타가메트정 400㎎에 대한 신일시메티딘정 400㎎의 생물학적동등성시험

윤미경,이병무,이성재,김선규,이재휘,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

Cimetidine is a histamine H₂-receptor antagonist, used for the treatment of endoscopically or radiographically comfirmed duodenal ulcer. pathologic GI hypersecretory conditions. and active, benign and gastric ulcer. Simple method for determining cimetidine in human plasma has been developed and validated. The analytical procedure for cimetidine showed a linear relationship in the concentration ranges from 0.05 to 5 pg/ml. Coefficient of variance (CV, ° o) for intraday and interdav validation and relative error (RE. ° o) were less than ±150 o. Based on this analytical method. the bioequivalence of two cimetidine 400 mg tablets, reference (Tagamet 400 mg) and test drug (Sinil CIMETIDINE 400 mg) was evaluated according to the guidelines set by the Korea Food and Drug Administration (KFDA). Release of cimetidine from the tablets in vitro was tested using KP VIII Apparatus II with various dissolution media (pH 1.2. 4.0. 6.8 butter solutions and water). Twenty-four healthy volunteers. 21.38±1.86 years in age and 68.71±8.68 kg in bode weight, were divided into two groups and a randomized 2x2 cross-over study was performed. After oral administration of a tablet containing 400 mg of cimetidine. blood samples were taken at predetermined time intervals and concentrations of cimetidine in plasma were determined using HPLC equipped with UV detector. The dissolution profiles of the two tablet formulations were very similar at all dissolution media. In addition. pharmacokinetic parameters such as AUC, and C_(max) were calculated and ANOVA was employed for the statistical analysis of parameters. The results were revealed that the diterences in AUCf and Cma, between the two tablets were 4.17% and 0.97% respectively. At 90% confidence intervals. the differences in these parameters were also within ± 20° o. All of the above mentioned parameters have met the criteria of KFDA guidelines for bioequivalence, indicating that the test drug tablet (Sinil CIMETIDINE tablet) is bioequivalent to Tagamet 400 mg tablet.

학부모기로의 전환에 관한 연구

윤기영,이미경,박민자 서원대학교 교육연구소 2003 敎育發展 Vol.22 No.1

Parents experience a qualitative change in terms of relationship with their hildren when they start to attend the first educational institute. Parents' role as a 'Hakbumo', whose children are attending school, could be quite different from parents' general role at home. Therefore, it might be needed to investigate the 'Hakbumohood' transition process for appropriate parents development and home-institute relationship After the investigation of literature, in-depth interview and discussion was conducted with 7 early childhood education center 'hakbumo', 2 kindergarten teachers, 1 professor. The result of this study, 1) Most parents take they become a 'Hakbumo' as a matter of course. 2) They feel anxiety about their children's adaptation to new circumstances. 3) They feel variety feelings during the 'Hakbumohood' transition. 4) Their feelings and concern are different between pre attending institute and post attending 5) They were influenced wholeness environment So, it might be concluded that developing a individualized guidance and support program for each new ‘Hakbumo’

유치원 특별활동 프로그램 운영분석

윤기영,권미경 서원대학교 교육대학원 2004 교육논총 Vol.9 No.-

The 'Extra Curricular Activities' in kindergarten has been developed rapidly in korea with the recognition of the importance of earlychildhood education. The purposes of this study were to analyze how an extra curricular activities of public kindergarten is operated and to search an concept about 'Extra Curricular Activities' in the kindergarten. And to recommend ideas in order to improvement way of it's problems. As result, The concept or character of 'Extra Curricular Activities' in kindergarten is different from other school's 'Extra Curricular Activities' Because, there is no 'subject' in kindergarten curriculum. and, it also had many problems, for example, curriculum, lecturer, shortage of facility and material, offical business costs, etc for kinderarten 'Extra Curricular Activities'. In conclusion, the 'Extra Curricular Activities' in kindergarten is an important and useful part on developing abilities of young children. There fore to improve the 'Extra Curricular Activities' in kindergarten and more positive supports for developing 'Extra Curricular Activities' curriculum are required.

