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- 저자 : Yune-Jung Park (검색결과 55 건)
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기혼여성의 수입의류와 국산의류의 평가기준에 관한 비교 연구
박혜정,박제옥,이연희 漢陽大學校 韓國生活科學硏究所 2002 韓國 生活 科學 硏究 Vol.- No.20
The purpose of this study is to identify differences that might exist between married women's evaluative criteria for imported and domestic clothing and to test the role of socioeconomic variables on those differences. Socioeconomic variables include age, education, income, and spouse's occupation. Sample selection criteria included married women living in Seoul, Korea, between ages 30-59. A purposive sample was obtained to secure respondents with experience with imported apparel (formal two piece suit). Of 400 distributed, 246 usable questionnaires were returned. Statistical analysis of results included mean, standard deviation, and paired t-tests. Purchasers of both imported and domestic clothing considered appearance as the most important evaluative criterion and approval of others and their recommendation as the least important criteria. The country of origin was not an important criterion in purchasing imported clothing. For both imported and domestic clothing, purchasers considered extrinsic criteria to be more important than intrinsic criteria. Respondents indicated significant differences in their criteria for evaluating imported versus domestic clothing for some socioeconomic variables. The results suggest the appropriateness of different marketing strategies for imported clothing and domestic clothing.
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Proteomics in Rheumatoid Arthritis Research
Park, Yune-Jung,Chung, Min Kyung,Hwang, Daehee,Kim, Wan-Uk The Korean Association of Immunobiologists 2015 Immune Network Vol.15 No.4
Although rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease, diagnosis of RA is currently based on clinical manifestations, and there is no simple, practical assessment tool in the clinical field to assess disease activity and severity. Recently, there has been increasing interest in the discovery of new diagnostic RA biomarkers that can assist in evaluating disease activity, severity, and treatment response. Proteomics, the large-scale study of the proteome, has emerged as a powerful technique for protein identification and characterization. For the past 10 years, proteomic techniques have been applied to different biological samples (synovial tissue/fluid, blood, and urine) from RA patients and experimental animal models. In this review, we summarize the current state of the application of proteomics in RA and its importance in identifying biomarkers and treatment targets.
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Park, Yune-Jung,Yoo, Seung-Ah,Choi, Susanna,Yoo, Hee-Soo,Yoon, Ho-Sung,Cho, Chul-Soo,Yoo, Ki-Dong,Kim, Wan-Uk Journal of Rheumatology 2013 The Journal of rheumatology Vol.40 No.6
<P><B>Objective.</B></P><P>Dyslipidemia, a risk factor for cardiovascular diseases, is more prevalent in patients with rheumatoid arthritis (RA) than in the general population. We investigated whether single-nucleotide polymorphisms (SNP) modulating low-density lipoprotein (LDL) cholesterol affect susceptibility, severity, and progression of RA.</P><P><B>Methods.</B></P><P>We enrolled 302 patients with RA and 1636 healthy controls, and investigated the SNP modulating LDL cholesterol. Clinical characteristics of RA, serum adipocytokine concentrations, and radiographic severity were analyzed according to genotype score based on the number of unfavorable alleles. The influence of genotype score on radiographic progression was also investigated using multivariable logistic models.</P><P><B>Results.</B></P><P>We identified 3 SNP (rs688, rs693, and rs4420638) modulating LDL cholesterol in Koreans, which correlated well with LDL cholesterol levels in both patients with RA and controls. Among them, 2 SNP, rs688 and rs4420638, were more prevalent in patients with RA than in controls. In patients with RA carrying more unfavorable alleles (genotype score ≥ 3), disease activity measures, serum adipocytokine levels, and radiographic severity were all increased. The genotype score was an independent risk factor for radiographic progression of RA over 2 years, and its effect was greater than the influence of conventional risk factors.</P><P><B>Conclusion.</B></P><P>SNP modulating LDL cholesterol influence the risk, activity, and severity of RA. These results provide the first evidence that genetic mechanisms linked to dyslipidemia may directly contribute to the susceptibility and prognosis of RA, a representative of chronic inflammatory diseases, explaining the high incidence of dyslipidemia in RA.</P>
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( Yune Jung Park ),( Seong Hye Hwang ),( Seung Hyun Jung ),( Sa Seong Lee ),( Susan Na Choi ),( Seung Ah Yoo ),( Ji Hwan Park ),( Dae Hee Hwang ),( Seung Cheol Shim ),( Chul Soocho ),( Yeun Jun Chung 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Copy number variations (CNVs) have been implicated in human diseases. However, it remains unclear how they affect immune dysfunction and autoimmune diseases, including rheumatoid arthritis (RA). Methods: To de. ne CNVs, we used SNP genotyping data from the 500 discovery set. The Lsp1 plasmid DNA was tagged with GFP and was then transfected into Jurkat cells. Mice genetically de. cient in Lsp1 (Lsp1 ./. mice) were induced of delayed-type hypersensitivity and antigen-induced arthritis. Results: Here, we identi. ed a novel Lsp1 deletion variant for RA susceptibility. Differentially expressed genes in Lsp1-de. cient primary T cells represent cell motility and immune and cytokine responses. Functional assays demonstrated that LSP1, induced by T cell receptor activation, negatively regulates T cell migration by hampering ERK activation in vitro. In mice with T cell-dependent chronic in. ammation, loss of Lsp1 promotes migration of T cells into the target tissues as well as draining lymph nodes, exacerbating disease severity. Moreover, RA patients show diminished expression of LSP1 in peripheral T cells with increased migratory capacity. Conclusions: Our data highlights the importance of Lsp1 CNVs in the pathogenesis of immune diseases and provides novel insights into the mechanisms underlying T cell migration toward the in. amed synovium in RA.
