석탄폐석을 이용한 폴리머 콘크리트의 물리 역학적 특성

연규석,최동순,장태연,주명기 강원대학교 석재복합신소재제품연구센터 석재연 논문집 Vol.1 No.-

최근의 급속한 경제성장과 건설물량의 증가로 인한 수요가 급격히 증대되고 있으나, 양질의 콘크리트용 골재 부족현상을 초래하고 있어 골재의 양적인 문제와 함께 질적인 문제의 해결이 건설재료 분야의 중요한 당면과제로 제기되고 있다. 따라서 본 연구에서는 강원도 탄광지역에 다량으로 산재되어 있는 석탄폐석을 콘크리트용 골재로서 활용하여 고강도이며 내구성이 우수한 폴리머 콘크리트를 제조하고 이에 대한 물리·역학적 특성을 실험적으로 구명하여 공장제품 재료로서의 이용을 위한 기초자료로서 제공코저 한다. Lately, rapid expansion of construction industry and following increment of demand for concrete in the construction created shortage of aggregates in the nation. Supplement of god quality aggregate is an immediate issue for the construction industry to solve. Therefore, this study evaluated a possibility of using coal mine waste collected from Kwangwon-do region as a source of aggregate in manufacturing polymer concretes which have high strength and high durability. First, aggregates were obtained by crushing coal mine waste and polymer concrete was manufactured using these aggregate. Mechanical property test results for the polymer concrete showed that the coal mine waste aggregates were acceptable to use as a replacement of the aggregate in polymer concrete manufacture.

MDVP와 Praat, Dr. Speech간의 음향학적 측정치에 관한 상관연구

유재연,정옥란,장태염,고도홍 한국음성과학회 2003 음성과학 Vol.10 No.3

The purpose of this study was to conduct a correlational analysis among Fo, Jitter, Shimmer, and NHR(HNR), and NNE estimated by three speech analysis softwares, MDVP, Praat and Dr, Speech. Thirty females and 15 males with normal voice participated in the study. We used Sound Forge 6.0 to record their voice. MDVP, Praat and Dr. Speech were used to measure the acoustic parameters. The Pearson correlation coefficient was determined through a statistical analysis. The results came out as follows: Firstly, there was a strong correlation between Fo and Shimmer of both instruments. However, there was no correlation between Jitter of both instruments. Secondly, Shimmer showed a stronger correlation with HNR, NHR, and NNE than Jitter. Therefore, Shimmer was considered to be more useful and sensitive parameter to identify dysphonic voice compared to Jitter.

씨름선수에서 체중 감량과 회복기의 Leptin과 PAI-1 변화

김용운,도경오,권태동,박덕일,장응찬,박소영,김종연,이석강 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2

Obesity which is defined as accumulation of excess body fat, is central factor of insulin resistance syndrome. Recently, it is revealed tat adipose tissue is not simply an energy storage organ but it also secretes a variety of molecules which affect the metabolism of the whole body, those are leptin and plasminogen activator inhibitor-1(PAI-1). Therefore, leptin and PAI-1 are increased in the obese state. Leptin regulates energy homeostasis and satiety and PAI-1 regulates fibrinolytic system. For these reasons, elevated levels of leptin and PAI-1 are considered as link factors between obesity and insulin resistance syndrome. However, the exact regulating mechanism for serum levels of leptin and PAI-1 is not fully understood yet. In this study, to evaluate the regulating mechanisms of serum levels of leptin and PAI-1 according to the weight changes, we measured leptin, PAI-1, physical, metabolic, and endocrine parameters during 10 days of weight reduction and 10 days of regain period in 7 young athletes. The mean body weight change was -4.7 kg(5.0%) in the weight reduction period and -2.4 kg(2.5%) in the weight regain period compared to baseline value. Baseline level of leptin in athletes was 1.7±0.66 ng/ml, which was significantly correlated with body weight, BMI, percent body fat, body fat mass, triglyceride, insulin, and PAI-1. Baseline level of PAI-1 in athletes was 16.6±5.26 ng/ml, which was significantly correlated with body weight, BMI, triglyceride, insulin, and leptin. Leptin was decreased to 0.7±0.39(44% of the basaline value) in the weight reduction period, and increased to 1.9±0.64(119% of the baseline value) in the regain period. PAI-1 was decreased to 7.4±2.72(44% of the basaline value) in the weight reduction period, and increased to 22.8±7.33(138% of the baseline value) in the regain period. The changes of leptin during weight reduction period were significantly correlated with the changes of insulin(r=0.890, P<0.01) and triglycerides(r=0.874, P<0.01). The changes of PAI-1 during weight reduction period were significantly correlated with the changes of FFA(r=0.889, P<0.01) and triglycerides(r=0.869, P<0.05). The changes of both leptin and AAI-1 during weight regain period were significantly correlated with the changes of insulin(r=0.755 and 0.849, P<0.05, respectively). In summary, these results suggest that serum levels of leptin and PAI-1 were affected by weight cycling, the percentages of change were more greater than that of weight change, and rebound phenomena were occurred during weight regain period.

