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진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과
정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2
Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.
기분장애를 주소로 내원한 Binswanger씨 병 1례
채정호,전태연,윤수정,최성빈,김대진,김광수 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1
We report a 70 year-old man with Binswanger's disease associated with mood symptoms. He was apparently well until 15 years ago when the treatment-resistant atypical mood symptoms had been appeared. He showed a fluctuating course in mental disturbance, such as irritable and labile affect, emotional incontinence, and irritable behavior. Two years ago, he was diagnose as hypertension, renal failure, and heart failure. He was admitted to psychiatric ward due to irritable mood, dysarthria, lack of bladder control, gait disturbance, and impulsive behaviors, which had been aggravated during the last 2 months. In physical examination, he had hypertension and both pretibial pitting edema was revealed, and also in neurological examination, exaggeration of deep tendon reflexes and weakness of extremities were found. On mental status examination, he showed irritable and labile mood with mild cognitive disturbances. Brain MRI demonstrated multifocal high signal intensity in periventricular white matter, both basal ganglia, and thalami on the T2 imaging. These findings were compatible with Binswanger's disease with mood symptoms.
Two Cases of Russell Body Gastritis Treated by Helicobacter pylori Eradication
Jung Bin Yoon,Tae Yeong Lee,Jin Sook Lee,Jong Min Yoon,Se Won Jang,Min Jung Kim,Su Jin Lee,김태오 대한소화기내시경학회 2012 Clinical Endoscopy Vol.45 No.4
Russell body gastritis was first defined in 1998, but not many cases have been reported since then. The exact causes and process of this condition are unknown yet; however, considering the reported cases, it has been highly suggested to have correlation with Helicobacter pylori infection. Russell body gastritis has a non-specific clinical presentation of gastritis such as gastric mucosal edema in the macroscopic view. It can be mistaken as xanthoma, signet ring cell carcinoma, or a malignant lymphoma including mucosa-associated lymphoid tissue lymphoma and plasmocytoma. Russell body gastritis features polyclonal immunoglobulin and is differentiated from Mott cancer, of which immune globulin has monoclonal aspect. Authors report here two cases of Russell body gastritis with examined endoscopic findings as well as a review of related literature on the association of all reported cases of Russell body gastritis with H. pylori infection.
Su-bin Lee,Eun Jung Thak,Jung Ho Kim,Seung Yeon Chung,Hyun Ah Kang 한국당과학회 2021 한국당과학회 학술대회 Vol.2021 No.01
The opportunistic human fungal pathogen Cryptococcus neoformans is the main causative agent of fungal meningoencephalitis in immunocompromised patients. The mannoprotein MP84 of C. neoformans, reported as an adhesion protein and as an immunoreactive antigen to host CD4(+) T cell, is highly mannosylated cell wall protein. In this study, we investigated the structure of N-glycans attached on MP84 and the effect of altered N-glycan structures on its interaction with host cells. We expressed the His tagged MP84 as a secretory form in WT and alg3Δ mutant, a N-glycosylation defective strain, to generate MP84 with the truncated core N-glycans. In in-vitro adhesion and uptake assay, the purified MP84 proteins carrying the truncated N-glycans did not show significant difference in host cell interactions compared to MP84 carrying the WT N-glycans. Moreover, we expressed a secretory MP84 lacking N-glycosylation site, constructed by protein engineering, to investigate the effect of full-deglycosylation on the interaction with MP84 with host cells. Aglycosylated MP84 revealed much higher adhesion affinity to host cells than MP84 carrying the WT and truncated N-glycans. On contrast, aglycosylated MP84 still retains the cytokine induction activity comparable to WT, although MP84 with truncated N-glycans showed a decreased immunostimulatory activity. In conclusion, the mixed effects of N-glycan structures of MP84 on the interaction with host cells strongly suggest the modulatory role of N-glycans to avoid non-specific interaction with host cells.
