金水六君煎이 吸煙한 白鼠의 肺損傷에 미치는 影響

甘哲宇,朴東一 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

This experiment was performed in order to study the clinical effects of Gyumsutykgunjun on the pulmonary injury caused by exposure of cigarette smoke in rats. Therefore, a writer reports on present experimental results having significant effects on the level of oxygen consumption, the lungs volume, the leukocyte, the hemoglobin levle, and the PaO₂. PaCO₂after administration of Gymsuyukgunjun in order to study the clinical effects of Gymsuyukgunjun on the pulmonary injury caused by exposure of cigarette smoke in rats. The results were obtained as follows: 1. In comparison with control group, The group of Gymsuyukgunjun administration was revealed significant effects (p<0.005) of increase on the level of oxygen consumption. 2. In comparison with control group, The group of Gymsuyukgunjun administration was revealed significant effects (p<0.005) of decrease on the lungs volume. 3. In comparison with control group, The group of Gymsuyukgunjun administration was revealed significant effects (p<0.005) of decrease on the leukocyte counts. 4. In comparison with control group, The group of Gymsuyukgunjun administration was revealed significant effects (p<0.005) of decrease on the hemoglobin level. 5. In comparison with control group, The group of Gymsuyukgunjun administration was revealed significant effects (p<0.005) of increase on the PaO₂, PaCO₂level. It was concluded from the above results that Gymsuyukgunjun has a significant effects on the pulmonary injury caused by cigarette smoke.

소청용탕이 알레르기성 비염에 미치는 영향에 대한 임상적 고찰

감철우,김종대 대구한의대학교 제한동의학술원 2001 東西醫學 Vol.26 No.2

五行和鍼法에 대한 연구

감철우(Chul Woo Gam),박동일(Dong Il Park) 한의병리학회 2005 동의생리병리학회지 Vol.19 No.2

침도침 시술을 가미한 복합한방치료를 시행한 결절성 다발 동맥염의 치험례

이은솔,감철우,윤현민,장경전,송춘호,김영균,김철홍 대한침구의학회 2012 대한침구의학회지 Vol.29 No.3

Objectives : Polyarteritis nodosa is a progressive disease of connective tissue that is characterized by nodules along arteries; nodules may block the artery and result in inadequate circulation to the particular area. This report is intended to estimate the efficacy using oriental complex treatment on a patient with Polyarteritis nodosa. Materials and Methods : From 19th March, 2012 to 12th May, 2012, One male inpatient diagnosed with polyarteritis nodosa was treated with general oriental medicine therapy : needle-embedding therapy ; acupuncture ; pharmacopuncture ; acupotomy therapy and herbal medication. VAS(visual analogue scale) was used for evaluation of both leg pain. Other subjective symptoms including night sweat, tinnitus, upper heat were evaluated by percentage comparing the symtoms before and after treatment. Results : The patient showed a certain degree of improvement in both leg pain and other subjective symtoms. Conclusions : Oriental treatments such as needle-Embedding therapy, acupuncture and moxibustion the- rapy, pharmacopuncture therapy, acupotomy therapy and herbal medication can be effective for controlling pain and other accompanied symtoms due to polyarteritis nodosa.

