간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

통합적 교수방법을 원용한 대학교양영어 교과과정 및 강의에 대한 연구

성기완,염문실 우송대학교 2000 우송대학교 논문집 Vol.5 No.-

Current English teaching in college needs to be improved to meet new challenge in this information and globalization age. In other words, instead of relying on fragmented and decontextualized teaching and learning, interdisciplinary approaches of teaching English using multiple texts or teaching materials and computer technology are necessary not only for learners to acquire different types of knowledge but also to utilize them in diverse social contexts. In other words, the field of English Education should work toward designing an integrated program, which helps establish a meaningful learning community to allow both teachers and learners to engage in transaction of meaning and knowledge. In so doing, teaching language in context necessitates the inclusion of the target and native cultures. Accordingly, this paper is a seminal work regarding the development of an integrated English program in college and explores a possibility of project in which a group of teachers engage in team teaching and leading workshops to encourage college students to experience many different types of learning. Though experimental and tentative, this paper will lay the groundwork of designing, developing, and, more importantly, implementing new types of curricular and instructional approaches in the context of teaching both cultural contents and linguistic elements in college.

흰쥐 젖샘신경으로 투사하는 중추신경내 Oxytocin 신경로에 관한 연구

백상호,강기동,김은아,조경제,최완성,이봉희 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.6

폐쇄성 좌측 대장 및 직장암의 일차절제 및 문합술

홍기훈,송인상,윤완희 대한대장항문학회 1997 Annals of Coloproctolgy Vol.13 No.3

Comparison of the Pharmacological Effects of Roasted and Non-roasted Zizyphi Spinosi Semen: Differences in Chemical Constituents

홍학기, 이기남, 마유안, 김윤배, 남상윤, 송인섭, 문동철, 오기완 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.3

본문참고

영어의 Yes/No의문문에 대한 한국학생들의 응답연구

성기완 우송대학교 부설 산업연구원 1999 산업연구 Vol.1 No.2

This study investigate some patterns and characteristics of reactions of Korean speakers of English to positive and negative yes/no questions and tag questions. It is observed that most Asian students manifest some difficulty in understanding the difference between structural aspects of language and semantic meaning of yes/no questions (e.g., Celce-Murcia &Larsen-freeman, 1983). Given that yes/no questions are one of the basic and yet important ways to seek and share information during communication, more in-depth research on second language learners' diverse responses to yes/no questions is much needed in the context of more real and concrete communicative settings. Accordingly, this study employed a methode of discourse analysis based on 6 taped dyadic conversations between native speakers of English and Korean speakers of English to classify and analyze reaction types of Korean speakers of English to yes/no questions. The results of the study showed that those whose levels of proficiency in English were relatively low seemed not to understand semantic structure of utterances and the specific context of communication. That is, they appeared to have difficulty in responding to both negative yes/no and tag questions. Based on the study, pedagogical suggestions of teaching various responding strategies to yes/no questions in the context of meaningful communication to help Korean nonnative speakers were also made.

A5083 同種材의 摩擦容接 特性에 關한 硏究

성기완,길남규,신석우,민택기 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

This study dealt with the mechanical properties of aluminum alloy A5083 friction welds contained upset length, tensile test, hardness test, observation of microstructure and tensile fractured surface. The welding conditions of the maximum tensile strength of friction weld were revolution 2000rpm, friction pressure 50MPa, upset pressure 110MPa, friction time 1.0sec, and upset time 6.0sec. This study came to these conclusion as follow : 1.The maximum tensile strength was 355MPa which was 102% of the tensile strength 348MPa of the base material. 2.The conditions when maximum tensile strength was acquired, occurred dimple on the tensile fracture surface and upset length was 4.9mm. 3.The maximum hardness was Hv89 in the weld interface and soft zone was confirmed on the heat affected zone(HAZ).

영어교육과 학습현장 : 우리는 어떤 교육을 원하는가?

성기완 우송대학교 2000 우송대학교 논문집 Vol.5 No.-

The field of English Education espouses many competing views regarding what to teach, how to teach, and why to teach. Even though many educators pay little attention to these pedagogical views, these views are main structuring principles of all teaching practices. Accordingly, this paper introduces five teaching positions (i, e., scientific method, humanist, student-centered, social reconstruction, market theory), among which four are adopted from Kliebard's (1986) and one is added to delineate critical aspects of existing educational discourses. More specifically, by comparing and drawing connections between these five positions and current classroom and/or other social contexts of learning, this paper demonstrates that one's teaching behavior is historically, socioculturally, and politically constructed. In addition, this paper highlights the importance of understanding one's association with one or more of these positions and emphasizes one's indeterminacy and reflective attitude about one's own teaching position(s) are major driving forces in developing oneself and one's own teaching.

