원발성 유방암에서 Sodium Iodide Symporter의 발현과 ^(99m)Tc-MIBI 유방스캔의 관계

석주원,김성장,곽희숙,이창훈,김인주,김용기,배영태,김동수 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: hNIS는 갑상선 조직 외에 다른 조직들에서도 발현된다고 알려져 있다. 유방암 세포는 그런 조직들 중에 하나이며, 그에 의한 유방암의 방사성옥소치료의 가능성이 제시되고 있다. 본 연구에서는 유방암 조직에서 hNIS의 발현정도를 알아보고, ^99mTc-MIBI 유방스캔과 hNIS의 발현 정도와의 관계를 조사하여 보았다. 대상 및 방법: 본 연구에서는 유방암으로 수술을 시행했던 56명의 환자를 대상으로 하였다. hNIS의 발현은 면역조직화학염색에 의해서 평가되었으며, 그 결과를 ^99mTc-MIBI 유방스캔의 판정 결과와 비교하였다. 결과: 전체 56명의 환자에서 hNIS의 발현율은 41.1%였다. 병리학적 진단에 의해 침윤성관상피암종이었던 49명에서의 발현율은 42.9%, 관상피내암종이었던 7명에서의 발현율은 28.6%였다. ^99mTc-MIBI 유방스캔에서 국소섭취 소견이 관찰되었던 41명에서의 hNIS의 발현율은 31.7%였다. 비정상적인 섭취 소견이 관찰되지 않았던 15명의 환자에서의 hNIS의 발현율이 의미있게 높게 관찰되었다(66.7%, p>0.05). 결론: 유방암 환자에서의 hNIS의 발현율은 그다지 높지 않았다. ^99mTc-MIBI 유방스캔에서 섭취증가 소견이 없을 때 hNIS의 발현율이 더 높았다. Purpose: Human Na^+/I- symporter (hNIS) is known to be expressed in many tissues other than thyroid gland. The breast cancer cells are one of them and the possibility of radioiodine therapy in treatment of the breast cancer may be suggested. We investigated the expression rate of hNIS and the relationship between the expression of hNIS and the finding of 99mTc-MIBI scintimammography in the breast cancer. Materials and Methods: Surgically proved 56 patients with breast cancer were the subjects of this study. The expression of hNIS were evaluated by immunohistochemistry and the results were compared to the findings of 99mTc-MIBI scintimammography. Results: Overall expression rate of hNIS was 41.1% in 56 patients. According to the pathologic diagnosis, it was 42.9% in 49 patients with invasive ductal carcinoma and 28.6% in the 7 patients with ductal carcinoma in situ. The expression rate of hNIS in the 41 cases with a focal increased uptake at he breast lesion on 99mTc-MIBI scintimammogram was 31.7%. That in the 15 cases without any abnormal uptake on the scan was significantly higher(66.7%, p<0.05). Conclusion: The expression rate of hNIS in the patients with breast cancer was not so high. The rate was higher in the patients with no increased uptake at the breast lesion on 99mTc-MIBI scintimammography. (Korean J Nucl Med 2002;36;325-32)

日本地域의 農工學, 獸醫學 및 電子工學의 硏究動向

金照雄,李熙碩,許麟洙,李相祚,孫鉉 慶北大學校 1983 論文集 Vol.35 No.-

18世紀 農村의 社會構造 : 慶尙道 丹城縣의 경우

金錫禧,朴容淑 부산대사학회 1979 역사와 세계 Vol.- No.3

釜山市 都心地內 駐車場의 實態調査分析

金熙鍾,吳錫氣 동아대학교 공과대학 부설 한국자원개발연구소 1977 硏究報告 Vol.2 No.1

A Study on parking problems in metropolitan regions in Korea is a recent concern. In case of Busan, although the master plan for traffic was established in 1974 the and survey for the parking problems were not considered. In this study, the area for this survey was limitted to 3 on-street parking places in Busan C.B.D. The data Survey was carried out for 8 hours from 9.00 A.M. to 17.00 P.M. on 15th oct. 1976. The method of this survey was performed through continuous observation and interview by each vehicles. The Contents of the survey are necessary basic data for the establishment of parking plans such as parking time, parking purpose, parking use and kinds of vehicles, etc. The results of this study are summarized as follows; ① Average parking time~61.7 min. (By the continuous observation method) ② Parking purpose Business and Commercial;88.8% ③ Method of parking use~Daily thicket use:77.1%, Monthly ticket use:22.9% ④ Major kind of vehicle~Taxi:91.1% ⑤ Average parking index~l.30 ⑥ Average rotation index~9.5.

