소아 호흡기 질환에서의 Fominoben의 진해효과에 관한 임상적 연구

고영률 최신의학사 1988 最新醫學 Vol.31 No.9

소아천식의 평가에 있어서의 폐기능검사에 관한 연구

고영률 대한알레르기학회 1989 천식 및 알레르기 Vol.9 No.2

Pulmonary function tests are being used in the aasessment of asthma to provide objective evidence of severity of the disease and of the response to therapy. The degree of airways obstruction in asthma differs in the various phases of the diseaae, and it has been noted that there are varing degrees of reidual abnormality of pulmonary function even in clinically asymptomatic patients. To make serial determinations and to aeaess the changes, pulmonary function of asthmatic children between 6 and 14 years of age was studied during an acute attack and in the ensuing aymptom-free period. The results are as follows: 1) During tbe acute attack, aU dynamic air flow rates were decreased, and a static lung volumes except total lung capacity and vital capacity were increased. The ratios of functional residual capacity and residual volume to total lung capacity were aignificantly elevated in comparison with during the aymptom-free period. 2) During the symptom-free period, all dynamic air flow rates except FEF and FEF returned to normal, but static lung volumes except vital capacity remsined elevated. In children with episodic asthma, the degree of abnormality was variable and the frequency of attacks seemed to be one of the factors in determining this Those with chronic continuing asthma had evidence of severe airways obstruction and pulmonary hyperinflation. The duration of asymptomatic stage over a period of months appeared not to have an influence on the degree of abnormality. 3) Inspiratory wheezing accomponied the expiratory wheezing in the majority of cases, although ezpiratory wheezing is generally emphasized on the auscultation of asthmatic patienta. Biphasic wheezing was associated with a lower flow rate(FEVFEF FEV,/FVC) than only expiratory or inspiratory wheezing or rhonchi. 4) Eosinophil total counte were statistically elevated during acute attack than during symptom-free period, and this was circumstantiated by that eosinophil counts were related negatively with air flow rate (FEV,).

소아 만성천식에서 서방형 thephylline ( Somophyllin - CRT ) 의 임상 및 약물동태학적 평가

고영률,신현택 대한천식알레르기학회 1987 천식 및 알레르기 Vol.7 No.1

Serum concentrations of theophylline and peak expiratory fiow rates were measured in 33 children with chronic asthma after morning dose at steadystate on different dosage regimens of 15mg/kg/day (8 hours and 12 hours dosing intervals (, 20mg /kg/day (8 hours and 12 hours dosing intervals), and 25mg/kg/day (8 hours and 12 hours dosing intervals). Evaluating serum concentrations on different dosage regimens and the improvements of pulmonary function associated with the increments of serum concentrations, the following conclusions have been made. L. 8 hours dosing rather than 12 hours dosing may be appropriate for pediatric population finding unacceptable large fluctuations of serum concentration on 12 hours dosing especially when large doses above 20mg/ kg/day are given. 2. Optimal dose to maintain therapeutic serum concentration will be in the ranges of 15-20mg /kg/day. 3. Bronchodilating effects of theophylline appeared to closely parallel the serum concentrations from 5 mcg/ml to 13 mcg/ml with no further improvement of pulmonary function test above 13mcg/ml suggesting probable lower therapeutic range in pediatric population than in adults. 4. Nonlinear patterns of serum concentrations reaching high doses suggested that theophylline dosage adjustment should be performed cautiously using small increments. 5. Theophylline clearance appeared to be correlated reversely to ages of 3 to 13 years in the males, although the correlations were not so significant. 6. Fast elimination rate associated with higher clearances appeared to result in smaller fluctuations of theophylline serum concentration. 7. Finding peak serum concentrations occurred around 4 to 5 hours post-dose, it is recommended that blood samples for peak drug concentrations should be obtained at 4 or 5 hours post-dose.

운동에 의한 기관지과민반응 운동후 24시간에 항원 유발에 의한 기도반응이 증가함

고영률,윤경애,채수안 대한천식알레르기학회 1992 추계학술대회 초록집 Vol.1992 No.-

소아의 알러지

고영률 주식회사 녹십자 1990 녹십자의보 Vol.18 No.6

소위 감기를 달고 사는 아이들 의 원인과 대책

고영률 대한소아알레르기호흡기학회 1995 Supplement Vol.5 No.2

N/A

소아천식의 진단

高永律 대한의사협회 1996 대한의사협회지 Vol.39 No.3

소아 기관지 천식에서의 호산구 및 IgE의 변화 - 천식발작시와 임상적 완해시의 비교 관찰

고영률,김영지 대한천식알레르기학회 1987 천식 및 알레르기 Vol.7 No.1

Eosinophil total count (ETC) and serum IgE level were measured in 49 pediatric asthmatics during asthmatic attack (AA) and clinical remission (CR) to determine if these parameters reflect the asthmatic activity. The results were as follows: 1) There was no significant difference of WBC count between AA and CR. 2) During CR, ETC was statistically higher in children with other allergic diseases, e.g. allergic rhinitis, allergic conjunctivitis and atopic dermatitis and children with positive skin reactivity than children without those factors, but no differences were noted during AA. No correlations were found between ETC and age, and sex during both AA and CR. 3) ETC was statistically elevated during AA than during CR, especially in boys and children without other allergic diseases. 4) IgE level was higher in children with positive skin reactivity than negative skin reactivity during CR, but not during AA. Statistically significant increase of IgE level by age was noted during CR, but not during AA. There were no differences of IgE level according to sex and allergic disease during both AA and CR. 5) Between AA and CR, no difference of IgE level was noted. 6) No significant correlation was found between IgE level and ETC during both AA and CR.

루우프 이뇨제 흡입이 항원유발후의 천식반응에 미치는 영향

고영률,윤경애,김희주 대한천식알레르기학회 1991 천식 및 알레르기 Vol.11 No.5

Inhaled furosemide, a loop diuretic that can interfere with ion and water transport across airway epithelium, prevents the immediate bronchoconstriction induced by exercise or allergen challenges in patients with asthma. To evaluate the effect of inhaled furosemide on both the immediate and late phases of the asthmatic response to the specific allergen challenge in patients with allergic asthma, and the role of inhibition of the Na /Cl cotransporter in the mechanisms of the protective properties of inhaled furosemide on asthmatic airways, seventeen asthma patients with dual responses to house dust mite(Dermatophagoides pteronyssinus) after normal saline were subjected to bronchial provocation with the same allergen after furosemide(n=10) or bumetanide(n=8) inhalation. Pulmonary function(FVC, FEV2, PEFR, MMEF) was monitored every one hour for 10 hours after allergen challenge, and 24 hours later methacholine sensitivity was measured. The data were compared between after furosemide or bumetanide inhalation and after normal saline inhalation. Treatment with furosemide profoundly inhibited both the early and late asthmatic reaction induced by a specific allergen challenge. Significant differences were seen in the postallergen bronchoconstrictor response to inhaled methacholine between after furosemide and after saline administration. Bumetanide, another loop diuretic, fails to inhibit both the early and late asthmatic reaction provoked by allergen, and to affect postallergen nonspecific bronchial hyperreactivity. Although further investigation as to clinical asthma is needed, results suggest that inhaled furosemide has clinical benefit in the treatment of allergic asthma. As the airway effects of furosemide were demonstrated apart from bumetanide, the protective effect of furosemide may be independent of its shared properties with bumetanide, Na/Cl transport inhibition.

운동유발성 천식

고영률 대한천식 및 알레르기학회 ( 구 대한알레르기학회 ) 1996 추계학술대회 초록집 Vol.1996 No.-