역행성 심정지 도관 삽입을 위한 술 중 경식도심초음파의 유용성

유미숙;최원주;김정원;박장수;김경태;김지연;어상일 인제대학교 2011 仁濟醫學 Vol.32 No.-

Background: Retrograde cardioplegia catheter (RCC) insertion is one of methods for administration of cardioplegics during cardiopulmonary bypass (CPB). However its success rate depends on only surgeon's experience. We thought the transesophageal echocardiography (TEE) can guide the R CC insertion, because TEE is commonly used for monitoring status of heart during cardiac surgery. This study was designed to evaluate the RC C insertion time by TEE guidance versus conventional method without T EE guidance. Methods: Sixty patients who were scheduled to undergo elective coronary artery bypass graft (CABG) surgery under general anesthesia were divided into groups as follows: group T [RCC insertion into coronary sinus (CS) by TEE guidance, n=30] and group C [RCC insertion into CS by conventional method, n=30]. We recorded the time of insertion of RCC in to CS in two groups. RCC insertion was done by TEE guidance in case that time was over two minutes by conventional methods in group C. Results: The overall time of RCC insertion into CS was 63.8 ± 23.6 seconds in the Group T and 102.3 ±55.7 seconds in the Group C, respectively (p=0.001). There were no complications during RCC into CS by T EE guidance. Conclusions: TEE guidance for RCC insertion into CS is shorten the time of insertion.

방사선조사와 Paclitaxel의 병합요법에 의한 신내막 과증식억제

장기육,승기배,강동헌,임상현,정해억,임효영,김태균,김연실,채장성,김재형,홍순조,윤세철,최규보 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

정신분열병 환자를 위한 인지재활훈련 프로그램의 개발 : Korean-Cognitive Differentiation Program 한국형 인지분화훈련 프로그램