世祖朝의 徙民에 關한 考察(Ⅱ) : 下三道民의 北方徙民을 中心으로

金錫禧 부산대사학회 1980 역사와 세계 Vol.- No.4

인체 간 Microsome에서의 우슬 추출물의 Cytochrome P450 약물 대사효소에 대한 억제작용

김경아,이지숙,박히준,김진우,김창주,심인섭,한승무,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : Achyranthes bidentata radix (Usul) has been used as anti-arthritic, antiallergic, antidiuretic and so on Recently extracts of Achyranthes bidentata radix have shown anti-inflammatory and cancer preventive effects in vitro and in vivo. Methods : We therefore evaluated the inhibitory potential of ehtanol extracts of Achyranthes bidentata radix on cytochrome P450(CYP) isoforms-catalyzecd reactions, which relate to causes of cancer and inflammation, including CYP1A2, CYP2C9, CYP2C19, CYP2E1, CYP2D6, CYP2C8, and CYP3A4, using human liver microsomal preparations. Results : The extracts showed weak or negligible inhibitory effects on CYP2C9-catalyzed (S)-warfarin 7-hydroxylation, CYP2C19-catalyzed S-mephenytoin 4-hydroxylation, and CYP2D6-catalyzed dextromethorphan O-demethylation with each IC50 over 1750 g/㎖, respectively. However, it showed relatively significant inhibitory effect on CYP1A2-catalyzed phenacetin O-deethylation and CYP2E1-catalyzed chloizoxazone 6-hydroxylation with IC50s of 970.5 g/㎖ and 821.4 g/㎖, respectively. Conclusions : These results suggest that extracts of Achyranthes bidentata radix have inhibitory effects on CYP-catalyzed reactions, expeciallyCYP1A2 and CYP2E1, in human liver microsomes. These effects appear to relate to anti-inflammatory and cancer prevention following decrease of reactive oxygen species formed by CYP, especially CYP1A2 and CYP2E1, by Achyranthes bidentata radix. However, further evaluation is necessary to demonstrate and to confirm its effects in human.

甲狀腺機能亢進症에 있에서 RAIU, 血淸 T_3 및 T_4의 診斷的 意義

金熙宅,黃基錫 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.2

著者들은 1980年 6月부터 1980年 10月까지 慶北醫大附屬病院 核醫學科에서 診斷한 91例의 甲狀腺機能亢進症 患者에서 RAIU, 血淸 T_3, 血淸 T_4 및 T_4/T_3를 測定하고 이들의 診斷的 意義를 檢討하여 다음과 같은 結果를 얻었다. 1) RAIU에서는 91例中 84例에서 增加하였으나 나머지 7例에서는 正常 또는 正常 以下로 低下되었다. 2) 血淸 T_3値 및 血淸 T_4値는 全例에서 例外없이 增加하였다. 3) T_4/T_3에 있어서는 91例中 79例에서 血淸 T_3値가 血淸 T_4値보다 不平衡하게 上昇하였다. 4) 甲狀腺機能亢進症에 있어서는 RAIU, 血淸 T_3 및 血淸 T_4 중 血淸 T_3가 가장 有用한 診斷的 檢査라고 생각되었다. The authors assessed a diagnostic value of RAIU, serum T_3, T_4 and T_4/T_3 in 91 patient with hyperthyroidism seen from June 1980 and to October 1980 at the Department of Nuclear Medicine, Kyungpook National University Hospital with the following results: 1) The RAIU % increased in 84 cases out of the total 91 patients, the remainder being the normal range or rather decreased. 2) Both serum T_3 and T_4 levels increased in all patients. 3) T_4/T_3 determinations revealed a dispropotionate increased serum T_3 comparing with serum T_4 in 79 cases. 4) The serum T_3 determination is considered to be the most reliable test in the diagnosis of hyperthyroidism among RAIU, both serum T_3 and T_4.

