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Do-Kyung Kim,Hyeok Bin Kwon,Hongsik Park,Eunji Choe,Jin-Hyuk Bae,Jaehoon Park,Seong-Ho Song 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.6
We report the importance of the inherent and the relative surface energies in generating a patterned organic semiconductor layer through a solution process. The inherent and the relative surface energies of the substrate can be effectively controlled using polydimethylsiloxane in combination with an UV/ozone treatment. The controlled inherent surface energy in each region, as well as the high-order difference of relative surface energy, plays a significant role in generating the patterned layer. In addition, the patterned metal-semiconductor-metal (MSM) structure shows a lower lateral current than the non-patterned MSM structure because the current path is limited.
( Do Young Kim ),( Si Hyun Bae ),( Ju Hyun Kim ),( Jae Seok Hwang ),( So Young Kwon ),( Won Young Tak ),( Jong Eun Yeon ),( Sang Young Han ),( Joon Hyeok Lee ),( Jung Hwan Yoon ),( Neung Hwa Park ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: In bioequivalence study, Baracle® from Dong-A ST was demonstrated to have its equivalent pharmacokinetic profile to Baraclude®. A comparative study was conducted to evaluate the antiviral activity and safety of Baracle® compared to Baraclude® in patients with chronic hepatitis B (CHB). Methods: In this multicenter, double-blinded, active-controlled, stratified- randomized, parallel group, comparative trial, we randomly assigned 118 patients with previously untreated hepatitis B e antigen (HBeAg)-positive or negative Hepatitis B virus (HBV) to receive either 0.5 mg of Baracle® or Baraclude® once daily for 48 weeks. The primary end point was virologic improvement (the mean reduction from baseline in serum HBV DNA levels) at week 24. Secondary end points included mean reduction of serum HBV DNA levels at week 48, proportion of patients with serum HBV DNA levels at undetectable titer (<300 copies/ml), the rate of HBeAg loss and seroconversion, HBsAg loss and seroconversion and normalization of the alanine aminotransferase (ALT) levels. Safety monitoring was also conducted at regular visit. Results: Analysis of covariance on the change in the HBV DNA levels (log10) from the baseline to week 24 was performed using the treatment groups and HBeAg (positive/negative), a stratification factor, as covariates; the results showed a decrease by 4.81 and 4.63 in the Baracle® group and Baraclude® group, respectively The upper limit of the two-sided 95% CI (equivalent to one-sided 97.5% CI) on the difference between the treatment groups was 0.208, which was below the non-inferiority margin of 1, therefore supporting the non-inferiority of Baracle® to Baraclude®. There were no statistically differences between two groups in all secondary and tertiary end points. Safety profile was not different between two groups. Conclusions: In patients with previously untreated HBeAg-positive or negative HBV infection, there were no significant differences in efficacy or safety between Baracle® and Baraclude®.
방사선 조사 시 혈구 및 장점막에 대한 흑마늘 추출물의 보호효과
정도영(Do Young Jung),최준혁(Jun hyeok Choi),김중선(Joong sun Kim),최형석(Hyeong seok Choi),배민지(Min ji Bae),박원석(Won suk Park),민병인(Byung in Min) 대한방사선과학회(구 대한방사선기술학회) 2016 방사선기술과학 Vol.39 No.1
교육, 의료, 산업분야에서 다양하게 이용되고 있는 방사선은 전신 피폭시 다양한 부작용을 야기한다. 이에 흑마늘 추출물을 이용하여 방사선 피폭으로 발생되는 부작용을 저감화 시키는 방사선방호효과를 확인하였다. 흑마늘추출물을 Sprague Dawley Rat에 일정기간 투여한 후 7, 13 Gy의 X-ray를 조사하여 혈구성분 및 소장조직을 비교 관찰하였다. 실험결과 흑마늘 추출물을 투여한 실험군에서 대조군에 비해 초기 백혈구(p<0.05) 및 적혈구(p<0.05), 혈소판(p<0.05)의 손상이 감소되었으며 소장움이 대조군에 비하여 유의성 있는 생존을 확인하였고 소장 융모의 길이는 정상군에 가깝게 남아있는 것을 확인하였다. 따라서 흑마늘 추출물이 방사선 피폭으로 인한 세포 손상을 줄여주어 방사선방호제로써의 역할을 할 수 있을 것이라 사료된다. The radiation has been utilized in a number of fields, even though the use of plenty cause a variety of side effects. This study was confirmed for radiation protective effects of aged garlic to contribute to the prevention of disasters that are radiation exposure. We studied the Complete Blood cell Count(CBC) and the small intestine after feeding aged garlic extract into Sprague Dawley Rat which irradiated X-ray beam 7 and 13 Gy. Garlic extract was administered to the results in the experimental group showed a notable difference in the CBC of platelets (p<0.05), red blood cells (p<0.05) and early damaged white blood cells (p<0.05). In addition, it was confirmed that experimental group's small intestine crypt is more survival than irradiation group significantly. And experimental group has small intestine villi length almost similar to the normal group. result of the aged garlic study will be able to be of great benefit for the radiation relevant emergency management.
