Validation of dietary reference intake equations for estimating energy requirements in Korean adults by using the doubly labeled water method

Eun-Kyung Kim,Jae-Hee Kim,Myung-Hee Kim,Didace Ndahimana,Seo-Eun Yean,Jin-Sook Yoon,Jung-Hyun Kim,Jonghoon Park,Kazuko Ishikawa-Takata 대한지역사회영양학회 2017 Nutrition Research and Practice Vol.11 No.4

BACKGROUND/OBJECTIVES: The doubly labeled water (DLW) method is considered the gold standard for the measurement of total energy expenditure (TEE), which serves to estimate energy requirements. This study evaluated the accuracy of predictive dietary reference intake (DRI) equations for determining the estimated energy requirements (EER) of Korean adults by using the DLW as a reference method. SUBJECTS/METHODS: Seventy-one participants (35 men and 36 women) aged between 20 and 49 years were included in the study. The subjects’ EER, calculated by using the DRI equation (EERDRI), was compared with their TEE measured by the DLW method (TEEDLW). RESULTS: The DRI equations for EER underestimated TEE by -36.3 kcal/day (-1.3%) in men and -104.5 kcal/day (-4.9%) in women. The percentages of accurate predictions among subjects were 77.1% in men and 62.9% in women. There was a strong linear correlation between EERDRI and TEEDLW (r = 0.783, P < 0.001 in men and r = 0.810, P < 0.001 in women). CONCLUSIONS: The present study supports the use of DRI prediction equations to determine EER in Korean adults. More studies are needed to confirm our results and to assess the validity of these equations in other population groups, including children, adolescents, and older adults.

알레르기비염 발생의 위험 인자와 현증 알레르기비염의 폐기능 및 기관지과민성

정은초 ( Eun Cho Chung ),박지원 ( Jee Won Park ),이소연 ( So Yeon Lee ),최연정 ( Yean Jung Choi ),홍수종 ( Soo Jong Hong ),박강서 ( Kang Seo Park ) 대한천식알레르기학회 2016 Allergy Asthma & Respiratory Disease Vol.4 No.1

Purpose: We analyzed the pulmonary function and risk factors of allergic rhinitis (AR) in dust mite-sensitized children with current AR and no history of asthma. Methods: In this cross-sectional study, demographic and disease-related information was obtained from 1,792 Korean children aged 9?12 years using a questionnaire, skin-prick testing, spirometric analysis, and methacholine challenge testing. Results: A total of 672 children were analyzed. The control group consisted of 583 children without any allergic diseases who were not sensitized to 16 common allergens. The group with current AR and dust mite sensitization consisted of 89 children. Binary logistic regression analysis showed that helminth infection (adjusted odds ratio [aOR], 2.88; 95% confidence interval [CI], 1.23?6.77) and antibiotic use during infancy (aOR, 1.89; 95% CI, 1.10?3.25) were the risk factors. Pet ownership (aOR, 0.32; 95% CI, 0.15?0.69) and older siblings (aOR, 0.58; 95% CI, 0.35?0.96) were protective factors. Spirometry results did not differ between the control and dust mite-induced AR groups. None of the children showed a bronchodilator response. However, 8.5%, 7.1%, and 2.1% of the control-group children and 28.7%, 23.0%, and 8.0% of the dust mite-induced AR-group children showed methacholine PC20 (provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second) values of ≤25 mg/mL, ≤16 mg/mL, and ≤8 mg/mL, respectively (P<0.01). Conclusion: The prevalence of current dust mite-induced AR may be reduced by controlling environmental factors. Even though the spirometry results seemed to be normal, bronchial hyperresponsiveness occurred more frequently in children with dust mite-induced AR than in normal children.

A novel photonumeric hand grading scale for hand rejuvenation

이종훈,Yean Su Choi,Eun Soo Park,Jong Seo Kim,Moon Seok Kang,Hwa Young Oh,So Dam Yang,Seon Hui Jeon 대한성형외과학회 2019 Archives of Plastic Surgery Vol.46 No.4

Background Few scales are currently available to evaluate changes in hand volume. We aimed to develop a hand grading scale for quantitative assessments of dorsal hand volume with additional consideration of changes in skin texture; to validate and prove the precision and reproducibility of the new scale; and to demonstrate the presence of clinically significant differences between grades on the scale. Methods Five experienced plastic surgeons developed the Hand Volume Rating Scale (HVRS) and rated 91 images. Another five plastic surgeons validated the scale using 50 randomly selected images. Intra- and inter-rater agreement was calculated using the weighted kappa statistic and intraclass correlation coefficients (ICCs). Paired images were also evaluated to verify whether the scale reflected clinical differences. Results The intra-rater agreement was 0.95 (95% confidence interval, 0.922–0.974). The interrater ICCs were excellent (first rating, 0.94; second rating, 0.94). Image pairs that differed by 1, 2, and 3 grades were considered to contain clinically relevant differences in 80%, 100%, and 100% of cases, respectively, while 84% of image pairs of the same grade were found not to show clinically relevant differences. This confirmed that the scale of the HVRS corresponded to clinically relevant distinctions. Conclusions The scale was proven to be precise, reproducible, and reflective of clinical differences.

