약학대학 내 한약학과 교과과정 및 한약사 국가시험에 대한 연구 - 현대과학 관련 과목을 중심으로 -

하동훈,강보혜,김명수,김성현,신진욱,이정후,이형우 한국지역사회건강관리협회 대한건강과학학회 2019 대한건강과학학회지 Vol.16 No.2

Background : This study reviewed the undergraduate curriculum of the De partment of Korean Pharmacy and the subjects of the National Examination o f Korean Pharmacist. The purpose of this study was to assess the suitability of Korean medicine as a leading role in the promotion of the separation of prescribing and dispensing and the insurance pay of packed Korean medicine. Methods : The contents of curriculum uploaded on the website of Kyunghe e University, Woosuk University, and Wonkwang University and the details o f each subject of the National Examination of Korean Pharmacist were summ arized. The subjects of modern science were analyzed. Results : As a result of analyzing the data of the subject universities open ed, nearly 68% of the subjects related to modern science, including modern theories, were found. In the national examination of Korean Pharmacist, 11 o f the remaining 15 subjects, excluding the legal part of all subjects, consiste d of contents related to modern science. Conclusion : Among the curriculum of the Department of Korean Pharmacy and the subjects of the National Examination of Korean Pharmacist, the prop ortion of subjects related to modern science was found to be high. This wou ld be sufficient data to prove the suitability of Korean Pharmacist in terms o f modern science.

약국 한약사의 영양요법 활용방안 : 건강기능식품의 기능성원료를 중심으로

하동훈,김명수,강보혜,송은미,신진욱,이정후,최혜빈 한국지역사회건강관리협회 대한건강과학학회 2021 대한건강과학학회지 Vol.18 No.1

Background : Research has been actively conducted on methods that can apply co mplementary medicine to various fields, but few studies have been conducted on how Korean Pharmacists working in pharmacies can use complementary medicine. Therefore, it is a meaningful study to provide a way for Korean Pharmacists to use complementary medicine to perform clinical pharmacy more effectively in pharmacies b y looking at the profession of Korean Pharmacists and analyzing various therapies of complementary medicine. In addition, these attempts will not only expand the capabilities of Korean Pharmacists, but will also help to develop methods that can utilize the knowledge and treatments of complementary medicine in the healthc are field. Methods : In this study, we will analyze in detail the role that Korean Pharmaci sts play in pharmacies, and focus on nutritional therapy among complementary me dicines that herbal pharmacists can use in pharmacies. Results : In this paper, among various raw materials for health functional foods, w e have summarized the functional raw materials made from natural products, and in p articular, we have dealt with only the notification-type raw materials listed in the revo lution of the Health Functional Food Code. Since it has been selected and summarize d mainly on items that have been verified for various types of functionality, it is expected to be a material that can sufficiently secure the clinical value of use in p harmacies. Conclusion : If Korean Pharmacists develops knowledge of complementary medic ine including nutrition therapy and engages in pharmacist work, it is expected that it will be possible to provide active advice so that patients can engage in more int egrated healthcare, not just explanations for selecting medicines in the process of consultation with the patient.

감태나무 에틸아세테이트 분획의 항염증 및 진통 효과

전훈,김종수,강보혜,박승주,양우인,김명수,이병수,차동석,이세연,권진 한국생약학회 2022 생약학회지 Vol.53 No.1

The present study was designed to evaluate the anti-inflammatory and anti-nociceptive potential of the ethyl acetate fraction of Lindera glauca (ELG). We found that ELG significantly suppressed NO production through decreased enzyme activity and expression of iNOS in the IFN-γ/LPS-activated murine peritoneal macrophages. The treatment of ELG also down-regulated the expression of COX-2. Our western blot data revealed that inhibitory effects of ELG on these pro-inflammatory mediators were attributed to inactivation of NF-κB. In addition, ELG-fed mice showed a marked decrease in paw edema induced by subplantar injection of trypsin, suggesting in vivo anti-inflammatory potential of ELG. We further investigated the anti-nociceptive properties of ELG using thermal and chemical nociception model. We found that ELG has a strong anti-nociceptive activities in both central and peripheral mechanism. An additional combination test with naloxone revealed that opioid receptor was not involved in the ELG-mediated anti-nociception. In conclusion, ELG may possibly be used as valuable anti-inflammatory and anti-nociceptive agent for the treatment of inflammatory diseases and pains.

