초오 약침 개발을 위한 백서 독성 연구 및 생리활성에 대한 연구

김성철,안성훈,김성하,이상관,송봉근,Kim, Sung-Chul,Ahn, Seong-Hun,Kim, Sung-Ha,Lee, Sang-Kwan,Song, Bong-Keun 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.1

Objective : We investigate toxicity of Aconiti ciliare tuber and antioxidant activity of Aconiti ciliare tuber Pharmacopuncture to develop safe Aconiti ciliare tuber Pharmacopuncture and find out the effect. Methods : In order to investigate toxicity of Aconiti ciliare tuberm, we administered Aconiti ciliare tuberm orally to rats and examined the survival rate, comparing with the survival rate of rats administered by Radix aconitum simmered with Semen Glycine and Radix Glycyrrhizae. We examined the in vitro biological activity of Aconiti ciliare tuber Pharmacopuncture, including the total polyphenol content, and ABTS radical scavenging. Results and Conclusions : The $LD_{50}$ of Radix aconitum simmered with Semen Glycine and Radix Glycyrrhizae was 9.0g/kg, on the other hand, the $LD_{50}$ of Aconiti ciliare tuberm was more than 15g/kg. The total polyphenol contents of Aconiti ciliare tuberm Pharmacopuncture was 2.31mg/L. The 2,2'-azinobis-3-ehtlbezothiazoline-6-sulfonic acid radical decolorization (ABTS) was 10.26%. We conclude that Aconiti ciliare tuberm is not highly toxic, Aconiti ciliare tuber Pharmacopuncture has a little antioxidant effect.

수순(水醇)추출법으로 조제된 오공 약침액의 생리활성 효과

김성철,서근영,이성원,박성주,김재효,안성훈,황성연,Kim, Sung-Chul,Seo, Geun-Young,Lee, Sung-Won,Park, Sung-Joo,Kim, Jae-Hyo,Ahn, Seong-Hun,Hwang, Sung-Yeoun 대한약침학회 2010 Journal of pharmacopuncture Vol.13 No.3

Reactive Oxygen Species(ROS) are continuously produced at a high rate as a by-product of aerobic metabolism. Since tissue damage by free radical increases with age, the reactive oxygen species(ROS) such as hydrogen peroxide($H_2O_2$), nitric oxide(NO). Several lines of evidence provided that ROS appears to cause to develop aging-related various diseases such as cancer, arthritis, cardiovascular disease. Our reserch objective was to examine the in vitro biological activity of Scolopendrid Pharmacopuncture, including the total poly-phenol content, DPPH radical scavenging, ABTS radical scavenging, Superoxide dismutase(SOD)-like activity, Nitrite scavenging ability. The total poly-phenol contents of Scolopendrid Pharmacopuncture was 35.859mg/L. Elctron donation ability on DPPH was 36.82%. The 2,2'-azinobis-3-ehtlbezothiazoline-6-sulfonic acid radical decolorization (ABTS) was 84.7%. The superoxide dismutase (SOD)-like activities of Scolopendrid Pharmacopuncture was 44.33%. The nitrite scavenging effects were pH dependent, and were highest at pH 1.5(45.2%) and lowest at pH 6.0(11.3%). We conclude that Scolopendrid Pharmacopuncture may be useful as potential sources of antioxidant.

X선영상증배관의 상대변환계수 측정에 관한 검토

김성철,신성일,이선숙,허준,김성수,Kim, Sung-Chul,Shin, Sung-Ill,Lee, Sun-Sook,Huh, Joon,Kim, Sung-Soo 대한방사선기술학회 1997 방사선기술과학 Vol.20 No.2

For the Evaluation of X-ray image intensifier, we measured radiation dose at input of I. I., brightness and fluorescence at output of I. I. by using X-ray exposure meter, optometer and fluorescence meter for the relative conversion factor. Especially, by using fluorescence meter, we could easily get relative conversion factor without having regulated machine by JIS. Since using, the quality of image intensifier is going down. Consequently, it needs continuous quality maintenance.

