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      • 2LO-9 Multiplexed digital assay in a three-dimensional paper-based microfluidic analytical device

        정성근,진시형,이병진,심규락,김동영,강소립,이창수 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1

        Here, we demonstrate 3-dimensional (3D) paper-based microfluidic channels to control 3D flow for automatic multiplexed digital assay. The 3D channels were fabricated by double-sided printing and lamination process. We print and laminate asymmetrical and symmetrical wax patterns on the paper to form 3D channels, and to create 3D fluidic flow for multiplexed digital assay. The 3D channels contains lateral and vertical channel. The asymmetrical wax-patterns form lateral and vertical channels. The symmetrical wax-patterns form vertical channels when the melted wax make contact with each other. We injected red dye into inlet of channels to track 3D capillary flow in the 3D channel. We conformed that the 3D fluid flow in a thickness of a paper. Based on this concept, we created 3D devices for automatic digital assay to detect glucose and albumin. Therefore, we expect that this method could be an instrument-free and multiplexed assay format for use in developing countries.

      • KCI등재

        세계화(世界化)를 향한 패션사진(寫眞)의 방향 모색(方向 模索)

        정성근 한국사진학회 1999 AURA Vol.6 No.1

        최근의 패션사진은 엄격한 의미에서 패션의 개념을 벗어나 다른 장르의 예술에서처럼 인접분야의 경계를 넘나들고 있다. 연극적 시도, 움직임, 주제에서 벗어나기 등과 같이 패션사진은 더 이상 패션에 대한 보고서로서 존재하는 것이 아니라 완전히 독립된 하나의 예술이 되고 있다. 즉, 20세기말의 패션사진은 창조적 경향이 강하여 옷 자체의 실루엣보다는 디자이너가 표현하고자 하였던 옷의 이미지를 감성적으로 형상화하는데 더 비중을 두고 있고, 앞으로의 패션사진은 단순히 패션사진에 머무르지 않고 디지털 이미지와 상호 소통방식을 가지는 멀티미디어로서의 그 이미지가 확장되어 가고 있는 만큼 그에 대비하기 위한 여러 각도의 검토가 필요하다고 본다. 본 연구의 목적은 사회적 커뮤니케이션으로서의 패션사진, 특히 의상을 소재로 한 패션사진의 개론적 고찰과 패션사진이 어떻게 표현되고 있는가를 분석하여 국내 패션사진이 직면하고 있는 여러 가지 한계와 문제점을 살펴보고 21세기 패션사진의 방향을 모색 하고자 하는 것이다. 본 연구를 통해 고찰하고 분석한 결과 국내 패션사진의 몇 가지 두드러진 현상과 문제점은 다음과 같다. 1. 아직도 세계화에 역행하는 모방차원에서 벗어나지 못하고 있으며 독창적인 패션사진이 드물다. 2. 국내 패션사진은 상당수가 스튜디오에 대한 고정관념을 탈피하지 못하고 있다. 3. 광고주의 인식부족으로 사진가만의 연출의도가 자유롭게 표현되지 못하고 있다. 4. 전통문화의 수용 부족으로 국적있는 패션이미지가 부족하다. 5. 응용사진인 패션사진이 실험적 창작사진 앞에서 아직도 사진 예술의 한 장르로 인정받기보다는 비판적인 시각이 많다. 본 연구 결과 21세기 패션사진 방향을 모색하기 위해 다음과 같이 제언을 하고자 한다. 1. 미래의 패션사진가는 아트 디렉터로서, 이미지 메이커로서의 전문성을 갖추어야 한다. 2. 철학적이고 기술적인 바탕 위에서 패션문화의 사회성을 인식한 독창적인 패션사진을 창조할 수 있어야 한다. 3. 디지털 사진과 컴퓨터 영상의 도입에 따른 기술적인 측면을 광범위하게 대처할 수 있어야 한다. 4. 전통문화에 대한 깊은 이해를 바탕으로 국적있는 패션문화 형성에 이바지할 수 있어야 한다. Freeing itself from strictly defined concept of fashion, fashion picture frequents it's neighbor field as other genres of art do. With dramatic attempt, motion, thematic deviation, fashion picture does not exist to seine as a mere report on fashion any more. It rather has become a completely independent entity of art Showing the strong trend toward creativity, fashion picture at the end of the 20th century places more stress on shaping emotionally the image of clothes which the designer tries to express rather than represent the silhouette of clothes itself. In addition, fashion picture will not remain mere fashion picture but will add the multimedia features to it's own image having interface with the digital image. Therefor, the diversified study is necessary to prepare for this trend. It is the goal of this work to introductorily study fashion picture as the means of social communication, especially with dresses being it's subject matter, and to analyse how it is expressed in order to see the restraints and problems it faces and search for the direction the 21st century's fashion picture should take. After thorough examination and analysis, there have been revealed such notable phenomena and problems as follows; 1.There hardly are the creative fashion pictures due to lack of effort to overcome the status quo of the imitation level, which betrays the wish of the globalization. 2. Not a few of the domestic fashion pictures abandon the stereotype sticking to the studies. 3. Sponsors' poor understanding prevents the fashion photographers from expressing their intention to the full. 4. The lukewarm attitude to the traditional culture makes it hard to secure the fashion image representing the nation identity. 5. Fashion picture as the application picture is not approved of as a genre of art compared with the experimental creative picture. Rather many critical opinions against it still are predominant. In an attempt to search for the direction of the fashion picture of the 21st century, based on this study we now suggest an answer to it as follows: 1. Fashion photographer of the future as an art director and image maker should prepare himself with speciality. 2. Understanding the social cause of the fashion culture on the philosophic and technical ground, the fashion picture photographer should be able to create an unique fashion picture. 3. Fashion picture should be able to brace for the wide spectrum of technical trend entailed by the introduction of digital picture and computer image. 4. Fashion picture should be able to contribute to forming the local fashion picture culture with the deep understanding of the traditional culture.

