The Report on the Medical Voluntary Activities for Cleft Lip and Palate in Vietnam by the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons

Tae-Hoon Hahm,Hyo-Keun Shin,Jong-Ryul Kim,Dong-Mok Ryu,Sun-Youl Ryu,Kyoung-Won Kim,Young-Wook Park,Young-Soo Jung 대한구순구개열학회 2010 대한구순구개열학회지 Vol.13 No.1

대한악안면성형재건외과학회는 2004년도부터 매년 인도적 차원에서 의료 환경이 낙후된 Vietnam의 cleft lip and palate 환자들을 치료하기 위해 무료로 해외 진료 봉사 활동을 해왔다. 초창기 해외 진료봉사 활동 당시 베트남 의료 기술 발달이 미비하여 준비해야 할 것들이 많았으나 이 후 베트남의 경제발전과 함께 의료 시설 및 의료 기술이 발달함에 따라 준비 품목 등이 간단명료해지고 현지 지원 및 수술 준비도 원활히 진행되었다. 이러한 무료 의료 봉사 활동을 계기로 개발도상국의 낙후된 의료 시설 및 의료 기술 발전, 의료 혜택을 받지 못한 구순 구개열 환자의 정상적 안모 및 기능 회복, 조건 없는 의료 봉사 활동을 통한 민간외교 효과 및 양국간의 우호 증진 등의 성과가 있었다. 대한악안면성형재건외과학회에서는 2009년도 역시 베트남 National Institute of Odonto-stomatology 에서 11월17일부터 26일까지 cleft lip and palate 무료수술진료단(단장 신효근)을 보내 수술봉사 활동을 펼치고 돌아 왔다. 일반적인 구순구개열 뿐만 아니라 양측성 안면열(Bilateral Facial Cleft), 사경(Torticollis) 등의 희귀 기형을 포함하여 수술을 진행하였으며 총 31례의 수술을 성공적으로 마쳤으며 지난 6년 동안의 성과와 함께 이에 대한 보고를 하고자 한다.

상악 전치부에 발생한 중심성 치성 섬유종 :

함태훈(Tae-Hoon Hahm),김학진(Hak-Jin Kim),김형준(Hyung Jun Kim),차인호(In-Ho Ch)a,남웅(Woong Nam) 대한구강악안면외과학회 2009 대한구강악안면외과학회지 Vol.35 No.5

Central odontogenic fibroma is an extremely rare benign tumor, accounting for less than 0.1% of all odontogenic tumors. The most recent literature review that only 69 cases have so far been reported. This tumor has a slow persistent growth that results in painless cortical expansion clinically, and well defined unilocular or multilocular radiolucent lesion. Root resorption of associated teeth is common, and lesions located between the teeth often cause root divergence. There is occurring tendency to female more than male, and occurring in the mandible and in the maxilla with equal frequency. The treatment is surgical excision with no tendency to undergo malignant transformation. We report a case of central odontogenic fibroma in the maxilla of a 27-year male with literatures review.

Nutritional and Hormonal Regulation of Fatty Acid Synthase Gene Expression

Dong-Hoon Shin,Byung-Yong Kim,Young-Tae Hahm,Eunki Kim,Won-Dai Cho 한국식품영양과학회 1997 Preventive Nutrition and Food Science Vol.2 No.3

The maximum 30-fold level of fatty acid synthase(FAS) mRNA was achieved by 6hr after intraperitoneal injection of insulin. The kinetics and maximum effect of insulin were most evident on the 7.2kb mRNA. In six hours after insulin administration there was about 100-fold increase in steady-state mRNA level. We observed a sharp decrease in 7.2kb mRNA by 8hr after insulin administration while there was no change in FAS mRNA content between the 6hr and 8hr-sampling periods. In contrast, a maximum induction of 4-fold was shown in the level of 5.1kb mRNA after insulin injection in streptozotocin-diabetic mice.

구개편도의 면역조직학적 연구

우훈영,김용선,함태영 인제대학교 1984 仁濟醫學 Vol.5 No.4

수술적 절제로 채취한 구개편도 122예에 대하여 PAP 염색을 시행하여 그 면역조직학적 검색을 한 결과 반복되는 편도염에서는 구개편도가 면역학적 barrier 역할을 하지 못함을 관찰하였다. Human palatine tonsil is an important lymphoid tissue which produces the immunoglobulin. The authors studied 122 palatine tonsils which were obtained post-operatively at Inje Medical College, Seoul Paik Hospital by immunohistological methods(P.A.P stain). We observed the distribution of Ig-producing cells related to age and clinical diagnosis of tonsillar disease: recurrent tonsillitis(RT) in 43 cases, hyperplastic tonsillitis(HT) in 67 cases and tonsillar hyperplasia(TH) in 12 cases. The results were: 1) Ig-producing cells were presented in 99 of 122 tonsils(81.2%). 2) The distribution of Ig-producing cells was not even; IgG positive cells(37.7%) were most common, IgA(29.0%) the next and IgM(15.7%) were least frequent. They were most common in subepithelia(50.0%) and least in germinal centers(13.4%). 3) Ig-producing cells were increased with age till 17 years old but after then IgA and IgM positive cells were decreased. In germinal centers all Ig-producing cells were decreased after 18 years old. 4) Intraepithelial IgA positive cells were most common in the age group of 7-11 years(31.2%) and markedly decreased after 18 years old(5.9%). 5) In RT group the distribution of Ig-producing cells was most prominent(33.1%), HT group (26.8%) the next and least in TH group(11.1%). 6) Intraepithelial IgA positive cells were most common in RT group but the densely stained (above ++) intraepithelial IgA positive cells were markedly decreased in RT and HT groups.

