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- 저자 : 도문홍(Moon Hong Doh) (검색결과 2 건)
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혈관 손상에 동반되는 혈관 내막 평활근의 중식에 미치는 Ramipril 의 효과
도문홍(Moon Hong Doh),신원호(Won Ho Shin),함종렬(Jong Yeol Ham),최동주(Dong Ju Choi),고경혁(Gyung Hyuck Ko),서봉관(Bong Kwan Seo),정순일(Sun Il Jung),최진학(Jin Hak Choi) 대한내과학회 1994 대한내과학회지 Vol.46 No.5
N/A Objective: Advanced atherosclerotic lesion consists mainly of intimal smooth muscle cell proliferation. Many factors are considered to be implicated in this process. The role of locally produced angiotensin II as a potent growth stimulus had been investigated. To evaluate the effect of ramipril, a new converting enzyme inhibitor, on the smooth muscle proliferative process this animal study was performed, Ramirpil was selected because of its unique physicochemical properties. Methods: Forty nine male New Zealand White or Chinchilla rabbits were randomly assigned to four groups: Group I (N=5), normal control; Group II (N=12), 2% cholesterol diet feeding without vascular injury; Group III (N =16), 2% cholesterol diet feeding after vascular injury; Group IV (N=16), ramipril treated group. Bilateral femoral atherosclerosis was induced by endothelial damage using desiccated nitrogen gas followed by a 4-week high cholesterol diet (2%-cholesterol & 6%-peanut oil). Ramipril, dose of 1 mg/kg/day, was given from 7 days before injury. Results: No definite atherosclerotic lesion was found in group II rabbits, But atherosclerotic lesion with intimal enlargement was induced in all group III & IV rabbits. The lesions were made of abundant cellular components, collagen fibers, & elastic fibers. The presence of intimal smooth muscle cells was confirmed by the immunohistochemical staining with muscle-specific monoclonal antibody HHF-35. Occasionally the foam cell lesions were scattered in the media as well as in the intima. There was frequent disruption of internal elastic lamina. Luminal area, neointimal area, media area, & ratio of intima to media were examined from the histologic sections of the femoral artery. There was no significant difference in all parameters between group I & group II rabbits. But between group I & group III rabbits was there significant difference in all 4 parameters. The same relationship was also found between group II & group III. So it was apparent that the hypercholesterolemic diet for 4 weeks alone could not induce atherosclerotic lesion in this animal model. The luminal area was not significantly different between group III & group IV. (0.10±0.08mm2 vs. 0.11±0.08mm2; p>0.05). The neointimal area of ramipril treated group was significantly smaller than that of group III rabbits (0.56±0.36mm2 vs. 0.17±0.12mm2; p<0.01). The media area was also smaller in ramipril treated group (0.34±0.17 mm2 vs. 0.22±0.06 mm2, p<0.05). The radio of neointima area to media area was higher in group III (1.67±0.80 vs. 0.76±0.44; p<0.01). Conclusion: This rabbit-desiccation injury-cholesterol diet model proved to be useful for the study of atherogenesis. Ramipril was considered to inhibit the intimal smooth muscle cell proliferation in this animal model.
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최진학(Jin Hak Choi),조중현(Joong Hyeon Cho),김영채(Young Chai Kim),정기문(Ki Mun Jung),심상군(Sang Gun Sim),우성경(Sung Kyeong Woo),도문홍(Moon Hong Doh) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2
Salmonella infection have long been known to lead to diffuse organ involvement, including such organs as thyroid, bone, heart, pericardium but has rarely been reported acute pancreatitis as a complication. Earlier reports of confirmed or probable acute pancreatitis associated with typhoid fever were published in the Korean literature. We describe a patient with typhoid fever who developed acute pancreatitis proved by laboratory and radiologic findings. His blood and stool grew Salmonella typhi. At the end of 2 weeks, body temperature and amylase level in the blood came down. In this point of views, acute pancreatitis with prolonged fever despite of treatment may be related to typhoid fever. Thus, proper diagnosis and effective treatment produced patients good outcome.
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