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혈관 손상에 동반되는 혈관 내막 평활근의 중식에 미치는 Ramipril 의 효과
도문홍(Moon Hong Doh),신원호(Won Ho Shin),함종렬(Jong Yeol Ham),최동주(Dong Ju Choi),고경혁(Gyung Hyuck Ko),서봉관(Bong Kwan Seo),정순일(Sun Il Jung),최진학(Jin Hak Choi) 대한내과학회 1994 대한내과학회지 Vol.46 No.5
N/A Objective: Advanced atherosclerotic lesion consists mainly of intimal smooth muscle cell proliferation. Many factors are considered to be implicated in this process. The role of locally produced angiotensin II as a potent growth stimulus had been investigated. To evaluate the effect of ramipril, a new converting enzyme inhibitor, on the smooth muscle proliferative process this animal study was performed, Ramirpil was selected because of its unique physicochemical properties. Methods: Forty nine male New Zealand White or Chinchilla rabbits were randomly assigned to four groups: Group I (N=5), normal control; Group II (N=12), 2% cholesterol diet feeding without vascular injury; Group III (N =16), 2% cholesterol diet feeding after vascular injury; Group IV (N=16), ramipril treated group. Bilateral femoral atherosclerosis was induced by endothelial damage using desiccated nitrogen gas followed by a 4-week high cholesterol diet (2%-cholesterol & 6%-peanut oil). Ramipril, dose of 1 mg/kg/day, was given from 7 days before injury. Results: No definite atherosclerotic lesion was found in group II rabbits, But atherosclerotic lesion with intimal enlargement was induced in all group III & IV rabbits. The lesions were made of abundant cellular components, collagen fibers, & elastic fibers. The presence of intimal smooth muscle cells was confirmed by the immunohistochemical staining with muscle-specific monoclonal antibody HHF-35. Occasionally the foam cell lesions were scattered in the media as well as in the intima. There was frequent disruption of internal elastic lamina. Luminal area, neointimal area, media area, & ratio of intima to media were examined from the histologic sections of the femoral artery. There was no significant difference in all parameters between group I & group II rabbits. But between group I & group III rabbits was there significant difference in all 4 parameters. The same relationship was also found between group II & group III. So it was apparent that the hypercholesterolemic diet for 4 weeks alone could not induce atherosclerotic lesion in this animal model. The luminal area was not significantly different between group III & group IV. (0.10±0.08mm2 vs. 0.11±0.08mm2; p>0.05). The neointimal area of ramipril treated group was significantly smaller than that of group III rabbits (0.56±0.36mm2 vs. 0.17±0.12mm2; p<0.01). The media area was also smaller in ramipril treated group (0.34±0.17 mm2 vs. 0.22±0.06 mm2, p<0.05). The radio of neointima area to media area was higher in group III (1.67±0.80 vs. 0.76±0.44; p<0.01). Conclusion: This rabbit-desiccation injury-cholesterol diet model proved to be useful for the study of atherogenesis. Ramipril was considered to inhibit the intimal smooth muscle cell proliferation in this animal model.
박영배,이영우,오동진,고창순,서정돈,서봉관,오병회 대한내과학회 1986 대한내과학회지 Vol.31 No.5
To assess the change in left ventricular function after hospital discharge, 57 patients with acute myocardial infarction were studied before discharge and 26 of them after discharge as well with either or both of treadmill test and radionuclide ventriculography(RNV). Follow-up study patients were 2g men with mean age of 53.1. Their infarct locations were anterior in 16 cases, inferior in 8 cases and anterior and inferior in 2 cases; 21 cases were in Killip class I, 3 cases in II, and 2 cases in III. Follow-up study was performed 2~19 months(mean 7.3 months) after acute myocardial infarction. The results were as follows: 1) Predischarge study showed that a relationship is present between regional wall motion abnormality, Killip class, peak serum CK and left ventricular ejection fraction(LVEF). 2) Predischarge and follow-up treadmill tests showed no significant change. 3) Follow-up RNV showed worsening of regional wall motion only in 1 case: Other cases showed either improvement or no change in regional wall motion. 4) Overall patients showed a significant increase in LVEF on follow-up. By location, only anterior infarction showed a significant increase in LVEF. 5) Killip class I patients showed a significant increase in LVEF on follow-up. 6) Most cases in this study were uncomplicated myocardial infarction and they showed improved LV function(suggested by RNV) on follow-up. Treadmill test also seems to be valuable for evaluationg improvement in exercise capacity on follow-up. So it is recomended that treadmill test or RNV be performed after discharge to evaluate change in LV function objectively.
이명철,박형근,고창순,최성재,김노경,서봉관,이훈용 대한핵의학회 1983 핵의학 분자영상 Vol.17 No.2
Traditionally, a positive bone scan shows single or multiple areas of increased uptake in them metastatic skeletal disease. The occurence of $quot;cold$quot; lytic-like or photon-deficient lesions in bone imaging is probably uncommon. Photon-deficient focus or cold lesion of the sternum was demonstrated on Tc-99m-MDP bone imaging in 2 individuals with acute myloid leukemia and primary hepatoma, respectively.