출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

유·무선 통합의 진화전망과 규제정책

장석윤(Suk-Yoon Chang) 한국인터넷법학회 2004 인터넷법연구 Vol.3 No.1

Fixed mobile convergence(FMC) services have launched starting from the european countries since early 1990s, and have been expanding around the world. FMC services beginning with UMS in Korea have been introduced since June 2002. FMC services are expected to be in full swing in the near future due to the rapid development of digital Information-Communication technologies lately. FMC is also expected to bring the changes in attributes of telecommunications services, value-chain of telecommunications business and business model, furthermore to be linked up with telecommunications industry's overall structural change and regulatory policy change. In this context, we first reviewed the outline of FMC and then looked over the evolution of FMC service, terminal device, and network. Finally we discussed on the future regulatory policy in the era of FMC evolution.

선천성 후비공 폐쇄증 : 7예의 분석

김창훈,이정권,최윤석,유신영,윤주헌 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.3

위선암종에서 Epstein-Barr Virus (EBV) 감염에 대한 연구

윤석중,이문수,김창진 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The gastric carcinoma is the most common malignant tumor in Koreans. The pathogenetic mechani는 are not clearly elucidated yet. There are several lines of evidence that Epstein-Barr viral latent infection has some relationship with certain type of gastric carcinoma. The epstein-Barr virus is ubiquitous and there is a report that 80%-90% of normal adults in Korea is seropositive for Epstein-Barr virus. This study is conducted to see the relationship between Epstein-Barr viral latent infection and gastric carcinoma with 60 cases of gastric carcinoma by plymerase chain reaction(PCR), EBER-1 in situhybridization and immunoshitochemistry for LMP-1. The results were as follows: 1. Epstein-Barr viral latent infection was detected in 3(5%) of 60 gastric carcinomas. and all of the were male. 2. The carcinomas with viral laten infection were at the body of the stomach. 3. Carcinomas with viral latent infection, 2 were diffuse type and 1 was mixed type. 4. Carcinomas with viral latent infection wre poorly differentiated adenocarcinomas and they showed extensive lymphocytic infilitration around the tumor cell nests. Above results showed tha tEpstein-Barr wival latent infection have some relationship with a subset of gastric carcinomas. Considering that the gastric carcinoma is the most common malignant tumor in Korea, and over 80% of normal adult is seropositive for Epstein-Barr virus, further studies on Epstein-Barr viral latent infecton in gastrci carcinoma should be carried out.

비평형제2상의 용체화거동에 미치는 응고조직의 영향

윤의박,안갑우,서창제,허태수 대한금속재료학회(대한금속학회) 1980 대한금속·재료학회지 Vol.18 No.5

偏析型 2元系合金의 溶體化末期에 있어서 非平衡第2相의 固溶擧動에 대해서는 아직까지 理論的으로 정립되어 있지 않았다. 本 論文에서는 主로 dendrite element의 境界에 晶出된 非平衡第2相의 유효擴散距離로써 1次arm 間隔을 考慮한 擴散 model인 尹의 近似解에 의해 이들 擧動을 調査하였다. 이를 위해 天然가스등의 輸送材料로 囑望되는 高濃度 Al-8%Mg合金을 사용하였다. 實驗結果, 理論的인 尹의 近似解의 實驗値는 近似的으로 一致되었고, 특히 溶體化末期에서는 完全히 一致됨을 알 수 있다. 結局 從來의 Flemings의 解析値보다 더욱 實驗値에 近似하였다. The solution kinetics of nonequilibrium second phase of a segregated binary alloy in the later stages of solution treatment have not yet been made theoretically clear. This paper attempted mainly to investigate this behaviour by Yoon's approximate analysis given by a simple model based upon primary arm spacing as an effective diffusion distance of the second phase which has crystallized at the boundary of dendrite element. For this purpose, we used the high magnesium Al-8% Mg alloy which is expected to be used for transport of liguified natural gas. The theoretically calculated results are in the approximate agreement with that of experiments for complete dissolution time and solution kinetics (expecially at the later stages) of β-phase. The Yoon's approximate analysis was in better agreement with the present experimental results than the Flemings conventional analysis

Microfluidic capacitive sensors with ionic liquid electrodes and CNT/PDMS nanocomposites for simultaneous sensing of pressure and temperature

Yoon, Sun Geun,Chang, Suk Tai The Royal Society of Chemistry 2017 Journal of Materials Chemistry C Vol.5 No.8