에나멜 상피종성 및 유두상 두개인두종의 임상상과 자기공명영상 ( MRI ) 소견의 비교

강태욱,양태영,김광원,이문규,민용기,이명식,정재훈,김종현,나동규,정인경,함종렬,권성욱,조건영,이지민,배문희,서연림,유재욱 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.2

Background : Craniopharyngioma is a suprasellar or intrasellar epithelial neoplasm that occurs in both children and adults. It accounts for 1.2 to 3 % of intracranial tumors with an incidence of 0.5 to 2 cases per one million populations each year. Recently, it has been postulated that it may have two pathogenetically separate subtypes, which are adamantinous and papillary craniopharyngioma, and that their clinical features may be different. However, there are some disagreements in this postulation. Therefore, we studied 22 consecutive patients with craniopharyngioma to evaluate the differences in clinical features and MRI findings between two subtypes. Methods : We studied 22 patients with histologically proven craniopharyngioma after surgery at Samsung Medical center from 1995 to 1999. Thirteen patients were male, and nine patients were female. The average age was 30 years, with a range from 1 to 58 years. We divided 22 patients into two histopathologically separate subtypes; adamantinous and papillary subtypes. We compared the clinical features and MRI findings of two subtypes by reviewing medical records. Results : Out of 22 patients with craniopharyngioma, 19 patients had an adamantinous subtype and 3 patients had a papillary subtype. The adamantinous subtype occurred frequently in the fifth decade and below twenty years, while the papillary subtype occurred predominantly in forth and fifth decades. The adamantinous subtype located in suprasellar or intrasellar portion as well as extrasellar portion, while the papillary subtype was restricted to the suprasellar location. The average tumor size of the adamantinous subtype was 3.7 cm, with a range from 1.4 to 6.0 cm, which was larger than that of the papillary subtype (average size 1.8 cm with a range from 1.5 to 2.3 cm, p $lt; 0.05). The adamantinous subtype was predominantly cystic, while the papillary subtype was predominantly solid (p $lt; 0.05). There were no significant differences in the preoperative clinical features and the postoperative complications between two subtypes. Conclusion : The adamantinous subtype had two peaks of occurrence in the fifth decade and below twenty years, while the papillary subtype occurred predominantly in forth and fifth decades. The adamantinous subtype was larger and had cystic portion, while the papillary subtype was smaller and had solid portion. The preoperative clinical features and the postoperative complications between two subtypes seemed not to be different (J Kor Soc Endocrinol 15:170-178, 2000).

중추성 요붕증과 신경 뇌하수체의 결절성 종괴를 보였던 림프구성 누두신경 뇌사수체염(Lymphocytic Infundibuloneurohypophysitis) 1 예

강태욱,김지향,양태영,김광원,이문규,민용기,이명식,정재훈,정인경,조건영,함종열,서연림 대한내과학회 2001 대한내과학회지 Vol.61 No.2

Lymphocytic infundibuloneurohypophysitis was known as a cause of idiopathic central diabetes insipidus. Until recent time, it is characterized into two groups. One has thickening of the pitutitary stalk, enlargement of the neurohypophysis and loss of hyperintense signal of the normal neurohypophysis, the other has only loss of hyperintense signal but not morphological change. A 51-year-old man presented with a one month history of polydipsia and polyuria. The interpretation of water deprivation test was compatible with complete central diabetes insipidus. Endocrinologic examination of the adenohypophysis hormones and its triple stimulation test were normal apart from thyroid stimulating hormone (TSH), which showed low response despite thyrotropin releasing hormone (TRH). Sellar MRI scan disclosed an loss of hyperintense singnal of normal neurohypophysis and about 10 mm-sized nodular mass lesion on neurohypophysis. However, thickness of the pituitary stalk was normal. Pathologic examination demonstrated diffuse infiltration of lymphocytes and plasma cells. No adenomas, menigitis, sarcoidosis or granulomas were present. We supposed that this case was an atypical type of lymphocytic infundibuloneurohypophysitis, which did not belong to any other part of two groups described above.(Korean J Med 61:168-172, 2001)

