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Song, Eyun,Ahn, Jonghwa,Oh, Hye-Seon,Jeon, Min Ji,Kim, Won Gu,Kim, Won Bae,Shong, Young Kee,Baek, Jung Hwan,Lee, Jeong Hyun,Ryu, Jin Sook,Chung, Ki Wook,Hong, Suck Joon,Kim, Tae Yong Elsevier 2019 Oral oncology Vol.91 No.-
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Persistence of thyroglobulin antibody (TgAb) in patients with papillary thyroid carcinoma (PTC) years after total thyroidectomy (TT) followed by ablation occurs even without any evidence of structural disease. Few studies have studied the natural course of TgAb positivity and factors that may influence this course. The present study evaluated the time trends of TgAb in ablated PTC patients and aimed to identify the predictive factors for the rate of negative conversion of TgAb.</P> <P><B>Materials and methods</B></P> <P>Overall, 1279 patients who underwent TT and subsequent ablation for PTC, with available data on thyroid peroxidase Ab (TPOAb) and TgAb prior to surgery (preop-) and ablation (abl-) were enrolled. Patients with initial distant metastasis or recurrence during follow-up were excluded.</P> <P><B>Results and conclusion</B></P> <P>Preop-TgAb was positive in 24.9% of patients (n = 319), whereas abl-TgAb positivity decreased to 12.8% (n = 164). In 164 patients positive for abl-TgAb, TgAb in patients with higher abl-TgAb levels decreased more gradually than those observed in patients with lower abl-TgAb levels (p < 0.001). Furthermore, in patients within the same range of abl-TgAb levels, patients positive for abl-TPOAb had a higher rate of negative conversion of TgAb compared with negative patients for abl-TPOAb (log rank p < 0.001). TPOAb significantly increased the rate of negative conversion in multivariate analysis adjusted for abl-TgAb (odds ratio 1.59, 95% confidence interval 1.11–2.28, p = 0.011). This study clearly showed that abl-TgAb titers and abl-TPOAb status can predict the rate of negative conversion. These findings can guide the optimal timing for additional examination in patients positive for TgAb during follow-up.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Positivity for preoperative TgAb in patients with PTC is higher than general population. </LI> <LI> The higher the TgAb levels at the time of postoperative ablation, the longer it takes to negative conversion. </LI> <LI> TPOAb status at the time of ablation is also associated with the time required for the disappearance of TgAb. </LI> <LI> TgAb and TPOAb together can predict the rate of negative conversion of TgAb. </LI> </UL> </P>
Eyun Song,Kyung Mee Song,김원구,최창민 대한갑상선학회 2016 International Journal of Thyroidology Vol.9 No.2
Sorafenib, an oral multi-kinase inhibitor, is used for the treatment of patients with radioactive iodine (RAI) refractory differentiated thyroid carcinoma (DTC) with favorable outcomes. Some unusual but fatal adverse effects are known for this drug and tracheoesophageal fistula (TEF) is one of them, which has never been reported in thyroid cancer patients. We present a successfully treated patient who had developed TEF associated with rapid tumor regression during sorafenib treatment for locally advanced papillary thyroid carcinoma (PTC). Sorafenib was discontinued and feeding jejunostomy tube was placed for nutritional support. 3 months later, the TEF had successfully healed and there was no visible fistula track or interval change of the viable tumor during 15 months of follow-up. Identifying patients at high risk for this potential complication and paying special attention when prescribing anti-angiogenics to these patients are crucial to prevent associated morbidity and mortality.
Concurrent Subacute Thyroiditis and Graves’ Disease After COVID-19: A Case Report
Nham Eliel,Song Eyun,Hyun Hakjun,Seong Hye,Yoon Jin Gu,Noh Ji Yun,Song Joon Young,Cheong Hee Jin,Kim Woo Joo 대한의학회 2023 Journal of Korean medical science Vol.38 No.18
There are many reports of subacute thyroiditis (SAT) that occurred after the coronavirus disease 2019 (COVID-19), but no such case has been reported in Korea. Moreover, the simultaneous occurrence of SAT and Graves’ disease (GD) is rare. Here, we describe a patient who developed SAT and GD after the second episode of COVID-19. A 27-year-old woman with no known history of thyroid disease presented with fever, upper respiratory tract symptoms, and painful neck swelling. Thyroid function tests revealed thyrotoxicosis, and thyroid ultrasound showed heterogeneous echogenicity of enlarged thyroid glands. Her initial clinical presentation was consistent with SAT after viral infection, with typical neck tenderness and spontaneous improvement of thyrotoxicosis without antithyroid drug use. However, this case had some atypical features, such as an elevated thyroid-stimulating immunoglobulin level, relapse of thyrotoxicosis in short-term follow-up, and increased Tc-99m pertechnetate uptake, suggesting the coexistence of GD. About two months after methimazole (15 mg/day) was prescribed, she was lost to follow up again. We report the first case of unusual co-occurrence of SAT and GD following COVID-19.