12주간의 유산소성 운동이 비만 초등학생의 신체조성과 혈액성분에 미치는 영향

윤미수,최건식,고성경,정소봉 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

[Purpose] The purpose of this study was to investigate the effect of aerobic exercise training on the body composition and blood components in obese elementary children after 12 weeks. [Methods] Subjects of this study were composed of 20 male students ranging in age from 9 to 12 years who were classified into two groups, obese exercise group(n=10) and normal control group(n=10). For 12 weeks, obese exercise group performed the aerobic exercise training that the program was composed by Yoon. The blood samples were taken before and after 12 week Paired t-Test was adopted to analyse the difference between before and after aerobic exercise training. [Results] body fat of obese exercise group was decreased 4.8% after aerobic exercise training(p<.01) and that of normal control group was decreased 0.1% during same time(NS). Among the blood lipoprotein, total cholesterol(p<.01), LCL-C(p<.01), and triglycerides(p<.05) of obese exercise group were decreased after aerobic exercise training, but not changed HDL-C of same group. Red blood cell, Hemoglobin(p<.65) of obese exercise group were increased after aerobic exercise training. Glucose of obese exercise group were decreased after aerobic exercise training(p<.05), but not changed in Ca and P. [Conclusion] In conclusion, aerobic exercise training for 12 weeks seems to reduce body might and body fat, and to change the profiles of blood Component in obese elementary children.

광양만 묘도해역의 魚類 군집의 종조성 및 양적변동

한경호,윤연미,양한춘 여수대학교 1998 論文集 Vol.13 No.2

전라남도 광양만 묘도 주변의 연안어장에서 1997년 2월부터 12월까지 6회에 걸쳐 소형 저인망을 이용하여 어획물을 채집하여 魚類 군집의 종조성 및 양적변동을 조사하였다. 채집된 어류는 총 8目 38科 56屬 66種 21,541개체, 175,330g 으로 농어目(Perciformes), 쏨뱅이目(Scorpaeniformes) 및 가자미목(Pleuronectiformes) 어류가 총 50種으로 전체 출현종수의 75.8%를 차지하였으며, 科別로는 망둑어科() 어류가 8種 出現하여 가장 많았다. 총 66種의 어류중 개체수는 주둥치(Leiognathus ruchalis), 전어(Konosirus punctatus), 멸치(Engraulis japonicus), 준치(Ilisha elongata), 실양태(Repomucenus valencinnei), 보구치(Argyrosomus argentatus), 및 청멸(Thryssa kammalensis)의 7種이 전 개체수의 95.4%를 차지하여 우점종으로 나타났다. 生體量은주둥치, 전어, 꼼치(Liparis tanakai), 숭어(Mugil cephalus), 준치, 보구치, 문절망둑(Acanthogobius flavimanus), 멸치, 쥐노래미(Hexagrammos otakii) 및 실양태의 順으로 이들 10種이 全生體量의 86.1%를 차지하여 우점하였다. 출현 개체수와 생체량은 고수온기인 봄과 여름에 높게 나타났으며, 저수온기의 가을과 겨울에 낮게 나타나 수온과 밀접한 관계가 있었다. 월별 출현종수는 수온이 낮은 2월과 높은 8월에 각 19種과 20種이 出現하여 적었고, 수온이 상승하기 시작한 4월에 37種으로 가장 많았다. 종다양도지수는 0.460∼1.833으로 2월에 가장 높았으며, 6월에 낮았다. 주요 魚種의 出現頻度는 주둥치, 전어, 준치 및 실양태가 年中 出現하여 본 해역에 우점하는 주거종으로 나타났다. To determine seasonal fluctuations in abundance and species composition, fish samples were collected by a bottom trawl from February to December 1997 off Myo-do in Kwangyang Bay. A total of 21,541 fishes were sampled and indentified into 66 species, 38 families and 8 orders. Of the eight orders, Perciformes, Scorpaniformes and Pleuronectiformes accounted for approximately 75.8% of the fish fauna in this area. Gobiidae was dominant representing 8 species. Of 66 species identified, Leiognathus nuchalis, Konosirus punctatus, Engraulis japonicus, Ilisha elongata, Repomucenus valenciennei, Argyrosomus argentatus and Thryssa kammalensis accounted for 95.4% of the individuals collected. Leiognathus nuchalis, Konosirus punctatus, Liparis tanakai, Mugil cephalus, Ilisha elongata, Argyrosomus argentus, Acanthogobius flavimanus, Engraulis japonicus, Hexagramus otakii and Repomucenus valenciennei constituted 88.1% of the total biomass. Fish fauna in both number and biomass were higher in spring and summer, than other in autumn and winter. A peak abundance of total fishes occurred in April: the following abundance July: the lowest abundance in February. The number of species showed some significant seasonal variations however, a larger number of individuals and greater biomass was observed from July to August than October to the next February.