알콜과 각막상피절삭기를 이용한 각막 상피층 분리 및 창상치유 정도 비교

김성철,김웅재,정성근,Sung Chul Kim,Wung Jae Kim,Sung Kun Chung 대한안과학회 2006 대한안과학회지 Vol.47 No.8

Purpose: Laser epithelial keratomileusis (LASEK) is a refractive surgery technique in which the cornea is covered with the epithelial flap after keratectomy. However, there have been reports of tissue damage by the alcohol utilized in this procedure while preparing the epithelial flap, which has led to novel methods. One of these is the mechanical designing of the epithelial flap named epipolis laser assisted in situ keratomileusis (Epi-LASIK). This study evaluates the histologic features and wound healing process of the corneal flap using Epi-Tome, which is the epithelial cutter of the newly introduced Epi-Lasik. Methods: Twenty-four eyes of 12 dogs were devided into two groups. In one group (n=12), 20% alcohol was used and, in the other group (n=12), Epi-Tome (Gebauer, Germany) was used to make a corneal flap. The size change of a fluorescein-stained epithelial defect was followed postoperatively at 6, 12, 24, and 36 hours. Results: The maximum decrease in defect size were observed at 0 to 6 hours in the Epi-Tome group, and from 6 to 12 hours in the alcohol group; the value were 10.01±5.32 mm2 and 9.23±4.75 mm2 respectively. Histologic review revealed that there was less tissue damage and smoother cut edge in the Epi-Tome group compared to the alcohol group, and the adhesion between stroma and epithelium was faster in the Epi-Tome group. Conclusions: Mechanically detached corneal flaps had favorable chances of survival such that re-epithelialization occurred early in the postoperative phase. A few epithelial fragments at a corneal section plane prevent corneal opacification and minimize inflammatory reaction, thus reducing postoperative pain.

GIS를 이용한 개발지역 주변 하늘다람쥐 잠재서식지 평가

김성철,전영신,임춘우,정철운,Sung Chul Kim,Young Shin Jeon,Chun Woo Lim,Chul Un Chung 한국환경과학회 2023 한국환경과학회지 Vol.32 No.5

In this study, 12 environmental factors were used to evaluate the potential habitat of Pteromys volans living around some development areas. The analyzed value ranged from 0 to 20.1, and the area with a score of 10 or less was analyzed to have a low possibility of inhabiting Pteromys volans. To verify the analyzed results, a field survey was conducted on areas with 10 or more scores, and traces of habitat of Pteromys volans were confirmed in areas with 16 or more scores. All the areas with an evaluation score of 16 or higher showed high crown density and age class. However, despite the high crown density and age class, the evaluation score in some areas was low owing to the influence of other environmental factors. Therefore, in evaluating Pteromys volans habitats, it is necessary to apply various and complex criteria suitable for field conditions rather than applying uniform and fragmentary environmental factors only.

편마비 환자의 트레드밀과 체중지지의 트레드밀 훈련이 균형능력 및 보행능력에 미치는 영향

김성철,허영구,Kim, Sung-Chul,Hur, Young-Goo 대한물리치료과학회 2018 대한물리치료과학회지 Vol.25 No.1

Purpose: The purpose of this study is to investigate and to verification of changes that the effect of treadmill and body weight support treadmill training on balance and gait ability for sub-acute stroke patients during 4 week. Method: 16 subjects who was diagnosed stroke were divided into 2 groups(8-treadmill training group, 8-body weight support treadmill group) by randomized control trial. Both training programs were consisted with 40 minuted, 5 times a week for 4 weeks and after training programs. Analysis: We analysed effects and changes on balance and gait ability. Analyses were performed using PASW ver. 18.0 and results were reported as mean ${\pm}$ standard deviation (S.D.). To investigate within group comparisons and to verification on effects of exercise, we did paired t test and repeated measured ANOVA test. Significance was set at p<.05. Result: Both training programs showed positive changes in Limit of Stability but significant results which is area of hemiside, area of intact side, area of posterior, total area were reported in body weight support treadmill training group. Changes of Berg Balance Scale was significantly increase and it had significant correlation between groups. Changes of 6 Minutes Walking Test was significant increase in both groups but there was no significant changes on Foot print and Romberg test. Conclusion: After considering all factors, both training programs showed effect on improvement of balance and gait ability in sub-acute stroke patients, but body weight support treadmill training group had better improvement in dynamic balance than treadmill training group. For the increase of balance and gait ability in sub-acute stroke patients, we need to continues study on difference of treadmill and body weight support treadmill and then we will give stroke patients a better satisfaction if we develop and provide a rehabilitation program for improvement of balance and gait ability.

