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백지연(Baek Ji-yeon),정창록(Jeong Chang-rok) 한국생명윤리학회 2017 생명윤리 Vol.18 No.1
본 논문은 의료 영역에서 비판적 사고력 향상을 위한 생명윤리교육의 한 방향을 제시하고 있다. 필자들은 사례를 기반으로 토론학습방법을 통하여 학생들의 비판적 사고력을 향상할 수 있다는 가정 하에 하나의 생명윤리교육과정을 설계하였다. 현대 한국의 의료사회는 생명과 관련된 기술 발전으로 인해 해결해 나가야 할 문제들이 여러 측면에서 새롭게 등장하고 있다. 그리고 그 복잡성은 의료사회의 다양한 구성원들의 이해관계가 대립하면서 더욱 심화되고 있으며 의료인 개인이나 의료 집단 간, 또는 의료 집단과 그 외 공동체가 비판적 검토와 토론을 통한 합의를 통해 해결점을 찾아나가야 하는 상황이다. 따라서 특히 한국의 의료인들은 이러한 불확실한 상황 속에서 복잡한 윤리적 상황에 직면하여 각기 다른 이해와 가치를 검증하여 선택할 수 있는 비판적 사고력을 가져야만 한다. 미래의 약학 관련 연구자나 약사가 될 약학대학원생들도 한국 의료계의 일원으로서 이러한 시대적 요청으로부터 자유로울 수는 없다. 필자들은 이러한 문제의식을 바탕으로 본 논문에서 약학윤리교육의 목표로서 비판적 사고력의 중요성을 강조하며 한국사회의 사례를 활용한 교육과정의 개발과 실제 수업안을 제시하고 있다. In this paper, authors were supposed to find solutions for a meaningful and valuable pharmacy ethics education for professional pharmacy graduated students. And this is on the basis of realization about pharmacy ethics educational problems on these days. We think that general ethics education has two ways, one is rationalism and another is sentimentalism. These ways are determined by considering how aspect important one of moral factors. We discuss the importance of development for ability of critical thinking in pharmacy ethics education including their meaning and characteristics. And this is based on rationalism ethics education improving moral judgment and ability of critical thinking. We suggest to have class focused on a reality case and discussion as way of pharmacy ethics education for critical thinking progress.
Bong-Hyeon Kye,이석환,Woon Kyung Jeong,Chang Sik Yu,In Ja Park,Hyeong Rok Kim,Jin Kim,In Kyu Lee,Ki-Jea Park,Hong-Jo Choi,Ho Young Kim,Jeong-Heum Baek,Yoon-Suk Lee 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.97 No.4
Purpose: The optimal treatment for synchronous liver metastasis (LM) from colorectal cancer (CRC) depends on various factors. The present study was intended to investigate the oncologic outcome according to the time of resection of metastatic lesions. Methods: Data from patients who underwent treatment with curative intent for primary CRC and synchronous LM between 2004 and 2009 from 9 university hospitals in Korea were collected retrospectively. One hundred forty-three patients underwent simultaneous resection for primary CRC and synchronous LM (simultaneous surgery group), and 65 patients were treated by 2-stage operation (staged surgery group). Results: The mean follow-up length was 41.2 ± 24.6 months. In the extent of resection for hepatic metastasis, major hepatectomy was more frequently performed in staged surgery group (33.8% vs. 8.4%, P < 0.001). The rate of severe complications of Clavien-Dindo classification grade III or more was not significantly different between the 2 groups. The 3-year overall survival (OS) rate was 85.0% in staged surgery group and 69.4% in simultaneous surgery group (P = 0.013), and the 3-year recurrence-free survival (RFS) rate was 46.4% in staged surgery group and 30.2% in simultaneous surgery group (P = 0.143). In subgroup analysis based on the location of primary CRC, the benefit of staged surgery for OS and RFS was clearly shown in rectal cancer (P = 0.021 and P = 0.015). Conclusion: Based on our results, staged surgery with or without neoadjuvant chemotherapy should be considered for resectable synchronous LM from CRC, especially in rectal cancer, as a safe and fairly promising option
Kim, Hyunkyung,Kim, Dongha,Choi, Seon Ah,Kim, Chang Rok,Oh, Se Kyu,Pyo, Ki Eun,Kim, Joomyung,Lee, Seung-Hoon,Yoon, Jong-Bok,Zhang, Yi,Baek, Sung Hee National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.46
