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禹鍾仁,延炳吉,徐維憲,朴贊雄,李定均 대한신경정신의학회 1991 신경정신의학 Vol.30 No.6
The uptake of C3H ) choline into synaptosomes prepared from rat corpus striatum and frontal cortex was studied at choline concentration varying from 0.05 to 2.0 |iM. The sodiumdependent high affinity choline uptake in these brain regions exhibited saturation kinetics with Km values o f 0.37 (iM in corpus striatum and 0.35(iM in frontal cortex. A l3+ inhibited total choline uptake at concentrations greater than 10-4 M. Double-reciprocal plots indicated that A l3+ was a noncompetitive inhibitor o f high affinity choline uptake with Ki values of 2.17X10 3 M in corpus striatum and 0.82 X10 3 M in frontal cortex. The presence of 1 m M Ca2+ neither influenced high affinity choline uptake, nor antagonized the inhibitory effects of A l3+. A l3+ did not alter the activities of choline acetyltransferase and acetylcholinesterase at all substrate and inhibitor concentrations studied. These data suggest that high A l3+ levels modify cholinergic transmission by inhibition of high affinity choline uptake
농존지역 거주노인의 연령,성별,교육수준이 한국판 MMSE 점수에 미치는 영향에 관한 연구
우종인,이정희,홍진표 대한신경정신의학회 1996 신경정신의학 Vol.35 No.1
In order to observe the sociodemographic effects on Mini-Mental State Examination-Korean version(MMSE-K), MMSE-K was administered to the residents aged 65 and older in Yonchon county, Kyungki-Do. Following results were found : 1) Forty percent of the variance in MMSE-K scores was accounted by educatonal level, age and sex. 2) Educational levels were closely correlated with MMSE-K scores(r=0.49). The group of elementary school graduates and over scored higher scores of 5-6 points and 1- 3 points higher in comparison to the noneducated group and the elementary school failure group, respectively. 3) Men received higher MMSE-K scores than women, especially in the noneducated group and the elementary school failure group. In conclusion, readjustments of MMSE-K scores for demographic variables, especially for educational level, are necessary in order to use the MMSE-K as a screening measure for dementia.
조경배식에 있어 지피식생조성에 관한 연구 -몽촌토성을 중심으로-
우종서,이경재 한국조경학회 1991 韓國造景學會誌 Vol.18 No.4
This research investigated soil, plants, insects and birds in the Mongchon Earth Fort, establishing the 11 plots, according to planting treatment, in order to present management method for ecological stability of species in the ground covering plots. The results of analysizing the investigated data summarize as follows. 1. In the ground covering plots without upper layer, the density and coverage of middle and low layer in the natural plots were higher than those in the artificial plots. 2. In the ground covering plots without upper layer, the density and coverage of low layer were higher than those in the artificial, while the density and coverage of herb layer in the natural plots were lower. 3. Whether there was upper layer or not, the total species diversity and enenness of the ground covering community in the natural plot without artificial treatment and natural treatment plot were higher than those ground covering. 4. In the ground covering plots with upper layer, the species diversity of ground covering in the plots without artificial treatment is high, while the species diversity in the plots with natural treatment caused the secondary succession is higher than that of the natural plot. 5. In the ground covering plots without upper layer, the species diversity in the plots with artificial management was higher than that of natural plots, while the evenness in the plots with artificial management was lower. 6. In the ground covering plots with upper layer the species diversity of insect in the plot of natural state was higher than that of insect in the plots with artifical treatment. 7. Synthetically, in the area with upper layer the species diversity of the ground covering community in the natural plot was high, while in the area without upper layer, the species diversity of it in the plots with artificial treatment was high. The insect turned up frequently in the plots of high species diversity of the ground covering, so the bird did in the plots of high species diversity of the ground covering and insects.
알쯔하이머 치매 환자의 뇌자기공명영상(腦磁氣共鳴影像)에 나타난 뇌위축(腦萎縮)과 뇌백질병변(腦白質病變)에 대한 연구
우종인,김주한,Woo, Jong Inn,Kim, Ju Han 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2
알쯔즈하이머형 치매 환자의 뇌자기공명영상(腦磁氣共鳴影像)에 나타난 뇌위축(腦萎縮) 및 백질병변(白質病變)과 치매 발병연령(發病年齡)과의 상관관계(相關關係)를 밝히기 위해, NINCDS-ADRDA 진단기준(診斷基準)에 의한 조발성(早發性)(n=9) 및 만발성(慢發性)(n=18) 알쯔하이머형 치매군과 각각의 정상대조군(n=10 : n=11)에서 뇌위축(腦萎縮)은 대뇌피질위축(大腦皮質萎縮)과 뇌실확장(腦室擴張)의 체적(體積)을 계측(計測)하고 백질병변(白質病變)은 뇌실주변, 심부백질, 기저핵 및 천막하영역의 백질(白質) 신호(信號) 고강도(高剛度)의 반정량적(半定量的) 평가척도(評價尺度)로 측정하였다. 조발성(早發性) 환자군의 뇌위축(腦萎縮)은 대조군보다 유의하게 컸고(p<0.05) 백질병변(白質病變)에서는 모든 영역에서 차이가 없었으며, 만발성(慢發性) 환자군은 뇌위축(腦萎縮) 정도에서는 대조군과 차이가 없었으나 백질병변(白質病變)은 심부백질 및 시상에서 유의한 차이(p<0.05)를 보였고 나머지 모든 영역에서도 대조군보다 심한 경향을 보였다. 알쯔하이머형 치매가 (1) 뇌위축(腦萎縮)을 주로 보이고 백질병변(白質病變)은 심하지 않은 조기발병군(早期發病郡)과, (2) 백질병변(白質病變)이 두드러지고 뇌위축(腦萎縮)은 심하지 않은 만기발병군(晩期發病郡)으로 나누어질 가능성과 양군의 병태생리(病態生理)가 상이(相異)할 가능성이 시사되었다. Objects : To investigate the relationship between the age of onset with the atrophy and the white matter hyperintensities observed in the brain MRI of Alzheimer patients. Methods : The authors measured volumetrically cortical and ventricular brain atrophy and rated semiquantitatively white matter signal hyperintensities in nine presenile and 18 senile Alzheimer patients, who were matched for dementia severity, according to NINCDS-ADRDA criteria and in age-matched 10 presenile and 11 senile control subjects. Results : Presenile Alzheimer patients showed significantly greater cortical and ventricular atrophy indices(p<0.05) but no difference in white matter hyperintensity scores compared to the age-matched control group. On the contrary, senile Alzheimer patients showed significantly greater white matter hyperintensity scores(p<0.05) but no difference in cortical and ventricular atrophy indices compared to the age-matched control group. Conclusion : An earlier onset was related to marked brain atrophy with less white matter lesions and a later onset is related to marked white matter lesions with less brain atrophy in Alzheimer's disease. Our results suggested the passible difference in the pathophysiology between the presenile and the senile-onset Alzheimer's disease.