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김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.
다이아몬드 와이어에 의해 절단된 다결정 실리콘 태양전지의 나노텍스쳐링 및 후속 식각 연구
김명현(Myeong-Hyun Kim),송재원(Jae-Won Song),남윤호(Yoon-Ho Nam),김동형(Dong-Hyung Kim),유시영(Si-Young Yu),문환균(Hwan-Gyun Moon),유봉영(Bong-Young Yoo),이정호(Jung-Ho Lee) 한국표면공학회 2016 한국표면공학회지 Vol.49 No.3
The effects of nanotexturing and post-etching on the reflection and quantum efficiency properties of diamond wire sawn (DWS) multicrystalline silicon (mc-Si) solar cell have been investigated. The chemical solutions, which are acidic etching solution (HF-HNO₃), metal assisted chemical etching (MAC etch) solutions (AgNO₃-HF-DI, HF-H₂O₂-DI) and post-etching solution (diluted KOH at 80℃), were used for micro- and nano-texturing at the surface of diamond wire sawn (DWS) mc-Si wafer. Experiments were performed with various post-etching time conditions in order to determine the optimized etching condition for solar cell. The reflectance of mc-Si wafer texturing with acidic etching solution showed a very high reflectance value of about 30% (w/o anti-reflection coating), which indicates the insufficient light absorption for solar cell. The formation of nano-texture on the surface of mc-Si contributed to the enhancement of light absorption. Also, post-etching time condition of 240 s was found adequate to the nano-texturing of mc-Si due to its high external quantum efficiency of about 30% at short wavelengths and high short circuit current density (Jsc) of 35.4 A/cm².
Yu, Min-Ah,Jeong, Hye Won,Park, Su-Jin,Kim, Young-Il,Kwon, Hyeok-Il,Kim, Eun-Ha,Si, Young-Jae,Yu, Kwang Min,Robles, Norbert John,Han, Hae Jung,Choi, Young Ki 대한백신학회 2018 Clinical and Experimental Vaccine Research Vol.6 No.1
<P>To develop the large scale serological assay for severe fever with thrombocytopenia syndrome virus (SFTSV) infection, we evaluated two different enzyme-linked immunosorbent assay (ELISA) methods using nucleocapsid protein (NP) and Gn proteins of CB1 (genotype B) SFTSV strains. The NP-based ELISA tests showed more sensitive with broad cross-reactivity between two different genotype A and B strains compared with those of Gn-based ELISA tests. However, Gn-based ELISA showed more genotype specificity and specificity. These result suggested that NP-based ELISA test could be applicable for general sero-prevalence studies of SFTSV infections, while Gn-based ELISA could be applicable for a certain specific genotype sero-prevalence study.</P>
( Young Youn Cho ),( Su Jong Yu ),( Hye Won Lee ),( Do Young Kim ),( Wonseok Kang ),( Yong-han Paik ),( Pil Soo Sung ),( Si Hyun Bae ),( Su Cheol Park ),( Young Seok Doh ),( Kang Mo Kim ),( Eun Sun Ja 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Sorafenib is the standard systemic therapy for treatment of advanced stage hepatocellular carcinoma (HCC), and progressive HCC after locoregional therapy. The efficacy and safety of the drug in clinical practice have been addressed by several real world studies. However, little data are available regarding clinical factors of good responders following sorafenib treatment. This study aimed to evaluate prognostic factors of long term survivors. Methods: This multi-center retrospective cohort study included 1,605 unresectable HCC patients who received sorafenib treatment between 2007 and 2014 in 9 tertiary centers in Korea. The patients were classified into long-term survivor group (survival longer than 2 years, n=246) or control group (n=1,359). The primary endpoint was prognostic factors on survival for overall patients. Secondary endpoints included time-to-progression and other safety profiles. Results: The patients were predominantly male (83.8%), chronic hepatitis B (77.3%), and Barcelona Clinic of Liver Cancer stage C (78.3%). The median overall survival was 9.0 months. After treatment, 12 patients (0.7%) achieved complete response, and 146 patients (9.1%) achieved partial response by mRECIST criteria. The prognostic factors predicting long-term survival were metformin use (hazard ratio [HR]=2.44; P=0.004), hand foot skin reaction (HR=1.77; P=0.001), and concomittent treatment with chemoembolization or radiotherapy (HR =2.59; P<0.001). Prognostic factors against long-term survival were child pugh score B (HR=0.375; P< 0.001), presence of extrahepatic metastasis (HR=0.625; P=0.002), main portal vein invasion (HR=0.625; P=0.002), and elevated AFP ( >1,000 ng/mL; HR=0.393; P<0.001). Conclusions: This large multi-center retrospective study showed that the objective response was 9.8%, and the proportion of long-term survivors was 15.3% in Korean patients. The prognostic factors predicting long-term survival after sorafenib treatment were hand foot skin reaction, metformin use, concomittent treatment, good liver function, absence of extrahepatic metastasis, low degree of portal vein thrombosis, and low AFP.
