Effects of High Cholesterol Diet on Newly Generated Cells in the Dentate Gyrus of C57BL/6N and C3H/HeN Mice

KIM, Il Yong,HWANG, In Koo,CHOI, Ji Won,YOO, Ki-Yeon,KIM, Yo Na,YI, Sun Shin,WON, Moo-Ho,LEE, In Se,YOON, Yeo Sung,SEONG, Je Kyung Japanese Society of Veterinary Science 2009 The Journal of veterinary medical science Vol.71 No.6

<P>In this study, we observed and compared the effects of a high cholesterol diet (HCD) on cell proliferation and differentiation in the subgranular zone of the dentate gyrus of C57BL/6N (B6, susceptible strain) and C3H/HeN (C3H, resistant strain) mice. Ki67 (a marker for cell proliferation) positive cells) were significantly decreased in HCD-fed B6 mice compared to those in B6 (49.7%) and C3H mice fed a low cholesterol diet (LCD). In addition, doublecortin (DCX, a marker for cell differentiation or neuroblasts)-immunoreactive cells in HCD-fed B6 mice were significantly decreased compared to those in LCD-fed B6 and C3H mice. These results suggest that B6 strains are sensitive to HCD, which impairs cell proliferation and differentiation.</P>

레이저와 2차원 배열의 광전검출기를 이용한 구조물의 변위측정 시스템의 개발에 관한 연구

강문필,이진이,김민수,김대정,최원하,강기훈,김종수,김훈 한국비파괴검사학회 2002 한국비파괴검사학회지 Vol.22 No.1

일반적으로 구조물은 외부의 정적 및 동적 하중과 외부환경으로 인하여 피로균열과 부식이 발생하며, 이것은 구조물의 변형을 유발하여 결국 파단으로 이어지기 때문에 균열과 부식의 검출 및 평가와 함께 구조물의 변형에 의한 진동, 변위 기울기와 같은 거동을 감시하는 것도 매우 중요하다. 이에 레이저 센서 시스템을 이용하여 이러한 거동을 측정하여 이상 유무를 모니터링할 수 있는 구조물 안전감시 시스템을 개발하였다. 본 시스템은 2차원으로 배열한 광전센서를 이용하여 구조물의 변형에 의해 유발된 광궤적의 변화를 감시하며 또한 데이터를 취득하고 신호처리 할 수 있는 운용 프로그램도 갖추고 있다. 본 연구에서는 개발한 안전 진단 시스템의 필드 적용에 앞서 실험실에서의 몇 가지 실험을 통하여 그 효용성을 검증하였다. A Safety Monitoring System using a laser and 2-D arrayed photo sensors is developed. To monitor of the deformation and small rotation of structure the developed optical system using 2-D photo sensor array was used to detect the variation of optical orbit of laser which was induced by deformation of the structure. Also, an operating program to manage the system and an algorithm for the data acquisition and the database are introduced. In this study, we demonstrated the capabilities of this system by laboratory experiments before applying the system to the field.

소아치과 영역에서 러버댐의 다양한 임상적 적용에 대한 증례보고

김종범,김종철,이성혁,장기택 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3

Usage of the rubber dam has been advocated by countless number of dentists. The advantages of the rubber dam such as the following are well-known 1. Moisture control. 2. Improved field of vision. 3. Ease of approach. 4. Soft tissue retraction and Injury prevention. 5. Prevention of aspiration of materials or instruments. 6. Shortened chair time. 7. Induction of nasal breathing during administration of N₂O-O₂sedation. Recent reports indicate the rubber dam can protect the dental staffs from the infection when treating HBV or HIV positive patients. Also, impreved moisture control and freeing of both handes allowed by the rubber dam makes it very useful when bonding orthodontic brackets. This case study presents the various clinial application of the rubber dam on patients visiting SNUDH dept. of pediatric dentistry to emphasize the importance of its use in pediatric dentistry.