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So Jung Yune,Ie Byung Park,Hyo Hyun Yoo,Kwi Hwa Park 한국의학교육학회 2024 Korean journal of medical education Vol.36 No.2
Purpose: The decision to enroll in medical school is largely influenced by extrinsic motivation factors. It is necessary to explore the factors that affect pre-med students’ motivation to enter medical school and their college adjustment, and to develop measures to help them adjust. Methods: A total of 407 pre-med students were surveyed regarding their motivation to enter medical school, fear of failure, and college adjustment. We analyzed the latent profiles of extrinsic motivation factors using latent profile analysis. One-way analysis of variance was conducted to examine the differences in fear of failure and adaptation to university life according to the latent groups. Results: After analyzing the latent profiles of entrance motivation, three latent profiles were selected. They were divided into high, medium, and low extrinsic motivation groups. Three profiles scored the highest on job security, followed by good grades and social status. Sophomores were more likely to be high extrinsic motivators than freshmen were. Fear of failure was high in the group with high extrinsic motivation, and adaptation to college life was highest in the group with low extrinsic motivation. Conclusion: Job security was the most important extrinsic motivator for entering medical school, and extrinsic entrance motivation influenced fear of failure and college adjustment. Given the high level of extrinsic motivation among medical students, it is meaningful to analyze the extrinsic motivation profile of entering medical students and how it affects failure motivation and college adjustment.
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( Seung Min Jung ),( Yune-jung Park ),( Kyung-su Park ),( Ki-jo Kim ) 대한류마티스학회 2022 대한류마티스학회지 Vol.29 No.3
Objective: The shared epitope (SE) and anti-citrullinated peptide antibody (ACPA) are involved in the pathogenesis of rheumatoid arthritis (RA). This study evaluated the clinical implications of SE and ACPA in terms of disease manifestation and response to biologic disease modifying anti-rheumatic drugs (DMARDs). Methods: Patients with identified human leukocyte antigen (HLA)-DRB1 alleles were included to compare the clinical characteristics and drug survival rate of tumor necrosis factor (TNF) inhibitors or abatacept based on the presence of SE and ACPA. Results: Of the 533 patients with identified HLA-DRB1 alleles, 329 patients (61.7%) with SE alleles showed higher disease activity and erosive changes compared to patients without SE alleles. SE-positive patients were more likely to start biologic (b-) or targeted synthetic DMARDs (tsDMARDs) within the first 5 years (p=0.020). The presence of SE, smoking, dyslipidemia, and higher erythrocyte sedimentation rate were independently associated with the initiation of b- or tsDMARDs (p=0.016, 0.028, 0.031, and 0.001, respectively). The presence of SE and ACPA did not affect the drug survival rate of TNF inhibitors, whereas the abatacept retention rate was higher in ACPA-positive patients (p=0.024). Conclusion: The presence of SE affected disease characteristics and prognosis in Korean patients with RA without a significant impact on drug survival rate of TNF inhibitors and abatacept. ACPA positivity was associated with abatacept drug retention, suggesting that abatacept may be helpful in ACPA-positive patients than in ACPA-negative patients.
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Magnetic Domain-wall Tilting Mechanism during the Transition of Domain-wall Chiralilty
Jung-Hyun Park,Dae-Yun Kim,Yune-Seok Nam,Hyun-Seok Whang,Sug-Bong Choe 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2
Spin structure inside domain wall (DW) has attracted great attention due to its potential application on data storage or logic memory. Among terms affecting chirality of DW, Dzyaloshinskii-Moriya interaction (DMI) has been investigated in magnetic thin layer with perpendicular magnetization anisotropy. Based on such platform, most of experimental schemes have measured the chirality change under application of external in-plane field. By changing in-plane field, the direction of magnetization inside DW is changed, resulting in modification of chirality, DW energy, DW dynamics, etc. But those schemes have an assumption that DW is straightly placed across wire and only one variable, direction of the magnetization inside DW, is changed. Here, we propose generalized equation of equilibrium chirality with not only the degree of freedom of DW chirality (Ψ), but also the DW tilting angle (θ). With coordinate system in fig. 1, we numerically calculated equilibrium angle of Ψ and θ, giving a result of DW tilting in the transition regime of DW chirality (fig. 2). This result is counterintuitive in a sense that DW would not be tilted in transition regime as its energy is maximum at Ψ=0. Tilting angle of DW is maximum when in-plane field is applied as much as effective DMI field. Interestingly, the transition regime is widened as both Ψ and θ contribute to reduction of DW energy when in-plane field is changed. Additionally, we analytically calculated the critical field at which the DW starts and ends tilting. This study provides more realistic understanding of chirality and tilting mechanism by considering both contribution to DW energy. 〈그림 본문참조〉
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