( Yu Young Joo ),( Jeong Won Jang ),( Sung Won Lee ),( Seawon Hwang ),( Pil Soo Sung ),( Sun Hong Yoo ),( Jung Hyun Kwon ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatocellular carcinoma (HCC) is typically a hypervascular tumor wherein angiogenesis plays a pivotal role in its progression. To date, no study carried out simultaneous determination of multiple pro- and anti-angiogenic factors during the multi-stage progression of liver diseases to HCC. This study aimed to investigate the dynamic balance between pro- and anti-angiogenic factors and angiogenic switch in a multi-step carcinogenesis and HCC progression. Methods: Serum levels of major pro-angiogenic [Vascular Endothelial Growth Factor (VEGF), Basic fibroblast growth factor (b-FGF)] and anti-angiogenic [Thrombospondin 1 (TSP-1), Endostatin] factors were determined by enzyme-linked immunosorbent assay and correlated with clinical features of various liver diseases and with outcome of HCC patients undergoing transarterial chemo-embolization. A total of 240 patients (160 HCC, 36 cirrhosis, and 44 chronic hepatitis) were enrolled in this study. Results: All pro- and anti-angiogenic factors displayed a trend towards increased levels from hepatitis, cirrhosis to HCC, with the most significant increase in b-FGF and endostatin levels (all P<0.05). Particularly, b-FGF yielded the highest AUROC value (0.863) for a diagnosis of HCC and its distinction from other disease groups. A trend towards increasing VEGF levels was observed from Child-Pugh class A, B to C (P=0.023). VEGF and TSP-1 levels increased with the advance of cancer stage, with a remarkable increase in TSP-1 at an intermediate stage. Low pretreatment serum levels of VEGF and endostatin were significantly associated with objective tumor response, while the corresponding level of TSP-1 predicted early progressive disease (all P<0.05). Pretreatment levels of VEGF and endostatin independently predicted the overall survival of patients (all P<0.05). Conclusions: Our study demonstrated the dynamic angiogenic switch and respective roles that individual pro- and anti-angiogenic factors contribute to carcinogenesis and HCC progression during the course of multi-step liver diseases. These imply the future possibility of testing pro- and anti-angiogenic panels as a diagnostic marker and a guide in decision-making regarding upcoming targeted therapies and outcome.
Si Young Lee,Sang Mi Chu,Si Myung Lee,Hyo Jin Kim,Hyun Suk Cho,Chang Yeon Yu,Jae Kwang Kim 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.2
A simple and sensitive method for determining indole-3-carbinol (I3C) and indole-3-acetonitrile (I3A) from Brassica vegetable was developed using high-performance liquid chromatography with fluorescence detection. The indolic glucosinolate as well as I3C a
Scalable Complementary Logic Gates with Chemically Doped Semiconducting Carbon Nanotube Transistors
Lee, Si Young,Lee, Sang Won,Kim, Soo Min,Yu, Woo Jong,Jo, Young Woo,Lee, Young Hee American Chemical Society 2011 ACS NANO Vol.5 No.3
<P>Use of random network carbon nanotube (CNT) transistors and their applications to complementary logic gates have been limited by several factors such as control of CNT density, existence of metallic CNTs producing a poor yield of devices, absence of stable n-dopant and control of precise position of the dopant, and absence of a scalable and cost-effective fabrication process. Here, we report a scalable and cost-effective fabrication of complementary logic gates by precisely positioning an air-stable n-type dopant, viologen, by inkjet printing on a separated semiconducting CNTs network. The obtained CNT transistors showed a high yield of nearly 100% with an on/off ratio of greater than 10<SUP>3</SUP> in an optimized channel length (∼9 μm). The n-doped semiconducting carbon nanotube transistors showed a nearly symmetric behavior in the on/off current and threshold voltage with p-type transistors. CMOS inverter, NAND, and NOR logic gates were integrated on a HfO<SUB>2</SUB>/Si substrate using the n/p transistor arrays. The gain of inverter is extraordinarily high, which is around 45, and NAND and NOR logic gates revealed excellent output on and off voltages. These series of whole processes were conducted under ambient conditions, which can be used for large-area and flexible thin film technology.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2011/ancac3.2011.5.issue-3/nn200270e/production/images/medium/nn-2011-00270e_0005.gif'></P>