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양주동,설소영,임선희,김용훈,Zhifu Sun,이주석,Snorri S. Thorgeirsson,추인선,Lewis R. Roberts,강구정 대한의학회 2011 Journal of Korean medical science Vol.26 No.11
Gene expression is suppressed by DNA methylation. The goal of this study was to identify genes whose CpG site methylation and mRNA expression are associated with recurrence after surgical resection for hepatocellular carcinoma (HCC). Sixty-two HCCs were examined by both whole genome DNA methylation and transcriptome analysis. The Cox model was used to select genes associated with recurrence. A validation was performed in an independent cohort of 66 HCC patients. Among fifty-nine common genes, increased CpG site methylation and decreased mRNA expression were associated with recurrence for 12genes (Group A), whereas decreased CpG site methylation and increased mRNA expression were associated with recurrence for 25 genes (Group B). The remaining 22 genes were defined as Group C. Complement factor H (CFH) and myosin VIIA and Rab interacting protein (MYRIP) in Group A; proline/serine-rich coiled-coil 1 (PSRC1), meiotic recombination 11 homolog A (MRE11A), and myosin IE (MYO1E) in Group B; and autophagy-related protein LC3 A (MAP1LC3A), and NADH dehydrogenase 1 alpha subcomplex assembly factor 1 (NDUFAF1) in Group C were validated. In conclusion,potential tumor suppressor (CFH, MYRIP) and oncogenes (PSRC1, MRE11A, MYO1E) in HCC are reported. The regulation of individual genes by methylation in hepatocarcinogenesis needs to be validated.
Yang, Ju Dong,Seol, So-Young,Leem, Sun-Hee,Kim, Yong Hoon,Sun, Zhifu,Lee, Ju-Seog,Thorgeirsson, Snorri S.,Chu, In-Sun,Roberts, Lewis R.,Kang, Koo Jeong The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.11
<P>Gene expression is suppressed by DNA methylation. The goal of this study was to identify genes whose CpG site methylation and mRNA expression are associated with recurrence after surgical resection for hepatocellular carcinoma (HCC). Sixty-two HCCs were examined by both whole genome DNA methylation and transcriptome analysis. The Cox model was used to select genes associated with recurrence. A validation was performed in an independent cohort of 66 HCC patients. Among fifty-nine common genes, increased CpG site methylation and decreased mRNA expression were associated with recurrence for 12 genes (Group A), whereas decreased CpG site methylation and increased mRNA expression were associated with recurrence for 25 genes (Group B). The remaining 22 genes were defined as Group C. Complement factor H (<I>CFH</I>) and myosin VIIA and Rab interacting protein (<I>MYRIP</I>) in Group A; proline/serine-rich coiled-coil 1 (<I>PSRC1</I>), meiotic recombination 11 homolog A (<I>MRE11A</I>), and myosin IE (<I>MYO1E</I>) in Group B; and autophagy-related protein LC3 A (<I>MAP1LC3A</I>), and NADH dehydrogenase 1 alpha subcomplex assembly factor 1 (<I>NDUFAF1</I>) in Group C were validated. In conclusion, potential tumor suppressor (<I>CFH</I>, <I>MYRIP</I>) and oncogenes (<I>PSRC1</I>, <I>MRE11A</I>, <I>MYO1E</I>) in HCC are reported. The regulation of individual genes by methylation in hepatocarcinogenesis needs to be validated.</P>
Comparison of Hepatic Differentiation Potential between Human ES and iPS Cells
Dongho Choi,Kye-Yoon Park,Jeonghoon Heo,Cheul Hyung Cho,Marian Durkin,Agnes Holczbauer,Jens U. Marquardt,Valentina M. Factor,Karim Si-Tayeb,Stephen A. Duncan,Snorri S. Thorgeirsson 한국간담췌외과학회 2010 한국간담췌외과학회 학술대회지 Vol.2010 No.3
Marquardt, J.U.,Seo, D.,Andersen, J.B.,Gillen, M.C.,Kim, M.S.,Conner, E.A.,Galle, P.R.,Factor, V.M.,Park, Y.N.,Thorgeirsson, S.S. Elsevier Science Publishers 2014 Journal of hepatology Vol.60 No.2
Background & Aims: Human hepatocarcinogenesis is as a multi-step process starting from dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC). However, the sequential molecular alterations driving malignant transformation of the pre-neoplastic lesions are not clearly defined. This lack of information represents a major challenge in the clinical management of patients at risk. Methods: We applied next-generation transcriptome sequencing to tumor-free surrounding liver (n=7), low- (n=4) and high-grade (n=9) dysplastic lesions, eHCC (n=5) and pHCC (n=3) from 8 HCC patients with hepatitis B infection. Integrative analyses of genetic and transcriptomic changes were performed to characterize the genomic alterations during hepatocarcinogenesis. Results: We report that changes in transcriptomes of early lesions including eHCC were modest and surprisingly homogenous. Extensive genetic alterations and subsequent activation of prognostic adverse signaling pathways occurred only late during hepatocarcinogenesis and were centered on TGFβ, WNT, NOTCH, and EMT-related genes highlighting the molecular diversity of pHCC. We further identify IGFALS as a key genetic determinant preferentially down-regulated in pHCC. Conclusions: Our results define new hallmarks in molecular stratification and therapy options for patients at risk for HCC, and merit larger prospective investigations to develop a modified clinical-decision making algorithm based on the individualized next-generation sequencing analyses.
Generation of Induced Pluripotent Stem Cells from Mouse Hepatocytic Lineage Cells
Dongho Choi,Kye-Yoon Park,Jeonghoon Heo,Cheul Hyung Cho,Marian Durkin,Agnes Holczbauer,Jens U. Marquardt,Valentina M. Factor,Karim Si-Tayeb,Stephen A. Duncan,Snorri S. Thorgeirsson 한국간담췌외과학회 2010 한국간담췌외과학회 학술대회지 Vol.2010 No.3