<P>We report a new class of simple fluidic capacitive sensors based on microfluidic techniques, which are capable of multimodal sensing performances. The microfluidic multifunctional capacitive sensors were realized by using ionic liquids acting as electrodes in microchannels and a CNT/PDMS composite as a dielectric layer. Our microfluidic capacitive sensors offer outstanding sensor performance to detect localized pressure and even lateral pressure variation as well as ambient temperature changes. The principle of our new microfluidic capacitive sensors is explained by the electric double layer capacitance and the ion distribution along the ionic liquid electrodes. In order to demonstrate their capability for practical usage, our simple structured microfluidic capacitive sensors were applied to a bottle and human skin for monitoring the variation of pressure and temperature simultaneously. The highly sensitive microfluidic capacitive sensors were successfully applied as keypads and potential platforms for distinctively detecting various hand or finger motions such as tapping, scratching, and stacking. Our novel microfluidic multimodal capacitive sensors show great promise for making future stretchable electronic devices, such as wearable electronics, soft robotics, and artificial skin.</P>

비감속 252Cf중성자선원에 대한 비등방성교정인자 및 선량당량환산인자

장시영,정덕연,윤석철,김종수 대한방사선 방어학회 1993 방사선방어학회지 Vol.18 No.2

중성자 측정장비 교정을 위한 표준중성자장을 제작하기 위하여 순수멕스월분포(kt=1.42MeV)로부터 ??Cf 자발핵분열 중성자선원의 밀봉이 교정인자에 미치는 영향을 고찰하였다. SR-Cf-100과 SR-Cf-1273 밀봉모형을 실제 제작조건으로 하여 MCNP 코드를 사용하여 몬테카를로 모의를 수행하여, 비등방성교정인자와 선속밀도-대-선량당량 환산인자를 산정하였고, 다른 연구결과와 비교하였다. 결과로서, Fi(θ=90˚)는 1.061(통계오차 : ±0.2%), H/??는 333.9[pSv·㎠] (통계오차 : ±0.5%)인 것으로 산정되었다. 이 환산인자(H/??)의 값은 ISO 8529의 권고보다 1.8%가 작은 것인데, 이것은 한국원자력연구소의 비감속 ??Cf중성자선원의 스펙트럼이 ISO의 것보다 약간 더 연화하다는 물리적 의미를 갖는다. Form the pure Maxwellian distribution(kT= 1.42MeV), the effects upon calibration factors of encapsulating a Cf spontaneous fission neutron source were invdwtigated to establish a standark neutron field in the Secondary Standark Kosimetry laboratory at Korea Atomic Inergy Research Institute(KAERI). A Monte Carlo code MCNP was used in simulating the encapsulation SR-Cf-100 and SR-Cf-1273 to be real conditions. The anisotropy(FI) and fluence-to-dose equivalents conversion factors(H/Φ) were evaluated and compared with other results. As the results, the FI was determined to be 1.061 atθ=90˚ with ±0.2% statistical error and the (H/Φ) was evaluated to be 333.9 [pSv·㎠] with ±0.5% statistical error, which is lower by 1.8% than that recommended by the ISO 8529. This means physically that the neutron spectrum of the unmoderated Cf source in KAERI is a little more softened than that by the ISO.

실업계 고교와 전문대학간 컴퓨터 교과 관련 연계교육의 운영실태 및 개선방안에 관한 교원들의 인식 연구

윤여춘,김창석 한국컴퓨터교육학회 2002 컴퓨터교육학회 논문지 Vol.5 No.4

컴퓨터 산업과 IT산업의 눈부신 발전으로 컴퓨터 관련 교육은 숙련된 인력을 양성하기 위하여 교육의 체제와 방법의 변화가 절실히 필요하게 되었다. 직업교육 훈련 촉진법 및 고등교육법 시행령의 법적 지원과 '신교육 체제의 수립을 위한 교육 개혁 방안(Ⅱ)' 발표로 실업계 고등학교와 전문대학간 교과 과정을 상호 연계하여 운영되고 있다. 그러나 실업계 고등학교와 전문대학간 컴퓨터 교과 관련 연계교육을 성공적으로 운영되기 위한 연구는 미흡한 실정이다. 이에 본 연구는 실업계 고교와 전문대학간 컴퓨터 교과와 관련하여 조사 연구결과 연계교육의 개선방안을 제안한다. With the rapid development of computer and IT industry, the education related to computer come to need computer need sincerely the system of an education and transform of a method in order to rear experienced people. With the publication of legal support of professional educational training promotional rule and high educational enforcement's rule and 'Educational reformation plan for establishing a new educational enforcement's rule and 'Educational reformation plan for establishing a new educational system (Ⅱ)', associated actions between a vocational high schools and technical colleges are being conducted together. But there have rarely been researches which operates successfully the computer curriculum between vocational high school and technical colleges. Accordingly the purpose of this research is proposed to improve the associated actions of the two schools.

