks, from 8.5±2.1 to 4.0±3.0 (p<0.05), and a further reduction was noted during the next two weeks, to 2.8±2.8 (p<0.05). Good to excellent improvement was obtained in 70.4% of the patients, but the improvement in symptoms was not related to age, duration of diabetes, glucose, Hb A1c, neuropathy, or retinopathy. Treatment with cisapride induced a significant regression of symptoms and a significant improvement of delayed gastric emptying from 104.0± 31.7 minutes to 79.5±17.1 (p<0.05). However, there was a lack of association between the changes in gastric emptying times and improvements in symptoms(r2=0.00186). Only 3 patients complained of loose stool, nausea, or dizziness. Conclusions: Cisapride was effective in improving dysmotility like dyspeptic symptoms in diabetic patients without serious side effects. (Korean Journal of Gastrointestinal Motility 2001;7:56-64)