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송영기 ( Young Kee Shong ) 대한갑상선학회 2009 International Journal of Thyroidology Vol.2 No.1
18F-fluorodeoxyglucose positron-Emission Tomography (FDG-PET) is very useful for the follow up of differentiated thyroid carcinoma. FDG-PET could determinate the recurrent or metastatic foci of thyroid cancer in 70∼90% of patients with elevated thyrogobulin level during thyroid hormone withdrawal, especially whose I-131 whole body scan were negative. However, currently neck ultrasonography (USG) is the primary choice to detect recurrent disease in neck because FDG-PET is rather expensive and available only in limited center. FDG-PET could be recommended in patients with negative USG result or for detecting distant metastasis in patients with local recurrence. The number of patients with incidentally found FDG uptake in thyroid gland after FDG-PET or PET/CT was increased. Diagnostic procedures such as USG and cytological examination or pathological examination including hemithyroidectomy were essential for these patients due to the high risk of malignancy. FDG-PET did not have any advantage for the preoperative evaluation comparing other diagnostic modalities. It could be selectively used in the high risk patients.
송영기(Young Kee Shong),박경수(Kyong Soo Park),조보연(Bo Youn Cho),고창순(Chang Soon Koh),오승근(Seung Keun Oh),박성희(Seong Hoe Park),김용일(Yong Il Kim) 대한내과학회 1986 대한내과학회지 Vol.30 No.6
N/A Five cases of differentiated carcinoma of thyroid associated with brain metastasis are reported. All of the patients had distant metastatic diseases or massive invasion of the surrounding tissue at the initial diagnosis. Metastatic lesions in the brain were not detected by conventional radioiodine whole body scan but by computerized axial tomography. TSH suppression, external radiotherapy, and radioactive iodine were tried but no consistently satisfactory effects were achieved. The prognosis of the patients with brain metastasis was poor, four patient diedat two to four months after detection of brain metastasis and only one patient is alive two months after detection, at the time of writing this paper.
Graves 병 환자에서 갑상선 아전절제술 후 갑상선자극항체와 갑상선자극홀몬 결합억제 면역글로불린의 변화
송영기(Young Kee Shong),이병두(Byoung Doo Rhee),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),오승근(Seung Keun Oh) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A The authors measured changes in thyroid stimulating antibody (TSAb) and thyrotropin binding inhibitor immunoglobulin (TBII) in 15 patients with Graves' disease treated with subtotal thyroidectomy. Before surgery all 15 had detectable TBII actvities, and 11 had TSAb activities. During the 12 month postoperative follow-up, TBII disappeared in 7 out of 15, and TSAb disappeared in 6 out of 11. Twelve months after surgery, 10 patients with negative TSAb (including 4 patients whose TSAb activities were negative before surgery) remained in remission, Of 5 patients whose TSAb remained persistently positivie during the 12 month observation period, one remained in remission, two experienced relapse, and two became hypothyroid. In the persistently positive TSAb and TBII group, their activities did not change after surgery. There was no difference in clinical and laboratory findings save for the higher TSAb and TBII activity preoperatively between the persistently positive group and disappearing group. In summary, after subtotal thyroidectomy, TSAb and TBII disappeared in some of the patients. Disappearance of TSAb is associated with remission but persistence of TSAb has no prognostic implication. The production sites of thyrotropin reccptor antibody are thought to be intrathyroidal, but in some patients extrathyroidal production might contribute significantly, due to the pattern of postoperative changes in thyrotropin receptor antibody activities.
백서 고환 간질 세포에서 TSH 와 TSH 수용체 항체에 대한 cAMP 와 Testosterone 의 반응
송영기(Young Kee Shong),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),이문호(Mun Ho Lee) 대한내과학회 1988 대한내과학회지 Vol.35 No.3
N/A To investigate the physiological role of TSH receptor in testes and the effect of various TSH receptor antibodies (TRAb), we measured cAMP production ad testosterone release in enzymatically dispersed rat testicular interstitial cells under the stimulation of TSH and TRAb, and compared the results with in those of tests done in FRTL-5 cells. TSH increased cAMP production and testosterone release in a dose-dependent manner similar to hCG. TSAb which stimulated thyroid adenylate cyclase (AC) were able to stimulate teaticular interstitial cell AC in 8 out of 30 patients (277p) and testosterone release in 12 out of 30(40%) patients with Graves' disease. Blocking type TRAb inhibited TSH-induced cAMP production and testosterone release in a dose-dependent manner but had no effect on basal cAMP production and testosterne release, These findings suggest that TSH receptors in testes might have a somewhat dissimilar nature from that in the thyroid and that testicular TSH receptor might be involved in testosterone production.
송영기,조보연,이홍규,김원배,고창순,오연상,이가희 대한내분비학회 1995 Endocrinology and metabolism Vol.10 No.4
We investigated the optimal condition of thyroid stimulating antibody(TSAb) assay using Chinese hamster ovary cells transfected with cDNA of human TSH receptor(TSHr-CHO) stably expressing functional TSH receptors. The extracellular cAMP responses of TSHr-CHO cells to the stimulation of bTSH or Graves' IgG were observed in three different incubation media. Stimulation indices of extracellular cAMP were higher when sucrose containing NaCl-free isotonic Hank's balanced salt solution(HBSS)(media A)was used as incubation media than those of NaCl-free hypotonic HBSS(media B) or those of NaCl containing isotonic HBSS(media C). The incubation of TSHr-CHO cells in media B caused marked increase in the basal cAMP level without concomittant fold-increase in the stimulated cAMP level at various doses of bTSH and Graves' IgG. Decreasing the stimulation indices of extracellular cAMP, use of media B failed to detect TSAb activities in two TSAb-positive Graves' IgG tested. In case of media C, extracellular cAMP responses are poor at 0.001 and 0.1U/L of bTSH and at all doses of Graves' IgG tested(0.5, 1, 5g/L). The incubation of TSHr-CHO cells in media B caused significant increase in the number of trypan blue-stained, nonviable cells(5.7+-1.5, 7.6+-1.9 and 8.5+-1.6% at 1, 2 and 3h of incubation, respectively; p<0.01) comparing to those incubated in media A or media C(about 2-3% in both media). Those decrease in the viability of TSHr-CHO cells when incubated in hypotonic incubation media may explain the decrease in the stimulation index of extracellular cAMP with the use of media B in contrast to the case of FRTL-5 cells. TSAb assay of 87 consecutive fresh Graves' patients with TSHr-CHO cells using media A detected TSAb activities in 90%(78 patients) of them, and moreover TSAb activities showed significant positive correlation with the pre-treatment serum T_3 and free T_4 levels of those patients. We conclude that TSAb assay with TSHr-CHO cells is a sensitive and physiologically relevant assay system to measure TSAb activities merely through measurements of extracellular cAMP provided that the cells are incubated in NaCl-free isotonic incubation media(J Kor Soc Endocrinol 10: 333-346, 1995).