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Aaron Rae Stephens(Aaron Rae Stephens),Min-Hyo Kang(Min-Hyo Kang),Charles Arthur Robb(Charles Arthur Robb) 동아시아무역학회 2022 Journal of East Asian Trade(JEAT) Vol.4 No.1
Purpose – Supply chain disruptions have dominated business planning and performance since the beginning of the COVID-19 pandemic and continue to mar organizations through 2022. This research carefully examines the role of organizational culture in developing both supply chain resilience and market performance amid supply chain disruptions. Design/Methodology/Approach – An empirical study of over 200 South Korean firms were tested. The model is tested using PLS-SEM; furthermore, mediation effects enrich the quality of the findings. This research is framed utilizing the stimulus-organism-response model; thus, emphasizing the highly dynamic business environment that has ensued. Findings – The research confirms that supply chain disruption orientation, a strategic orientation and a proxy for a well-prepared organizational culture, leads to both supply chain resilience and market performance. Results also confirm that resilience reinforces market performance throughout the supply chain. Study contributions suggest that firms should consider themselves as organisms within a highly dynamic environment and develop a highly prepared organizational culture in order to bolster supply chain resilience and market performance. Research Implications – Scholars can further employ the stimulus-organism-response model in firm-level research and further study the link between organizational culture and supply chain performance amid COVID-19. Finally, the results of this research provide guidelines for organizations when they decide on operational procedures during the pandemic, as they aim to produce greater returns for their ventures.
Min Ju Park,이은경,허형삼,Min-Sun Kim,성보경,Mi Kyung Kim,이재원,김남득,Stephen Anton,최재수,Byung Pal Yu,정해영 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.2
Kaempferol, one of the phytoestrogens, is found in berries and Brassica and Allium species and is known to have antioxidative and anti-inflammatory properties. In the present study, we examined the molecular mechanisms underlying the anti-inflammation effect of kaempferol in an aged animal model. To examine the effect of kaempferol in aged Sprague-Dawley rats, kaempferol was fed at 2 or 4 mg/kg/day for 10 days. The data show that kaempferol exhibited the ability to maintain redox balance. Kaempferol suppressed nuclear factor-κB (NF-κB) activation and expression of its target genes cyclooxygenase-2, inducible nitric oxide synthase, monocyte chemoattractant protein-1, and regulated upon activation, and normal T-cell expressed and secreted in aged rat kidney and in tert-butylhydroperoxide-induced YPEN-1 cells. Furthermore, kaempferol suppressed the increase of the pro-inflammatory NF-κB cascade through modulation of nuclear factor-inducing kinase (NIK)/IκB kinase (IKK) and mitogen-activated protein kinases (MAPKs) in aged rat kidney. Based on these results, we concluded that anti-oxidative kaempferol suppressed the activation of inflammatory NF-κB transcription factor through NIK/IKK and MAPKs in aged rat kidney.
Park, Min-Ju,Lee, Eun-Kyeong,Heo, Hyoung-Sam,Kim, Min-Sun,Sung, Bok-Young,Kim, Mi-Kyung,Lee, Jae-Won,Kim, Nam-Deuk,Anton, Stephen,Choi, Jae-Sue,Yu, Byung-Pal,Chung, Hae-Young The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.2
Kaempferol, one of the phytoestrogens, is found in berries and Brassica and Allium species and is known to have antioxidative and anti-inflammatory properties. In the present study, we examined the molecular mechanisms underlying the anti-inflammation effect of kaempferol in an aged animal model. To examine the effect of kaempferol in aged Sprague-Dawley rats, kaempferol was fed at 2 or 4 mg/kg/day for 10 days. The data show that kaempferol exhibited the ability to maintain redox balance. Kaempferol suppressed nuclear factor-${\kappa}B$ (NF-${\kappa}B$) activation and expression of its target genes cyclooxygenase-2, inducible nitric oxide synthase, monocyte chemoattractant protein-1, and regulated upon activation, and normal T-cell expressed and secreted in aged rat kidney and in tert-butylhydroperoxide-induced YPEN-1 cells. Furthermore, kaempferol suppressed the increase of the pro-inflammatory NF-${\kappa}B$ cascade through modulation of nuclear factor-inducing kinase (NIK)/$I{\kappa}B$ kinase (IKK) and mitogen-activated protein kinases (MAPKs) in aged rat kidney. Based on these results, we concluded that anti-oxidative kaempferol suppressed the activation of inflammatory NF-${\kappa}B$ transcription factor through NIK/IKK and MAPKs in aged rat kidney.