보중익기탕이 알레르기반응에 미치는 영향에 대한 실험적연구

강대성,감철우,박동일 한국생명과학회 2003 생명과학회지 Vol.13 No.1

보중익기탕이 즉시형 및 지연형 알레르기에 대한 면역 반응에 미치는 영향을 알아보고자 항 알레르기에 대한 실험을 즉시형과 지연형으로 구분하여 시행하여 다음과 같은 결론을 얻었다 Compound 48/80 유발 아나필락시스 반응에 미치는 영향은 농도별 실험에서 보중익기탕 투여군은 생존율이 비순차적이었으나 생존율이 증가하였다. 또한 시간의존적 실험에서 보중익기탕 투여군은 다소의 생존율 변화를 보였으며, Compound 48/80 유발 비만세포 탈 과립 율의 측정을 통하여 대조군에 비해 보중익기탕 투여군은 현저하게 유의한 (p<0.005) 감소효과가 인정되었다. Picryl chloride에 의한 접촉성 피부염증 반응에 미치는 효과에 관한 실험과 면양적혈구에 의한 지연형 족부종 반응에 미치는 효과에 관한 실험에서 대조군에 비하여 보중익기탕 투여군은 유의한 억제효과가 인정되었다. 이러한 실험결과에서 보중익기탕이 즉시형 및 지연형 알레르기반응에 있어 모두 효과를 발휘하는 것으로 나타났으며 보중익기탕의 항 알레르기 효과를 질병의 치료에 응용할 수 있을 것으로 생각된다. 또한 향후 지속적인 실험과 연구를 통해 임상적 치료와 활용에 발전이 있을 것이라 사료된다. This experimental research has been done to study the effects of Bojungikgi-tang(BJIKT) on the anti-allergic reaction. We found the several important results from the research which has been performed by two experiments toward immediately type and delayed type in order to study the effects of BJIKT on hypersensitivity response to mice. The results obtained from our research are as following: 1. The survival rate of one group to which we injected only the compound 48/80 is almost 0% according to its density and timing test. In the other hand, the survival rates of the other group to which we injected both of the compound 48/80 and BJIKT are 20%, 10%, 30%, 10%, 40%, and 70% according to 0.025, 0.05, 0.1, 0.25 0.5 and 1(mg/g) of compound 48/80. Time dependency test also shows the 10% and 0% survival rates in 5 and 10 minutes. 2. BJIKT revealed the significantly inhibitory effect on Compound 48/80 induced Mast cell degranulation. 3. BJIKT showed the significantly inhibitory effect in the delayed type hypersensitivity response to picryl chloride. 4. BJIKT showed the significantly inhibitory effect in the delayed type hypersensitivity response to sheep red blood tell. Our research provides the important evidence that BJIKT is benificial to the prevention and treatment of allergy related diseases.

속발성 간암으로 인한 협통(脇痛) 치험(治驗) 1례(例)

정광식,감철우,박동일,전종철,Jeong, Gwang-Sik,Gam, Chul-Woo,Park, Dong-Il,Jeon, Jong-Chul 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4

This study was performed on the basis of clinical consideration about patient who has hepatocholangiocarcinoma, and pancreatic cancer. Cancer has gradually increased morbidity and mortality all over the world including Korea. Western medicine has treated with surgical therapy, chemotherapy, radiotherapy and immunotherapy, but has not obtained outstanding results and has a difficulty due to side effects by those therapies. In this study, we recognized that symptom including hypochondriac pain by cancer are rapidly decreased with herbal medication treatment and acupuncture therapy. Oriental medicine treatment is applied throughly on the basis of the oriental medicine principle and the prescriptions were used Naeso-oksultang(內消沃雪湯). According to the above results, we can know this patient has improvement of patient's symptom on administration of oriental medicine treatment, it is helpful in decresing symptoms of patient and in improving quality of life.

류마티스성 승모판 협착증을 동반한 뇌경색 환자의 치험 1예

전종철,감철우,박동일,정광식,Jeon, Jong-Chul,Gam, Chul-Woo,Park, Dong-Il,Jeong, Gwang-Sik 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.3

