Kidney Toxicity Induced by 13 Weeks Exposure to the Fruiting Body of Paecilomyces sinclairii in Rats

Jeong, Mi-Hye,Kim, Young-Won,Min, Jeong-Ran,Kwon, Min,Han, Beom-Suk,Kim, Jeong-Gyu,Jeong, Sang-Hee Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.3

Paecilomyces sinclairiis (PS) is known as a functional food or human health supplement. However concerns have been raised about its kidney toxicity. This study was performed to investigate the kidney toxicity of PS by 13 week-oral administration to rats. Blood urea nitrogen (BUN), serum creatinine, and kidney damage biomarkers including beta-2-microglobulin (${\beta}2m$), glutathione S-transferase alpha (GST-${\alpha}$), kidney injury molecule 1 (KIM-1), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), vascular endothelial growth factor (VEGF), calbindin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) and osteopontin were measured during or after the treatment of PS. BUN, creatinine and kidney damage biomarkers in serum were not changed by PS. However, kidney cell karyomegaly and tubular hypertrophy were observed dose-dependently with higher severity in males. KIM-1, TIMP-1 and osteopontin in kidney and urine were increased dose dependently in male or at the highest dose in female rats. Increased urinary osteopontin by PS was not recovered at 2 weeks of post-exposure in both genders. Cystatin C in kidney was decreased at all treatment groups but inversely increased in urine. The changes in kidney damage biomarkers were more remarkable in male than female rats. These data indicate that the PS may provoke renal cell damage and glomerular filtration dysfunction in rats with histopathological lesions and change of kidney damage biomarkers in kidney or urine. Kidney and urinary KIM-1 and cystatin C were the most marked indicators, while kidney weight, BUN and creatinine and kidney damage biomarkers in serum were not influenced.

Kidney Toxicity Induced by 13 Weeks Exposure to the Fruiting Body of Paecilomyces sinclairii in Rats

Mihye Jeong,Young-Won Kim,Jeong-Ran Min,Min Kwon,Beom-Suk Han,Jeong-Gyu Kim,Sang-Hee Jeong 한국독성학회 2012 Toxicological Research Vol.28 No.3

Paecilomyces sinclairiis (PS) is known as a functional food or human health supplement. However concerns have been raised about its kidney toxicity. This study was performed to investigate the kidney toxicity of PS by 13 week-oral administration to rats. Blood urea nitrogen (BUN), serum creatinine, and kidney damage biomarkers including beta-2-microglobulin (β2m), glutathione S-transferase alpha (GST-α), kidney injury molecule 1 (KIM-1), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), vascular endothelial growth factor (VEGF), calbindin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) and osteopontin were measured during or after the treatment of PS. BUN, creatinine and kidney damage biomarkers in serum were not changed by PS. However, kidney cell karyomegaly and tubular hypertrophy were observed dose-dependently with higher severity in males. KIM-1, TIMP-1 and osteopontin in kidney and urine were increased dose dependently in male or at the highest dose in female rats. Increased urinary osteopontin by PS was not recovered at 2 weeks of post-exposure in both genders. Cystatin C in kidney was decreased at all treatment groups but inversely increased in urine. The changes in kidney damage biomarkers were more remarkable in male than female rats. These data indicate that the PS may provoke renal cell damage and glomerular filtration dysfunction in rats with histopathological lesions and change of kidney damage biomarkers in kidney or urine. Kidney and urinary KIM-1 and cystatin C were the most marked indicators, while kidney weight, BUN and creatinine and kidney damage biomarkers in serum were not influenced.

원불교 교리의 현대적 건축 구현 방법 연구

조한(Joh, Hahn),김원석(Kim, Won-Suk) 한국실내디자인학회 2008 한국실내디자인학회논문집 Vol.17 No.5

The Longitudinal Trend of Cardiac Surgery in Korea from 2003 to 2013

Lee, Kyeong Soo,Kim, Chang Suk,Park, Jong Heon,Hwang, Tae Yoon,Kim, Sang Won,Sim, Sung Bo,Lee, Kun Sei The Korean Society for Thoracic and Cardiovascular 2016 The Korean Journal of Thoracic and Cardiovascular Vol.49 No.sup

Background: The purpose of this study was to investigate longitudinal changes of the utilization of operational and surgical medical care inside and outside a metropolitan area over 10 years, analyzing the residential areas of patients and the locations of medical facilities for major cardiovascular surgery. Methods: Data analysis was conducted by classifying the addresses of patients and the locations of medical care facilities of metropolitan cities and provinces, using data from the National Health Insurance Corporation from January 2003 to December 2013. Results: There is serious concentration of major heart surgery to medical facilities in Seoul; this problem has not improved over time. There were differences in percentages of surgical procedures performed in the metropolitan areas according to major diseases. In the case of Busan and Daegu provinces, at least 50% of the patients underwent surgery in medical facilities in the city, but there are other regions where the percentage is less than 50%. In the case of provinces, the percentage of surgical procedures performed in medical facilities in Seoul or nearby metropolitan cities is very high. Conclusion: Policies to strengthen the regional capabilities of heart surgery and to secure human resources are required to mitigate the concentration of patients in the capital area. Many regional multi-centers must be designated to minimize unnecessary competition among regional university hospitals and activate a win-win partnership model for medical services.