미세혈관문합때 염산 Ticlopidine의 항혈전 효과

강진성,전종완,한기환,정재홍,김선영 大韓成形外科學會 1987 Archives of Plastic Surgery Vol.14 No.1

Recent progress in microvascular surgery has opened new clinical possibilities in tissue transplantation and replantation by direct anastomoses of vessels less than one mm in external diameter. However, a large obstacle still remains in microsurgery, that is, occlusion of the anastomosis site by thrombosis which is mainly composed of platelets. Many anticoagulants and topical vasodilatic agents such as heparin, aspirin, persantin, coumarin and magnesium sulfate have been used to solve this problem. Heparin inhibits the conversion of prothrombin to thrombin and Factos Ⅴ,Ⅸ,--, Aspirin inhibits collagen-induced platelet aggregation whereas the primary action of persantin is to inhibit ADP-induced platelet aggregation and the release reaction of platelets. Currently, ticlopidine-HCI which is known to inhibit the platelet aggregation to ADP, collagen and epinephrine, is widely in use as an effective anticoagulant for the patients of atherosclerosis, hemodialysis, and subarachoid hemorrhage. Animal study was carried out for the ticlopidine-HCI to investigate the possibility of this agent to be used as a choice of anticoagulant in microvascular surgery. One hundred and twenty rats were divided into 3 groups. Group A was the control group. Aspirin and persantin were given orally in group B. Ticlopidine-HCI was given orally in group C. A femoral artery in one inguinal region and one femoral vein in the other side were severed and then were anastomosed with 10-0 nylon. The wounds were closed with 4-0 black silk. The patency was confirmed grossly and microscopically at 20 minutes, 3 days, and 3 weeks after anastomoses. The patency rates were as follows: 1. At 20 minutes after anstomoses, patency rates of arteries and veins were 100% in all groups. 2. At 3 days after anastomoses, in the control group the patency rates of arteries and veins were 95% and 85% respectively. Group B (aspirin-persantin)were 100% and 90% each. Compared with these, the patency rates of group C (ticlopidine) were better, all of the arteries and veins were patent. 3. At 3 weeks after anastomoses, the patency rates of arteries were 90% and veins were 80% in the control group. Arteries were 95% and veins were 90% in group B, whereas arteries were 100% and veins were 95% in group. C. Therefore, it is concluded that the ticlopidine can be used in microvasular surgery as an anticoagulant of choice.

술중 전향적 대장세척술과 대장아전절제술을 이용한 폐쇄성 좌측 대장 및 직장암의 일차절제 및 문합술

윤완희,홍기훈,송인상 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The proper surgical management of obstructing left colorectal cancers in an issue of debate. Staged operation including proximal colostomy has generally been accepted as a safe and standard method of management. But staged colonic procedures are associated with significant morbidity and mortality, and many patients, unfit for further surgery, are left with a permanent colostomy. Many other methods such as the use of long intestinal tube, transanastomotic obturation balloon colostomy, intracolonic bypass tube (Coloshield) were developed, but they have failed to gain wide accepance. We have already reported the initial results of intraoperative antegrade colonic irrigation for one-stage operation in obstructing left colorectal cancers. In this investigation, we evaluated the results of prospective trials of primary resection and anastomosis using intraoperative colon irrigation and subtotal colectomy in obstructing loft colon and rectal carcinomas. During recent five years, 19 cases of obstructing left colon and rectal carcinomas which could not received regular colon preparation due to marked abdominal distension were enrolled to this study. There were 12 men and 7 women, and mean age was 61. 14 of the 19 patients which tumors located below mid-descending colon were subjected to primary resection and anastomosis using intraoperative antegrade colonic irrigation, 4 patients which tumors located above the mid-descending colon were treated with subtotal colectomy, and remaining one patient which tumor located upper rectum was performed subtotal coloectomy because of underlying colonic ischemia. There was no mortality and significant postoperative complications such as anastomotic leakage, pelvic abscess of intraabdominal sepsis which seemed to related with anastomotic dehiscence. Therefore, primary resection and anastomosis using intraoperative colonic irrigation of subtotal colectomy depending on tumor locations in cases of obstructing left colon and rectal carcinomas might be useful methods to obtain safe one-stage restorative colorectal resections