Kim Jung A,박민정,Eyun Song,노은,박소영,이다영,김재영,유지희,서지아,최경묵,백세현,류혜진,김난희 대한당뇨병학회 2022 Diabetes and Metabolism Journal Vol.46 No.6
Self-monitoring of capillary blood glucose is important for controlling diabetes. Recently, a laser lancing device (LMT-1000) that can collect capillary blood without skin puncture was developed. We enrolled 150 patients with type 1 or 2 diabetes mellitus. Blood sampling was performed on the same finger on each hand using the LMT-1000 or a conventional lancet. The primary outcome was correlation between glucose values using the LMT-1000 and that using a lancet. And we compared the pain and satisfaction of the procedures. The capillary blood sampling success rates with the LMT-1000 and lancet were 99.3% and 100%, respectively. There was a positive correlation (r=0.974, <i>P</i><0.001) between mean blood glucose levels in the LMT-1000 (175.8±63.0 mg/dL) and conventional lancet samples (172.5±63.6 mg/dL). LMT-1000 reduced puncture pain by 75.0% and increased satisfaction by 80.0% compared to a lancet. We demonstrated considerable consistency in blood glucose measurements between samples from the LMT-1000 and a lancet, but improved satisfaction and clinically significant pain reduction were observed with the LMT-1000 compared to those with a lancet.
Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy
Park, Suyeon,Jeon, Min Ji,Song, Eyun,Oh, Hye-Seon,Kim, Mijin,Kwon, Hyemi,Kim, Tae Yong,Hong, Suck Joon,Shong, Young Kee,Kim, Won Bae,Sung, Tae-Yon,Kim, Won Gu The Endocrine Society 2017 The Journal of clinical endocrinology & metabolism Vol.102 No.4
Association between urinary sodium levels and iodine status in Korea
( Jonghwa Ahn ),( Jang Ho Lee ),( Jiwoo Lee ),( Ji Yeon Baek ),( Eyun Song ),( Hye-seon Oh ),( Mijin Kim ),( Suyeon Park ),( Min Ji Jeon ),( Tae Yong Kim ),( Won Bae Kim ),( Young Kee Shong ),( Won Gu 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2
Background/Aims: To evaluate the association between the urinary sodium concentration and iodine status in different age groups in Korea. Methods: This nationwide, population-based, cross-sectional study used data from the Korean National Health and Nutrition Examination Survey (VI 2-3, 2014 to 2015). We included 3,645 subjects aged 10 to 75 years with normal kidney function and without a history of thyroid disease. Adequate iodine intake was defined as a urinary iodine/creatinine (I/Cr) ratio of 85 to 220 μg/g. The urinary sodium/ creatinine (Na/Cr) ratios were classified as low (< 47 mmol/g), intermediate (47 to 114 mmol/g), or high (> 114 mmol/g). Results: The median urinary iodine concentration (UIC) was 292 μg/L (interquartile range [IQR], 157 to 672), and the median urinary I/Cr ratio was 195 μg/g (IQR, 104 to 478). Iodine deficiency (< 100 μg/L) and iodine excess (> 300 μg/L) were observed in 11.3% and 49.0% of subjects, respectively. The UIC was significantly associated with the urinary sodium concentration, and the urinary I/Cr ratio was significantly correlated with the urinary Na/Cr ratio (both p < 0.001). The distributions of UIC, urinary I/Cr ratio, and Na/Cr ratio varied among age groups. Low urinary I/Cr and Na/Cr ratios were most common in young adults (age, 19 to 29 years), while high urinary I/Cr and Na/Cr ratios were most common in elderly people (age, 60 to 75 years). Conclusions: Iodine intake was significantly associated with sodium intake in the Korean population. Our study suggested that an adequately low salt intake might be helpful for preventing iodine excess in Korea.
신승환 ( Seung Whan Shin ),성유나 ( You Na Sung ),소훈섭 ( Hoonsub So ),송의연 ( Eyun Song ),오충렬 ( Chung Ryul Oh ),홍승모 ( Seung-mo Hong ),박도현 ( Do Hyun Park ) 대한내과학회 2018 대한내과학회지 Vol.93 No.4
췌장의 간세포양 암종은 전세계적으로 매우 드문 암종으로, 기존의 원발성 췌장암, 간세포암종의 췌장 전이와의 감별을 위해서 임상적, 영상학적, 병리학적 소견을 모두 검토하여 신중한 진단이 필요하다. 현재까지 확립된 치료 방법은 없는 상태로, 수술적 절제가 항암치료보다 우수한 경과를 보여 수술이 가능할 경우 수술적 치료가 필요하다. 수술이 불가능한 종양에 대한 치료법은 향후 추가적인 연구를 통하여 찾아야 하는 노력이 필요하다. Hepatoid carcinoma is extrahepatic neoplasm showing similar morphologic, immunohistochemical features with hepatocellular carcinoma. It’s a very rare disease and has been reported most frequently in the stomach. Herein, we report a case of hepatoid carcinoma of pancreas presented with acute pancreatitis. The hepatoid carcinoma was diagnosed by his needle biopsy specimen and it showed pleomorphic nuclei and predominantly eosinophilic and occasionally clear cytoplasm in hematoxylin and eosin staining, and positive for HepPar-1 and cytokeratin 19 in immunohistochemical staining. Surgical treatment seems to be the best choice, if possible. However, there is no standard regimen for palliative chemotherapy. In our case, the patient was treated with 5-Fluorouracil (5-FU), folinic acid, irinotecan, oxaliplatin (FOLFIRINOX). The response was stable disease up to 4 month of follow up. (Korean J Med 2018;93:387-392)