<P><B>Significance</B></P><P>An aberrant covalent histone modification which drives dysregulation of transcriptional program is related to human diseases such as cancer. Thus, identifying signaling pathways modulating transcription factors and epigenetic enzymes are coming into view as attractive therapeutic targets. In this study, we provide evidence that KDM3A is tyrosine-phosphorylated by JAK2, and tyrosine-phosphorylated KDM3A acts as a coactivator for STAT3, thereby exerting increased cancer cell growth and motility. We propose that JAK2-dependent tyrosine phosphorylation of KDM3A could be a potential therapeutic target for epigenetic control of oncogenic effect governed by JAK2−STAT3 signaling pathway.</P><P>Janus tyrosine kinase 2 (JAK2)−signal transducer and activator of transcription 3 (STAT3) signaling pathway is essential for modulating cellular development, differentiation, and homeostasis. Thus, dysregulation of JAK2−STAT3 signaling pathway is frequently associated with human malignancies. Here, we provide evidence that lysine-specific demethylase 3A (KDM3A) functions as an essential epigenetic enzyme for the activation of JAK2−STAT3 signaling pathway. KDM3A is tyrosine-phosphorylated by JAK2 in the nucleus and functions as a STAT3-dependent transcriptional coactivator. JAK2−KDM3A signaling cascade induced by IL-6 leads to alteration of histone H3K9 methylation as a predominant epigenetic event, thereby providing the functional and mechanistic link between activation of JAK2−STAT3 signaling pathway and its epigenetic control. Together, our findings demonstrate that inhibition of KDM3A phosphorylation could be a potent therapeutic strategy to control oncogenic effect of JAK2−STAT3 signaling pathway.</P>
Jieun Lee,HyoJin Kim,Yong Uk Kye,Dong Yeon Lee,Wol Soon Jo,Chang Geun Lee,Jeung Kee Kim,Jeong-Hwa Baek,Yeong-Rok Kang Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7
The radioactivity concentration of environmental radionuclides was analyzed for soil and sand at eight locations within a radius of 255 m centered on the Dongnam Institute of Radiological & Medical Science (DIRAMS), Korea. The average activity concentrations of <sup>40</sup>K, <sup>137</sup>Cs, <sup>226</sup>Ra, and <sup>232</sup>Th were 661.1 Bq/kg-dry, 0.9 Bq/kg-dry, 21.9 Bq/kg-dry, and 11.1 Bq/kg-dry, respectively. The activity of <sup>40</sup>K and <sup>137</sup>Cs was lower than the 3-year (2017-2019) average reported by the Korea Institute of Nuclear Safety, respectively. Due to the nature of granite-rich soil, the radioactivity of <sup>40</sup>K was 0.6-fold higher than in other countries, while <sup>137</sup>Cs was in the normal fluctuation range (15-30 Bq/kg-dry) of the concentration of radioactive fallout from nuclear tests. The activity of <sup>226</sup>Ra and <sup>232</sup>Th was lower than in Korean soils reported by the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). The average activity concentrations of <sup>232</sup>Th and <sup>40</sup>K for the soil and sand samples from DIRAMS were within the range specified by UNSCEAR in 2000. The radium equivalent activity and internal and external hazard index values were below the recommended limits (1 mSv/y). These radionuclide concentration (<sup>226</sup>Ra, <sup>232</sup>Th, <sup>40</sup>K, and <sup>137</sup>Cs) data can be used for regional environmental monitoring and ecological impact assessments of nuclear power plant accidents.