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Pregnancy outcome following exposure of herbal medicine in early pregnancy
최준식 ( June Seek Choi ),( Jung Yeol Ham ),( Hyun Kyong Ahn ),( Joo Oh Kim ),( Moon Young Kim ),( Jae Hyug Yang ),( Min Hyoung Kim ),( Jin Hoon Chung ),( Hyun Mee Ryu ),( Kyu Hong Choi ),( Alejandro A. 대한산부인과학회 2006 대한산부인과학회 학술대회 Vol.92 No.-
전방 경추 수술 후 발생한 세균성 뇌수막염과 동반된 척수염
함동훈(Dong-Hun Ham),최병열(Byeong-Yeol Choi),정명철(Myung-Cheol Jung) 대한정형외과학회 2021 대한정형외과학회지 Vol.56 No.6
척추 수술 후 뇌수막염은 매우 드물게 발생하지만 치명적일 수 있다. 49세 남자 환자가 제5, 6 경추부의 추간판 탈출증에 의한 압박성 척수증 진단하에 전방 경추부 감압술 및 유합술을 시행받았다. 술 후 심한 경부통 및 경부 강직, 발열이 발생하였고 수술 일주일 째 갑자기 사지 마비 증상을 보였다. 추시 자기공명영상 검사 및 뇌척수액 검사상 세균성 뇌수막염과 동반된 척수염이 확인 되었다. 환자는 항생제 및 스테로이드 치료를 시행받았으나 결과는 불량하였다. 저자들은 전방 경추 수술 이후 발생한 뇌수막염과 동반된 척수염 증례에 대하여 문헌 고찰과 함께 보고하고자 한다. Meningitis after spinal surgery occurs rarely but can be fatal. A 49-year-old male was diagnosed with compressive myelopathy due to cervical disc herniation at the C 5, 6 level and underwent anterior cervical discectomy and fusion (ACDF). He complained of severe neck pain and stiffness with fever postoperatively and one week after surgery, the patient presented with abrupt tetraplegia. The follow-up magnetic resonance imaging and cerebrospinal fluid analysis revealed bacterial meningitis complicated by myelitis. The patient was treated with antibiotics and steroid, but the outcome was poor. The authors report a case of meningitis combined with myelitis following anterior cervical spinal surgery.
혈관 손상에 동반되는 혈관 내막 평활근의 중식에 미치는 Ramipril 의 효과
도문홍(Moon Hong Doh),신원호(Won Ho Shin),함종렬(Jong Yeol Ham),최동주(Dong Ju Choi),고경혁(Gyung Hyuck Ko),서봉관(Bong Kwan Seo),정순일(Sun Il Jung),최진학(Jin Hak Choi) 대한내과학회 1994 대한내과학회지 Vol.46 No.5
N/A Objective: Advanced atherosclerotic lesion consists mainly of intimal smooth muscle cell proliferation. Many factors are considered to be implicated in this process. The role of locally produced angiotensin II as a potent growth stimulus had been investigated. To evaluate the effect of ramipril, a new converting enzyme inhibitor, on the smooth muscle proliferative process this animal study was performed, Ramirpil was selected because of its unique physicochemical properties. Methods: Forty nine male New Zealand White or Chinchilla rabbits were randomly assigned to four groups: Group I (N=5), normal control; Group II (N=12), 2% cholesterol diet feeding without vascular injury; Group III (N =16), 2% cholesterol diet feeding after vascular injury; Group IV (N=16), ramipril treated group. Bilateral femoral atherosclerosis was induced by endothelial damage using desiccated nitrogen gas followed by a 4-week high cholesterol diet (2%-cholesterol & 6%-peanut oil). Ramipril, dose of 1 mg/kg/day, was given from 7 days before injury. Results: No definite atherosclerotic lesion was found in group II rabbits, But atherosclerotic lesion with intimal enlargement was induced in all group III & IV rabbits. The lesions were made of abundant cellular components, collagen fibers, & elastic fibers. The presence of intimal smooth muscle cells was confirmed by the immunohistochemical staining with muscle-specific monoclonal antibody HHF-35. Occasionally the foam cell lesions were scattered in the media as well as in the intima. There was frequent disruption of internal elastic lamina. Luminal area, neointimal area, media area, & ratio of intima to media were examined from the histologic sections of the femoral artery. There was no significant difference in all parameters between group I & group II rabbits. But between group I & group III rabbits was there significant difference in all 4 parameters. The same relationship was also found between group II & group III. So it was apparent that the hypercholesterolemic diet for 4 weeks alone could not induce atherosclerotic lesion in this animal model. The luminal area was not significantly different between group III & group IV. (0.10±0.08mm2 vs. 0.11±0.08mm2; p>0.05). The neointimal area of ramipril treated group was significantly smaller than that of group III rabbits (0.56±0.36mm2 vs. 0.17±0.12mm2; p<0.01). The media area was also smaller in ramipril treated group (0.34±0.17 mm2 vs. 0.22±0.06 mm2, p<0.05). The radio of neointima area to media area was higher in group III (1.67±0.80 vs. 0.76±0.44; p<0.01). Conclusion: This rabbit-desiccation injury-cholesterol diet model proved to be useful for the study of atherogenesis. Ramipril was considered to inhibit the intimal smooth muscle cell proliferation in this animal model.
간경변증 환자에서 식도정맥류 출혈의 계절적 변화의 관련 요인 분석
이선해 ( Sun Hae Lee ),김선주 ( Sun Joo Kim ),정승원 ( Seung Won Jung ),김지욱 ( Ji Wook Kim ),김환열 ( Hwan Yeol Kim ),김영훈 ( Young Hoon Kim ),이보영 ( Bo Young Lee ),함정호 ( Jeung Ho Ham ),김인호 ( In Ho Kim ),정일권 ( Il ksu 대한소화기학회 2002 대한소화기학회지 Vol.40 No.6
Background/Aims: The circadian variation of portal blood pressure and diurnal incidence of esophageal variceal bleeding (EVB) is well known, but the seasonal variation of EVB is still controversal. This study was performed retrospectively to evaluate the seasonal variation of EVB in patients with liver cirrhosis. Methods: Three hundred and seventy-five liver cirrhotic patients with EVB were enrolled. We evaluated the seasonal variation of EVB and correlations between bleeding and other clinical factors including recent alcohol intake. Results: The incidence of EVB was highest in April (50% higher than the monthly average), followed by March and lowest in July and August (45.8% lower than the monthly average), which did not reach statistical significance. The pattern of seasonal variation in patients with a history of recent alcohol intake was similar to that in the overall patient population, whereas the incidence of EVB was highest in December and lowest in August in patients without a history of recent alcohol intake. This may indicate that a history of recent alcohol intake is an important factor for EVB. Other factors such as age and Child-Pugh classification did not correlate with the seasonal variation of EVB. Conclusions: There seems to be a seasonal variation of EVB in patients with liver cirrhosis and alcohol intake may affect this seasonal variation. This result could be explained by the fact that the spring is a busy farming season and suitable for drinking in a rural district. (Korean J Gastroenterol 2002;40:386-393)