http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김윤근,지영구,윤호주,조상헌,민경업,김유영 대한천식알레르기학회 1994 천식 및 알레르기 Vol.14 No.3
Asthma is a disease commonly encounter'ed in the clinical practice of medicine, with a prevalence in the general population of approximately 3%. Up to 85% of asthmatic individuals experience their first symptoms before the age of 45, but only 3% of all asthmatic patients develop their first symptom after the age of 60. And there has been few descriptions in the literature of old ageonset asthma in non-smoking poplations. To characterize the non-smoking patients with old ageonset asthma, We compared the patients who had experienced the first asthmatic attack after the age of 60(old age group) with the patients who had experienced it before the age of 30(young age group) and between the age of 30 to 60 (middle age group). The results were as follows.' 1. The young age group complained the nasal symptoms more frequently than the other groups. 2. The old age group required systemic steroids more frequently than the other groups. 3. The positivity of skin prick test to common inhalant allergens was higher in the young age group(84.8%) than in the other groups. However, it was more common in the old ageonset group and the other gropus. In conclusion, it is suggested that even in patients with old age-onset asthma atopy plays a important role in the development of asthma, systemic steroid is required more frequently than the other groups, and, therefore, it is important to manage with an appropriate use of steroid as well as an avodance of causative allergens.
김윤근,이상록,손지웅,김우경,박재경,지영구,송숙희,이명현,조상헌,민경업,고영률,김유영 대한천식알레르기학회 1996 천식 및 알레르기 Vol.16 No.3
Background: The bronchial hyperresponsiveness (BHR) may precede the development of asthma and constitutes a risk factor for the development of asthmatic symptoms, and may be developed by environmental factors in persons with genetic susceptibility. Controversy still exists whether atopy and airway responsiveness are factors determining the asthma diathesis or not. Qbjective: It was evaluated that airway responsiveness is related with the sensitization to common inhalant allergens, especially house dust mite. Methods: We performed the methacholine bronchial provocation test(MBPT) and skin prick test with 10 common inhalant allergens, including D. farinae and D. pteronyssinus in 502 nonasthmatic adults, which was composed of 223 atopics(Atopy) and 297 nonatopics (Normal), or 173 house dust mitesensitive atopics(HDM) and 347 house dust mite- insenstive persons(NHDM). Brindex(log[% fall of FEV, + 10]/log[last concentration of methacholine, mg/ml]) was used to quantify the degree of airway responsiveness, and we measured the Brindex of Atopy, Normal, HDM, and NHDM, respectively, and assessed correlations between atopy index(the sum of skin index by 10 allergens) and the skin index (mean wheal size by allergens per mean wheal size by histamine) of individual allergens, including D. farinae and D. pteronyssinus, and the Brindex. Results: The Brindex was significantly increased in Atopy(0.880+0.011) compared with Normal(0.840+0.003) (p=0.002), and in HDM(0.888+0.013) compared with NHDM (0842+0.007) (p=0.0008), respectively. The Brindex was significantly correlated with the atopy index(p<0.001) and the skin index of D.p, D.f, and cat(p<0.001), but not with other allergens(p > 0.05). Conclusion: The sensitization to common inhalant allergens, especially house dust mite and cat fur, was significantly correlated with the bronchial responsiveness to methacholine.