Preference Analysis for Flower Jewelry Using Conjoint Analysis

김연희(Yeon Hee Kim),김미진(Mi Jin Kim),윤숙영(Suk Young Yun),장태원(Taeg Won Chang),최병진(Byung Jin Choi) 인간식물환경학회 2022 인간식물환경학회지 Vol.25 No.3

Background and objective: This study was conducted to determine the preferences in flower jewelry by conducting a surveyusing conjoint analysis on the perception of flower jewelry and provide basic data for development of flower jewelryproducts. Methods: For the conjoint analysis, four attributes of flower jewelry were selected. Attribute 1 was related to the mainmaterial of flower jewelry, presented in three levels: cut flowers, potted flowers, and processed flowers. Attribute 2 wasrelated to wearing area presented in five levels of wearing area: hair, neck, ear, arm (wrist) and chest (shoulder). Attribute3 was related to price provided for selling products in flower shops, presented in three levels: less than 30,000 won,50,000-70,000 won, and more than 100,000 won. Attribute 4 was related to flower jewelry wearing time, presented inthree levels: less than 6 hours, 12-24 hours, and more than 24 hours. After extracting 25 profiles through orthogonaldesign, a questionnaire survey was conducted on 402 general participants, from which the responses of 343 participantswere analyzed. Results: By attribute of flower jewelry, the respondents attached most importance to price (34.14%), followed by wearingarea (29.18%), wearing time (18.51%), and material (18.17%), proving that the general public attached most importanceto price (Pearson's R = .987, p = .000). The preference in levels by attribute was highest for processed flowers in material,less than 30,000 won in price, hair in wearing area, and 12-24 hours in wearing time. Conclusion: By making flower jewelry based on the results of the analysis, it would be possible to help increase items soldin flower shops as well as their income.

수술환자에 있어 수술실내에서 수술대기 시간이 불안에 미치는 영향에 관한 연구

이혜원,이규정,김해옥,이해옥,김혜숙,이미경,송말순,Lee, Hea-Won,Lee, Kyu-Chung,Kim, Hae-Ock,Lee, Haik-Ock,Kim, Hea-Suk,Lee, Mi-Kyung,Song, Mal-Soon 대한간호협회 1990 대한간호 Vol.29 No.3

This study was attempted to provide us with basic information on how to improve understanding with patients for operation, and to offer then better nursing and treatment. This kind of study will help scientific application to nursing practice and operating room. The data was collected by interviewing 29 patients who underwent the elective surgery under the general anesthesia at Y hospital in Seoul. The interview ran from October 15 to December 15, 1989. The research instrument was a anxiety measurement device (SAAI) originally developed by Spielberger, et al and modified by Jung-Tack Kim. 1. Hypothesis Testing Hypothesis one was that there would be a difference in state anxiety level according to a time difference in watiting for operation. This hypothesis was rejected(state.anxiety level one hour before operation P>.05, r-.747, State anxiety level half an hour before operation P>.05, r-.1550, state anxiety level just before operation, P>.05, r=.1099). However, state anxiety, evel appeared to be associated with a longer watiting period, like one day before operation (P<.05, r-.4628). Hypothesis two was that there would be a difference according to state anxiety level of patients for operation. This was rejected. (Change of blood perssure in systolie P>.05 r=.1082, Change of blood pressure in diastolic P>.05, r=.088, Change of pulse rate, P>.05, r-1.909) 2. Examining trait anxiety and state anxiety levels, the average level of trait anxiety was 42.034, and the average level of state anxiety one day before operation was 43,000. The average level of state anxiety was averaged 42.356 in a waiting room for operation. 3. Examining the state anxiety level by time period, the one hour before was 42.379 the level half an hour before 42.276, and the level just before operation 42.414. The low level of state anxiety was due to the fact that premedication was not eliminated. 4. Age and time period like one day before operation was related to state anxiety level (F=5.271, P<.0.01) and blood pressure in waiting room for operation. That is, state anxiety level and blood pressure of patients one day before operation appeared high. Sex was relation to changes of blood pressure ; the blood pressure of male patients appeard higer than of female patients. A marital status was also related anxiety level one hour before operation the married patient for operation showed a higher state anxiety level than that of the unmarried patient for operation. Education was similarily related to trait anxiety level in which highly educated patients show lower levels of trait anxiety than poorly educated ones. Motive for hospitalization was related to state anxiety level for patient one hour before operation (F=6.464, P<.05) likewise, patients who are supposed to undergo operation hastily showed higher levels of anxiety than patients who expect elective surgeries.