렛트에서 단기간의 갑상선 기능 변화에 따른 혈중 렙틴 농도의 변화
김민선,윤초야,조영민,정혜승,신찬수,박경수,김성연,조보연,이홍규,Stephen R. Bloom 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2
Background: Leptin, an adipocyte derived hormone, and thyroid hormone have similar effects on energy homeostasis, such that a shortage of both hormones is associated with decreased energy expenditure and increased body weight. Therefore, for the maintenance of energy homeostasis may require a close interaction between leptin and thyroid hormone. This study was performed to investigate the change in plasma leptin levels relating to short-term thyroid manipulation causing no significant change in body weight. Methods: Hypothyroidism was induced by surgical thyroidectomy and hyperthyroidism by subcutaneous injection of 50 g of L-T_3/100 g body weight/day, for 5 days, in 6∼8 weeks old male Wistar rats. Body weights and food intakes were monitored daily until sacrifice. Plasma samples were collected, and the thyroid stimulating hormone (TSH), free triiodothyronine (T_3) and leptin levels measured. The plasma leptin levels in rats with hypothyroidism and hyperthyroidism were compared with those of body weights at death and food intakes during the study, atched controls. Results: The rats treated with L-T_3 consumed equal amount of food as freely fed, rats but their final body weights were significantly lower (L-T_3 treated 220.0±1.8 vs. freely fed 226.0±2.0 g, p<0.05). There was no difference in food intake during study, and final body weight, between the thyroidectomised rats and their paired controls (thyroidectomised 220.4±1.7 vs. paired 223.9±4.7g, P=NS). Plasma leptin levels in the L-T3 treated rats were significantly lower than those in freely fed rats (L-T3 treated 1.7±0.1 vs. freely fed 4.8±0.2 ng/ml, p<0.005). Conversely, the thyroidectomised rats had higher plasma leptin levels, compared to those of their paired controls (thyroidectomised 4.8±0.3 vs. paired 1.7±0.1 ng/ml, p<0.005). Conclusion: The Plasma leptin levels in the rats were decreased by short term hyperthyroidism, while they were increased by short term hypothyroidism. These findings suggest that thyroid hormones may affect the production or secretion of leptin
Min Shen,H. Dean Hosgood,Luoping Zhang,이경무,Roel Vermeulen,Guilan Li,Songnian Yin,Nathaniel Rothman,Stephen Chanock,Martyn T. Smith,Qing Lan 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.6
Benzene, a recognized hematotoxicant and carcinogen,can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149gene regions of six pathways were included in the analysis. Six gene regions were significant for their association with white blood cell (WBC) counts (MBP,VCAM1, ALOX5, MPO, RAC2, and CRP) based on gene-region (P < 0.05) and SNP analyses (FDR <0.05). VCAM1 rs3176867, ALOX5 rs7099684, and MPO rs2071409 were the three most significant SNPs. They showed similar effects on WBC subtypes, especially granulocytes, lymphocytes, and monocytes. A 3-SNP block in ALOXE3 (rs7215658, rs9892383, and rs3027208) showed a global association (omnibus P =0.0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary.
( Stephen Gyung Won Lee ),( Hui Jai Lee ),( Jonghwan Shin ),( Kyoung Min You ) 대한응급의학회 2020 대한응급의학회지 Vol.31 No.2
Objective: Practice guidelines for diverticulitis have been developed in countries where left-colon diverticulitis is dominant, but there is limited information on right-colon diverticulitis. This study examined the clinical characteristics and risk factors of clinically severe right-colon diverticulitis. Methods: A retrospective chart review of patients diagnosed with diverticulitis in an emergency department in Korea between 2013 and 2017 was performed. Clinically severe diverticulitis was defined as any cause of death, intensive care unit admission, surgery, or invasive intervention due to diverticulitis, and admission for seven or more hospital days. Multivariable logistic regression was used to identify the risk factors for clinically severe diverticulitis. Results: This study analyzed 302 patients. Patients with older age (odds ratio [OR], 1.044; 95% confidence interval [CI], 1.009-1.080; P=0.013), complications observed on computed tomography (CT) (OR, 6.906; 95% CI, 2.514-18.968; P<0.001), rebound tenderness on a physical examination (OR, 2.542; 95% CI, 1.041-6.218; P=0.041), high alkaline phosphatase (ALP) levels (OR, 1.014; 95% CI, 1.002-1.026; P=0.026), and high C-reactive protein (CRP) levels (OR, 1.095; 95% CI, 1.017-1.178; P=0.013) were at higher risk of clinically severe diverticulitis. Conclusion: Among patients diagnosed with right-colon diverticulitis in the emergency department, those of older age, distinct complications on CT, rebound tenderness on physical examination, high ALP, and high CRP levels are related to clinically severe disease.