위암 주위 점막에서 장화생과 Carcinoembryonic Antigen (CEA) 표출과의 관계에 대한 연구

윤석중,강상균,김창진 순천향대학교 1994 논문집 Vol.17 No.4

Stomach carcinoma is the most common tumor in Korea and it's pathogenic mechanisms have not been elucidated. Through vast histologic studies on the mucosa adjacent to the carcinoma, intestinal metaplasia was known as one of the possible candidates for the precancerous lesion of gastric carcinoma. Moreover, further close relationship between intestinal metaplasia and gastric carcinoma was brought out by several lines of study showing that alpha-fetoprotein and carcinoembryonic antigen, which are oncofetal protein expressed frequently in malignant tumor or transforming growth factor alpha, which is mitogenic oncoprotein, are expressed in metaplastic mucosa. To investigate the close relationship between intestinal metaplasia(IM) and gastric carcinoma, immunohistochemical expression of carcinoembryonic antigen was studied on the mucosa adjacent to gastric carcinoma(n=90), to peptic ulcer(n=20) and on normal mucosa resected for duodenal ulcer(n=20). The results were as follows; 1. Among 90 gastric carcinomas, type Ⅰ, type Ⅱ and type Ⅲ intestinal metaplasia were 11(24%), 25(28%) and 32(36%) respectively. 2. CEA was expressed in 45% of type Ⅰ metaplasia, 84% of type Ⅱ metaplasia and 91% of type Ⅲ metaplasia. 3. Among 20 cases of peptic ulcer, 15 cases(75%) showed type Ⅰ metaplasia, while type Ⅱ and type Ⅲ metaplasia were 2 cases(10%) each. 4. CEA was expressed in 80% of type Ⅰ metaplasia, and all 2 cases of type Ⅱ a nd typeⅢ metaplasia showed CEA positivity. 5. Among 20 cases of normal gastric mucosa resected due to duodenal ulcer, type Ⅰ, Ⅱ and Ⅲ metaplasia were found in 13 cases(65%), 3 cases(15%) and 2 cases(10%) respectively. 6. CEA was expressed in 9(69%) among 13 cases of type Ⅰ metaplasia, in 2(67%) among 3 cases of type Ⅱ metaplasia and in all 2(100%) cases of type Ⅲ metaplasia. Above results suggest that the mucosa adjacent to gastric carcinoma show frequent sulphomucin secreting incomplete intestinal metaplasia and most of the metaplastic lesion express CEA, which imply close relationship between sulphomucin secreting intestinal metaplasia and gastric carcinogenesis. However, the metaplasia occurred in the mucosa adjacent to peptic ulcer or in normal mucosa resected dor duodenal ulcer showed CEA positivity as well, though the number of cases is not enough. Therefore, further studies on the relationship between sulphomucin secreting intestinal metaplasia and gastric carcinoma should be done to elucidate the pathogenesis of gastric carci

Asphalt로 피복된 Portland Cement를 使用한 Concrete의 諸性質

尹錫天,李昌甲,洪元杓,鄭秀永,南宰鉉 충남대학교 공업교육연구소 1982 論文集 Vol.5 No.1

The construction works with concrete has the potential problems of water tightness. The conventional treatments for water-tight concrete are not satisfactory in terms of strength and water tightness. This study was to investigate the effects and application of the asphalt-coated portland cement on water-proof of the concrete and its influences on the physical properties of the concrete. The asphalt-coated portland cement, which is hereafter referred to as ACPC, was made by coating ordinary portland cement with asphalt in the rate of weight ranging from 0.5 to 1.0 percent. In this process, Calcium Chloride and Sodium Silicate were tried as the hardening time accelerator for producing ACPC, and carbon black, talc and other materials were tested for their effectiveness as pore filler. The specimens were prepared and tested with the various amounts of additives as a variable factor to find the optimum material. The analysis was mainly focused at water tightness, physical properties of the concrete and working conditions. The major findings of this experiment are as follows ; 1) Water-proof Test ① The specimens of ACPC and ordinary portland cement(OPC) were tested under the pressures of 3 and 9 kilograms per square centimeter per 24hours respectively and compared. The OPC specimens showed considerable amount of leakaged water while the ACPC specimens were rated lower permeabilities of 89%/28days, 40%/56days and21%/84days under the abovementioned pressure conditions. The most successful composition for water-proof was identified as ACPC added with Calcium Chloride and carbon black. ② The ACPC demonstrated its superiority in absorption test. The absorption amount of OPC for l hour was greater than that of ACPC for 24hours. 2) Compressive Strength Test Four kinds of specimens of ACPC aging 7, 28, 56 and 84days were tested and compared for their respective results of OPC. The ACPC added with carbon black was lower than OPC in compressive strength in the case of curing ages of 7 and 28days but ACPC was superior to the OPC in the specimens aging 56 and 84days. The ACPC added with others except carbon black exposed their lower compressive strength in all circumstances compared with the OPC specimens. 3) Slump Test The slump of ACPC with various additives such as carbon black, talc or clay was 21.6 centimeter which was higher than the OPC of 18.4centimeter slump. This result concluded that ACPC was much favorable in workability in comparison with that of the OPC. The conclusions are summarized as follows; 1) The optimum mixture for water tightness and compressive strength of concrete was found at 0.5% of SACPC, Calcium Chloride and carbon black respectively at the rate of the weight of cement.