침감(鍼感) 및 침향(鍼響)에 대한 문헌적(文獻的) 고찰(考察)

김성철,Kim, Sung-chul 대한침구의학회 2001 대한침구의학회지 Vol.18 No.3

Objective : To study needling sensation and the flow of the needling sensation the ancient and the present literatures were reviewed. Results : 1. The needling sensation was getting the Qi and a normal reaction of acupuncture. 2. The flow of the needling sensation was promoted the Qi and normalized the flow of the Qi 3. The needling sensation of a patient expressed soreness, distension, heaviness, numbness, tingling, flushing, fervor, chill, itching, and so forth. 4. The needling sensation of a patient expressed simple or complex syndrome. 5. The needling sensation of a doctor expressed objectively more than the needling sensation of a patient in the hand feeling of a doctor. 6. The doctor was compared good needling sensation and bad needling sensation. 7. The needling sensation and the flow of the needling sensation were processed continuously. 8. The needling sensation and the flow of the needling sensation were connected with a nervous system and expressed variously in the anatomical structure and hand acupuncture tenchnique.

경기론(經氣論)에 근거(根據)한 사상체질(四象體質) 형성(形成)에 관한 문헌적(文獻的) 고찰(考察)

김성철,Kim, Sung-Chul 사상체질의학회 2003 사상체질의학회지 Vol.15 No.2

Objective: The purpose of this study is to discourse upon that the construction of Sasang Constitutional Medicine has a significant property of Oriental Medicine by explaining the disparity of the viscera and bowels of four constitutions through the special quality of ying-qi and wei-qi circulating in human body on the basis of the channel-qi theory of ${\ulcorner}Huangdi$ $Neijing{\lrcorner}$ Conclusion: 1. Primordial-qi is the congenital essence inherited from the parents and pectoral-qi, ying-qi and wei-qi is the acquired essence derived from the food and air that human eat and breathe. 2. Ying-qi and wei-qi circulates in the meridian system by the strength and pushing of pectoral-qi under the influence of primordial-qi 3. Ying-qi, by the pushing function of pectoral-qi, determines large lung-small liver and small lung-large liver according to the innate quantity of qi and blood. 4. Wei-qi, by the pushing function of pectoral-qi, determines large spleen-small kidney and small spleen-large kidney according to the innate quantity of qi and blood. 5. The heart in the theory of the meridian system's fetus-nourishing and Sasang Constitutional Medicine is involved in the formation of viscera and bowels as governing human body and seven emotions. 6. It is considered that Taiyang person and Taiyin person have the constitution influenced by ying-qi. 7. It is considered that Shaoyang person and Shaoyin person have the constitution influenced by wei-qi. The inquiry into several literatures on the basis of the channel-qi theory of ${\ulcorner}Huangdi$ $Neijing{\lrcorner}$ leads us to the idea that the construction of Sasang Constitotional Medicine is another well-implied representation of the property of the meridian doctrine in the existing Oriental Medicine. And it is considered that the more continual studies of literatures and Sasang Constitutional Medicine Acupuncture are necessary henceforth.

Who' Calling the Shots on State AFDC Policy ; The Governor , the State Legislature or the Bureaucracy ?

김성철,Kyu Cheon Lee,Robert Jay Dilger (Sung Chul Kim) 한국정책학회 1996 한국정책학회 기타자료 Vol.1996 No.2

근위축성 측삭경화증에 대한 한방 치료의 임상선행연구

김성철,나원민,임나라,이도상,장은하,송봉근,Kim, Sung-Chul,Na, Won-Min,Lim, Na-Ra,Lee, Do-Sang,Jang, Eun-Ha,Song, Bong-Keun 대한약침학회 2009 Journal of pharmacopuncture Vol.12 No.1

Objectives : This study was to investigate the effect of Oriental medical treatment on ALS. Methods : We investigated 12 ALS patients which were admitted to Gwang-Ju O.M. hospital from Oct. 14, 2008 to Nov. 14, 2008. All patients were treated by SAAM-acupuncture, herb medication, Bee venom Pharmacopuncture therapy, Needle-embedding therapy, etc. We evaluated patients using the Amyotrophic lateral sclerosis Functional Rating Scale-Revised(ALSFRS-R), Medical Research Council (MRC) Scale. Results : After 30 days, mean ALSFRS-R score of patients was improved from $28.42{\pm}7.83$ to $29.08{\pm}7.99$, and mean MRC Scale of patients was improved from $24.79{\pm}8.37$ to $25.34{\pm}8.45$. But in both cases, the variation was not statistically significant. After 30 days, mean ALSFRS-R score and mean MRC Scale of patients was more improved in subjects with bulbar-onset, onset age: 51-60yrs., disease duration: 24-48mo. And the results showed partially significant difference. Conclusions : We think that the results of this case be a pilot study that proves the effect of Oriental Medical treatment on ALS.