현명호,안석균,이만홍,조현상,최충식,이연희,송선미,유계준,김장우,김태용,이희상 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구배경 : 정신분열병 환자들은 인지장애를 보이는바, 저자들은 이들을 대상으로 한국형 인지분화훈련 프로그램을 개발하여 정신분열병 환자들을 대상으로 인지재활훈련을 실시한 후 환자들의 인지기능, 정신병리 및 문제해결기술에 미치는 효과를 조사하였다. 방 법 : 28명의 정신분열병 환자를 훈련군(n=14)과 대조군(n=14)으로 나누어 훈련군에게 한국형 인지분화훈련 프로그램을 1회 60분씩, 주당 2회씩, 11주간 총 22회를 실시하였다. 환자들의 인지기능은 K-WAIS의 산수, 빠진곳찾기, 어휘, 공통점찾기 소검사로 측정하였고 정신병리는 양성 및 음성증상 척도로 측정하였으며 문제해결기술은 사회문제해결척도로 평가하였다. 인지재활훈련의 효과를 평가하기 위해 훈련 전후의 인지기능, 정신병리 및 문제해결기술의 변화를 종속변수로 하고 훈련 유무를 독립변수로 하여 반복측정에 의한 변량분석으로 자료를 분석하였다. 결 과 : 한국형 인지분화훈련이 시간에 따른 인지기능검사 중 산수 소검사, 문제해결기술 중 시회문제해결척도의 전체 점수와 문제해결기술 소척도의 점수의 변화에 유의한 영향을 미쳤으나, 시각적 주의력, 개념화 능력 및 정신병리의 점수의 변화에 유의한 영향을 미치지 않았다. 결 론 : 한국형 인지분화훈련 프로그램은 정신분열병 환자에서 청각적 주의력 및 문제해결기술의 호전을 꾀할 가능성이 있음을 시사한다. Objectives : The purpose of this study was to investigate the effects of cognitive differentiation training program- Korean version(a training program of attention and conceptual abilities) on cognitive function, psychopathology and problem solving skills in patients with schizophrenia. Methods : A total of patients diagnosed as schizophrenia using DSM-Ⅳ were randomly assigned to 2 groups. The training group went through a total of 22 sessions of cognitive differentiation training(60 min/ session×2 sessions/wk×11 wks). The attention-placebo control group received psychoeducation program during the same period. Arithmetic, vocabulary, similarities, picture completion of Wechsler Adult Intelligence Scale-Korean version, Positive and Negative Syndrome Scale, and Social Problem Solving Scales were administered to all patients, both before and after the training program. Results : In the arithmetic scores(F=6.35, af=1, p=0.018) of Wechsler Adult Intelligence Scale-Korean version, and total scores(F=6.35, af=1, p=0.018) and problem solving skill scale scores(F=4.88, af=1, p=0.036) of social problem solving scale, interaction effects of training was significant. Conclusion : Our findings suggest that cognitive differentiation training program-Korean version is effective on improving auditory attention and problem solving skills in patients with schizophrenia.

Partially purified <i>Curcuma longa</i> inhibits alpha-melanocyte-stimulating hormone-stimulated melanogenesis through extracellular signal-regulated kinase or Akt activation-mediated signalling in B16F10 cells

Jang, Ji Yeon,Lee, Jun Hyuk,Jeong, Seong Yun,Chung, Kyung Tae,Choi, Yung Hyun,Choi, Byung Tae Blackwell Publishing Ltd 2009 Experimental dermatology Vol.18 No.8

<P>Abstract: </P><P>Bioassay-guided fractionation of <I>Curcuma longa</I> by solvent partitioning and purification with octadecylsilane open column chromatography yielded a partial purification. The active 80% methanol chromatographic fraction from the ethyl acetate layer [partial purification from <I>C. longa</I> (PPC)] was used to investigate the alpha-melanocyte-stimulating hormone (&agr;-MSH)-stimulated melanogenesis signal pathway in B16F10 cells. In cells stimulated &agr;-MSH, PPC inhibited cellular melanin contents, tyrosinase activity and expression of melanogenesis-related proteins including microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related proteins (TRP). Melanogenesis-regulating signalling such as mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K)/Akt was activated by PPC in &agr;-MSH-stimulated B16F10 cells. The suppressive activity of PPC on &agr;-MSH-induced melanogenesis was abrogated by selective inhibition of MEK/ERK (PD98059) and PI3K (LY294002). MEK/ERK or Akt activation by PPC may contribute to reduced melanin synthesis via MITF and its downstream signal pathway including tyrosinase and TRPs in &agr;-MSH-induced melanogenesis.</P>

<i>neo</i>-Clerodane Diterpenoids from <i>Scutellaria barbata</i> and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

Yeon, Eung Tae,Lee, Jin Woo,Lee, Chul,Jin, Qinghao,Jang, Hari,Lee, Dongho,Ahn, Jong Seog,Hong, Jin Tae,Kim, Youngsoo,Lee, Mi Kyeong,Hwang, Bang Yeon American Chemical Society and American Society of 2015 Journal of natural products Vol.78 No.9

