HBx형질전환 생쥐에서 발생한 간세포암종에서 H-ras 및 c-myc의 발현에 관한 연구

문형배,소병준,김학철,윤기중,한원철,조향정,유대열,정영진 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

<연구목적> HBx형질전환 생쥐에서 발생한 간세포암종의 발암과정에 종양유전자(H-rgs, c-myc)의 발현 정도를 조사하고자 하였다. <연구방법> 정상생쥐 12마리(4-18개월) 및 HBx 형질전환 생쥐 44마리(4-18개월)를 대상으로 포르말린에 고정하고 파라핀에 포매한 간 조직을 이용하여 면역조직화학적염색을 실시하였다. 실험군은 정상 부위, 이형성 부위 및 종양 부위로 구분하였으며, 종양 부위는 소결절성병변 부위와 간세 포암종 부위로 구분하였고, 이형성병변 부위는 이형성병변만 발견되는 부위, 소결절성병변과 동반된 이형성병변 부위 및 간세포암종과 동반된 이형성병변 부위로 구분하였다. <연구결과> H-rgs의 발현은 정상 간조직에 비하여 이형성병변 부위(P<0.05) 및 종양 부위(P<0.01)에서 증가하였으며, 소결절성병변 부위과 간세포암종 부위 사이에서는 간세포암종 부위에서 증가된 경향이었으나 통계학적으로 유의한 차이가 없었으며, 각 이형성병변 부위 사이에서도 유의한 차이는 없었다. c-myc의 발현은 정상 간조직 및 이형성병변 부위에 비해 종양 부위에서 증가하였으며(P<0.001), 소결절성병변 부위와 간세포암종 부위에서는 비슷하였고, 각 이형성병변부위 사이에서도 비슷하였다. <결론> HBx형질전환 생쥐에서 발생하는 간세포암종의 발생에 H-rgs는 이형성 변화를 일으키는 시기에 관여하며, c-myc은 이형성병변에서 암으로 이행하는 시기에 관여할 것으로 생각한다. Background: This experiment was designed for the expression of H-ras and c-myc in hepatocarcinogenesis of the HBx transgenic mice. Methods: Immunohistochemical stains in the paraffin embedded tissue of the liver were used for the detection of H-ras and c-myc in the 12 normal mice and 44 HBx transgenic mice of the 4-18 month old. Results: Expression of the H-ras was significantly increased in the dysplastic area (P<0.05) and tumor area (P<0.01) than in the normal liver. But there were no differences of H-ras expression between areas of microscopically identified hepatocellular carcinoma (MI-HCC) and grossly identified hepatocellular carcinoma (GI-HCC) and dysplastic areas among the only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Expression of the c-myc was significantly increased in the tumor area (P<0.001) than in the normal liver and dysplastic area. But there were no differences of c-myc expression between areas of MI-HCC and GI-HCC, and dysplastic areas among only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Conclusions: Our study suggests that H-ras is related to the dysplastic change and c-myc is related to the neoplastic change in the hepatocarcinogenesis of the HBx transgenic mice.

성인 암환자의 질병 특성에 따른 증상발생 정도

허혜경,이은현,이원희,소향숙,정복례,강은실 성인간호학회 2002 성인간호학회지 Vol.14 No.3

Purpose: This study was to investigate symptom occurrence related to the disease characteristics of patients with cancer. Method: A total of 301 patients with cancer participated in this study. The participants were recruited from University Hospitals located in Seoul, Wonju, Kwangju, Daegu, and Pusan. Data collection was performed by using a questionnaire on symptom occurrence. The obtained data was analyzed using SPSS computer program that included descriptive statistics, Pearson correlation, one-way ANOVA, and t-test. Result: The mean score of fatigue was the highest (3.24), followed by loss of appetite, lack of concentration, change in appearance, pain, insomnia, change in bowel pattern, nausea/vomiting, coughing, and dyspnea. Most symptoms were significantly correlated with each other. The level of symptom occurrence in patients with lung cancer or cervix cancer was significantly higher than the level in patients with stomach cancer. Patients receiving radiation therapy or a combined therapy of radiation therapy and chemotherapy experienced significantly higher level of symptom occurrence significantly higher level of symptom occurrence than those receiving chemotherapy only. Also, female patients experienced higher level of symptom occurrence than male patients did. Conclusion: The sites of cancer, types of treatment, and gender influence the level of symptom occurrence of patients with cancer. Thus, these variables should be considered when assessing and planing for symptom occurrence of patients with cancer.