Comparison of total energy intakes estimated by 24-hour diet recall with total energy expenditure measured by the doubly labeled water method in adults

Kim Eun-Kyung,Fenyi Justice Otoo,Kim Jae-Hee,Kim Myung-Hee,Yean Seo-Eun,Park Kye-Wol,Oh Kyungwon,윤성하,Ishikawa-Takata Kazuko,Park Jonghoon,Kim Jung Hyun,Yoon Jin-Sook 한국영양학회 2022 Nutrition Research and Practice Vol.16 No.5

BACKGROUND/OBJECTIVES The doubly labeled water (DLW) method is the gold standard for estimating total energy expenditure (TEE) and is also useful for verifying the validities of dietary evaluation tools. In this study, we compared the accuracy of total energy intakes (TEI) estimated by the 24-h diet recall method with TEE obtained using the doubly labeled water method. SUBJECTS/METHODS This study involved 71 subjects aged 20–49 yrs. Over a 14-day period, three 24-h diet recalls per subject (2 weekdays and 1 weekend day) were used to estimate energy intakes, while TEE was measured using the DLW method. The paired t-test was used to determine the significance of differences between TEI and TEE results, and the accuracy of the 24-h recall method was determined by accuracy predictions percentage, root mean square error, and bias. RESULTS Average study subject age was 33.4 ± 8.6 yrs. The association between TEI and TEE was positive and significant (r = 0.463, P < 0.001), and the difference between TEI (2,084.3 ± 684.2 kcal/day) and TEE (2,401.7 ± 480.3 kcal/day) was also significant (P < 0.001). In all study subjects, mean TEI was 12.0% (307.5 ± 629.3 kcal/day) less than mean TEE, and 12.2% (349.4 ± 632.5 kcal/day) less in men and 11.8% (266.7 ± 632.5 kcal/day) less in women. Rates of TEI underprediction for all study subjects, men, and women, were 60.5%, 51.4%, and 66.7%, respectively. CONCLUSIONS This study shows that 24-h diet recall underreports energy intakes. More research is needed to corroborate our findings and evaluate the accuracy of 24-h recall with respect to additional demographics.

Approach for Optimized TB Control of Homeless TB Patients in Urban Settings

( Hae Sook Seo ),( Jong Kyung Kim ),( Jae Rak Hong ),( Jung Eun Suh ),( Oh Woo Kwon ),( Bu Yean Kim ),( Young Soo Cho ) 대한결핵 및 호흡기학회 2011 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.112 No.-

발달지체 영유아의 문제행동이 부모 양육스트레스에 미치는 영향

서주연 ( Ju Yean Seo ),하은혜 ( Eun Hye Ha ) 한국놀이치료학회 2014 한국놀이치료학회지(놀이치료연구) Vol.17 No.4

본 연구에서는 발달지체 영유아의 문제행동이 부모 양육스트레스에 미치는 영향력을 검증하였다. 이를 위해 소아정신과 병원 1곳과 재활의학센터 1곳에서 발달지체로 판정된 만 1.5-5세 영유아 148명을 표집하였다. 연구도구는 CBCL 1.5-5 유아행동평가척도, 양육스트레스 척도(K-PSI)를 사용하였다. 본 연구의 결과는 다음과 같다. 첫째, 발달지체 영유아의 문제행동은 부모 양육스트레스와 모두 정적인 상관관계를 나타냈고, 그 중 문제행동 총점이 부모 양육스트레스와 가장 높은 상관관계를 보였다. 둘째, 전반적 발달장애 집단의 부모 양육스트레스가 의사소통 장애 집단의 부모 양육스트레스보다 높게 나타났다. 셋째, 문제행동 증후군척도에서는 위축 척도가 부모 양육스트레스를 유의미하게 예측하였고, DSM 방식 척도에서는 정서문제, 전반적 발달문제, 주의력결핍/과잉행동문제 척도 순으로 부모 양육스트레스에 대한 영향력이 크게 나타났다. 넷째, 의사소통 장애군에서는 DSM 정서문제 척도가 부모 양육스트레스를 유의미하게 예측하였고, 전반적 발달장애군에서는 영유아의 CBCL 1.5-5 문제증후군 척도 중 위축 척도가, DSM 방식 척도 중 정서문제 척도가 부모 양육스트레스에 영향을 미치는 것으로 검증되었다. The purpose of this study was to verify the effects of behavior problems upon the parenting stress of developmentally delayed infants. The subjects comprised 148 male and female infants with developmental delays in the department of child psychiatry and rehabilitation at a general hospital in Seoul, Korea. The parents of infants were assessed by means of the Child Behavior Checklist 1.5-5 and the K-PSI. The results revealed the following: First, behavior problems of developmentally delayed infants and parenting stress had significantly positive correlations. Among the scales, the total scores of behavior problems showed the highest correlations. Second, the parenting stress of pervasive developmental disorder group was higher than the communication disorder group. Third, withdrawn scale significantly predicted parenting stress among 7 syndrome scales. Amongst the 5 DSM oriented scales, affective problems, pervasive developmental problems and attention deficit/hyperactivity problem scales significantly predicted parenting stress as orderly. Fourth, DSM affective problems scale significantly predicted parenting stress in communication disorder group. Additionally, withdrawn and DSM affective problems scales had an effect on parenting stress in the pervasive developmental disorder group.