제조기업의 해외직접투자 결정요인 분석

조희영,김령석 동국대학교 경제경영연구원 1996 經濟經營硏究 Vol.20 No.1

The borderless competition around the world has forced companies to adopt internationalization and globalization strategy for survival and growth. Foreign Direct Investment, as one of the strategies, is necessary for Korean firms to extend their market. therefore continue the sales growth and secure the necessary resources and technologies. Foreign Direct Investment(FDI) by Korean manufacturing companies has been increasing and reaches up to 602 million dollars, with 3521 cases as of July 1996. This paper examines the theoretical and empirical studies on the FDI theory, especially the determinants of FDI. Also, this paper analyze the determinants of FDI of Korean manufacturing firms on the basis of Dunning's eclectic theory. The purpose of the empirical section of this study is to analyze how ownership specific, location specific. and internalization incentive advantage have an influence the FDI and to explain the differences in the determinants by FDI firms size and invested countries. In the analysis, nine independent variables for three advantages and fourteen hypotheses are tested.. The data for the empirical analysis were collected by questionnaires on 78 FDI firms. To test the hypotheses, reliability tests, factor analyses, multiple regressions are used. The results are as fallows : First, ownership specific, location specific, and internalization incentive advantages increase the satisfaction on the FDI firm performance. Second, both for large and Small-medium firms, the above results are supported. Third, same results are supported for both developed and developing countries. Fourth, by firm size and invested countries, different variables are significant in changing the satisfaction level on the firm performance. In conclusion, ownership specific, location specific, and internalization incentive advantages in eclectic theory was supported empirically on Korean mannufacturing firms in determing FDI.

神門穴 鍼刺戟이 母性分離 스트레스로 야기된 攝食 障碍와 시상하부 neuropeptide Y 발현에 미치는 영향

박히준,류연희,홍미숙,김승태,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : The purpose of this study is to find out the effect of acupuncture at HT7(Shinmun) on the feeding behavior and hypothalamic neuropeptide Y(NPY) expression in the maternally separated rat pups. Methods : To show the effect of acupuncture, we performed maternal separation(MS) for 7 days beginning on postnatal day 14, and observed body weight, food intake, and NPY immunoreactivity in the paraventricular nucleus(PVN) of hypothalamus after acupuncturing at HT7, the end of the transverse crease of the ulnar wrist of the forepaw. Results : MS induced a significant decreases in body weight and food intake, while acupuncture treatment at acupoint HT7 showed much more improvement in those evaluations. NPY-immunoreactivity in area PVN were decreased in the MS group, but significantly increased in the HT7 group. Conclusions : These findings suggest that acupuncture has an effect on the feeding disorders caused by MS, possibly by modulating NPY expression in the PVN.

계지의 항염 효과에 관한 연구

박히준,이지숙,이재동,김남재,표지희,강전모,최일환,김수영,심범상,이제헌,임사비나 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : Cinnamomi Ramulus (CR), the young twing of Cinnamomi loureirii nees, has been used for treating symptoms related to pain. rheumatic arthritis and inflammation in Korean herb medicine. This study was carried out to investigate the anti-inflammatory effect of CR in vivo and in vitro. Methods : Extracts of CR were prepared and the chemical components of the extracts were examined by gas chromatography-mass spectrometry (GC-MS). The extracts were administrated to the rat paw edema model induced by carrageenan to evaluate the anti-inflammatory effect of CR. The expressions of nitric oxide (NO). prostaglandin E2(PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were also quantified in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages to survey the effect of CR in vitro. The main components were cinnamaldechyde and coumarin. Results : We examined the anti-inflammatory activity of the 80% ethanol extract of Cinnamomi Ramulus in vivo by using carrageenan-induced rat paw edema model. Maximum inhibition of 54.9% was noted at the dose of 1000㎎/㎏ after 2 hours of drug administration in carrageenan-induced rat paw edema and this showed a potent anti-inflammatory effect. Conclusions : The results showed that Cinnamomi Ramulus suppressed dose-dependently LPS-induced NO production in RAW 264.7 macrophages and also decreased iNOS protein expression. Cinnamomi Ramulus also showed a significant inhibitory effect in LPS-induced PGE2 production and COX-2 expression.