<P>Three new <I>neo</I>-clerodane diterpenoids (<B>1</B>–<B>3</B>) along with 12 known compounds (<B>4</B>–<B>15</B>) were isolated from a methanol extract of the aerial parts of <I>Scutellaria barbata</I>. The structures of <B>1</B>–<B>3</B> were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds <B>1</B>–<B>4</B>, <B>7</B>, and <B>10</B>–<B>12</B> were found to inhibit nitric oxide production with IC<SUB>50</SUB> values ranging from 20.2 to 35.6 μM.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2015/jnprdf.2015.78.issue-9/acs.jnatprod.5b00126/production/images/medium/np-2015-00126d_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np5b00126'>ACS Electronic Supporting Info</A></P>

The feasibility of fertility sparing surgery in women with advanced stage malignant ovarian germ cell tumors

( Tae-kyu Jang ),( Chi-heum Cho ),( Su-ah An ),( Dae-yeon Kim ),( Yong-man Kim ),( E Sun Paik ),( Tae-joong Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: To analyze the oncologic outcomes of women with advanced stage malignant ovarian germ cell tumors (MOGCTs). Methods: Women with advanced stage (FIGO stage III-IV) MOGCT were eligible for this study. Medical records about patients treated for advanced stage MOGCT between January 2000 and December 2016 at three centers were analyzed retrospectively. Results: 60 patients with advanced stage MOGCT met the inclusion criteria and the median age was 23 years (range, 7-73 years). Of these, 41 patients underwent fertilization sparing surgery (FSS), which was defined as the preservation of at least one adnexa and the uterus and 19 patients underwent non-fertilization sparing surgery (NFSS), which was defined as the removal of both adnexa or the uterus. The most common histologic type was yolk sac tumor (20 patients 33.3%), and 56 patients (93.3%) had stage III MOGCT. 7 patients (11.6%) had recurrent disease, and 4 patients (6.6%) died of disease. The 5-year disease-free survival (DFS) rate of all patients was 88.3%, and the 5-year overall survival (OS) rate was 90%. After surgery, all patients received adjuvant chemotherapy with bleomycin, etoposide, and cisplatin (BEP) (median, 4 cycles; range, 1-7 cycles). After a median follow-up time of 64.2 months (range, 4-210months), 5 patients recurred in FSS group, 2 patients recurred in NFSS group. The 5-year DFS rates were 87.8% and 89.5% after FSS group and NFSS group (p=0.83). The 5-year OS rates were 90.2% and 89.5%, respectively (p=0.987). No patient who underwent FSS had premature ovarian failure. Conclusion: The advanced stage MOGCT showed a good prognosis at the 5-year DFS and OS. Especially, there was no difference in 5-year DFS and OS between FSS and NFSS group. Even in an advanced stage, the oncologic outcomes of FSS were excellent and found to be non-inferior compared to those of NFSS. The advanced stage could not be the reason of abandoning fertility.

Electric-field-induced spin disorder-to-order transition near a multiferroic triple phase point

Jang, Byung-Kweon,Lee, Jin Hong,Chu, Kanghyun,Sharma, Pankaj,Kim, Gi-Yeop,Ko, Kyung-Tae,Kim, Kwang-Eun,Kim, Yong-Jin,Kang, Kyungrok,Jang, Han-Byul,Jang, Hoyoung,Jung, Min Hwa,Song, Kyung,Koo, Tae Yeon Nature Publishing Group 2017 Nature physics Vol.13 No.2

<P>The emergence of a triple phase point in a two-dimensional parameter space (such as pressure and temperature) can offer unforeseen opportunities for the coupling of two seemingly independent order parameters. On the basis of this, we demonstrate the electric control of magnetic order by manipulating chemical pressure: lanthanum substitution in the antiferromagnetic ferroelectric BiFeO3. Our demonstration relies on the finding that a multiferroic triple phase point of a single spin-disordered phase and two spin-ordered phases emerges near room temperature in Bi0.9La0.1FeO3 ferroelectric thin films. By using spatially resolved X-ray absorption spectroscopy, we provide direct evidence that the electric poling of a particular region of the compound near the triple phase point results in an antiferromagnetic phase while adjacent unpoled regions remain magnetically disordered, opening a promising avenue for magnetoelectric applications at room temperature.</P>