Acceleration of Mesenchymal-to-Epithelial Transition (MET) during Direct Reprogramming Using Natural Compounds

( Ji-hye Seo ),( Si Won Jang ),( Young-joo Jeon ),( So Young Eun ),( Yean Ju Hong ),( Jeong Tae Do ),( Jung-il Chae ),( Hyun Woo Choi ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.10

Induced pluripotent stem cells (iPSCs) can be generated from somatic cells using Oct4, Sox2, Klf4, and c-Myc (OSKM). Small molecules can enhance reprogramming. Licochalcone D (LCD), a flavonoid compound present mainly in the roots of Glycyrrhiza inflata, acts on known signaling pathways involved in transcriptional activity and signal transduction, including the PGC1-α and MAPK families. In this study, we demonstrated that LCD improved reprogramming efficiency. LCD-treated iPSCs (LCD-iPSCs) expressed pluripotency-related genes Oct4, Sox2, Nanog, and Prdm14. Moreover, LCD-iPSCs differentiated into all three germ layers in vitro and formed chimeras. The mesenchymalto- epithelial transition (MET) is critical for somatic cell reprogramming. We found that the expression levels of mesenchymal genes (Snail2 and Twist) decreased and those of epithelial genes (DSP, Cldn3, Crb3, and Ocln) dramatically increased in OR-MEF (OG2^+/+/ROSA26^+/+) cells treated with LCD for 3 days, indicating that MET effectively occurred in LCD-treated OR-MEF cells. Thus, LCD enhanced the generation of iPSCs from somatic cells by promoting MET at the early stages of reprogramming.

A novel photonumeric hand grading scale for hand rejuvenation

Lee, Jong Hun,Choi, Yean Su,Park, Eun Soo,Kim, Jong Seo,Kang, Moon Seok,Oh, Hwa Young,Yang, So Dam,Jeon, Seon Hui Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.4

Background Few scales are currently available to evaluate changes in hand volume. We aimed to develop a hand grading scale for quantitative assessments of dorsal hand volume with additional consideration of changes in skin texture; to validate and prove the precision and reproducibility of the new scale; and to demonstrate the presence of clinically significant differences between grades on the scale. Methods Five experienced plastic surgeons developed the Hand Volume Rating Scale (HVRS) and rated 91 images. Another five plastic surgeons validated the scale using 50 randomly selected images. Intra- and inter-rater agreement was calculated using the weighted kappa statistic and intraclass correlation coefficients (ICCs). Paired images were also evaluated to verify whether the scale reflected clinical differences. Results The intra-rater agreement was 0.95 (95% confidence interval, 0.922-0.974). The interrater ICCs were excellent (first rating, 0.94; second rating, 0.94). Image pairs that differed by 1, 2, and 3 grades were considered to contain clinically relevant differences in 80%, 100%, and 100% of cases, respectively, while 84% of image pairs of the same grade were found not to show clinically relevant differences. This confirmed that the scale of the HVRS corresponded to clinically relevant distinctions. Conclusions The scale was proven to be precise, reproducible, and reflective of clinical differences.