코골음과 수면 무호흡증에 대한 구개인두 성형술의 임상적 연구

우훈영,정철호,김영기,함태영 인제대학교 1992 仁濟醫學 Vol.13 No.1

코골음은 단순히 불편한 증상으로 생각될 수도 있지만, 사회적, 의학적으로 중요한 영향을 미칠 수 있으며, 고혈압, 심부전증 및 무호흡증을 유발할 수 있다. 저자들은 코골음과 수면무호흡증을 주소로 내원한 환자들에게 구개인두 성형술을 시행하여 만족할 만한 증상호전을 얻을 수 있었다. Snoring is a common obnoxious disturbance in human society. Although considered a mere nuisance by most, it can have significant social and medical effects. It can lead to hypertension, heart failure, and the obstructive sleep apnea syndrome(OSAS). The authors performed palatopharyngoplasty(PPP), modification of Simmons et al(1983) for snoring and obstructive sleep apnea syndrome. Symptoms such as snoring, daytime sleepiness and sleep apneic attack were improved significantly Elimination or improvement fo their snoring, daytime sleepiness and sleep apneic attarks were reported by 90%, 86%, 83% of the patients.

개의 췌장소도 자가이식 결과에 영향을 미치는 인자들

이상훈,김성주,김병준,오승훈,정인경,양태영,김동준,김광원,이문규,민용기,이명식,정재훈,안규정,함종렬 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.2

Background: Islet cell transplantation is an attractive alternative to whole organ pancreas transplantation, since it is clearly safer and simpler surgical procedure for the recipients. However, several obstacles still remain, because the free islets appear to be more susceptible to non-specific inflammatory damage or immune mediated destruction than islets in an intact pancreas. Therefore, the purpose of this study is to examine the functional outcome of islet autograff and the factors related to the islets graft survival in mongrel dogs. Methods: Twelve adult mongrel dogs weighting 12∼16 kg were used for the experiment of total pancreatectomy and islet autotransplantation. The islets were properly isolated by a modified Recordi method. The obtained islets were further purified by centrifugation on discontinuous gradients using cell separation system (Model 2991, Cobe, Lakewood Colo). After the heparization (50 U/kg), the islets were injected slowly into the liver through the portal vein for 30 minutes. The post-transplantation intravenous glucose tolerence test (IVGTn with glucose disappearance rate (K), liver function test (LFT), fasting plasma glucose (FPG) were measured periodically. Results: 1) The median of Ks were 1.3%min (range 0.3∼2.1) and the IEq/kg (150 m equivalents/kg of recipient body weight) was 3520 (range 1350∼6550). The Ks in recipients with high IEq/kg (≥5,000) were significantly higher than those in recipients with low IEq/kg ($lt;5,000)(r=0.78, p$lt;0.05). 2) The islet cell viability were estimated to be 95% and the median of the required insulin dosage for the maintenance of normal FPG were 0.7 (range 0∼1.6) U/kg/day. The insulin requirement correlated well with the level of IEq/kg (r=0.90, p$lt;0.01). 3) The median of the volume of the transplanted pancreatic islet cell were 2.1 mL (range 0.7∼5.0) and the purity was 60% (range 10∼95). The portal pressure gradients of during the transplant procedure were 4.0 (range 0.5∼12.0) cmH2O. The portal pressure gradients in recipients with high purity were significantly lower than those in recipients with low purity (r=-0.80, p$lt;0.05). Conclusions: In this study, we confirmed that autotransplantation of islet cell on the pancreatectomized dogs can render nearly normogiycemia, and transplanted islet mass was most critical factor to successful autotransplantation in canine model.

Vestibular Neuritis 4 예

전병훈,국형철,김석경,최덕주,우훈영,함태영 인제대학교 1985 仁濟醫學 Vol.6 No.4

Vestibular neuritis is a discrete degenerative neuropath of the vestibular nerve trunks. The etiology for the loss of the vestibular function is postulated to be a viral neuritis, An awareness of this disorder as a disease entity will minimize diagnostic and therapeutic frustration on the part of the physician and provide a realistic prognosis for the patient. We have exprienced 4 cases of vestibular neuritis and all of them were well responded to vestibular suppresant drugs.

甲狀舌管 囊腫 1例

田丙勳,盧永洙,李鮮亨,趙賢熙,咸泰英 인제대학교 1982 仁濟醫學 Vol.3 No.3

본 교실에서는 최근 14세 된 남아에서 右側下頸部의 瘻管을 동반한 甲狀舌管 襄腫 1例를 치험하였기에 약간의 문헌적 고찰과 더불어 보고하는 바이다. Thyroglossal duct cyst is one of the most common congenital cystic lesions in childhood. And the lesion has long been of interest to surgeons because it can be a source of morbidity resulting from recurrent infection and often pose a problem of different diagnosis. Authors experienced a case of thyrogossal duct cyst which was attested by a fistulogram. The patient was 14 year old and the fistula was extirpated completely from external orifice to foramen cecum by Sistrunk method. The histological examination revealed thyroid follicles around the cyst capsule which was uncommon on thyroglossal duct cyst. This paper was attemted to report a case with a brief review of literatures.