Valvular heart disease is one of the main current of cardiac problems and has many problems must be solved by sequelae and complications, etc. Rheumatic Mitral Stenosis is mainly attacked by rheumatic fever and developed by process of treatment of mitral valve or formation of trace. The purpose of this study is to examine the efficacy of oriental treatment for Cerebral Infarction with Rheumatic Mitral Stenosis. At the time of visiting ER, he was shown the symptoms of dull mentality, Rt. hemiplegia, global aphasia, dysphagia, chest discomfort, insomnia, dyspnea, etc, It showed that Atrial fibrillation in EKG monitoring, Atrial fibrillation, Rheumatic Mitral Stenosis, Ejection-Fraction slope 60% in Cardiac echography, Lt. atrial hypertrophy, Rt. atrial hypertrophy, Rt. ventricular hypertrophy with pulmonary congestion in chest X-ray. From the view of oriental diagnostic criteria. We classified the patient's clinical conditions and treated accordingly. As a result of treatment, symptoms were markedly improved and he was discharged. Further elaboration of oriental diagnostic classification could possibly lead to the fundamental treatment.

瀉白散 추출물에 의한 인체 폐암세포의 Apoptosis 유도 기전에 관한 연구

이재훈,강병령,감철우,박동일,최영현 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2

We investigated the effects of Sabaek-san (SBS) water extract on the growth of human lung carcinoma A549 cells. Upon treatment with SBS extract, a concentration-dependent inhibition of cell viability was observed and cells developed many of the hallmark features of apoptosis, including condensation of chromatin. Flow cytometry analysis confirmed that SBS treatment increased populations of apoptotic-sub Gl phase. In addition, proteolytic cleavages of poly(ADP-ribose) polymerase and β-catenin protein were observed after treatment of SBS extract. These apoptotic effects of SBS in A549 cells were associated with marked inhibition of Bcl-2 and Bcl-xL mRNA in a dose-dependent manner, however the levels of Bax expression were not affected. SBS treatment also induced a proteolytic activation of caspase-3, which is believed to play a central role in the apoptotic signaling pathway. The previous and present results indicated that SBS-induced inhibition of lung cancer cell proliferation is associated with the blockage of G1/S progression and the induction of apoptosis.

뇌졸중에 병발한 요로감염으로 인한 발열, 부종에 대한 마황가출탕 치험 1례

임제민,이아람,감철우,김원일,Yim, Je-Min,Lee, Ah-Ram,Kam, Cheol-Woo,Kim, Won-Il 대한한의학방제학회 2011 大韓韓醫學方劑學會誌 Vol.19 No.1

Objectives : The purpose of this study is to report the improvement after treatment with Mahwanggachul-tang on fever and edema due to urinary tract infection combined with stroke. Methods : From December 8th to 22nd 2010, We treated a ischemic stroke patient having fever and edema due to urinary tract infection with Mahwanggachul-tang. We checked body temperature, intake-output, urine analysis and chest X-ray. Results : There were improvement on body temperature, Intake-output, urin analysis and chest X-ray. Conclusions : This report shows Mahwanggachul-tang has effectiveness on fever and edema due to urinary tract infection combined with stroke.

八物湯이 알레르기반응에 미치는 효과

허만규,홍현우,감철우,박동일 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.4

This experimental research has been done to study the effects of Palmul-tang on the anti-allergic reaction. We found the several important results from the research which has been performed by two experiments toward immediately type and delayed type in order to study the effects of Palmul-tang on hypersensitivity response to mice. The results obtained from our research are as following: The survival rate of one group to which we injected only the compound 48/80 is almost 0% according to its density and timing test. In the other hand, the survival rates of the other group to which we injected both of the compound 48/80 and Palmul-tang are 20%, 0%, 40%, 10%, 20% and 50% according to 0.025, 0.05, 0.1, 0.25 0.5 and 1 (mg/g) of compound 48/80. Time dependency test also shows the 30% and 20% survival rates in 5 and 1 O minutes. Palmul-tang revealed the significantly inhibitory effect on Compound 48/80 induced Mast cell degranulation. Palmul-tang showed the significantly inhibitory effect in the delayed type hypersensitivity response to picry1 chbride. Palmul-tang showed the significantly inhibitory effect in the delayed type hypersensitivity response to sheep red blood cell. Our research provides the important evidence that Palmul-tang is benificial to the prevention and treatment of allergy related oiseases.