多衆 채널 DPSK Heterodyne/Coherent 光通信 시스템의 性能 評價

金玄起,李天熙 청주대학교 산업과학연구소 1992 産業科學硏究 Vol.10 No.-

In this paper, system modeling for multichannel DPSK communications system is presented and its receiver performance is evaluated. The receiver is deteriorated due to shot noise originating from the photo diode, phase noise stemming from transmisson and local source, and crosstalk between adjacent channels. Such noise exist in signal is estimated Bit Error Rate(BER) and sensitivity penalty by the transmisson power, when it is in consideration of laser linewidth. And it account for the impact of the laser linewidth. It is assumed that the IF bandwidth needed to avoid intersymbol interference is 2.2 bit rates for a modulation index m=1; it is larger for other modulation index values. For DPSK systems, desired channel spacing is rapidly increased from 2.08R_(b) to 3R_(b), when channel spacing increased from △?? T=0% to △?? T=0.5%, Such a criterion gives a 1dB penalty in the optical receiver sensitity at P_(e)=10^(-9)

자전거 에르고미터운동시 유ㆍ무산소성 역치수준의 근전도 변화

김기진,조현철,홍관이,정정진,손태열 龍仁大學校 體育科學硏究所 1991 體育科學硏究論叢 Vol.1 No.1

The aim of present study is investigate the change of IEMG and PEMG in the aerobic, anaerobic threshold by ventilation an blood locate concentration. Subjects of this study is adult sedentary men of age 32.18±4.28yrs. Subjects performed an incremental test on the bicycle ergometer from an initial work load of 0.5KP(60 rpm) to exhaustion by 3-min steps of 0.5KP. The results of this study was as follows: 1. The levels of relative exercises load in the ventilation, lactate, PEMG and IEMG by aerobic threshold were appeared 39.88±15.62%, 39.66±13.05%, 34.31±13.74% and 36.69±13.05%, respectively. It was not significant difference between variables. 2. The levels of relative exercise load in the ventilation, lactate, PEMG and IEMG by aerobic threshold were appeared 70.02±7.72%, 65.69±8.82%, 64.61±8.65% and 69.64±9.76%, respectively. It was not significant difference between variables. In this results above, It is considered that analysis methods by non-linear increase point of PEMG and IEMG related to both respiratory gas variables, blood lactate accumulation type and muscle function, muscle fiber recruitment type for determination of aerobic and anaerobic threshold.

유치열에서 Chlorhexidine Varnish와 Polyurethane Sealant의 Streptococcus mutans억제 효과에 대한 연구

이성혁,장기택,김종철 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1

Numerous chemical agents have been developed to reduce the activity of cariogenic bacteria. Of these, chlorhexidine is acknowledged as the most effective. Gel and mouthrinse have been the traditional method of its application in the mouth. It has been reported that chlorhexidine varnish has prolonged inhibitory effect on the number of streptococcus mutans in saliva and plaque. Recently, chlorhexidine varnish and polyurethane sealant have been developed to promote prolonged anticariogenic effect of chlorhexidine. Products containing 10% chlorhexidine varnish and polyurethane sealant have been developed to prevent caries by reducing the number of streptococcus mutans in the oral cavity. The purpose of this study is to investigate the inhibitory effect of chlorhixidine varnish and polyurethane sealant on streptococcus mutans in the primary dentition. Children with primary dentition containing no active carious lesion were divided into two groups. To the experimental group(n=11), chlorhexidine varnish and polyurethane sealant ( Chlorzoin , Knowell Therapeutic Technologies, Inc. Canada.) was applied once a week for four weeks according to the manufacturer's instruction. Only oral prophylaxis was performed on the control group(n=7). Cariesactivity was measured after using Chlorzoin SM(Knowell Therapeutic Technologies, Inc. Canada.) to incubate streptococcus mutans before and 5, 12, 24 weeks after initial varnish application. The following results were observed.: 1. There was statistically significant decrease in the number of streptococcus mutans in the experimental group for 5 weeks(P<0.01), 12 weeks(P<0.05) after the initial application. but, by 24 weeks significant difference had disappeared. 2. As the inhibitory effect of chlorhexidine varnish and polyurethane sealant application is not everlastion, reapplication at 12-24 weeks should be needed.