이중과제를 활용한 노인인지기능 선별검사 개발

곽호성(Kwak, Ho-Soung),유은영(Yoo, Eun-Young),박혜연(Park, Hae Yean),이서현(Lee, Seo-Hyun),한대성(Han, Dae-Sung),박지혁(Park, Ji-Hyuk) 대한신경계작업치료학회 2020 재활치료과학 Vol.9 No.4

목적 : 본 연구의 목적은 인지기능저하 노인을 선별할 수 있는 이중과제를 활용한 노인인지기능 선별검사를개발하는 것이다. 연구방법 : 2019년 5월부터 8월까지 경기도 및 충청도에 있는 지역사회 기관에서 60세 이상 노인 229명을대상으로 개발된 Y-DuCog(Yonsei Dual Task Cognitive Screening Test)의 신뢰도 및 타당도 검증과인지기능저하 노인의 분류 기준점을 확인하였다. 결과 : MMSE-K, MoCA-K와 Y-DuCog와의 상관분석을 실시한 결과 Y-DuCog의 이중과제 효과와 이중과제초당 정답 수에서 상관관계를 보였다. 내적 일치도 분석 결과 이중과제 효과와 이중과제 초당 정답 수의Cronbach’s-α 값은 각각 .848(p<.01), .916(p<.01)의 신뢰도를 보였고, 검사-재검사 신뢰도는 ICCs가.969∼.996으로 높게 나타났다. 선별기준점은 총 수행시간 DTE에서 31.76초를 기준으로 88.7%의 민감도와 83.5%의 특이도를, 총 이중과제 CRR에서 0.38개를 기준으로 84.5%의 민감도와 76.6%의 특이도를 보였다. 결론 : 본 연구를 통해 Y-DuCog의 신뢰도 및 타당도가 검증되었다. Y-DuCog는 기존 지필 평가의 제한점인 교육수준과 문자에 영향을 받지 않으며 간편하고 빠르게 검사를 시행할 수 있어 노인의 인지기능 평가 및 중재 방법에 대한 효과성 검증 시 사용될 수 있을 것으로 기대한다. Objective : The purpose of this study was to develop a Yonsei dual task cognitive screening test (Y-DuCog) for the elderly. Methods : The reliability and validity test of Y-DuCog (Yonsei Dual Task Cognitive Screening Test) was developed by 229 elderly people aged over 60 years from community organizations at Gyeonggi-do and Chungcheong-do from May 2019 to August 2019. In addition, the criteria for classifying elderly with cognitive impairment were presented. Results : The correlation analysis between MMSE-K, MoCA-K and Y-DuCog were a correlation between the DTE and CRR of Y-DuCog. As a result of internal consistency, Cronbach’s-α values of DTE and CRR showed .848 (p<.01) and .916 (p<.01), respectively. The test-retest reliability was high. The screening point showed 88.7% sensitivity and 83.5% specificity at 31.76 seconds in total DTE, and 84.5% sensitivity and 76.6% specificity at 0.38 in total dual-task CRR. Conclusion : This study verified the reliability and validity of Y-DuCog. It was found that the level of education was not a barrier to the undertaking of this test. Furthermore, the test could be performed easily and quickly. It is also expected to be used to evaluate the effectiveness of cognitive function assessment and intervention methods in the elderly.

Characteristics of Cognitive Function Changes and Related Factors in Individuals With Cognitive Impairment During the Pandemic of COVID-19: A Retrospective Chart Review Study

Choi Jin-Hui,Koo Bon-Hoon,Seo Wan-Seok,Cheon Eun-Jin,Sung Hyung-Mo,Kim Ji Yean,Jeong Hyun-Seok,Kim Younggyo,Kim Hye-Geum 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.2

Objective This study aimed to explore the characteristics and factors related to changes in cognitive function in vulnerable individuals with cognitive impairment during the coronavirus disease 2019 (COVID-19) pandemic.Methods Among patients who visited a local university hospital with subjective cognitive complaints, those who had been tested for cognitive function at least once after the onset of COVID-19 and tested regularly at least three times within the last 5 years were included (1st, the initial screening; 2nd, the test immediately before the COVID-19 pandemic; 3rd, the most recent test after the pandemic). Finally, 108 patients were included in this study. They were divided into groups according to whether the Clinical Dementia Rating (CDR) was maintained/improved and deteriorated. We investigated the characteristics of the changes in cognitive function and related factors during COVID-19.Results When comparing CDR changes before and after COVID-19, there was no significant difference between the two groups (p=0.317). Alternatively, the main effect of the time when the test was conducted was significant (p<0.001). There was also a significant difference in the interaction between the groups and time. When the effect of the interaction was analyzed, the CDR score of the maintained/ improved group significantly decreased before COVID-19 (1st–2nd) (p=0.045). After COVID-19 (2nd–3rd), the CDR score of the deteriorated group was significantly higher than that of the maintained/improved group (p<0.001). Mini-Mental State Examination recall memory and changes in activity during COVID-19 were significantly associated with CDR deterioration.Conclusion Memory dysfunction and decreased activity during the COVID-19 pandemic are strongly related to the deterioration of cognitive impairment.