정수빈(Su Bin Jung),황의홍(Euy Hong Hwang),최한빛(Han Bit Choi),이성은(Sung Eun Lee) 한국화재소방학회 2022 한국화재소방학회 학술대회 논문집 Vol.2022 No.추계
2015년 화재안전기준(NFSC203)의 개정으로 연기감지기의 설치범위가 특정소방대상물의 거실로 확대되며 연기감지기의 수요 및 공급이 늘어나는 추세이다. 국내의 연기감지기 감도시험은 감지기의 형식승인 및 제품검사의 기술기준 제19조에 의거하여 실시된다. 이에 본 연구는 연기감지기의 감도시험 시 내부환경의 특성을 분석 및 수치화하여 감도시험 개선 기반 기술자료로 활용하고자 수행하였다. 연기감지기의 감도시험은 작동시험 및 부작동시험을 별도로 진행하는데 실험 시 내부환경 측정하기 위한 센서를 시험 시 감지기의 설치 위치와 동일하게 설치하였다. 실내환경을 측정하기 위한 센서로는 CO, CO2, PM 1.0, PM 2.5, PM 10.0으로 구성하였다. 기준이 되는 광감율은 제2종 연기감지기의 시험조건을 설정하였고 감도시험기 내부에 셀레늄광전지를 이용한 감광식 농도계를 이용해 감광율을 측정하였다. 감광율 값은 작동시험에서는 기준광감율이 15%/m일 경우를 의미하고, 부작동시험에서는 기준감광율이 5%/m인 경우를 의미한다. 온⋅습도 및 풍속 조건 등 기타 조건은 기존 시험조건과 동일하게 구성하였다. 내부환경을 특성 분석결과로 측정한 센서값 중 CO, CO2, PM 10.0에 대해서 작동시험과 부작동시험에서 유의미한 차이가 있는 것을 확인하였다. 먼저, CO는 작동시험에서 6.40 ± 1.41 ppm의 범위로 진행되었고, 부작동시험에서는 5.43 ± 1.14 ppm의 범위로 진행되었다. 다음으로, CO2는 작동시험에서 6.40 ± 1.41 ppm의 범위로 진행되었고, 부작동시험에서는 5.43 ± 1.14 ppm의 범위로 진행되었다. 마지막으로 PM 10.0은 작동시험에서 7,837 ± 169 ㎍/㎥ 범위로 진행되었고, 부작동시험에서는 4,959 ± 219 ㎍/㎥의 범위로 진행되었다. 결론적으로 추후 발전된 감도시험으로 기준을 개선하기 위해서는 실험결과를 바탕으로 감도시험기 내부환경에 대한 기술적 사항으로 추가하여 시험이 진행되어야 한다고 판단된다. 또한 감도시험에 내부환경 특성에 대한 기술적 사항이 추가된다면 CO 등을 활용한 복합형화재감지기의 개발에 적용할 수 있는 기준으로도 활용할 수 있을 것으로 판단된다.
청소년의 신체적 유능감, 자아존중감, 공동체의식, 학교생활적응의 구조적 관계 모형
정수빈(Jung, Su-Bin),김지태(Kim, Ji-Tae),김은성(Kim, Eun-Sung) 한국웰니스학회 2016 한국웰니스학회지 Vol.11 No.3
이 연구에서는 청소년의 신체적 유능감이 학교생활적응을 설명하는 데에 있어 자아존중감과 공동체의식이 어떠한 매개효과를 지니는지를 규명하는데 목적을 두고, 신체활동을 통한 종합적인 학교생활적응을 설명하는 이론적 모형을 제시하고자 한다. 연구 대상자는 중학교와 고등학교에 재학 중인 청소년들로 선정하였고, 중학교 3개소, 고등학교 3개소에서 집락표집을 실시하여 총 370명의 자료를 분석하였다. 수집한 자료의 처리는 SPSS 21.0과 Amos 20.0 프로그램을 사용하였고, 측정모형과 구조모형을 통해 가설을 검증하였다. 이 연구목적에 따른 결론은 다음과 같다. 신체적 유능감은 긍정적 자아존중감과 부정적 자아존중감에 각각 정적인 영향과 부적인 영향을 미치는 것으로 나타났고, 공동체의식에도 정적인 영향을 미치는 것으로 나타났다. 또한 긍정적 자아존중감은 공동체의식과 학교생활적응에 모두 정적인 영향을 미치는 것으로 나타났고, 부정적 자아존중감은 공동체의식에는 통계적으로 유의한 영향을 미치지는 않았지만, 학교생활적응에 부적인 영향을 미치는 것으로 나타났다. 아울러 공동체의식은 학교생활적응에 정적인 영향을 미치는 것으로 나타났다. 이를 통해 신체적 유능감을 높일 경우 긍정적 자아존중감, 공동체의식, 학교생활적응 모두가 증가하므로, 신체적 유능감을 높일 수 있는 다양한 전략 및 방안을 마련해야 할 것이다. The purpose of this study was to determine the mediating effects of self-esteem and community spirit on explaining school adjustment by means of physical competence of adolescents. Research participants were selected from adolescents attending middle schools and high schools; and to collect data, purposive sampling was carried out at 3 middle schools and 3 high schools, and data from 370 participants were analyzed. For data process, SPSS 21.0 and Amos 20.0 programs were used to verify hypothesis. The conclusions were as follows: Physical competence had a positive and a negative effect on positive self-esteem and negative self-esteem respectively; it also had a positive effect on community spirit. Positive self-esteem had a positive effect on both community spirit and school adjustment; negative self-esteem did not have a statistically significant effect on community spirit, but had a negative effect on school adjustment. And community spirit had a positive effect on school adjustment. In that case, positive self-esteem and community spirit were statistically significant parameters in the relationship between physical competence and school adjustment. The results of this study showed that if physical competence was enhanced, positive self-esteem, community spirit, and school adjustment could be also increased. Therefore, diverse strategies and measures should be prepared to enhance physical competence.