편도체 중심핵 손상이 갈등 스트레스에 의해 유발되는 위궤양에 미치는 영향

이종택,김기석 한국심리학회 1990 한국심리학회지 생물 및 생리 Vol.2 No.1

본 연구에서는 흰쥐를 대상으로 편도체 중심핵의 손상이 갈등 스트레스에 의해 유발되는 위궤양 발생을 억제하는 가를 살펴보고자 하였다. 피험동물을 편도체 중심핵 손상집단과 모의시술 통제집단으로 나누어 각각 20마리씩 시술하였다. 시술 1주일 후, 피험동물을 스키너 상자에 넣고 갈등 스트레스 인자로 전기쇼크를 48시간동안 주었다. 실험결과 행동지표인 지렛대 누르기, 체중 및 물섭취량에는 두 집단간에 차이가 없었다. 그러나 편도체 중심핵을 손상한 집단의 피험동물에게서는 모의시술 통제집단의 피험동물보다 유의미하게 위궤양의 수, 위궤양의 길이 및 미란발생이 억제되었다. 이러한 결과는 편도체 중심핵이 갈등 스트레스에 관여하는 뇌의 신경실체임을 시사한다. This experiment was conducted to answer the question whether or not the lesion of central amygdaloid nucleus inhibites the development of a conflict stress induced stomach ulcer, 40 rats were randomly assigned into two groups, that is, a central amygdaloid nucleus lesion group and a sham-operationed group. One week after surgery, they were put in Skiner Box and received electric shock as a conflict stress. After the experiment, the stomach was removed as soon as possible. The lesion group had inhibited significantly the development of stomach ulcer, whereas the sham-operated group did not inhibit the development of the ulcer. The results suggest that the central amygdaloid nucleus is a neural substrate that responds to the conflict stress as well as any other type of stress.

핵간안근마비를 보인 중추신경계 크립토콕쿠스병 1례

이지영,김재일,김기선,강문철,이창민,양대웅,이근호,김상준 대한신경과학회 1997 대한신경과학회지 Vol.15 No.5

迎日灣의 ECOSYSTEM 硏究 3. 水溫

尹伊鏞,朴相來,李東澈,金基台,崔銀珠,安由煥 嶺南大 海洋科學硏究所 1988 Marine Nature Vol.1 No.1

In order to observe hydrological characteristics in the Gulf of Yoeng-il, measurements of water temperature have been carried out from February to August 1983, and from August 1985 to December 1986. Surface water temperatures are closely linked to air temperature and solar-radiation for all littoral stations. Seasonal and annual variations of all horizontal stations are very similar to one another. Vertical variations of water temperatures for the stations located along the central-line of the Gulf are characteristic (and observed) as thermoclines and thermal stratification in the hottest summer-time (August). It is interesting to note that water column temperature of July and September are rather warmer than August, on account of a cold water mass coming from NE direction. For example, surface temperature in June 1982 was above 19℃, but the water below a depth of about 30m drastically drops to 4℃. It is indicative of invasion of water mass from cold current or deep sea.

우수여자 유도선수들의 연간 트레이닝과 디트레이닝에 따른 무산소성 역치의 변화

홍관이,정정진,김학렬,김기진,조현철,손태열,노성규 龍仁大學校 體育科學硏究所 1992 體育科學硏究論叢 Vol.2 No.1

The seasonal variance for estimate of exercise intensity, energy expenditure, maximal oxygen uptake and anaerobic threshold of elite women judo players(Group Ⅰ:4,Group Ⅱ: 4) was measured during 3,5,7,9,10month. The results of this study is as follows. 1. Exercise intensity by %HRmax during seasonal training was shown range of 56.45-73.62, 65.56-82.15, 80.03-86.62, 62.06-68.83%HRmax, respectiveley, from 3 to 9month in the warm up, additional exercise, main exercise and cooling down. 2. Energy expenditure per min during seasonal training was shown range of 4.09-7.96, 5.41-8.66, 8.95-9.90 and 5.05-6.41Kcal/min, respectiveley, from 3 to 9month in the warn up, additional exercise, main exercise, main exercsie and cooling down. 3. Changes of maximal oxygen uptake(VO₂max)during seasonal training and detraining not significant difference between both group, and in the seasonal variance. However, maximal heart rate during detraining expressed significant difference(p<0.05) between both group. 4. Anaerobic threshold levels during seasonal training and detraining not significant difference between both group, and in the seasonal variance. However, AT-VE(1/min) and AT- work time(min) of group Ⅱ expressed significant difference(p<0.01) in the seasonal variance.