Keratoconus With Unilateral Horizontal Stress Lines

Chung, So-Hyang,Kim, Eung Kweon Lippincott Williams Wilkins, Inc. 2005 Cornea Vol.24 No.7

Menkes 병의 뇌 자기공명 영상 및 자기공명 혈관 조영술의 소견

정소희(So Hee Chung),이문향(Mun Hyang Le),윤혜경(hye Kyung Yoon),김보경(BoKyung Kim),정희정(Hee Jung Chung) 대한소아신경학회 1998 대한소아신경학회지 Vol.6 No.1

저자들은 심한 발달 저하 및 발작을 주소로 방문한 8개월 남아에서 특징적인 머리카락, 혈액, 소견 등을 통해 드문 질환으로 알려진 Menkes 병을 진단하였고 또한 Menkes 병의 특징적인 뇌 자기공명 및 자기공명 뇌혈관 조영술의 소견을 보고하는 바이다. 자기공명 뇌혈관 조영술은 이 병이 의심되는 환아에서 조기 진단을 내릴 수 있는데 도움이 될뿐만아니라 추적 검사시에도 유용할 것으로 사료된다. Menkes disease is an X-linked recessively inherited neurodiegenerative disorder of copper metabolism leading to death in early childhood. This disease is characterized by low serum, liver and brain Cu levels, whereas the Cu content in nearly all other organs is increased. the main clinical features are irregular kinky hair, characteristic face, progressive degeneration of the central nervous system, bone changes, arterial rupture and thrombosis, and instability of temperature. We have experienced a case of Menkes disease in a eight months old male patient, who manifested by seizure, developmental delay, hypotonia, characteristic hair and face along with low lwvels of serum copper and ceruloplasmin. We report the characteristic findings of cranial MRI and MR angiography in this Menke's patient. I n cranial MRI, he showed progressive brain atrophy with subdural hemorrhage and effusion. MR angio-graphy revealed tortuosity of vessels clearly obviating necessity of more invasive conventional arteriography in diagnosis of this disease. This study suggested that cranial MRI and especially MR angiography might be helpful in making early diagnosis of this disease.

간전이를 일으킨 원발성 회장선암 1예

정인식,양진모,정규원,최명규,송윤상,선희식,송소향,채현석 대한소화기내시경학회 1990 Clinical Endoscopy Vol.11 No.1

Adenocarcinoma of small intestine is rare disease, but its incidence of iluem is the least of small intestinal adenocarcinoma. Its rarity and vague symptoms results in delayed diagnosis, treatment and poor prognosis, Recently we experienced a 65 years old man of ileal adenocarcinoma with liver metastasis, which does not obstuct intestinal lumen, We treat the metastatic tumor with chemoembolization(lipiodol and doxorubicin) through the hepatic artery and so we report the case with review of literature.

미만성 범세기관지염에서 흉부 고해상도 전산화 단층촬영의 임상적 의의 및 폐환기주사 소견

송소향 ( So Hyang Song ),김휘정 ( Hui Jung Kim ),김영균 ( Young Kyoon Kim ),문화식 ( Hwa Sik Moon ),송정접 ( Jeong Sup Song ),박성학 ( Sung Hak Park ),김학희 ( Hak Hee Kim ),정수교 ( Soo Kyo Chung ) 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.1

A comparison of ankle function between adults with and without Down syndrome

Yoon, Hyang-Woon,Yu, Tae-Ho,Seo, U-Hyeok,Lee, Jee-Won,Kim, So-Yeon,Chung, Soo-Jin,Chun, Hye-Lim,Lee, Byoung-Hee korean Academy of Physical Therapy Rehabilitation 2017 Physical therapy rehabilitation science Vol.6 No.4

Objective: The purpose of this study was to compare ankle function between adults with and without Down syndrome (DS). Design: Cross-sectional study. Methods: Ten adults with DS and 18 without participated in this study and underwent manual muscle test (MMT), range of motion (ROM) assessment, star excursion balance test (SEBT), and functional movement screen (FMS). The tests were demonstrated to increase their accuracy and the actual measurements were assessed after one or two demonstrations. To minimize the standby time and fatigue, the travelled distance and measuring order were adjusted. To remove the influence of shoes on the measurements, the shoes were taken off and only socks were worn. Results: Dorsal and plantar flexion MMTs of both ankles were significantly weaker and plantar flexion ROM of both ankles were significantly lower in adults with DS compared with those without (p<0.05). However, dorsal flexion ROM of both ankles were not significantly different between them. There were significant differences in distances measured in all the directions (anterior, anterolateral, lateral, posterolateral, posterior, posteromedial, medial, and anteromedial directions) of SEBT (p<0.05). Significant differences were also demonstrated in the scores of hurdle step, inline lunge, shoulder mobility, and rotary stability among the seven items of FMS (p<0.05). Conclusions: To enhance the dynamic stability of adults with DS, it is necessary to improve ankle stability by strengthening the ankle dorsal and plantar flexors.