한약조제지침서에 대한 과학적 고찰 - 다빈도 수재 한약재를 중심으로 -

김명수,하동훈,강보혜,정종우,신진욱,이정후,최혜빈 한국지역사회건강관리협회 대한건강과학학회 2020 대한건강과학학회지 Vol.17 No.2

Purpose : The purpose of this study is to provide a modern scientific basis that can be utilized when a Korean pharmacist consults at a pharmacy. We will provide application plans in the clinical field, and at the same time, provi de basic materials necessary for the development of education. We will impr ove the qualifications of Korean pharmacists and expand the scientificization of Korean medicine to contribute to the development of Korean pharmacist. Methods : In order to produce data related to the preparation of herbal me dicines based on herbal remedies, the' Guidelines for Korean Medicine Prepa ration' was referenced. The ingredients and efficacy of each herbal medicin e were summarized through literature research. We organized the number of talented Korean medicines, selected frequent Korean medicines listed 10 tim es or more, and summarized the active ingredients and pharmacological react ions of each Korean medicine. Discussion & Conclusion : A Korean pharmacist who operates a pharmacy in the situation of division of labor or is engaged in clinical pharmacy at a p harmacy can consult based on the results of modern scientific research from the perspective of active ingredients and pharmacology of medicinal herbs. In the case of korean pharmacists, it is useful to consult with them using mode rn scientific evidence in clinical situations at pharmacies, and it will contribut e to the improvement of public health.

한약 복약지도 프로세스에 대한 고찰 : 서비스 청사진 활용의 필요성을 중심으로

하동훈,김명수,강보혜,김건호,김성현,송은미,신진욱,이정후,최혜빈 한국지역사회건강관리협회 대한건강과학학회 2022 대한건강과학학회지 Vol.19 No.1

통합의학으로서의 보완대체요법

하동훈,김명수,송은미,강보혜,신진욱,이정후,김성현,최혜빈 한국지역사회건강관리협회 대한건강과학학회 2023 대한건강과학학회지 Vol.20 No.1

National Center for Complementary and Integrative Health(NCCIH) has divided complementary medicine into five main types. The first is biologically based therapy. Biological-based therapy is a field of treatment through an approach to human physical structure, which is not overlapped in modern medicine or is not deeply studied. The second is mind-body therapy. Mind-body therapy is medicine that mainly approaches the mind and treats the mind to treat physical diseases. The third is manual therapy. Manual therapy is a treatment that uses the hands directly on the patient's body part to treat. It is believed that humans are made up of the mind, body, and energy, and maintains an approach that local parts of the body are connected to the body as a whole. The fourth classification is energy therapy. Energy therapy is usually a therapy that approaches and treats the energy structure in the human body. Lastly, it is a therapy that is establishing a comprehensive medical system. Therapy, which establishes a comprehensive medical system, refers to a treatment that has been introduced from various cultures around the world for a long time and has its own independent system. Among the various complementary and alternative therapies, this study examines the most widely used biological-based therapy, mind and body therapy, and manual therapy, except for oriental medicine, excluding korean medicine, in consideration of the domestic medical dualization system.

팥배나무의 진통 효과

김봉석,윤선화,신윤철,강보혜,박승주,양우인,이세연,차동석,전훈 한국생약학회 2020 생약학회지 Vol.51 No.3

In this study, we evaluated the anti-nociceptive activities of Sorbus alnifolia. To investigate the anti-nociceptive properties of the methanolic extract of Sorbus alnifolia (MSA), we conducted several tests using various experimental mouse pain models. Herein, MSA significantly delayed the latency time and writhing motion in the hotplate test and acetic acid test, respectively. These result indicated that MSA has an ability to manage both peripheral and central nociception. We could further confirm the analgesic effects of MSA by performing formalin test. In combination test using naloxone, a non-selective opioid receptor antagonist, analgesic activity of MSA was partly antagonized by naloxone, but not completely, indicating that the MSA acts as a partial opioid receptor agonist. Out results suggest that the S. alnifolia may be possibly used as valuable anti-nociceptive agent.

Microphysiological system with continuous analysis of albumin for hepatotoxicity modeling and drug screening

Arun Asif,박성혁,Afaque Manzoor Soomro,Muhammad Asad Ullah Khalid,Abdul Rahim Chattikatikatuveli Salih,강보혜,Faheem Ahmed,김경환,최경현 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.98 No.-

In microfluidics, the emergingfield of microphysiological systems (MPS) is overcoming the challenge ofphysiological irrelevancy by animal models for drug discovery and development. Liver function iscritically influenced by drugs owing to its role in drug metabolism and detoxification. Human serumalbumin (HSA) is one of the most important secreted biomarkers which indicate normal liver function. Amicrofluidic albumin immunosensor was developed to be integrated with liver-on-a-chip MPS forcontinuous feedback over disease modeling and treatment. A gold-electrode based electrochemicalimmunosensor was established by anti-HSA antibody immobilization. The liver MPS was found to beefficient for live monitoring of disease modelling and drug treatment over the period of 6 days. Thesystem emulated and analyzed real-time toxicity modeling with HSA sensing. The detection limit ofintegrated sensor was 1 mg/ml with successive reproducibility. The proposed sensor was also validatedwith metabolic biomarkers’ assays. Molecular assays supported the sensor monitoring and depicted liverinjury and recovery. The liver MPS with combined albumin sensor chip may be a promising platform tomimic real-time drug assessment.