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Review of the Current Research on Fetal Bovine Serum and the Development of Cultured Meat
이다영,이승윤,윤승현,정재원,김재현,김현우,최정석,김갑돈,주선태,최인호,허선진 한국축산식품학회 2022 한국축산식품학회지 Vol.42 No.5
The purpose of this review is to summarize studies that investigate blood and the main components of fetal bovine serum (FBS) in vertebrates, including major livestock, and review the current research on commercializing cultured meat. Detailed research on FBS is still lacking; however, some studies have shown that FBS consists of proteins, carbohydrates, growth factors, cytokines, fats, vitamins, minerals, hormones, non-protein nitrogen, and inorganic compounds. However, there are few studies on how the composition of FBS differs from blood or serum composition in adult animals, which is probably one of the main reasons for not successfully replacing FBS. Moreover, recent studies on the development of FBS replacers and serum-free media have shown that it is difficult to conclude whether FBS has been completely replaced or serum-free media have been developed successfully. Our review of the industrialization of cultured meat reveals that many basic studies on the development of cultured meat have been conducted, but it is assumed that the study to reduce or replace ingredients derived from fetuses such as FBS has not yet been actively developed. Therefore, developing inexpensive and edible media is necessary for the successful industrialization of cultured meat.
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Therapeutic Effects of Amino Acids in Liver Diseases: Current Studies and Future Perspectives
이다영,김은희 대한암예방학회 2019 Journal of cancer prevention Vol.24 No.2
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and the third most common cause of cancer-related death worldwide. HCC is caused by infection of hepatitis B/C virus and liver dysfunctions, such as alcoholic liver disease, nonalcoholic fatty liver disease, and cirrhosis. Amino acids are organic substances containing amine and carboxylic acid functional groups. There are over 700 kinds of amino acids in nature, but only about 20 of them are used to synthesize proteins in cells. Liver is an important organ for protein synthesis, degradation and detoxification as well as amino acid metabolism. In the liver, there are abundant non-essential amino acids, such as alanine, aspartate, glutamate, glycine, and serine and essential amino acids, such as histidine and threonine. These amino acids are involved in various cellular metabolisms, the synthesis of lipids and nucleotides as well as detoxification reactions. Understanding the role of amino acids in the pathogenesis of liver and the effects of amino acid intake on liver disease can be a promising strategy for the prevention and treatment of liver disease. In this review, we describe the biochemical properties and functions of amino acids and to review how they have been applied to treatment of liver diseases. (J Cancer Prev 2019;24:72-78)
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이다영,조재민,윤선미,홍경숙,지상덕,손종곤,김은희 한국잠사학회 2017 International Journal of Industrial Entomology Vol.35 No.1
Gastric ulcer is a clinical symptom characterized by inflammation of the gastric mucosa. Stress and alcohol consumption have been identified as the major cause of gastric ulcer. However, the effects of silkworms on ethanol-induced gastric ulcer have not been studied yet. The mature silkworms that are difficult to eat have become easier to ingest due to recent technological development to make steaming and freeze-drying mature silkworm larval powder (SMSP). In this study, we investigated whether three silkworm varieties, Baekokjam, Golden-silk and Yeonnokjam could alleviate ethanol-induced gastric mucosal damage in vivo. Sprague-Dawley rats pretreated with 3 SMSPs (0.1 or 1 g/kg BW) or normal diet (AIN-76A) were exposed to absolute ethanol (3 g/kg BW, 3 h) by oral gavage. Morphological examination included ulcer index as a measurement of hemorrhages and hematoxylin and eosin staining was performed to analyze the severity of gastric ulcer. Results of macroscopic examination suggested that all 3 SMSPs pretreatment significantly protected gastric mucosa against ethanol-induced damage. Microscopic observations demonstrated significant mucosal erosion and inflammation in ethanol-treated rats, which was abrogated in rats pretreated with 3 SMSPs. In addition, pretreatment with all 3 SMSPs showed significant decreases the expression of pro-inflammatory mediators, IL-6 and cyclooxygenase-2. Among SMSP from 3 varieties of silkworm, preadministration of 1 g/kg Baekokjam SMSP showed the most effective protective effect against ethanol-induced gastric ulcer. These results suggest that Baekokjam SMSP can be a potential gastroprotective agent against ethanol-induced gastric ulcer.
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트랜스코딩 작업의 분배를 활용한저전력 트랜스코딩 서버 설계 및 구현
이다영,송민석 한국차세대컴퓨팅학회 2019 한국차세대컴퓨팅학회 논문지 Vol.15 No.4
A dynamic adaptive streaming server consumes high processor power because it handles a large amount of transcoding operations at a time. For this purpose, multi-processor architecture is mandatory for which effective transcoding task distribution strategies are essential. In this paper, we present the design and implementation details of the transcoding workload distribution schemes at a 2-tier (frontend node and backend node) transcoding server. For this, we implemented four schemes: 1) allocation of transcoding tasks to appropriate back-end nodes, 2) task scheduling in the back-end node and 3) the communication between front-end and back-end nodes. Experiments were conducted to compare the estimated and the actual power consumption in a real testbed to verify the efficacy of the system. It also proved that the system can reduce the load on each node to optimize the power and time used for transcoding. 동적 적응 스트리밍 서버는 일시에 많은 양의 트랜스코딩 연산을 처리하기 때문에 높은 프로세서 전력을 소모한다. 많은 연산량을 위하여 다중 프로세서 구조가 필요하고, 이에 대한 효과적인 트랜스코딩 태스크 분배가 필요하다. 본 논문에서는 2 티어 (프론트엔드 노드 (frontend node)와 백엔드 노드 (backend node)) 트랜스코딩 서버의 전력 상한을 보장하고 스트리밍 되는 비디오의 인기도 및 품질을 고려한 트랜스코딩 서버의 설계 및 구현 방법을 제안한다. 이를 위하여 1) 각 백엔드 노드에 트랜스코딩 태스크 분배, 2) 백엔드 노드에서의 태스크 스케줄링, 3) 프론트엔드와 백엔드 노드 통신 기법들을 구현하고, 테스트베드를 구축하였다. 실제 테스트베드에서의 예상 소모 전력과 실제 소모 전력을 비교하는 실험을 진행함으로써 본 시스템의 효용성을 확인했다. 또한 본 시스템이 각 노드의 부하를 감소시킴으로써 트랜스코딩에 사용되는 전력 및 시간 최적화가 가능함을 보였다.
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