내과적 질환에 병발된 반사성 교감신경계 위축 증후군 20 예의 분석

송소향(So Hyang Song),이정득(Jeong Deuk Lee),이상헌(Sang Heon Lee),홍연식(Yeon Sik Hong),조철수(Chul Su Cho),박동준(Dong Joon Park),정수교(Soo Kyo Chung),김호연(Ho Yun Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.5

N/A Reflex sympathetic dystrophy syndrome (RSDS) is an distinct symptom complex characterized by diffuse distal-limb pain, edema, vasomotor skin change and dystrophic skin change. It has been associated with limb-trauma, acute stoke, myocardial ischemia, peripheral neuropathy, phamacological agents such as phenobarbital and antituberculosis agents and malignancy. We report the clinical and radiological features of 20 patients who were diagnosed of RSDS at Kangnam Saint Mary's Hospital between January 198S and May 1991. The results were as fo1lows: 1)According to Kozin's criteria, seven (35%) are diagnosed of definite RSDS, eight (40%) of probable RSDS, and five (25%) of doubtful RSDS. 2) Disorders associated with RSDS were cerebrovascular disease (7 patients), malignancy (4 patients), myocardial ischemia (4 patients) and antituberculosis drug (2 patients). The remaining 6 padtients (30%) had no specific precipitating events. 3) Review of the Three phase bone scitigraphy (TPBS) for 20 patients indicated that nineteen of twenty patients (95%) has asymmetric and abnormal blood flow in TPBS. 4) Most patients were diagnosed early, therefore, had symptomatic relief without sequele such as flexion contracture of skin or subcutaneous atrophy by analgesics, steroid, calcitonin and physical therapy. In summary, the TPBS is a potentially sensitive and specific test to corroborate the diagnosis of RSDS and we can expect to have symptomatic relief without sequence if this disorder could be diagnased and treated, early.

Quality of Life Index-Cancer의 구성타당도 검증

소향숙(So, Hyang-Sook),이원희(Lee, Won-Hee),이은현(Lee, Eun-Hyun),정복례(Chung-Bok-Yae),허혜경(Hur, Hea-Kung),강은실(Kang, Eun-Sil) 한국간호과학회 2004 Journal of Korean Academy of Nursing Vol.34 No.5

대학생 글쓰기 수업에서의 학습관리시스템 활용 사례 연구 -블랙보드(Blackboard)를 중심으로-

이소라 ( So Ra Lee ),정인경 ( In Kyung Chung ),유미향 ( Mi Hyang Yu ),김중신 ( Jung Sin Kim ) 한국작문학회 2015 작문연구 Vol.0 No.26

본 연구는 대학 글쓰기 교육에서 학습관리시스템 블랙보드(Blackboard)를 활용한 사례를 소개하고, 블랙보드를 활용한 대학 글쓰기 교육의 성과 및 함의를 밝히는 것을 목적으로 한다. 기존의 면대면 대학 글쓰기 교육에서 교수·학습 주체 간 상호 작용이 저조하며, 교수자가 학습자에게 피드백을 제공하는 것에 대한 부담을 갖고 있다. 이러한 대학 글쓰기 교육에서 갖는 문제점 과 한계를 보완하기 위해서 본 연구에서는 블랙보드를 활용한 블렌디드 러닝(Blended learning)을 수행하였다. 이를 위해 대학 글쓰기 교육에서 수업 전, 중, 후의 진행 맥락에 따라 블랙보드를 활용할 수 있는 사례를 제안하고, 글쓰기 수업에서 블랙보드를 활용한 성과 및 과제를 제시하였다. 연구 결과를 정리해 보면 블랙보드는 글쓰기 과정에서 교수·학습 주체의 상호작용 강화 측면과 피드백의 활성화를 통한 글쓰기 밀착 지도 측면에서 함의를 찾을 수 있었다. 또한 본 연구는 국내 대학에 미래지향적 학습관리시스템의 도입의 필요함을 시사하고, 소통 중심의 밀착 지도형 대학 글쓰기 교육을 강조하였다. The purpose of this essay was to introduce cases that Blackboard as a learning management system has been used for developing academic writing proficiency and to disclose educationally good results and significance of using Blackboard in college writing. Blackboard Learn platform has been used primarily for online or blended learning, supporting the placement of course materials online, associating students with courses, and mediating communication between the students as well as their instructor etc. in oder to enhance and support collaborative learning in classroom teaching. This essay also tried to establish a categorial model, "Before instruction" "In instruction", and "After instruction" to interrogate the actual condition and the cases when Blackboard was utilized for college writing. Results of this research were as follows. First, Blackboard carried out the effective function mediating communication between the students as well as their instructor in aspect of the developable management. Second, Blackboard could have implications for providing feedback in aspect of customer relationship management. Here was to study effective strategy to introduce LMS as future-oriented educational technology. A instructional design guideline was proposed for effective management of interactivity and communication in college writing.