SPME와 GC/MS를 이용한 녹나무 향기성분 특성분석

원미미,차은주,윤옥경,김남선,김건,이동선 서울여자대학교 자연과학연구소 2007 자연과학연구논문집 Vol.19 No.-

Recently, land managers have come to realize that, outside Asia, camphor trees grow like street-tree or weeds, infesting forests and displacing native trees. This is because camphor trees are prolific seed producers that do not have serious predators or diseases outside their native range. The camphor tree (Cinnamomum camphora), belongs to lauraceae, is the aromatic evergreen tree from which camphor was derived. Headspace solid-phase microextraction (HS-SPME) and GC-MS were applied for the analysis of volatile fragrances emanated from camphor tree. Divinylbenzene / Carboxen / PDMS fiber was used for HS-SPME adsorption materials. (+)-Camphor (31.00%) and cineol (21.89%) were found as the major volatile aroma components from Chinese camphor tree, whereas (+)-camphor (62.06%) and β-caryophyllene (10.01%) from Japanese camphor tree. Camphor tree is a promising garden tree for well-being.

일개 대학병원 간호사들의 근무형태에 따른 건강행태

권미경,강복수,황태윤,이경수 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.1

일부 지역 농촌 노인의 철분 영양상태에 관한 연구

신소영,최미경,이윤신,승정자 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.2

The purpose of this study was to examine nutritional status of iron in 27 rural elderly subjects. The daily intake, urinary excretion and serum level of iron were determined by 24-hr food collection method, and 24-hr urine and serum collection for 3 days. The results were summarized as follows. 1. The mean age, height, weight, and blood pressure were 67.7 years, 163.2㎝, 55.9㎏, and 121.1/80.0㎜Hg in men and 69.9 years, 146.5㎝, 47.6㎏, and 108.9/71.1㎜Hg in women, respectively. 2. The daily intake of energy, protein, vitamin A, vitamin B₁, vitamin B₂, niacin, vitamin C, and iron were lower than Korean recommended dietary allowances. 3. The daily iron intake was 7.82㎎. The proportion of heme iron and nonheme iron to the total iron intake were 8.05% and 91.94%, respectively. Major iron sources of the rural elderly were cooked rice, Ko Chu Jang, beef blood, anchovy, soybean paste, and leafy radish. 4. The hemoglobin, hematocrit, serum iron, and total iron binding capacity were 14.3g/dl, 42.9%, 79.4 ㎍/dl, and 268.4 ㎍/dl in men and 12.9g/dl, 38.8%, 92.4 ㎍/dl, and 277.9 ㎍/dl in women, respectively. 5. There was a significant positive correlation between dietary intake and urinary excretion of iron.

2×2 교차설계에 의한 생물학적 동등성 시험에서 결측치가 있을 때의 통계적 해석 방법

박상규,이재영,최성업,윤미경,이재휘,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

Statistical interpretations in a bioequivalence trial are considered and studied when the missing observations occurred in 2 × 2 crossover experiment. Patel (1985) suggested the approximate test procedures for carryover effect and drug effect in 2 × 2 crossover design when some of data are missing in the second period. A modified Patel method is newly pro-posed to the bioequivalence trial and it is compared with the current method through the simulation study.

SF-36을 이용한 농촌 노인들의 건강상태 평가

전진용,김상아,박웅섭,오미경,홍윤미 관동대학교 의과학연구소 2001 關東醫大學術誌 Vol.5 No.1

This study was conducted to understand health status by general characteristic, and to find out relationship between the general characteristics and rural elderly's health status. Health status was measured using SF-36(Medical Outcome Study Short From 36). The finding of this study were as follow; Mean scores of health status by sex were higher in male on physical function, social function and role limitation-emotion. The elderly educated more reported good health on physical function, role limitation-physical, vitality, bodily pain and general health than did the elderly educated less. The elderly who have disease reported bad health on social function, mental health and general health. Therefore we reviewed the evidence that sex, education and illness are associated with health status in the elderly, and that specific public health service that related such condition should be considered for the rural elderly.