      • KCI우수등재
      • KCI등재
      • KCI등재

        5-[(3-Carboxy-4-hydroxyphenyl)diazenyl] nicotinic acid, an azo-linked mesalazine-nicotinic acid conjugate, is a colon-targeted mutual prodrug against dextran sulfate sodium-induced colitis in mice

        정성근,주상현,박소희,정연진 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.3

        Purpose We aimed to develop a 5-aminosalicylic acid (5-ASA, mesalazine)-based anti-colitic drug with higher efficacy than sulfasalazine (SSZ), a colon-targeted prodrug of 5-ASA, for the treatment of inflammatory bowel disease (IBD). To this end, we synthesized a colon-targeted mutual prodrug (ASA-azo-NA) consisting of 5-ASA and the GPR109A agonist nicotinic acid, 5-[(3-carboxy-4-hydroxyphenyl)diazenyl] nicotinic acid. Methods In our previous study, oral gavage of ASA-azo-NA delivered 5-ASA and 5-aminonicotinic acid specifically to the large intestine in a 2,4-dinitrobenzene sulfonic acid (DNBS)-induced rat colitis model and ameliorated colonic damage and inflammation more effectively than oral SSZ. To increase the therapeutic convincibility of ASA-azo-NA for the treatment of IBD with multifactorial pathologies, the colon targetability and therapeutic activity of ASA-azo-NA were examined using a dextran sulfate sodium (DSS)-induced colitis mouse model with a different pathogenesis from that of DNBS-induced colitis in rats. Results ASA-azo-NA liberated 5-ASA in the cecal contents of mice while remaining stable in the small intestinal contents, with a cecal conversion rate and extent comparable to those of SSZ. Oral ASA-azo-NA and SSZ accumulated similar concentrations of 5-ASA in the cecum, indicating that ASA-azo-NA was delivered to and activated in the large intestine as efficiently as SSZ. In mice with DSS-induced colitis, oral ASA-azo-NA mitigated colonic damage and inflammation, as assessed using macroscopic and molecular indices, and was therapeutically superior to SSZ. Conclusion ASA-azo-NA acted as a colon-targeted mutual prodrug against DSS-induced mouse colitis. Thus, ASA-azo-NA may be therapeutically applicable to patients with IBD who are resistant to SSZ treatment.

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