Double Autologous Stem Cell Transplantation for Multiple Myeloma: A Korean Single Center Study
( Ock Bae Ko ),( Shin Kim ),( Hyeok Shim ),( Jung Hun Lee ),( Jung Min Ahn ),( Soon Man Yoon ),( Min Hyok Jeon ),( Il No Do ),( So Young Lee ),( Yong Gil Kim ),( Sang We Kim ),( Sung Bae Kim ),( Sang 대한내과학회 2005 The Korean Journal of Internal Medicine Vol.20 No.3
Background: Although high dose chemotherapy coupled with an autologous stem cell transplantation (ASCT) is widely accepted as effective therapy for multiple myeloma (MM), few reports are available in Korea, especially in the area of double ASCT. We present the results of an institutional retrospective study of 12 patients with MM treated by double ASCT. Methods: Eligible patients received induction therapy using vincristine, adriamycin, dexamethasone (VAD), and mobilization was performed using cyclophosphamide plus lenograstim. High-dose melphalan (total 200㎎/㎡) was used to condition the ASCT. Results: The median interval from diagnosis to ASCT was 6 months (range, 1.8-15.3 months). The median interval between the 1st and 2nd ASCT was 4.4 months (range 2.1-48.7 months). The median follow up was 18.3 months (range 8.1-50.5 months) for the nine surviving patients. No therapy-related mortality occurred. Following induction chemotherapy, two patients experienced CR. Following double ASCT, eight patients experienced CR. The 5 year OS was 59%. The median duration of event free survival was 2.13 years (95% CI, 0.84-3.42). Conclusion: Although the results of study did not demonstrate the advantage of double ASCT, this is the first report to outline the outcome of double ASCT for Korean MM patients.
Kim, Do-Kyung,Kwon, Hyeok Bin,Park, Hongsik,Choe, Eunji,Bae, Jin-Hyuk,Park, Jaehoon,Song, Seong-Ho 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.
<P>We report the importance of the inherent and the relative surface energies in generating a patterned organic semiconductor layer through a solution process. The inherent and the relative surface energies of the substrate can be effectively controlled using polydimethylsiloxane in combination with an UV/ozone treatment. The controlled inherent surface energy in each region, as well as the high-order difference of relative surface energy, plays a significant role in generating the patterned layer. In addition, the patterned metal-semiconductor-metal (MSM) structure shows a lower lateral current than the non-patterned MSM structure because the current path is limited.</P>
Vincent, Premkumar,Kim, Do-Kyung,Kwon, Jin-Hyuk,Bae, Jin-Hyuk,Kim, Hyeok Elsevier 2018 THIN SOLID FILMS - Vol.660 No.-
<P><B>Abstract</B></P> <P>The optical characteristics of nanoparticles will vary according to particle size. With decrease in the size of the nanoparticle (NP), the bandgap of the material increases, thus providing a blue-shift in the refractive index of the material. In this study, we analyzed the effect of different sized zinc oxide (ZnO) nanoparticle optical spacer on the ideal short-circuit current density (J<SUB>sc,ideal</SUB>) of an hybrid photovoltaic cell. ZnO was used as an optical spacer in the solar cell structure to improve the light absorbed in the active layer. Refractive index and extinction coefficient of different sized ZnO nanoparticles were calculated using tight binding model. We implemented these results in two different morphological models: nanoparticle model, and thin-film model. In the nanoparticle model, the ZnO NPs were considered as nanospheres which scatter the incoming light. Comparison of these models helped us to evaluate the improvement in the J<SUB>sc,ideal</SUB> due to scattering effects from nanoparticles. Finally, the optimized structure was obtained for different active layer thicknesses by varying the thickness of the ZnO layer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Refractive index of ZnO nanoparticles is size-dependent. </LI> <LI> Optical spacer's ZnO nanoparticles' size affects the light absorption. </LI> <LI> Two morphological FDTD models, nanoparticle spheres 3D model, and thin-film 1D model. </LI> <LI> The optimized structure was obtained by varying the thickness of the ZnO layer. </LI> </UL> </P>
Preparation and Optical Properties of $SrGa_2S_4$:Eu Phosphor
도영낙,배재우,김유혁,양홍근,Do, Yeong Nak,Bae, Jae U,Kim, Yu Hyeok,Yang, Hong Geun Korean Chemical Society 2000 Bulletin of the Korean Chemical Society Vol.21 No.3
The photoluminescence and cathodoluminescence of $SrGa_2S_4:EU$ phosphor were optimized with the process and chemical variables (activators, fluxes and reaction temperature) used in solid state reaction. Firing the powder with flux at $800^{\circ}C$ for 2hr gave the highest photoluminescence efficiency under near-UV excitation and the highest cathodoluminescence efficiency of 20.1 lm/W at 2 kV and 33.3 lm/W at 10 kV. The suitability of $SrGa_2S_4:EU$ for application as a phosphor in LCDs and FEDs is discussed.