오공약침의 안전성에 대한 임상적 연구

소기숙,최회강,박소영,고강훈,김성남,이옥자,윤민영,문형철,김성철,이정훈,나원경,So, Ki-suk,Choi, Hoi-kang,Park, So-young,Koh, Kang-hun,Kim, Sung-nam,Lee, Ok-ja,Yun, Min-young,Mun, Hyung-chul,Kim, Sung-chul,Lee, Jung-hun,Na, Won-kyung 대한침구의학회 2004 대한침구의학회지 Vol.21 No.1

Objective: Recently scolopendrid aquacupuncture has been a good effect on pain control but it has not been known about clinical safety. So, In order to prove the clinical safety of scolopendrid aquacupuncture, We have observed the physical reac-tion and clinical pathology test after scolopendrid aquacupuncture treatment. Methods: We analyzed physical reaction and clinical pathology test before and after Scolopendrid aquacupuncture treatment of 30 patients suffering from pain, who admitted department of Acupunture and Moxibustion, College of Oriental Medicine, Won-Kwang University Kwangju hospital. Results & Conclusions: The results were summarized as follows. 1) The distribution of sex was 14 males and 16 females, and the average of patients age was 46.2 years. 2) The distribution of symptom was lumbago, lumbago with radiating pain, nuchal pain and knee joint pain. 3) In the 30 patients treated with Scolopendrid aquacupuncture, hematologic test did not show remarkable change. 4) In the 30 patients treated with Scolopendrid aquacupuncture, Liver function test(AST, ALT, ALP) showed a slight decrease on the contrary, and abnormal rate showed a decrease of 1.0%(from 3.3% to 2.3%) compared with previous study. 5) In the 30 patients treated with Scolopendrid aquacupuncture, Renal function test(BUN, Cr) and abnormal rate(from 2.5% to 2.0%) showed a slight decrease on the contrary. 6) In the 30 patients treated with Scolopendrid aquacupuncture. Electrolyte were normal range before & after treatment. 7) In the results of the Urine analysis of 30 patients, Leukocyte, Protein. Glucose, Keton, Bilirubin, U-bilinogen were not detected before and after Scolopendrid aquacupuncture treatment, and the rest almost made no difference. 8) In the Physical reactions, all of the patients complained of pain of body partially, only one patient showed reddish and itch, but symptoms like those were entirely disappeared within 24 hours and whole body pain, swelling, headache, dizziness, fatigue and nausea was not observed.

Characteristics of hypertension subtypes and treatment outcome among elderly Korean hypertensives

Choi, Suk-Won,Kim, Min-Kyu,Han, Seong-Woo,Kim, Sung Hea,Kim, Hyun Joong,Kang, Seok-Min,Kim, Dae-Kyeong,Kim, Byung Soo,Kim, Won Ho,Kim, Jang-Young,Kim, Hee-Yeol,Rhew, Jay-Young,Park, Keum-Soo,Cho, Kyou Elsevier 2014 Journal of the american society of hypertension Vol.8 No.4

Obesity induced by high fat diet in Rhomboid family member 2 (Rhbdf2) KO mice

Sung-Jun Kim(Sung-Jun Kim),Seul Gi Park(Seul Gi Park),Young-Sub Byun(Young-Sub Byun),Eun-Kyoung Kim(Eun-Kyoung Kim),Sang-Mi Cho(Sang-Mi Cho),Harim Kim(Harim Kim),Young-Suk Won(Young-Suk Won),Hyoung-Ch 한국예방수의학회 2017 한국예방수의학회 학술대회자료집 Vol.2017 No.-

Changes of Superoxide Dismutase Activity in Tissues of Mice treated with Methylmercury

Ryoji, Tamamoto,Kimiaki, Sumino,Lee, Myeong Jin,Lee, Won Chang,Kim, Jin Suk 대한보건협회 1992 대한보건연구 Vol.18 No.2

메칠水銀(Methylmercury)을 經口投與한 마우스 組織內 SOD(superoxide dismutase)活性의 變化를 觀察한바, 腎臟內의 메칠水銀과 總水銀分布는 初回 및 再投與 모두에서 他臟器의 水準 보다 높았다(p<0 05). 그리고 腦, 肝 및 腎臟組織內의 SOD活性은 메칠水銀의 初回投與에서 減少됨을 보였으나, 實驗末期에는 實驗前의 水準으로 恢復되었다. 腦組織中의 SOD活性은 肝과 腎臟에서의 그것보다 메칠水銀의 量이 낮은 水準에서 抑制되고 있었다. (p<0.05) Methylmercury(MeHg) shows remarkable toxicity in the central nervous system. while the living systems have specific protective action reacted with enzymes like as quenching systems to peroxidation. The change of superoxide dismutase(SOD) activity was examined in tissues of mice treated with MeHg. Kidneys contained the higest concentration of MeHg and total mercury leves compared to those in other tissues after one or reapeted administration of MeHg. Activity of SOD in brain, liver and kidneys were decreased with an increase of mercurial concentrations at the first stage after MeHg administration but got back to normal levels at the end of experiment. The SOD activity in the brain was inhibited at comparatively lower leyels of MeHg than those in liver and kidneys(p<0.05).